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The map label for this gene is trxA

Identifier: 148267637

GI number: 148267637

Start: 1249195

End: 1249509

Strand: Direct

Name: trxA

Synonym: SaurJH9_1204

Alternate gene names: 148267637

Gene position: 1249195-1249509 (Clockwise)

Preceding gene: 148267636

Following gene: 148267638

Centisome position: 42.98

GC content: 33.97

Gene sequence:

>315_bases
ATGGCAATCGTAAAAGTAACAGATGCAGATTTTGATTCAAAAGTAGAATCTGGTGTACAACTAGTAGATTTTTGGGCAAC
ATGGTGTGGTCCATGTAAAATGATCGCTCCGGTATTAGAAGAATTAGCAGCTGACTATGAAGGTAAAGCTGACATTTTAA
AATTAGATGTTGATGAAAATCCATCAACTGCAGCTAAATATGAAGTGATGAGTATTCCAACATTAATCGTCTTTAAAGAC
GGTCAACCAGTTGATAAAGTTGTTGGTTTCCAACCAAAAGAAAACTTAGCTGAAGTTTTAGATAAACATTTATAA

Upstream 100 bases:

>100_bases
ATTTGAAATAAGCATAAAAATTGAGCAAATAGAAATACATGAAGCATGTTATCTGATATAATTTGAACATCATAATAATA
ATTAAGGAGGATTGGCATTT

Downstream 100 bases:

>100_bases
GTTATAACCAATGACGACTGGGGCATTTCTTTAATGAATTGCTCCAGTTTTTGTTTGTGTTTTTAATATAAAAAGTTGAA
TGATAAGTCATCATATTGTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIVKVTDADFDSKVESGVQLVDFWATWCGPCKMIAPVLEELAADYEGKADILKLDVDENPSTAAKYEVMSIPTLIVFKD
GQPVDKVVGFQPKENLAEVLDKHL

Sequences:

>Translated_104_residues
MAIVKVTDADFDSKVESGVQLVDFWATWCGPCKMIAPVLEELAADYEGKADILKLDVDENPSTAAKYEVMSIPTLIVFKD
GQPVDKVVGFQPKENLAEVLDKHL
>Mature_103_residues
AIVKVTDADFDSKVESGVQLVDFWATWCGPCKMIAPVLEELAADYEGKADILKLDVDENPSTAAKYEVMSIPTLIVFKDG
QPVDKVVGFQPKENLAEVLDKHL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=82, Percent_Identity=42.6829268292683, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI21361657, Length=105, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI224493972, Length=106, Percent_Identity=31.1320754716981, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI42794771, Length=90, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=50.9615384615385, Blast_Score=111, Evalue=1e-26,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=36.9047619047619, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=36.1904761904762, Blast_Score=75, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=83, Percent_Identity=49.3975903614458, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17507705, Length=83, Percent_Identity=38.5542168674699, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=66, Percent_Identity=46.969696969697, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=101, Percent_Identity=37.6237623762376, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=93, Percent_Identity=41.9354838709677, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=96, Percent_Identity=37.5, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=35.1063829787234, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=51.7241379310345, Blast_Score=90, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=53.4883720930233, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=41.9354838709677, Blast_Score=75, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664269, Length=69, Percent_Identity=53.6231884057971, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=38.7755102040816, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24639826, Length=88, Percent_Identity=42.0454545454545, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=40.4494382022472, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=40.4494382022472, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24658597, Length=76, Percent_Identity=46.0526315789474, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17530795, Length=92, Percent_Identity=33.695652173913, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358065, Length=97, Percent_Identity=39.1752577319588, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_STAA3 (Q2FHT6)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493742.1
- ProteinModelPortal:   Q2FHT6
- SMR:   Q2FHT6
- STRING:   Q2FHT6
- EnsemblBacteria:   EBSTAT00000037155
- GeneID:   3914790
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_1044
- eggNOG:   COG0526
- GeneTree:   EBGT00050000025178
- HOGENOM:   HBG493509
- OMA:   TLMLFKG
- ProtClustDB:   CLSK885161
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11440; Mature: 11309

Theoretical pI: Translated: 4.14; Mature: 4.14

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVKVTDADFDSKVESGVQLVDFWATWCGPCKMIAPVLEELAADYEGKADILKLDVDEN
CEEEEECCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
PSTAAKYEVMSIPTLIVFKDGQPVDKVVGFQPKENLAEVLDKHL
CCCCCEEEEEECCEEEEEECCCCHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AIVKVTDADFDSKVESGVQLVDFWATWCGPCKMIAPVLEELAADYEGKADILKLDVDEN
EEEEECCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
PSTAAKYEVMSIPTLIVFKDGQPVDKVVGFQPKENLAEVLDKHL
CCCCCEEEEEECCEEEEEECCCCHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA