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The map label for this gene is atpB

Identifier: 148284440

GI number: 148284440

Start: 750181

End: 750909

Strand: Direct

Name: atpB

Synonym: OTBS_0771

Alternate gene names: 148284440

Gene position: 750181-750909 (Clockwise)

Preceding gene: 148284439

Following gene: 148284441

Centisome position: 35.27

GC content: 29.77

Gene sequence:

>729_bases
ATGTTAGCTAATCCATTAAGCCAGTTTTTGATTAAACCTATTATACCTCTAAAAGCGCTAGGTTATAATATCAGCATTAC
TAACTCAGCAGTGGCTATGATATTTGTCAGCATAGCCGCTAGTTTGTTGTTGATTATAGCATTTGTTAATAGTAAACTTG
TTCCTTCAAGGTGGCAAGCTTTTGGAGAAATATTATACGAGTCAAACATAAAACTAGTACATAGCATTATAGGTCCACAA
GGGAAAGTTTTTTTTCCTTTGATACTTACTTTATTTCTTTTTATTAGTCTTGGTAACATTATTGGAATGGTTCCACATGC
CTTTACATTTACTAGCCATATAATAGTTACATTCAGTTTAGCAATGATAGTATTTACTACTACTTTAGTTTATGGCATCT
ATAGACACAAGTTAGGATTTTTTTCGTTATTCTTACCCAAAAATATACCTCTTTGGTTAGCACCGATAATGGTCATAATT
GAATTATGTGTTTTCATTTCTAAACCAATTAGTTTATCTCTACGACTAACTGCAAATATGGTAGCAGGACATATATTACT
AAAAATTATTGCTTGGTCTATTGTTAGTTTAACTTGGTTTTTTAAGCCATTGCCTATAGCTTTAGTTATTGTACTCATTG
GATTTGAATTATTTATTTCTATCCTACAAGCATATATTTTTACAATTTTATCTTGTGTATATTTAAGAGATGTAGTAAAT
TTACATTGA

Upstream 100 bases:

>100_bases
GCTTAAGGAAATTGGCGTACTGAGCGGTAGTAGGGCTTACCGGGCAACAGAAAAGCCCTAATTAATCTACTTAAAACACA
AAAATATACTATTTCTTGTA

Downstream 100 bases:

>100_bases
AAATATAGTATGTAATACTATATTTAAATAACAAAATTATACAGGAGATTAATGCATGGACCCTATATCTTTTAAGTACA
TAGCTATAGCTTTCATGGCG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLANPLSQFLIKPIIPLKALGYNISITNSAVAMIFVSIAASLLLIIAFVNSKLVPSRWQAFGEILYESNIKLVHSIIGPQ
GKVFFPLILTLFLFISLGNIIGMVPHAFTFTSHIIVTFSLAMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVII
ELCVFISKPISLSLRLTANMVAGHILLKIIAWSIVSLTWFFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
LH

Sequences:

>Translated_242_residues
MLANPLSQFLIKPIIPLKALGYNISITNSAVAMIFVSIAASLLLIIAFVNSKLVPSRWQAFGEILYESNIKLVHSIIGPQ
GKVFFPLILTLFLFISLGNIIGMVPHAFTFTSHIIVTFSLAMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVII
ELCVFISKPISLSLRLTANMVAGHILLKIIAWSIVSLTWFFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
LH
>Mature_242_residues
MLANPLSQFLIKPIIPLKALGYNISITNSAVAMIFVSIAASLLLIIAFVNSKLVPSRWQAFGEILYESNIKLVHSIIGPQ
GKVFFPLILTLFLFISLGNIIGMVPHAFTFTSHIIVTFSLAMIVFTTTLVYGIYRHKLGFFSLFLPKNIPLWLAPIMVII
ELCVFISKPISLSLRLTANMVAGHILLKIIAWSIVSLTWFFKPLPIALVIVLIGFELFISILQAYIFTILSCVYLRDVVN
LH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=194, Percent_Identity=28.3505154639175, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6226527, Length=251, Percent_Identity=33.4661354581673, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_ORITB (A5CDC5)

Other databases:

- EMBL:   AM494475
- RefSeq:   YP_001248530.1
- ProteinModelPortal:   A5CDC5
- STRING:   A5CDC5
- GeneID:   5219357
- GenomeReviews:   AM494475_GR
- KEGG:   ots:OTBS_0771
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   YIFTILT
- ProtClustDB:   PRK05815
- BioCyc:   OTSU357244:OTBS_0771-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27034; Mature: 27034

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe729d88)-; HASH(0xec752ac)-; HASH(0xdd4b7e0)-; HASH(0xb1f5060)-; HASH(0xec38070)-; HASH(0xe5ef7b8)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CH
>Mature Secondary Structure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CH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA