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The map label for this gene is pdhA

Identifier: 148267586

GI number: 148267586

Start: 1195420

End: 1196532

Strand: Direct

Name: pdhA

Synonym: SaurJH9_1153

Alternate gene names: 148267586

Gene position: 1195420-1196532 (Clockwise)

Preceding gene: 148267585

Following gene: 148267587

Centisome position: 41.13

GC content: 37.29

Gene sequence:

>1113_bases
ATGGCTCCTAAGTTACAAGCCCAATTCGATGCAGTAAAAGTTTTAAATGATACTCAATCGAAATTTGAAATGGTTCAAAT
TTTGGATGAGAATGGTAACGTCGTAAATGAAGACTTAGTACCTGATCTTACGGATGAACAATTAGTAGAATTAATGGAAA
GAATGGTATGGACTCGTATCCTTGATCAACGTTCTATCTCATTAAACAGACAAGGACGTTTAGGTTTCTATGCACCAACT
GCTGGTCAAGAAGCATCACAATTAGCGTCACAATACGCTTTAGAAAAAGAAGATTACATTTTACCGGGATACAGAGATGT
TCCTCAAATTATTTGGCATGGTTTACCATTAACTGAAGCTTTCTTATTCTCAAGAGGTCACTTCAAAGGAAATCAATTCC
CTGAAGGCGTTAATGCATTGAGCCCACAAATTATTATCGGTGCACAATACATTCAAGCTGCTGGTGTTGCATTTGCACTT
AAAAAACGTGGTAAAAATGCAGTTGCAATCACTTACACTGGTGACGGTGGTTCTTCACAAGGTGATTTCTACGAAGGTAT
TAACTTTGCAGCAGCTTATAAAGCACCTGCAATTTTCGTTATTCAAAACAATAACTATGCAATTTCAACACCAAGAAGCA
AGCAAACTGCTGCTGAAACATTAGCTCAAAAAGCAATTGCTGTAGGTATTCCTGGTATCCAAGTTGATGGTATGGATGCG
TTAGCTGTATATCAAGCAACTAAAGAAGCACGTGACCGCGCAGTTGCAGGTGAAGGTCCAACATTAATTGAAACTATGAC
ATATCGTTATGGTCCTCATACAATGGCTGGTGACGATCCAACTCGTTACAGAACTTCAGACGAAGATGCTGAATGGGAGA
AAAAAGACCCATTAGTACGTTTCCGTAAATTCCTTGAAAACAAAGGTTTATGGAATGAAGACAAAGAAAATGAAGTTATT
GAACGTGCAAAAGCTGATATTAAAGCAGCAATTAAAGAGGCTGATAACACTGAAAAACAAACTGTTACTTCTCTAATGGA
AATTATGTATGAAGATATGCCTCAAAACTTAGCAGAACAATATGAAATTTACAAAGAGAAGGAGTCGAAGTAA

Upstream 100 bases:

>100_bases
GAACTTTTTCAAATGGTTTAACAGTCCCATTTATTTGTGGTACAATTAGTAAGGATAAAATGAATTTCTATACAATTATG
GGAAAGGTATGGTGAATTGA

Downstream 100 bases:

>100_bases
GCCATGGCACAAATGACAATGGTTCAAGCGATTAATGATGCGCTTAAAACTGAACTTAAAAATGACCAAGATGTTTTAAT
TTTTGGTGAAGACGTTGGTG

Product: pyruvate dehydrogenase (acetyl-transferring)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAPKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRILDQRSISLNRQGRLGFYAPT
AGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEAFLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFAL
KKRGKNAVAITYTGDGGSSQGDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVRFRKFLENKGLWNEDKENEVI
ERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLAEQYEIYKEKESK

Sequences:

>Translated_370_residues
MAPKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRILDQRSISLNRQGRLGFYAPT
AGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEAFLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFAL
KKRGKNAVAITYTGDGGSSQGDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVRFRKFLENKGLWNEDKENEVI
ERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLAEQYEIYKEKESK
>Mature_369_residues
APKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRILDQRSISLNRQGRLGFYAPTA
GQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEAFLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFALK
KRGKNAVAITYTGDGGSSQGDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDAL
AVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVRFRKFLENKGLWNEDKENEVIE
RAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLAEQYEIYKEKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=353, Percent_Identity=34.8441926345609, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI258645172, Length=353, Percent_Identity=34.8441926345609, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI4505685, Length=309, Percent_Identity=29.126213592233, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI291084742, Length=309, Percent_Identity=29.126213592233, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI4885543, Length=294, Percent_Identity=29.5918367346939, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI291084744, Length=268, Percent_Identity=29.8507462686567, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI291084757, Length=292, Percent_Identity=28.7671232876712, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=361, Percent_Identity=35.1800554016621, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI86563357, Length=361, Percent_Identity=35.1800554016621, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32564172, Length=288, Percent_Identity=31.5972222222222, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17536047, Length=288, Percent_Identity=31.5972222222222, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=326, Percent_Identity=30.6748466257669, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21355903, Length=349, Percent_Identity=31.2320916905444, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24639744, Length=319, Percent_Identity=30.0940438871473, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28571106, Length=319, Percent_Identity=30.0940438871473, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24639740, Length=319, Percent_Identity=30.0940438871473, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24639746, Length=286, Percent_Identity=31.1188811188811, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24639748, Length=274, Percent_Identity=31.7518248175182, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ODPA_STAAC (Q5HGZ1)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185966.1
- ProteinModelPortal:   Q5HGZ1
- SMR:   Q5HGZ1
- STRING:   Q5HGZ1
- EnsemblBacteria:   EBSTAT00000009353
- GeneID:   3237845
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1102
- TIGR:   SACOL1102
- eggNOG:   COG1071
- GeneTree:   EBGT00050000024894
- HOGENOM:   HBG753263
- OMA:   MPIHYGC
- ProtClustDB:   CLSK873381
- BioCyc:   SAUR93062:SACOL1102-MONOMER
- GO:   GO:0006096
- InterPro:   IPR001017
- InterPro:   IPR017596
- TIGRFAMs:   TIGR03181

Pfam domain/function: PF00676 E1_dh

EC number: =1.2.4.1

Molecular weight: Translated: 41383; Mature: 41252

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRI
CCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
LDQRSISLNRQGRLGFYAPTAGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEA
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCHHHH
FLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFALKKRGKNAVAITYTGDGGSSQ
HHHHCCCCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
GDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
CCHHHCCCCEEECCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCHH
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
FRKFLENKGLWNEDKENEVIERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLAEQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
YEIYKEKESK
HHHHHHHCCC
>Mature Secondary Structure 
APKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRI
CCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
LDQRSISLNRQGRLGFYAPTAGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEA
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCHHHH
FLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFALKKRGKNAVAITYTGDGGSSQ
HHHHCCCCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
GDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
CCHHHCCCCEEECCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCHH
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
FRKFLENKGLWNEDKENEVIERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLAEQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
YEIYKEKESK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA