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The map label for this gene is adk

Identifier: 148268669

GI number: 148268669

Start: 2397282

End: 2397929

Strand: Reverse

Name: adk

Synonym: SaurJH9_2256

Alternate gene names: 148268669

Gene position: 2397929-2397282 (Counterclockwise)

Preceding gene: 148268670

Following gene: 148268668

Centisome position: 82.5

GC content: 35.65

Gene sequence:

>648_bases
ATGAATATCATTTTGATGGGTTTACCTGGCGCAGGTAAAGGAACTCAAGCAAGTGAAATTGTCAAGAAATTCCCAATACC
CCACATTTCAACTGGTGACATGTTCAGAAAAGCTATAAAAGAAGAAACTGAATTAGGTAAAGAAGCTAAGTCTTATATGG
ACCGTGGCGAATTAGTTCCTGATGAAGTGACTGTAGGTATCGTTAAGGAAAGAATTTCTGAAGACGATGCAAAAAAAGGC
TTTTTATTAGATGGCTTCCCAAGAACAATCGAGCAAGCTGAGGCATTAAATAATATTATGTCTGAGCTTGACAGAAACAT
TGATGCTGTCATCAATATCGAAGTTCCGGAAGAAGAATTAATGAACCGTCTTACAGGTCGTCGAATCTGTGAGTCATGTG
GTACAACGTATCATCTTGTATTTAATCCTCCGAAGGTCGAAGGTATTTGTGATATCGATGGTGGTAAATTGTATCAACGA
GAAGATGATAATCCTGAAACGGTAGCTAATCGTTTGAGTGTTAATATTAAACAATCTAAGCCTATTTTAGATTTCTATGA
TCAAAAAGGTGTATTGAAAAATATTGATGGTTCAAAAGATATTAGCGACGTTACCAAAGATGTCATTGATATTTTAGATC
ATTTGTAA

Upstream 100 bases:

>100_bases
GTTATTGGTGTAGCGATTGAAACAATGAAATCTTTAGAAGCTCAAGTATCTCAAAAAGAATATAAAGGCTTTGGTGGTAG
ATAATTTTAGGAGGGCACTT

Downstream 100 bases:

>100_bases
TAGATCAACTTTTAGCGGTCTATTTTAAGTGAGGCATGATTTAATCATATTAGATAGATGAGAGTGGCAATTAACGATAA
TTAATTCCCGTAATTTTTGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNIILMGLPGAGKGTQASEIVKKFPIPHISTGDMFRKAIKEETELGKEAKSYMDRGELVPDEVTVGIVKERISEDDAKKG
FLLDGFPRTIEQAEALNNIMSELDRNIDAVINIEVPEEELMNRLTGRRICESCGTTYHLVFNPPKVEGICDIDGGKLYQR
EDDNPETVANRLSVNIKQSKPILDFYDQKGVLKNIDGSKDISDVTKDVIDILDHL

Sequences:

>Translated_215_residues
MNIILMGLPGAGKGTQASEIVKKFPIPHISTGDMFRKAIKEETELGKEAKSYMDRGELVPDEVTVGIVKERISEDDAKKG
FLLDGFPRTIEQAEALNNIMSELDRNIDAVINIEVPEEELMNRLTGRRICESCGTTYHLVFNPPKVEGICDIDGGKLYQR
EDDNPETVANRLSVNIKQSKPILDFYDQKGVLKNIDGSKDISDVTKDVIDILDHL
>Mature_215_residues
MNIILMGLPGAGKGTQASEIVKKFPIPHISTGDMFRKAIKEETELGKEAKSYMDRGELVPDEVTVGIVKERISEDDAKKG
FLLDGFPRTIEQAEALNNIMSELDRNIDAVINIEVPEEELMNRLTGRRICESCGTTYHLVFNPPKVEGICDIDGGKLYQR
EDDNPETVANRLSVNIKQSKPILDFYDQKGVLKNIDGSKDISDVTKDVIDILDHL

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=43.21608040201, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=40.6698564593301, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=40.6698564593301, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=41.7910447761194, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=41.7910447761194, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=41.7910447761194, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=41.7910447761194, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI4502011, Length=217, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=29.9539170506912, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI22749187, Length=199, Percent_Identity=28.1407035175879, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI28144897, Length=217, Percent_Identity=27.6497695852535, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI28144899, Length=217, Percent_Identity=27.6497695852535, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=47.926267281106, Blast_Score=203, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=37.7358490566038, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=30.5164319248826, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17537943, Length=212, Percent_Identity=31.6037735849057, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=216, Percent_Identity=24.537037037037, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=41.7840375586854, Blast_Score=182, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6321018, Length=202, Percent_Identity=38.1188118811881, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=27.6995305164319, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=41.9811320754717, Blast_Score=176, Evalue=9e-45,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=40.8163265306122, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=40.8163265306122, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=31.2796208530806, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=31.2796208530806, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24663208, Length=212, Percent_Identity=25, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17647141, Length=212, Percent_Identity=25, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_STAAC (Q5HDX9)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_187028.1
- ProteinModelPortal:   Q5HDX9
- SMR:   Q5HDX9
- STRING:   Q5HDX9
- EnsemblBacteria:   EBSTAT00000010571
- GeneID:   3237692
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2218
- TIGR:   SACOL2218
- eggNOG:   COG0563
- GeneTree:   EBGT00050000025326
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- ProtClustDB:   PRK00279
- BioCyc:   SAUR93062:SACOL2218-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR008144
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23975; Mature: 23975

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00113 ADENYLATE_KINASE; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILMGLPGAGKGTQASEIVKKFPIPHISTGDMFRKAIKEETELGKEAKSYMDRGELVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DEVTVGIVKERISEDDAKKGFLLDGFPRTIEQAEALNNIMSELDRNIDAVINIEVPEEEL
HHHHHHHHHHHHCCCHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHH
MNRLTGRRICESCGTTYHLVFNPPKVEGICDIDGGKLYQREDDNPETVANRLSVNIKQSK
HHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCEEECCCCCCHHHHHHHHHEEECCCC
PILDFYDQKGVLKNIDGSKDISDVTKDVIDILDHL
CHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIILMGLPGAGKGTQASEIVKKFPIPHISTGDMFRKAIKEETELGKEAKSYMDRGELVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DEVTVGIVKERISEDDAKKGFLLDGFPRTIEQAEALNNIMSELDRNIDAVINIEVPEEEL
HHHHHHHHHHHHCCCHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHH
MNRLTGRRICESCGTTYHLVFNPPKVEGICDIDGGKLYQREDDNPETVANRLSVNIKQSK
HHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCEEECCCCCCHHHHHHHHHEEECCCC
PILDFYDQKGVLKNIDGSKDISDVTKDVIDILDHL
CHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA