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The map label for this gene is wecC [H]

Identifier: 148266589

GI number: 148266589

Start: 175336

End: 176598

Strand: Direct

Name: wecC [H]

Synonym: SaurJH9_0149

Alternate gene names: 148266589

Gene position: 175336-176598 (Clockwise)

Preceding gene: 148266588

Following gene: 148266590

Centisome position: 6.03

GC content: 34.28

Gene sequence:

>1263_bases
ATGAAGTTAACAGTAGTTGGCTTAGGTTATATTGGTTTACCAACATCAATTATGTTTGCAAAGCATGGCGTCGATGTGCT
TGGTGTTGATATTAATCAGCAAACGATTGATAAGTTACAAAGTGGTCAAATTAGTATTGAAGAACCTGGGTTACAAGAGG
TTTATGAAGAGGTACTGTCATCGGGAAAATTGAAGGTATCTACAACGCCAGAAGCATCTGATGTTTTTATCATTGCCGTT
CCGACGCCGAATAATGATGATCAGTACCGGTCATGTGACATTTCGCTAGTTATGCGTGCATTAGATAGTATTTTACCATT
TTTAGAAAAAGGGAATACTATTATTGTAGAGTCGACAATTGCGCCTAAAACGATGGATGATTTTGTAAAACCAGTCATTG
AAAATTTAGGATTTACAATAGGTGAAGATATTTGTTTAGTGCATTGTCCAGAACGTGTACTGCCAGGAAAAATTTTAGAA
GAATTAGTTCATAACAATCGTATCATTGGCGGTGTGACTAAAGCTTGTATTGAAGCGGGTAAATATGTCTATCGCACATT
CGTTCAGGGAGAAATGATTGAAACAGATGCACGTACTGCTGAAATGAGTAAGCTAATGGAAAACACATATAGAGACGTGA
ATATTGCTTTAGCTAATGAATTAACAAAAATTTGCAATAACTTAAATATTAATGTATTAGATGTGATTGAAATGGCAAAC
AAACATCCGCGTGTTAATATCCATCAACCTGGTCCAGGTGTAGGCGGTCATTGTTTAGCTGTTGATCCGTACTTTATTAT
TGCTAAAGACCCTGAAAATGCAAAGTTAATTCAAACTGGACGTGAAATTAATAATTCAATGCCGGCCTATGTTGTTGATA
CAACGAAGCAAATCATCAAAGCGTTGAGCGGGAATAAAGTCACAGTATTTGGTTTAACTTATAAAGGTGATGTTGATGAT
ATAAGAGAATCGCCAGCATTTGATATTTATGAGCTATTAAATCAAGAACCAGACATAGAAGTATGTGCTTATGATCCACA
TGTTGAATTAGATTTTGTGGAACATGATATGTCACATGCTGTCAAAGACGCATCGCTAGTATTGATTTTAAGTGACCACT
CAGAATTTAAAAATTTATCGGACAGTCATTTTGATAAAATGAAGCATAAAGTGATTTTTGATACAAAAAATGTTGTGAAA
TCATCATTTGAAGATGTATCGTATTATAATTATGGCAATATATTTAATTTTATCGACAAATAA

Upstream 100 bases:

>100_bases
TTATTGCGGACATCATGGATGAAACGACAACCAAAGATAAGGCATAAGTCATCTATTAAATAAAATCAACATACAAATCG
TTTTATTTGGAGGTTATAGT

Downstream 100 bases:

>100_bases
AATGTGTCAAACTAGGGCATACATGATTAAGGAAAGATAAGCTGTCATGTGTTTGAACTTCAGAGAGGATAATGTTATGA
AAAAAATTATGGTTATTTTC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAV
PTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILE
ELVHNNRIIGGVTKACIEAGKYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMAN
KHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDD
IRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVK
SSFEDVSYYNYGNIFNFIDK

Sequences:

>Translated_420_residues
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAV
PTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILE
ELVHNNRIIGGVTKACIEAGKYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMAN
KHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDD
IRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVK
SSFEDVSYYNYGNIFNFIDK
>Mature_420_residues
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAV
PTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILE
ELVHNNRIIGGVTKACIEAGKYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMAN
KHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDD
IRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVK
SSFEDVSYYNYGNIFNFIDK

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=451, Percent_Identity=23.7250554323725, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI48994968, Length=420, Percent_Identity=42.1428571428571, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1788340, Length=418, Percent_Identity=23.9234449760766, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=463, Percent_Identity=23.7580993520518, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17136908, Length=449, Percent_Identity=22.9398663697105, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46743; Mature: 46743

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLS
CEEEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHCCCEEECCCCHHHHHHHHHC
SGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTI
CCCEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
APKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAG
CCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEHHHHHHHHHHC
KYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMAN
HHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHC
KHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIK
CCCEEEEECCCCCCCCEEEEECCEEEEEECCCCCHHHHCCHHHCCCCCEEEEHHHHHHHH
ALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHA
HHCCCEEEEEEEEECCCHHHHHCCCCHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHH
VKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVSYYNYGNIFNFIDK
HCCCEEEEEEECCHHHHCCCHHHHHHHHHHEEECCHHHHHHHHHHCCEECCCCHHHHHCC
>Mature Secondary Structure
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLS
CEEEEEEECCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHCCCEEECCCCHHHHHHHHHC
SGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTI
CCCEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
APKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAG
CCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEHHHHHHHHHHC
KYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMAN
HHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHC
KHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIK
CCCEEEEECCCCCCCCEEEEECCEEEEEECCCCCHHHHCCHHHCCCCCEEEEHHHHHHHH
ALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHA
HHCCCEEEEEEEEECCCHHHHHCCCCHHHHHHHCCCCCEEEEEECCCEEEEHHHHHHHHH
VKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVSYYNYGNIFNFIDK
HCCCEEEEEEECCHHHHCCCHHHHHHHHHHEEECCHHHHHHHHHHCCEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA