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The map label for this gene is dut [H]

Identifier: 148267313

GI number: 148267313

Start: 934423

End: 934956

Strand: Direct

Name: dut [H]

Synonym: SaurJH9_0879

Alternate gene names: 148267313

Gene position: 934423-934956 (Clockwise)

Preceding gene: 148267312

Following gene: 148267314

Centisome position: 32.15

GC content: 39.7

Gene sequence:

>534_bases
ATGACTAACACATTACAAGTAAAACTATTATCAGAAAATGCTAGAATGCCCGAACGAAATCATAAGACAGATGCAGGTTA
TGACATATTCTCAGCCGAAACCGTCGTACTTGAGCCGCAAGAAAAGGCAGTGATTAAAACAGATGTAGCTGTAAGTATAC
CAGAGGGCTATGTCGGGCTATTAACTAGCCGTAGTGGTGTAAGTAGTAAAACGTATTTAGTGATTGAAACAGGAAAGATA
GACGCGGGATATCATGGCAATTTAGGGATTAATATCAAGAATGATATTGAAACGTTAGAGATTTGGGATGATGGTAACTT
TAGTCGAAATGTTGCTGGGATAGACGGAAAGTATGCCCCACCACATCCATCAGATAAAATTTTATTTATGAATGGTAGTT
ATGTCATAAACAAAGGCGACAAACTAGCTCAATTGGTTATCGTGCCTATATGGACACCGGAACTAAAGCAAGTGGAGGAA
TTCGAGAGTGTTTCAGAACGTGGAGCAAAAGGCTTCGGAAGTAGCGGAGTGTAA

Upstream 100 bases:

>100_bases
AGTTTAGACGAAGCAGAAAATGAGGCGCATGATATTGCGAGAATGGAAGTGCCATTTGATTGTGATGAGTATGAAATTTA
TGTAGATGTGGAGCAGGAAA

Downstream 100 bases:

>100_bases
AGACATCTTAGATCGAGTCAAGGAGGTTTTGGGGAAATGATACAATACTTAGTTACAACATTCAAAGATTCAACAGGACG
TAAGCATACACACATAACTC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase Dut

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTNTLQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTYLVIETGKI
DAGYHGNLGINIKNDIETLEIWDDGNFSRNVAGIDGKYAPPHPSDKILFMNGSYVINKGDKLAQLVIVPIWTPELKQVEE
FESVSERGAKGFGSSGV

Sequences:

>Translated_177_residues
MTNTLQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTYLVIETGKI
DAGYHGNLGINIKNDIETLEIWDDGNFSRNVAGIDGKYAPPHPSDKILFMNGSYVINKGDKLAQLVIVPIWTPELKQVEE
FESVSERGAKGFGSSGV
>Mature_176_residues
TNTLQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTYLVIETGKID
AGYHGNLGINIKNDIETLEIWDDGNFSRNVAGIDGKYAPPHPSDKILFMNGSYVINKGDKLAQLVIVPIWTPELKQVEEF
ESVSERGAKGFGSSGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=172, Percent_Identity=31.9767441860465, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI4503423, Length=172, Percent_Identity=31.9767441860465, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI70906441, Length=172, Percent_Identity=31.9767441860465, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71988561, Length=173, Percent_Identity=29.4797687861272, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319729, Length=176, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583610, Length=176, Percent_Identity=31.25, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921126, Length=176, Percent_Identity=31.25, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 19299; Mature: 19168

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTLQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGL
CCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCEEEEECEEEECCCCEEEE
LTSRSGVSSKTYLVIETGKIDAGYHGNLGINIKNDIETLEIWDDGNFSRNVAGIDGKYAP
EECCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCEEECCCCCCCC
PHPSDKILFMNGSYVINKGDKLAQLVIVPIWTPELKQVEEFESVSERGAKGFGSSGV
CCCCCEEEEECCCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TNTLQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGL
CCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEEECCCCCEEEEECEEEECCCCEEEE
LTSRSGVSSKTYLVIETGKIDAGYHGNLGINIKNDIETLEIWDDGNFSRNVAGIDGKYAP
EECCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCEEECCCCCCCC
PHPSDKILFMNGSYVINKGDKLAQLVIVPIWTPELKQVEEFESVSERGAKGFGSSGV
CCCCCEEEEECCCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA