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The map label for this gene is lon [H]

Identifier: 148284484

GI number: 148284484

Start: 837881

End: 840241

Strand: Direct

Name: lon [H]

Synonym: OTBS_0855

Alternate gene names: 148284484

Gene position: 837881-840241 (Clockwise)

Preceding gene: 148284482

Following gene: 148284488

Centisome position: 39.39

GC content: 31.39

Gene sequence:

>2361_bases
GTGGCACAAGTTTTAAATGATATTAGTAATCGTGTTTTACCATTATTTCCAATAAGAAACACAGTATTATTTCCTGGGCT
AGTATTGCCTATATTAATTGGCAGAGATGATTCGGTTAAAAATTTGCTAAGATTAGGCAATGATTCTGAGAATCAGCATA
CTATCTTGCTTACTACTCAAAAAAATGCTGATGATATCAAACCTTCAATAAATTCTTTATATAAAATTGGAGTATTGGCA
AAAATAACTGAGCTAGTTCAATTGCCTAATGACAATTATAAAATCTTGATAAAAGTATTAGATCGAGTCAGACTGACAAT
AAGACGCTCGCAGGACCTTTTAGTAGCTGAATATGTAATTGTTCCAGATGATGAAATTAATAATGCTGAGGAAATAAAAG
ATAAGTTAGCAAATGCAATTGTTCTTTTTAATAAATATATTAGGTTAAGTAAAAAAATCAACCCAGACTTATTAGTTCAT
GTTTTATCGTACACTAATCAAAGCTATGTAGTTAACGCTTTAGCTGCAAATTTAATTTGCAGTGTTTCTAACAAGCAATC
TTTGTTAGAAATAACTGATGTTAAACAAAGAATAGAAAAGCTAACTGATCATGTTGCTAAAGAAATCATTATAATGGAAA
CAGATGAGTTGATTACTTCAAAGGCTCAGAAAAATCTAGAAAAAATGCAGCGTGATTGCTTTCTTAATGAAAAGATGAAA
ATAATTAAAAACGTTTTAGGAGTAGATGATGAAAAATCTGATATTGCTGAACTGCAAAAAAAAATCGACACTCTCCATCT
TTCAAAAGAAGCAAAAGCTAAAGCTGAAAGCGAGTTAAAAAAATTAAAGATGATGAATCCAATTTCTGCTGAAGCTGCAT
TAACGCGTAATTATTTAGATATTCTTCTAGGATTACCATGGAAAAAAGAAAAAGAAAGTAAGATTAACATTAATATTGAC
AATGCCTTACAAGACTTGAATGCAGATCATCATGGGCTAGAAAAAGTTAAGGAAAGAATAACTGAATATTTAGCAGTACT
GCAAAGGACTAAAAAATCTATAGGGACAATCTTATGTTTTATTGGTCCACCTGGAGTAGGAAAAACATCTTTAGTAAAAT
CTATTGCAGAAGCTACAAAATGTAAATATGCGAAATTTGCTCTAGGTGGAGTGAGAGATGAAGCAGAAATTCGTGGGCAC
AGAAAAACTTATATTGGAGCAATGCCAGGTAAAATTATTTCTTTAATAAAAAGGGAAAATAGTAATAATCTTGTCATATT
ACTAGATGAAATTGATAAGATTTCTAGAGATTCTAGAGGTGATCCAGCATTTGCTTTATTAGAAGCATTAGATCCAGAGC
AAAATAGCCGATTTCAAGATAATTACCTAGAAGTAGAGTATGATCTTTCAAAAGTACTTTTTATTGCTACTGCTAACAGT
TTTAATTTTCCTCTTCCTTTGCGTGATCGTATGGAAATCATTCAAATTCCTGGGTATGTTGAAGATGAAAAATTAGAAAT
AGCTAAACATCACCTCATTCCTAAACAGATCAAAAATAACGGCTTAAAAAATACTGAAATCAGTTTTTCAGATGAAGCAA
TATTAGAGTTAATAAGATATTATACACGAGAAGCTGGAGTTAGAGGTCTAGAAAGAAATATCGGAGGAATATGCCGTAAG
GTGCTTAAGAAAATTTTAAGTTCTAAAGATATAAAATCAGAAAATGTTAGCAAAGAAAATATTAAAGATTATCTTGGATC
TAGAAAATATAAGTATGGGCTTGCTGAAGATGATAATCAAGTAGGTATTACTATTGGATTAGCTTATACTGAAACAGGTG
GAGATTTGATTTGGGTTGAAGCAGTAATGATACCTGGCAAAGGAAAAATTAAAGCTACAGGTAAGTTAGGTGATGTTATG
AAGGAGTCAAGCCAAACTGCATTTAGCTATTTTTGCTCCAGAGCACAAAAATATAATGTAAAGTATGAGCAATATCATAA
GTATGATATTCATCTTCATTTTCCTGAAGGAGCTACACCTAAAGATGGACCTTCTGCAGGTATAGCTATTTTTACTACGA
TAGTTTCCTTAATGACAGGAATACCTGTCAAGCTTTCAGTAGCAATGACTGGTGAAATTACTTTAAGAGGACGGATATTA
CCTATTGGAGGACTTAAAGAAAAGTTAATGGCAGCAAAACGAGGAGGAATTAAAACAGTAATTATTCCAGAAGGAAATAC
TAGTGATTTAGAAGATATACCTAATAGTATTAAAGATGATTTAGATATTATCCCATTATCAGAAGCAGATCAAGTACTAG
ATATTGCTTTGGCTACTACAGTAACCAGTTTTCATGCATAA

Upstream 100 bases:

>100_bases
CTATGCAAAATATTCATATGTAAAATAATTGAATTTAATTATCTGTGTGATTATATAGATTATCATGATATACTAGTAAA
TAAAAATTTAATTATATTTA

Downstream 100 bases:

>100_bases
AAAGCTTGTTAGTATTTGTTAATTTCTCTATAAAATAGAAAGCAAATCAGAATATAGCTTTAAAGCCTTTGATATACTAC
TTAAGTAGCTCTTTGAGTAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 786; Mature: 785

Protein sequence:

>786_residues
MAQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQKNADDIKPSINSLYKIGVLA
KITELVQLPNDNYKILIKVLDRVRLTIRRSQDLLVAEYVIVPDDEINNAEEIKDKLANAIVLFNKYIRLSKKINPDLLVH
VLSYTNQSYVVNALAANLICSVSNKQSLLEITDVKQRIEKLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLDILLGLPWKKEKESKININID
NALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCFIGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGH
RKTYIGAMPGKIISLIKRENSNNLVILLDEIDKISRDSRGDPAFALLEALDPEQNSRFQDNYLEVEYDLSKVLFIATANS
FNFPLPLRDRMEIIQIPGYVEDEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRYYTREAGVRGLERNIGGICRK
VLKKILSSKDIKSENVSKENIKDYLGSRKYKYGLAEDDNQVGITIGLAYTETGGDLIWVEAVMIPGKGKIKATGKLGDVM
KESSQTAFSYFCSRAQKYNVKYEQYHKYDIHLHFPEGATPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKDDLDIIPLSEADQVLDIALATTVTSFHA

Sequences:

>Translated_786_residues
MAQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQKNADDIKPSINSLYKIGVLA
KITELVQLPNDNYKILIKVLDRVRLTIRRSQDLLVAEYVIVPDDEINNAEEIKDKLANAIVLFNKYIRLSKKINPDLLVH
VLSYTNQSYVVNALAANLICSVSNKQSLLEITDVKQRIEKLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLDILLGLPWKKEKESKININID
NALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCFIGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGH
RKTYIGAMPGKIISLIKRENSNNLVILLDEIDKISRDSRGDPAFALLEALDPEQNSRFQDNYLEVEYDLSKVLFIATANS
FNFPLPLRDRMEIIQIPGYVEDEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRYYTREAGVRGLERNIGGICRK
VLKKILSSKDIKSENVSKENIKDYLGSRKYKYGLAEDDNQVGITIGLAYTETGGDLIWVEAVMIPGKGKIKATGKLGDVM
KESSQTAFSYFCSRAQKYNVKYEQYHKYDIHLHFPEGATPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKDDLDIIPLSEADQVLDIALATTVTSFHA
>Mature_785_residues
AQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQKNADDIKPSINSLYKIGVLAK
ITELVQLPNDNYKILIKVLDRVRLTIRRSQDLLVAEYVIVPDDEINNAEEIKDKLANAIVLFNKYIRLSKKINPDLLVHV
LSYTNQSYVVNALAANLICSVSNKQSLLEITDVKQRIEKLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMKI
IKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLDILLGLPWKKEKESKININIDN
ALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCFIGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGHR
KTYIGAMPGKIISLIKRENSNNLVILLDEIDKISRDSRGDPAFALLEALDPEQNSRFQDNYLEVEYDLSKVLFIATANSF
NFPLPLRDRMEIIQIPGYVEDEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRYYTREAGVRGLERNIGGICRKV
LKKILSSKDIKSENVSKENIKDYLGSRKYKYGLAEDDNQVGITIGLAYTETGGDLIWVEAVMIPGKGKIKATGKLGDVMK
ESSQTAFSYFCSRAQKYNVKYEQYHKYDIHLHFPEGATPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRILP
IGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKDDLDIIPLSEADQVLDIALATTVTSFHA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=840, Percent_Identity=37.3809523809524, Blast_Score=498, Evalue=1e-140,
Organism=Homo sapiens, GI21396489, Length=621, Percent_Identity=40.5797101449275, Blast_Score=464, Evalue=1e-130,
Organism=Escherichia coli, GI1786643, Length=774, Percent_Identity=49.3540051679587, Blast_Score=741, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=687, Percent_Identity=39.0101892285298, Blast_Score=440, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17556486, Length=529, Percent_Identity=40.0756143667297, Blast_Score=400, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319449, Length=652, Percent_Identity=40.6441717791411, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI221513036, Length=614, Percent_Identity=42.3452768729642, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24666867, Length=614, Percent_Identity=42.3452768729642, Blast_Score=466, Evalue=1e-131,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87917; Mature: 87786

