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The map label for this gene is groEL [H]

Identifier: 148284512

GI number: 148284512

Start: 891344

End: 893008

Strand: Direct

Name: groEL [H]

Synonym: OTBS_0917

Alternate gene names: 148284512

Gene position: 891344-893008 (Clockwise)

Preceding gene: 148284511

Following gene: 148284516

Centisome position: 41.91

GC content: 35.98

Gene sequence:

>1665_bases
ATGAGTAAACAAATTGTACATAGCGATCAATGTCGTAAAAAAATAATAGAAGGCATAAATGTTGTAGCTAACGCAGTAGG
TATAACATTAGGACCTAAAGGTAGATGTGTAGCAATAGAACAATCTTATGGTCCACCTAAAATTACTAAAGATGGAGTTA
GTGTTGCTAAAGCAATTCAACTTAAGGATAAATCTCTTAATGTTGGAGCCCAATTTGTTATATCAGTTGCTAGTAAAACA
GCTGATGTAGCTGGTGATGGTACAACTACTGCGACAGTTATAGCTGATGCTGCAGTTAGGGAGCTAAATAAAGCTGAAGT
TGCAGGCATTGATATACAGGAAGTAAGAAAAGGTGCTGAGAAAGCTGTTGAAGCAGTTATTGCAGATGTACGTAAAAACA
GTAGCCCTGTTAAAAACGAAGAAGAAATTGCTCAAGTAGCTACTGTTTCATCTAATGGAGACCGTGAAATTGGTGAAAAG
ATTGCTAATGCAATGAAACAAGTTGGCCAAGAAGGAGTGATAACTGTTGAAGATTCTAAAAATTTTAACTTTGAAGTTGA
AGTTGTTAAAGGAATGAGATTTGACCGTGGATATATATCACAGTACTTTGCAACGAATCGTGAAAAGATGATTACCGAAT
TTGAAAATCCTTATATTTTGCTGTTGGATCAGAAGGTATCTACAGTACAGCCACTTGTCCCTGTTCTTGAGGCAGTTGCT
CATACTGGCAAACCATTAGTATTAATTGCTGATGATGTAGACGGAGAAGCTCTTACCGCATTGATATTAAACAATTTAAA
AGGTTCCATTAAAGTAGTGGCAGTTAAAGCGCCAGGTTTTGGTGATCGTAAAAAAGAAATGTTGGAAGATATTGCTATTT
TAACAAATGGAGAAGTAATTACTGAACAACTAGGAATCAAACTAGAAAAGGTTAATGATACATCTAAGTTAGGAACTGCA
AATAGAGTTATTGTTACAAAAGATCATACTACTATAGTTCATGATAAGAATAATAGTGATATAGAGAAGAAAGTTAATTC
TCGTTGTGAACAGATTCGTGAAGCAATTAAAGATACAACTTCAGATTATGAAAAAGAAAAATTACAAGAGCGCTTAGCAA
AACTTAGAAACGGTGTAGCTGTACTAAAAGTTGGTGGTGCTACTGAAGTAGAACAAAAAGAACGTAAGGATAGAGTAGAA
GATGCTTTACATGCTACTAGAGCAGCTGTTGAAGAAGGTATAGTGCCTGGTGGTGGTGTTGCGCTATTTTATGCCTCTCG
TGTTTTAGATAGTTTGAAGTTTGATAATGAAGATCAAAGGGTAGGTATTAACATTATCAAAAAAGTATTAGAAGCTCCGG
TAAGACAAATAGTTAAAAATGCTGGAGGCAAAGAGGATGTTGTTGTTAATGAACTAAGCAAGAGTAACGATAAAAACCGT
GGATTTGATGCTAGAACAATGCAATATGTTGATATGATAAAAGCAGGTATTGTGGATCCAACTAAAGTCGTACGTACTGC
ATTACAAGACGCTTTTTCTGTGGCTTCATTAGTAATTGCTACCTCAGCTATGATTACTGATCATGAGGAAGATAATAATA
CTAACCGCAGTGGTGGTGGAGTAGGTGGCGGACATCATGGTGGTATGGGCGGAATGGATTTCTAA

Upstream 100 bases:

>100_bases
ATCAGATATATTATTAGTTAAAAGCTAAAATGCTTAATGAATTAATAATTAAATGATGCTAGACTAATCAAATTATAAAA
TATTTTAAGGAGTTTTCAGT

Downstream 100 bases:

>100_bases
TCCGCCCACATGTCTACCTTCAAAAAAAAATAGAGTATAACTTTTGTATAAGGTTGCTAGTTATGTATTTTTTTACAAAA
TTGCAGTATAATATTTCAAG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSKQIVHSDQCRKKIIEGINVVANAVGITLGPKGRCVAIEQSYGPPKITKDGVSVAKAIQLKDKSLNVGAQFVISVASKT
ADVAGDGTTTATVIADAAVRELNKAEVAGIDIQEVRKGAEKAVEAVIADVRKNSSPVKNEEEIAQVATVSSNGDREIGEK
IANAMKQVGQEGVITVEDSKNFNFEVEVVKGMRFDRGYISQYFATNREKMITEFENPYILLLDQKVSTVQPLVPVLEAVA
HTGKPLVLIADDVDGEALTALILNNLKGSIKVVAVKAPGFGDRKKEMLEDIAILTNGEVITEQLGIKLEKVNDTSKLGTA
NRVIVTKDHTTIVHDKNNSDIEKKVNSRCEQIREAIKDTTSDYEKEKLQERLAKLRNGVAVLKVGGATEVEQKERKDRVE
DALHATRAAVEEGIVPGGGVALFYASRVLDSLKFDNEDQRVGINIIKKVLEAPVRQIVKNAGGKEDVVVNELSKSNDKNR
GFDARTMQYVDMIKAGIVDPTKVVRTALQDAFSVASLVIATSAMITDHEEDNNTNRSGGGVGGGHHGGMGGMDF

Sequences:

>Translated_554_residues
MSKQIVHSDQCRKKIIEGINVVANAVGITLGPKGRCVAIEQSYGPPKITKDGVSVAKAIQLKDKSLNVGAQFVISVASKT
ADVAGDGTTTATVIADAAVRELNKAEVAGIDIQEVRKGAEKAVEAVIADVRKNSSPVKNEEEIAQVATVSSNGDREIGEK
IANAMKQVGQEGVITVEDSKNFNFEVEVVKGMRFDRGYISQYFATNREKMITEFENPYILLLDQKVSTVQPLVPVLEAVA
HTGKPLVLIADDVDGEALTALILNNLKGSIKVVAVKAPGFGDRKKEMLEDIAILTNGEVITEQLGIKLEKVNDTSKLGTA
NRVIVTKDHTTIVHDKNNSDIEKKVNSRCEQIREAIKDTTSDYEKEKLQERLAKLRNGVAVLKVGGATEVEQKERKDRVE
DALHATRAAVEEGIVPGGGVALFYASRVLDSLKFDNEDQRVGINIIKKVLEAPVRQIVKNAGGKEDVVVNELSKSNDKNR
GFDARTMQYVDMIKAGIVDPTKVVRTALQDAFSVASLVIATSAMITDHEEDNNTNRSGGGVGGGHHGGMGGMDF
>Mature_553_residues
SKQIVHSDQCRKKIIEGINVVANAVGITLGPKGRCVAIEQSYGPPKITKDGVSVAKAIQLKDKSLNVGAQFVISVASKTA
DVAGDGTTTATVIADAAVRELNKAEVAGIDIQEVRKGAEKAVEAVIADVRKNSSPVKNEEEIAQVATVSSNGDREIGEKI
ANAMKQVGQEGVITVEDSKNFNFEVEVVKGMRFDRGYISQYFATNREKMITEFENPYILLLDQKVSTVQPLVPVLEAVAH
TGKPLVLIADDVDGEALTALILNNLKGSIKVVAVKAPGFGDRKKEMLEDIAILTNGEVITEQLGIKLEKVNDTSKLGTAN
RVIVTKDHTTIVHDKNNSDIEKKVNSRCEQIREAIKDTTSDYEKEKLQERLAKLRNGVAVLKVGGATEVEQKERKDRVED
ALHATRAAVEEGIVPGGGVALFYASRVLDSLKFDNEDQRVGINIIKKVLEAPVRQIVKNAGGKEDVVVNELSKSNDKNRG
FDARTMQYVDMIKAGIVDPTKVVRTALQDAFSVASLVIATSAMITDHEEDNNTNRSGGGVGGGHHGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=51.2333965844402, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=51.2333965844402, Blast_Score=498, Evalue=1e-141,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=53.4220532319392, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=50.7575757575758, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=53.5885167464115, Blast_Score=214, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=528, Percent_Identity=50.3787878787879, Blast_Score=502, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=49.5256166982922, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=49.5256166982922, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=48.4848484848485, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=48.4848484848485, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=48.4848484848485, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17864606, Length=556, Percent_Identity=38.8489208633094, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24584129, Length=521, Percent_Identity=36.2763915547025, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI19921262, Length=521, Percent_Identity=36.2763915547025, Blast_Score=297, Evalue=1e-80,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59716; Mature: 59585

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQIVHSDQCRKKIIEGINVVANAVGITLGPKGRCVAIEQSYGPPKITKDGVSVAKAIQ
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHH
LKDKSLNVGAQFVISVASKTADVAGDGTTTATVIADAAVRELNKAEVAGIDIQEVRKGAE
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHH
KAVEAVIADVRKNSSPVKNEEEIAQVATVSSNGDREIGEKIANAMKQVGQEGVITVEDSK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
NFNFEVEVVKGMRFDRGYISQYFATNREKMITEFENPYILLLDQKVSTVQPLVPVLEAVA
CCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
HTGKPLVLIADDVDGEALTALILNNLKGSIKVVAVKAPGFGDRKKEMLEDIAILTNGEVI
HCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHH
TEQLGIKLEKVNDTSKLGTANRVIVTKDHTTIVHDKNNSDIEKKVNSRCEQIREAIKDTT
HHHHCCEEEECCCCHHCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
SDYEKEKLQERLAKLRNGVAVLKVGGATEVEQKERKDRVEDALHATRAAVEEGIVPGGGV
CHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
ALFYASRVLDSLKFDNEDQRVGINIIKKVLEAPVRQIVKNAGGKEDVVVNELSKSNDKNR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
GFDARTMQYVDMIKAGIVDPTKVVRTALQDAFSVASLVIATSAMITDHEEDNNTNRSGGG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VGGGHHGGMGGMDF
CCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQIVHSDQCRKKIIEGINVVANAVGITLGPKGRCVAIEQSYGPPKITKDGVSVAKAIQ
CCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHH
LKDKSLNVGAQFVISVASKTADVAGDGTTTATVIADAAVRELNKAEVAGIDIQEVRKGAE
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHH
KAVEAVIADVRKNSSPVKNEEEIAQVATVSSNGDREIGEKIANAMKQVGQEGVITVEDSK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
NFNFEVEVVKGMRFDRGYISQYFATNREKMITEFENPYILLLDQKVSTVQPLVPVLEAVA
CCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHH
HTGKPLVLIADDVDGEALTALILNNLKGSIKVVAVKAPGFGDRKKEMLEDIAILTNGEVI
HCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHH
TEQLGIKLEKVNDTSKLGTANRVIVTKDHTTIVHDKNNSDIEKKVNSRCEQIREAIKDTT
HHHHCCEEEECCCCHHCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
SDYEKEKLQERLAKLRNGVAVLKVGGATEVEQKERKDRVEDALHATRAAVEEGIVPGGGV
CHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
ALFYASRVLDSLKFDNEDQRVGINIIKKVLEAPVRQIVKNAGGKEDVVVNELSKSNDKNR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
GFDARTMQYVDMIKAGIVDPTKVVRTALQDAFSVASLVIATSAMITDHEEDNNTNRSGGG
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VGGGHHGGMGGMDF
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA