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The map label for this gene is gyaR [H]

Identifier: 148268334

GI number: 148268334

Start: 2048862

End: 2049812

Strand: Reverse

Name: gyaR [H]

Synonym: SaurJH9_1916

Alternate gene names: 148268334

Gene position: 2049812-2048862 (Counterclockwise)

Preceding gene: 148268335

Following gene: 148268333

Centisome position: 70.52

GC content: 30.28

Gene sequence:

>951_bases
ATGAAAGTTGTTGGGTTAAATCGTATGCGTGAAGTTGAAACTGAATTACAACAACGCTTTTCAGATTTAGATTTTAAATT
TTATAAAAAAGCATCAGAAATACCTGAGAGTGACTTGGCTGATTTAGATATATTAGTTGGTTATGATGGCGGTATCAATG
AGGCATTTTTACAACGTTGCCCGAATTTAAAATGGATTGCATGGTTTGCAACGGGTGTAAATACATTACCGTTAGATTAT
ATTGCAGATCACGGCATACTTTTAACTAATGGAAAAGGTGTTCAAGCTAAACAATTATCTGAATACATTTTAGCTTTCAT
TTTAGATGATTATAAAAAGATGAAACTATCATATGATAACCAAAGACAACATATATATGATTCGAAAATAACTGGTAAAC
GCCTATCAGGACAAACAGTTTTATTTTTAGGTACAGGTGCAATTGCTACTAGAACTGCGAAGTTAGCAAAGGCTTTTAAT
ATGAATTTAATTGGTCTGAGCAAGTCAGGTCAGAACAAAGATGAGTTTGACGAGATATATACTATCGAATCACTTGAAAG
CACATTACCAAATGCTGACATTATTATAAATGCTTTACCAGAAACGCAAGAAACGATTCATTTACTAAAGAAAAAACATT
TTGAATTAATGAAAGATGAAGCACTTTTTATAAATATAGGACGAGGTAGCATAGTTAAAGAAGCGCTCTTAATAGAAGTA
TTAAAAAGTAAAGTTATTCGACATACATATTTAGATGTGTTTGAAAATGAACCTTTGAAACCTAATCATGAATTATATGA
ATTGGAAAATGTAACTATAACAGCGCATATAACTGGTAATGATTATGAGGCAAAGTATGACTTATTAGATATTTTTAAAA
ACAATCTAGTTAATTTTCTCAATAAGAATGGTCTAATTGAGAATGAAGTTGATGCTAAAAAAGGCTATTAA

Upstream 100 bases:

>100_bases
CTTTTATAATAGATGAACAAGGTAAAGTATTAGATGTTATCGAGAAGGTTAAGGTTAAAACACAAATAGAAGAACTTAAA
AACATTTTGGGGTGACATAT

Downstream 100 bases:

>100_bases
ATGAAATCATCATGTAAATATTGACACGCGCGCAATACTACAGTTATATTTATAGTAAGTAATAATAATTATTATATAAG
AAAGATGGTGATATAGATGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLQRCPNLKWIAWFATGVNTLPLDY
IADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
LKSKVIRHTYLDVFENEPLKPNHELYELENVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY

Sequences:

>Translated_316_residues
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLQRCPNLKWIAWFATGVNTLPLDY
IADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
LKSKVIRHTYLDVFENEPLKPNHELYELENVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY
>Mature_316_residues
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLQRCPNLKWIAWFATGVNTLPLDY
IADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
LKSKVIRHTYLDVFENEPLKPNHELYELENVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=248, Percent_Identity=28.2258064516129, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87082289, Length=298, Percent_Identity=26.510067114094, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=24.3801652892562, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787645, Length=202, Percent_Identity=25.2475247524752, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789279, Length=242, Percent_Identity=24.7933884297521, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=241, Percent_Identity=27.3858921161826, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=287, Percent_Identity=25.4355400696864, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=293, Percent_Identity=24.5733788395904, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=30.4597701149425, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=25.6, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=24.901185770751, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=24.901185770751, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=24.901185770751, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=24.901185770751, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=24.901185770751, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=22.1343873517787, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571528, Length=178, Percent_Identity=28.0898876404494, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35970; Mature: 35970

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLQRC
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHC
PNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDN
CCCEEEEEEECCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIY
CHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHE
TIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
EHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LKSKVIRHTYLDVFENEPLKPNHELYELENVTITAHITGNDYEAKYDLLDIFKNNLVNFL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
NKNGLIENEVDAKKGY
HCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLQRC
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHC
PNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDN
CCCEEEEEEECCCCCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIY
CHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHE
TIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEALLIEV
EHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LKSKVIRHTYLDVFENEPLKPNHELYELENVTITAHITGNDYEAKYDLLDIFKNNLVNFL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
NKNGLIENEVDAKKGY
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]