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQ
CHHHHHHHHCCCEEEEECCCHHHCCHHHHHHEECCCHHHHHHHHCCCCCCCCEEEEEEEC
KNADDIKPSINSLYKIGVLAKITELVQLPNDNYKILIKVLDRVRLTIRRSQDLLVAEYVI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VPDDEINNAEEIKDKLANAIVLFNKYIRLSKKINPDLLVHVLSYTNQSYVVNALAANLIC
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHE
SVSNKQSLLEITDVKQRIEKLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
ECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLD
HHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILLGLPWKKEKESKININIDNALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCF
HHHCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
IGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGHRKTYIGAMPGKIISLIKREN
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHCCC
SNNLVILLDEIDKISRDSRGDPAFALLEALDPEQNSRFQDNYLEVEYDLSKVLFIATANS
CCCEEEEEECHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEEECCC
FNFPLPLRDRMEIIQIPGYVEDEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRY
CCCCCCCHHCHHEEECCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHH
YTREAGVRGLERNIGGICRKVLKKILSSKDIKSENVSKENIKDYLGSRKYKYGLAEDDNQ
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEECCCCCCCCC
VGITIGLAYTETGGDLIWVEAVMIPGKGKIKATGKLGDVMKESSQTAFSYFCSRAQKYNV
EEEEEEEEEECCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
KYEQYHKYDIHLHFPEGATPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
CHHHEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEE
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKDDLDIIPLSEADQVLDIALATT
ECCCHHHHHHHHHCCCEEEEEECCCCCCCHHHCCHHHHCCCCEEECCCCHHHHHHHHHHH
VTSFHA
HHHCCC
>Mature Secondary Structure 
AQVLNDISNRVLPLFPIRNTVLFPGLVLPILIGRDDSVKNLLRLGNDSENQHTILLTTQ
HHHHHHHHCCCEEEEECCCHHHCCHHHHHHEECCCHHHHHHHHCCCCCCCCEEEEEEEC
KNADDIKPSINSLYKIGVLAKITELVQLPNDNYKILIKVLDRVRLTIRRSQDLLVAEYVI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VPDDEINNAEEIKDKLANAIVLFNKYIRLSKKINPDLLVHVLSYTNQSYVVNALAANLIC
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHE
SVSNKQSLLEITDVKQRIEKLTDHVAKEIIIMETDELITSKAQKNLEKMQRDCFLNEKMK
ECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKNVLGVDDEKSDIAELQKKIDTLHLSKEAKAKAESELKKLKMMNPISAEAALTRNYLD
HHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ILLGLPWKKEKESKININIDNALQDLNADHHGLEKVKERITEYLAVLQRTKKSIGTILCF
HHHCCCCCCCCCCEEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
IGPPGVGKTSLVKSIAEATKCKYAKFALGGVRDEAEIRGHRKTYIGAMPGKIISLIKREN
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHCCC
SNNLVILLDEIDKISRDSRGDPAFALLEALDPEQNSRFQDNYLEVEYDLSKVLFIATANS
CCCEEEEEECHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEEECCC
FNFPLPLRDRMEIIQIPGYVEDEKLEIAKHHLIPKQIKNNGLKNTEISFSDEAILELIRY
CCCCCCCHHCHHEEECCCCCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHHH
YTREAGVRGLERNIGGICRKVLKKILSSKDIKSENVSKENIKDYLGSRKYKYGLAEDDNQ
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEECCCCCCCCC
VGITIGLAYTETGGDLIWVEAVMIPGKGKIKATGKLGDVMKESSQTAFSYFCSRAQKYNV
EEEEEEEEEECCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCC
KYEQYHKYDIHLHFPEGATPKDGPSAGIAIFTTIVSLMTGIPVKLSVAMTGEITLRGRIL
CHHHEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEEE
PIGGLKEKLMAAKRGGIKTVIIPEGNTSDLEDIPNSIKDDLDIIPLSEADQVLDIALATT
ECCCHHHHHHHHHCCCEEEEEECCCCCCCHHHCCHHHHCCCCEEECCCCHHHHHHHHHHH
VTSFHA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA