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The map label for this gene is purK [H]

Identifier: 148358427

GI number: 148358427

Start: 305074

End: 306153

Strand: Reverse

Name: purK [H]

Synonym: LPC_0293

Alternate gene names: 148358427

Gene position: 306153-305074 (Counterclockwise)

Preceding gene: 148358428

Following gene: 148358423

Centisome position: 8.56

GC content: 41.2

Gene sequence:

>1080_bases
ATGAAACTTGGTATTCTAGGTGGGGGCCAACTTGCAAGAATGTTGGCATTAGCAGCATATCCTTTAGGGATTAACACTGT
CTGCCTGGATCCCAGTCCTGACGCCTGTGCTGGTCAACTCACCAAACTGATAGTCTCTGATTTTAATGATGAATTGGCTT
TAAAACAATTTTTGTCAGAAGTGGATTGCGTCACAATAGAAACCGAAAATATACCTTTTTCTTGCGCCGAATTGGCTGCC
CAAATAAAGCCTTTCTATCCATCAACCCAAGCTTTGAAAATTACGCAAGACAGATTGTATGAAAAAAATTTTTTCAGAAC
TCTGAATATTCCTGTACCAGAATTTTTACCGGTTGAATCAGAAGATGAATTGATGCAGGCTATTTCAGTTATAGGAATGC
CTGCTGTGTTAAAAACAAGAAGGTTTGGCTATGATGGCAAGGGCCAATATGTCTTGCGAACCCAAGCTGATATTTCAAAA
AGTTGGAGCCTGTTAGGCAGCCAAGCTCTCATTCTTGAAAAATTAATCTCCTTTGAAAGCGAATTTTCGTTAATTGCTGT
TCGTAATAAGAGTGGTGAAACAAGTTTCTACCCATTGATTAAAAATCATCACAGGAAGGGCATTTTACATTTCTCAGAAG
CCCCTGTTCATCAGGATACCTTACAACAGGAGGCGCAAACTCATGCATTCAAAATTTTAGAAGCCCTGAATTATGTCGGT
GTACTTACCATTGAGTTTTTTTATCAAGGCAACCAATTGATTGCGAATGAGATAGCGCCACGCGTACATAATTCTGGCCA
CTGGACTATTGAGGGAGCACATACCAGCCAATTCGAAAATCATCTGCGCGCTCTTTTTGATTTGCCCTTGGGAAGCACTG
AAGTGAGCGGCTCTTGTTTTTTATTAAATTGCATTGGCAATCTGCTGCCATTGGAGCCCTGTTTATCGATCCCGGGCGTT
CATTATCACGCCTATGGAAAAGCACCCCGGCCAGATCGCAAGGTAGGCCACGTTACCCTTGTCGATACTGATTTGGAACG
TTATACAAAAAGTAAAGACTTACTTCTTGACATTTCATGA

Upstream 100 bases:

>100_bases
TTGCTAATAAATATCCTGACATTCGAGCTGCCTTAAAACGTTATCGAGAACAACAAACACAAAAAGTGCTCGACAATCCA
AACCCTAAAGAGGAAAAGTC

Downstream 100 bases:

>100_bases
GTAGCAGATAGTGAGAAAGCAAGCAATGGCAGTCAGTGCATAATATTGTTCGCAATTTGGAAAGCTGAGTTTTGTATTCT
GTTTCCTACTGCTCATCTAC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTKLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELAA
QIKPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVESEDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISK
SWSLLGSQALILEKLISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCFLLNCIGNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLVDTDLERYTKSKDLLLDIS

Sequences:

>Translated_359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTKLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELAA
QIKPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVESEDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISK
SWSLLGSQALILEKLISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCFLLNCIGNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLVDTDLERYTKSKDLLLDIS
>Mature_359_residues
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTKLIVSDFNDELALKQFLSEVDCVTIETENIPFSCAELAA
QIKPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVESEDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISK
SWSLLGSQALILEKLISFESEFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCFLLNCIGNLLPLEPCLSIPGV
HYHAYGKAPRPDRKVGHVTLVDTDLERYTKSKDLLLDIS

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=357, Percent_Identity=36.1344537815126, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1788155, Length=308, Percent_Identity=25.974025974026, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=365, Percent_Identity=33.1506849315069, Blast_Score=200, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39915; Mature: 39915

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTKLIVSDFNDELALKQFLSE
CEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VDCVTIETENIPFSCAELAAQIKPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVES
CCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCEEEECCCCCCCCCCCC
EDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISKSWSLLGSQALILEKLISFES
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHCCCC
EFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
CCEEEEEECCCCCCEEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHE
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCF
EEEEEEEECCCEEEHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEE
LLNCIGNLLPLEPCLSIPGVHYHAYGKAPRPDRKVGHVTLVDTDLERYTKSKDLLLDIS
EHHHHHCCCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKLGILGGGQLARMLALAAYPLGINTVCLDPSPDACAGQLTKLIVSDFNDELALKQFLSE
CEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VDCVTIETENIPFSCAELAAQIKPFYPSTQALKITQDRLYEKNFFRTLNIPVPEFLPVES
CCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCEEEECCCCCCCCCCCC
EDELMQAISVIGMPAVLKTRRFGYDGKGQYVLRTQADISKSWSLLGSQALILEKLISFES
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHCCCC
EFSLIAVRNKSGETSFYPLIKNHHRKGILHFSEAPVHQDTLQQEAQTHAFKILEALNYVG
CCEEEEEECCCCCCEEEHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHE
VLTIEFFYQGNQLIANEIAPRVHNSGHWTIEGAHTSQFENHLRALFDLPLGSTEVSGSCF
EEEEEEEECCCEEEHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCEE
LLNCIGNLLPLEPCLSIPGVHYHAYGKAPRPDRKVGHVTLVDTDLERYTKSKDLLLDIS
EHHHHHCCCCCCHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]