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The map label for this gene is sdhA [H]

Identifier: 148267640

GI number: 148267640

Start: 1252604

End: 1254370

Strand: Direct

Name: sdhA [H]

Synonym: SaurJH9_1207

Alternate gene names: 148267640

Gene position: 1252604-1254370 (Clockwise)

Preceding gene: 148267639

Following gene: 148267641

Centisome position: 43.09

GC content: 38.43

Gene sequence:

>1767_bases
ATGGCAGAGAAACATCTTATTGTTGTCGGAGGTGGCCTAGCGGGCTTAATGTCAACAATTAAAGCGGCAGAAAAAGGTGC
ACATGTAGATTTGTTCTCAGTTGTACCAGTAAAGCGTTCGCACTCTGTTTGTGCCCAAGGTGGCATTAATGGTGCGGTCA
ATACTAAAGGGGAAGGCGATTCTCCTTGGATTCACTTTGATGATACAGTGTATGGTGGCGACTTCCTTGCAAACCAACCA
CCTGTTAAAGCGATGACAGAGGCAGCACCTAAAATTATTCATTTATTAGACCGTATGGGTGTAATGTTCAATAGAACAAA
TGAAGGTCTATTAGATTTTAGACGTTTCGGTGGTACATTACACCACAGAACAGCATATGCAGGGGCAACAACTGGACAAC
AATTATTATATGCATTGGATGAACAAGTTCGTGCATATGAAGTAGATGGATTAGTTACGAAGTATGAAGGATGGGAATTT
CTTGGCATAGTTAAAGGTGACGATGATAGTGCAAGAGGTATCGTTGCACAAAATATGACAACTGCTGAGATTGAAACATT
TGGTTCAGATGCAGTTATTATGGCAACGGGTGGCCCTGGTATTATTTTCGGTAAAACAACAAACTCAATGATTAATACAG
GATCAGCGGCTTCCATTGTTTACCAACAAGGCGCTATTTATGCTAATGGTGAGTTCATTCAAATTCATCCTACTGCAATC
CCTGGTGATGATAAACTGCGACTAATGAGTGAATCAGCACGTGGTGAAGGTGGACGAATTTGGACATATAAAGATGGTAA
GCCTTGGTACTTCTTAGAAGAGAAATATCCTGATTATGGTAACTTAGTACCTCGTGATATCGCAACGCGTGAAATTTTCG
ATGTATGTATTAACCAAAAATTAGGTATAAATGGCGAAAACATGGTATATCTTGATTTGTCACATAAAGATCCACATGAG
TTAGATGTAAAACTAGGTGGTATCATTGAAATTTATGAAAAATTCACTGGTGATGACCCACGCAAAGTACCAATGAAGAT
TTTCCCAGCTGTTCACTATTCAATGGGTGGTCTATATGTAGATTATGATCAAATGACAAATATTAAAGGGTTATTTGCAG
CTGGAGAATGTGACTTCTCTCAACATGGTGGTAACCGCTTAGGTGCCAATTCATTGTTATCAGCGATTTATGGTGGTACA
GTAGCAGGTCCAAACGCGATTGATTATATTTCAAATATTGATCGATCATATACTGATATGGACGAAAGTATTTTTGAAAA
ACGTAAAGCTGAAGAGCAAGAACGTTTTGATAAATTATTAGCTATGCGCGGTACAGAAAATGCCTATAAATTACACCGTG
AACTTGGTGAAATTATGACAGCAAATGTAACTGTTGTTCGTGAAAATGAAAAACTGTTAGAAACAGATAAAAAGATTGTT
GAATTGATGAAACGTTATGAAGATATTGATATGGAAGATACTCAAACTTGGAGTAACCAAGCGGTATTCTTTACCCGTCA
ACTATGGAACATGTTAGTACTTGCACGTGTTATTACGATTGGTGCATATAACCGTAACGAATCACGCGGTGCCCATTATA
AACCAGAATTCCCAGAGCGTAATGATGAAGAGTGGTTAAAAACGACAATGGCCTCATTCCAAGGCGCATTTGAAAAACCA
CAGTTTACTTATGATGACGTCGATGTGAGTTTAATACCACCTCGTAAACGTGATTACACAAGTAAGTCTAAAGGGGGTAA
AAAATAA

Upstream 100 bases:

>100_bases
TTTAGTTATTTCGTATATTGGTGTTACTGCAATTATTGCCTTTATGTAATACATCGCATTTAACAAATATAGATTGAAAA
TTTAGGGGAGTGAAATTTTT

Downstream 100 bases:

>100_bases
TGACTGAACAATCAGTGAAAAACACTCCACAACATGAAACACAATCTAAACCGAAACAAAAAACAGTAAAATTAATTATT
AAACGACAAGATACAAGTGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MAEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTVYGGDFLANQP
PVKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRAYEVDGLVTKYEGWEF
LGIVKGDDDSARGIVAQNMTTAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQKLGINGENMVYLDLSHKDPHE
LDVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYVDYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGT
VAGPNAIDYISNIDRSYTDMDESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIV
ELMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPERNDEEWLKTTMASFQGAFEKP
QFTYDDVDVSLIPPRKRDYTSKSKGGKK

Sequences:

>Translated_588_residues
MAEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTVYGGDFLANQP
PVKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRAYEVDGLVTKYEGWEF
LGIVKGDDDSARGIVAQNMTTAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQKLGINGENMVYLDLSHKDPHE
LDVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYVDYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGT
VAGPNAIDYISNIDRSYTDMDESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIV
ELMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPERNDEEWLKTTMASFQGAFEKP
QFTYDDVDVSLIPPRKRDYTSKSKGGKK
>Mature_587_residues
AEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTVYGGDFLANQPP
VKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRAYEVDGLVTKYEGWEFL
GIVKGDDDSARGIVAQNMTTAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQKLGINGENMVYLDLSHKDPHEL
DVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYVDYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGTV
AGPNAIDYISNIDRSYTDMDESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIVE
LMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPERNDEEWLKTTMASFQGAFEKPQ
FTYDDVDVSLIPPRKRDYTSKSKGGKK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=605, Percent_Identity=29.5867768595041, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1790597, Length=564, Percent_Identity=33.1560283687943, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1786942, Length=556, Percent_Identity=31.4748201438849, Blast_Score=228, Evalue=9e-61,
Organism=Escherichia coli, GI1788928, Length=549, Percent_Identity=28.0510018214936, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17550100, Length=543, Percent_Identity=31.6758747697974, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17505833, Length=604, Percent_Identity=29.3046357615894, Blast_Score=221, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6322701, Length=588, Percent_Identity=31.8027210884354, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6322416, Length=589, Percent_Identity=30.7300509337861, Blast_Score=226, Evalue=9e-60,
Organism=Drosophila melanogaster, GI17137288, Length=584, Percent_Identity=30.9931506849315, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655642, Length=584, Percent_Identity=30.9931506849315, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24655647, Length=584, Percent_Identity=30.9931506849315, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24663005, Length=604, Percent_Identity=29.9668874172185, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65504; Mature: 65373

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCC
SPWIHFDDTVYGGDFLANQPPVKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTL
CCEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCH
HHRTAYAGATTGQQLLYALDEQVRAYEVDGLVTKYEGWEFLGIVKGDDDSARGIVAQNMT
HHHEEECCCCCHHHHHHHHHHHHHEEEECCEEEEECCEEEEEEEECCCCCCCCEEECCCC
TAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAI
HHHHHHCCCCEEEEEECCCEEEEECCCCCHHCCCCCEEEEEECCEEEECCEEEEEECCCC
PGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCC
LGINGENMVYLDLSHKDPHELDVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYV
CCCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCEEE
DYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGTVAGPNAIDYISNIDRSYTDM
EHHHHCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHH
DESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
ELMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPER
HHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDEEWLKTTMASFQGAFEKPQFTYDDVDVSLIPPRKRDYTSKSKGGKK
CHHHHHHHHHHHHHCCCCCCCCEECCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGD
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCC
SPWIHFDDTVYGGDFLANQPPVKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTL
CCEEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCH
HHRTAYAGATTGQQLLYALDEQVRAYEVDGLVTKYEGWEFLGIVKGDDDSARGIVAQNMT
HHHEEECCCCCHHHHHHHHHHHHHEEEECCEEEEECCEEEEEEEECCCCCCCCEEECCCC
TAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAI
HHHHHHCCCCEEEEEECCCEEEEECCCCCHHCCCCCEEEEEECCEEEECCEEEEEECCCC
PGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCC
LGINGENMVYLDLSHKDPHELDVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYV
CCCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCEEE
DYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGTVAGPNAIDYISNIDRSYTDM
EHHHHCCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHH
DESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
ELMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPER
HHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDEEWLKTTMASFQGAFEKPQFTYDDVDVSLIPPRKRDYTSKSKGGKK
CHHHHHHHHHHHHHCCCCCCCCEECCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]