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The map label for this gene is gatD [H]

Identifier: 148266675

GI number: 148266675

Start: 285130

End: 286173

Strand: Direct

Name: gatD [H]

Synonym: SaurJH9_0235

Alternate gene names: 148266675

Gene position: 285130-286173 (Clockwise)

Preceding gene: 148266674

Following gene: 148266676

Centisome position: 9.81

GC content: 38.12

Gene sequence:

>1044_bases
GTGAAAGCATTGAAATTATATGGCGTAGAAGATTTACGGTATGAGGATAATGAAAAGCCAGTCATTGAAAGTGCGAATGA
CGTTATTGTTAAAGTACGAGCGACTGGCATATGTGGTTCAGACACGTCACGATACAAAAAAATGGGGCCATACATTAAAG
GTATGCCATTTGGTCATGAATTTTCAGGTGTAGTAGATGCCATTGGAAGTGATGTTACGCATGTTAATGTGGGCGACAAA
GTGACAGGTTGCCCAGCAATACCTTGTTATCAATGCGAGTATTGTTTGAAAGGTGAATATGCACGATGTGAAAAGTTATT
CGTCATTGGCTCATATGAACCTGGATCGTTCGCGGAATATGTCAAATTGCCAGCGCAAAATGTTTTAAAGGTTCCAGACA
ATGTTGATTACATTGAAGCAGCAATGGTTGAGCCATCAGCCGTTGTTGCGCATGGGTTTTATAAATCGAATATACAACCT
GGTATGACTGTTGCAGTAATGGGGTGTGGCAGTATAGGTTTGTTAGCTATTCAATGGGCACGAATATTTGGTGCTGCACA
TATCATCGCTATAGATATAGATGCGCATAAACTAGATATTGCAACATCATTGGGCGCACATCAAACAATCAATTCAAAAG
AAGAAAATCTTGAGAAATTCATCGAAAATCATTACGCCAATCAAATCGATTTAGCTATAGAATCATCAGGTGCTAAAGTT
ACGATTGGTCAAATATTGACGCTACCTAAAAAAGGTGGCGAGGTGGTATTACTCGGAATACCATATGATGATATTGAGAT
TGATCGCGTTCATTTTGAAAAAATTCTGCGTAACGAGTTGACAGTATGTGGCTCTTGGAACTGTTTGTCCAGTAATTTTC
CGGGCAAAGAGTGGACGGCAACCTTACATTATATGAAGACGAAAGATATTAATGTAAAGCCTATTATTTCTCATTTTTTA
CCGTTAGAAAAAGGCCCGGAGACATTTGATAAATTAGTTAACAAGAAAGAACGATTTGATAAAGTCATGTTTACGATTTA
TTAG

Upstream 100 bases:

>100_bases
TACTCGTAAGTAATTCCATCGTCATTGCAGGTTATTTTGCGACAGGTATTTTTAAAAAGAAAAAAGTTGTGAATTAAATC
AAATTTGAGGTGATTTACAA

Downstream 100 bases:

>100_bases
TATGCACCTTTGAGGACGAAAACGCTGGTATAGTTATAGCTATGAAAGTGCGAATGCCGTCTGGTCTACAGATACTATCG
AAATAATTCATCTTCGAATA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKALKLYGVEDLRYEDNEKPVIESANDVIVKVRATGICGSDTSRYKKMGPYIKGMPFGHEFSGVVDAIGSDVTHVNVGDK
VTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEYVKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQP
GMTVAVMGCGSIGLLAIQWARIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTATLHYMKTKDINVKPIISHFL
PLEKGPETFDKLVNKKERFDKVMFTIY

Sequences:

>Translated_347_residues
MKALKLYGVEDLRYEDNEKPVIESANDVIVKVRATGICGSDTSRYKKMGPYIKGMPFGHEFSGVVDAIGSDVTHVNVGDK
VTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEYVKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQP
GMTVAVMGCGSIGLLAIQWARIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTATLHYMKTKDINVKPIISHFL
PLEKGPETFDKLVNKKERFDKVMFTIY
>Mature_347_residues
MKALKLYGVEDLRYEDNEKPVIESANDVIVKVRATGICGSDTSRYKKMGPYIKGMPFGHEFSGVVDAIGSDVTHVNVGDK
VTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEYVKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQP
GMTVAVMGCGSIGLLAIQWARIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTATLHYMKTKDINVKPIISHFL
PLEKGPETFDKLVNKKERFDKVMFTIY

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=30.4843304843305, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI71565152, Length=355, Percent_Identity=24.7887323943662, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=27.6536312849162, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501933, Length=351, Percent_Identity=26.7806267806268, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI34577061, Length=351, Percent_Identity=26.2108262108262, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073058, Length=354, Percent_Identity=24.2937853107345, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI71743840, Length=354, Percent_Identity=24.2937853107345, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI156523966, Length=343, Percent_Identity=26.530612244898, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI71565154, Length=216, Percent_Identity=26.3888888888889, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1788407, Length=310, Percent_Identity=36.7741935483871, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1788073, Length=335, Percent_Identity=30.7462686567164, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=30.791788856305, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=27.1676300578035, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1788075, Length=357, Percent_Identity=27.4509803921569, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787863, Length=348, Percent_Identity=27.8735632183908, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786825, Length=269, Percent_Identity=33.457249070632, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790718, Length=316, Percent_Identity=25.9493670886076, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082125, Length=344, Percent_Identity=25.5813953488372, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081918, Length=263, Percent_Identity=29.277566539924, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=271, Percent_Identity=37.2693726937269, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=244, Percent_Identity=32.7868852459016, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71988145, Length=244, Percent_Identity=31.9672131147541, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=268, Percent_Identity=29.8507462686567, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=300, Percent_Identity=25.3333333333333, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=267, Percent_Identity=25.0936329588015, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997431, Length=302, Percent_Identity=25.1655629139073, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=283, Percent_Identity=28.6219081272085, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=342, Percent_Identity=31.8713450292398, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=342, Percent_Identity=31.8713450292398, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323099, Length=322, Percent_Identity=29.8136645962733, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=386, Percent_Identity=25.9067357512953, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=348, Percent_Identity=25.8620689655172, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=27.9883381924198, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=384, Percent_Identity=25.78125, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=243, Percent_Identity=27.9835390946502, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=257, Percent_Identity=26.8482490272374, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=258, Percent_Identity=27.906976744186, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=250, Percent_Identity=30, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137530, Length=335, Percent_Identity=28.955223880597, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17737897, Length=338, Percent_Identity=29.8816568047337, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI17737895, Length=350, Percent_Identity=25.1428571428571, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550770, Length=307, Percent_Identity=22.8013029315961, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45551930, Length=307, Percent_Identity=22.8013029315961, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221457811, Length=307, Percent_Identity=22.8013029315961, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 38388; Mature: 38388

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALKLYGVEDLRYEDNEKPVIESANDVIVKVRATGICGSDTSRYKKMGPYIKGMPFGHE
CCCEEEECCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCH
FSGVVDAIGSDVTHVNVGDKVTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEY
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCHHHH
VKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQPGMTVAVMGCGSIGLLAIQWA
HHCCCHHEEECCCCCCHHHHHHCCCCHHEEECEECCCCCCCCEEEEEECCCHHHHHHHHH
RIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
HHHCCEEEEEEEECCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEE
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTA
EEEEEEECCCCCCCEEEEECCCCCCEEHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEE
TLHYMKTKDINVKPIISHFLPLEKGPETFDKLVNKKERFDKVMFTIY
EEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure
MKALKLYGVEDLRYEDNEKPVIESANDVIVKVRATGICGSDTSRYKKMGPYIKGMPFGHE
CCCEEEECCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCH
FSGVVDAIGSDVTHVNVGDKVTGCPAIPCYQCEYCLKGEYARCEKLFVIGSYEPGSFAEY
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEECCCCCCHHHH
VKLPAQNVLKVPDNVDYIEAAMVEPSAVVAHGFYKSNIQPGMTVAVMGCGSIGLLAIQWA
HHCCCHHEEECCCCCCHHHHHHCCCCHHEEECEECCCCCCCCEEEEEECCCHHHHHHHHH
RIFGAAHIIAIDIDAHKLDIATSLGAHQTINSKEENLEKFIENHYANQIDLAIESSGAKV
HHHCCEEEEEEEECCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCEE
TIGQILTLPKKGGEVVLLGIPYDDIEIDRVHFEKILRNELTVCGSWNCLSSNFPGKEWTA
EEEEEEECCCCCCCEEEEECCCCCCEEHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEE
TLHYMKTKDINVKPIISHFLPLEKGPETFDKLVNKKERFDKVMFTIY
EEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]