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The map label for this gene is hemA

Identifier: 148268153

GI number: 148268153

Start: 1828590

End: 1829936

Strand: Reverse

Name: hemA

Synonym: SaurJH9_1730

Alternate gene names: 148268153

Gene position: 1829936-1828590 (Counterclockwise)

Preceding gene: 148268154

Following gene: 148268152

Centisome position: 62.96

GC content: 33.78

Gene sequence:

>1347_bases
ATGCATTTTATTGCAATTAGTATAAATCATCGCACAGCTGATGTTGCACTAAGAGAGCAAGTTGCTTTTAGAGATGATGC
CTTACGAATTGCCCATGAAGATTTATATGAAACTAAATCTATTTTAGAAAATGTCATATTATCAACATGTAATCGAACTG
AAGTATATGCTGTTGTTGATCAAATTCACACAGGTCGTTACTATATTCAACGATTTCTAGCTCGTGCATTTGGATTTGAA
GTAGATGATATTAAAGCAATGTCAGAAGTAAAAGTGGGGGACGAAGCAGTAGAACATTTATTGCGTGTCACTTCTGGTTT
AGATTCAATCGTACTTGGAGAAACTCAAATTTTAGGTCAAATAAGAGATGCATTTTTCTTAGCGCAAAGCACAGGTACGA
CAGGAACAATTTTTAATCATCTATTTAAACAGGCAATTACTTTTGCAAAAAGAGCACATAATGAAACAGATATAGCTGAT
AATGCTGTAAGTGTGTCTTATGCTGCGGTCGAGTTGGCGAAAAAAGTATTTGGCAAATTGAAAAGTAAGCAAGCTATCAT
TATTGGTGCAGGGGAAATGAGTGAATTATCACTATTAAATCTTCTTGGTTCTGGAATTACTGATATTACAGTAGTAAATA
GAACAATTGAAAATGCTATGAAATTAGCAGCAAAGCATCAAGTGAAATATGATGAACTATCATCATTACCAAATTTACTT
GAAAGTGCAGATATTGTGATTAGTTCAACGAGTGCACAATCTTATATCATTACAAATGAAATGATAGAAAGAATTGCAGA
AAATAGAAAGCAAGATTCACTAGTATTGATTGATATTGCAGTTCCTCGAGATATTGAACCTGGTATTAGTGCCATCACAA
ACATCTTTAATTATGATGTTGATGACTTAAAAGGTTTAGTTGATGCAAACTTACGTGAGCGACAATTAGCGGCTGCAACA
ATTTCGGAACAAATTCCTGCAGAAATACATGCACACAATGAGTGGATTAGTATGTTGGGTGTTGTTCCAGTGATTAGAGC
TTTACGTGAAAAAGCTATGGCAATTCAAGCAGAAACGATGGACAGTATTGATCGTAAATTGCCAGGGTTAAGCGAAAGAG
AACGTAAAATTATATCTAAACATACAAAAAGTATCATCAATCAAATGTTGAAAGATCCTATTAAACAGGCCAAAGAATTA
AGTAGTGATAAGAAAAGTAATGAAAAATTAGAGCTATTTCAAAATATATTTGATATCGAAGCTGAATGTCCTCATGAGCA
AGCGAAGCAACAAAAAGAAAGCAAGGTCAAGGAAATTTCAGCGCGACGTATCTTTAGTTTTGAATAA

Upstream 100 bases:

>100_bases
GTAAATTAGAAAGATTATAATTTATTTAAGCATCGTACTTAATTGGATTTTAAATTATGTTATAATATTTGTATTGTTAG
TATATATGGGGGCGTTTCAA

Downstream 100 bases:

>100_bases
GCATATTAATATGGTGATAATATGCAAGAAAACCTGTTTATTCGATTCAATGAAATTATATTATTAATATACTTAATCAG
TATCATTTGCTATTTTTATG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MHFIAISINHRTADVALREQVAFRDDALRIAHEDLYETKSILENVILSTCNRTEVYAVVDQIHTGRYYIQRFLARAFGFE
VDDIKAMSEVKVGDEAVEHLLRVTSGLDSIVLGETQILGQIRDAFFLAQSTGTTGTIFNHLFKQAITFAKRAHNETDIAD
NAVSVSYAAVELAKKVFGKLKSKQAIIIGAGEMSELSLLNLLGSGITDITVVNRTIENAMKLAAKHQVKYDELSSLPNLL
ESADIVISSTSAQSYIITNEMIERIAENRKQDSLVLIDIAVPRDIEPGISAITNIFNYDVDDLKGLVDANLRERQLAAAT
ISEQIPAEIHAHNEWISMLGVVPVIRALREKAMAIQAETMDSIDRKLPGLSERERKIISKHTKSIINQMLKDPIKQAKEL
SSDKKSNEKLELFQNIFDIEAECPHEQAKQQKESKVKEISARRIFSFE

Sequences:

>Translated_448_residues
MHFIAISINHRTADVALREQVAFRDDALRIAHEDLYETKSILENVILSTCNRTEVYAVVDQIHTGRYYIQRFLARAFGFE
VDDIKAMSEVKVGDEAVEHLLRVTSGLDSIVLGETQILGQIRDAFFLAQSTGTTGTIFNHLFKQAITFAKRAHNETDIAD
NAVSVSYAAVELAKKVFGKLKSKQAIIIGAGEMSELSLLNLLGSGITDITVVNRTIENAMKLAAKHQVKYDELSSLPNLL
ESADIVISSTSAQSYIITNEMIERIAENRKQDSLVLIDIAVPRDIEPGISAITNIFNYDVDDLKGLVDANLRERQLAAAT
ISEQIPAEIHAHNEWISMLGVVPVIRALREKAMAIQAETMDSIDRKLPGLSERERKIISKHTKSIINQMLKDPIKQAKEL
SSDKKSNEKLELFQNIFDIEAECPHEQAKQQKESKVKEISARRIFSFE
>Mature_448_residues
MHFIAISINHRTADVALREQVAFRDDALRIAHEDLYETKSILENVILSTCNRTEVYAVVDQIHTGRYYIQRFLARAFGFE
VDDIKAMSEVKVGDEAVEHLLRVTSGLDSIVLGETQILGQIRDAFFLAQSTGTTGTIFNHLFKQAITFAKRAHNETDIAD
NAVSVSYAAVELAKKVFGKLKSKQAIIIGAGEMSELSLLNLLGSGITDITVVNRTIENAMKLAAKHQVKYDELSSLPNLL
ESADIVISSTSAQSYIITNEMIERIAENRKQDSLVLIDIAVPRDIEPGISAITNIFNYDVDDLKGLVDANLRERQLAAAT
ISEQIPAEIHAHNEWISMLGVVPVIRALREKAMAIQAETMDSIDRKLPGLSERERKIISKHTKSIINQMLKDPIKQAKEL
SSDKKSNEKLELFQNIFDIEAECPHEQAKQQKESKVKEISARRIFSFE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=422, Percent_Identity=33.4123222748815, Blast_Score=218, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_STAA1 (A7X393)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442249.1
- ProteinModelPortal:   A7X393
- SMR:   A7X393
- STRING:   A7X393
- EnsemblBacteria:   EBSTAT00000004481
- GeneID:   5558975
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1659
- eggNOG:   COG0373
- GeneTree:   EBGT00050000025161
- HOGENOM:   HBG732626
- OMA:   LLIDIAN
- ProtClustDB:   PRK00045
- BioCyc:   SAUR418127:SAHV_1659-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 50100; Mature: 50100

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFIAISINHRTADVALREQVAFRDDALRIAHEDLYETKSILENVILSTCNRTEVYAVVD
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QIHTGRYYIQRFLARAFGFEVDDIKAMSEVKVGDEAVEHLLRVTSGLDSIVLGETQILGQ
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCHHHHHHH
IRDAFFLAQSTGTTGTIFNHLFKQAITFAKRAHNETDIADNAVSVSYAAVELAKKVFGKL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KSKQAIIIGAGEMSELSLLNLLGSGITDITVVNRTIENAMKLAAKHQVKYDELSSLPNLL
CCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ESADIVISSTSAQSYIITNEMIERIAENRKQDSLVLIDIAVPRDIEPGISAITNIFNYDV
HCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCH
DDLKGLVDANLRERQLAAATISEQIPAEIHAHNEWISMLGVVPVIRALREKAMAIQAETM
HHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSIDRKLPGLSERERKIISKHTKSIINQMLKDPIKQAKELSSDKKSNEKLELFQNIFDIE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
AECPHEQAKQQKESKVKEISARRIFSFE
CCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHFIAISINHRTADVALREQVAFRDDALRIAHEDLYETKSILENVILSTCNRTEVYAVVD
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QIHTGRYYIQRFLARAFGFEVDDIKAMSEVKVGDEAVEHLLRVTSGLDSIVLGETQILGQ
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCHHHHHHH
IRDAFFLAQSTGTTGTIFNHLFKQAITFAKRAHNETDIADNAVSVSYAAVELAKKVFGKL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KSKQAIIIGAGEMSELSLLNLLGSGITDITVVNRTIENAMKLAAKHQVKYDELSSLPNLL
CCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ESADIVISSTSAQSYIITNEMIERIAENRKQDSLVLIDIAVPRDIEPGISAITNIFNYDV
HCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCH
DDLKGLVDANLRERQLAAATISEQIPAEIHAHNEWISMLGVVPVIRALREKAMAIQAETM
HHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DSIDRKLPGLSERERKIISKHTKSIINQMLKDPIKQAKELSSDKKSNEKLELFQNIFDIE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
AECPHEQAKQQKESKVKEISARRIFSFE
CCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA