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The map label for this gene is murC

Identifier: 147675354

GI number: 147675354

Start: 2121726

End: 2123186

Strand: Reverse

Name: murC

Synonym: VC0395_A1978

Alternate gene names: 147675354

Gene position: 2123186-2121726 (Counterclockwise)

Preceding gene: 147675068

Following gene: 147673236

Centisome position: 70.21

GC content: 50.44

Gene sequence:

>1461_bases
ATGACGATTAAACATACCCAAGACCTCGCCCAAATTCGCGCTATGGTGCCAGAGATGCGCCGTGTAAAAGCGATCCACTT
TATTGGCATTGGCGGGGCGGGGATGAGCGGGATTGCGGAAGTGCTGCTCAATGAAGGCTATCAAATTTCAGGCTCCGATC
TGGCCGCGAATGCGGTCACTGACCGTTTAGCTGACAAAGGCGCGACCATTTTTATTGGTCATGAAGCGCACAATGTTGCT
CACGCAAGCGTGGTCGTGGTCTCGACGGCTATTAATGAACAAAACCCTGAAATCCAAGCGGCGCGTGAAAAACGCATCCC
GATTGTTCGTCGTGCTGAAATGTTGGCAGAGCTGATGCGTTTTCGCCACGGTATTGCGGTCGCGGGAACTCACGGTAAAA
CCACCACGACGGCACTCGTCACTCAGATTTATTCTGAAGCCGGATTGGATCCGACCTTTGTGAATGGTGGTTTGGTGAAA
AGCGCTGGCACCAACGCACGTTTGGGCTCTAGCCGCATTTTGATCGCTGAAGCGGATGAAAGTGATGCTTCATTCTTGCA
TCTGCAACCTATGGTCACCATTGTCACCAATATCGAAGCGGATCATATGGATACTTACGGCGGCGATTTTGAAAACCTTA
AACAGACCTTTATCGACTTTTTGCACAATCTGCCTTTTTACGGCCAAGCGATTTTGTGTATTGATGATCCAGTGATTCGT
GAGCTTATTCCGCGTGTCAGCCGCCAAGTGATCACTTATGGATTCTCAGAAGATGCCGACGTGCGCATTGAAAATTACCG
CCAGAATGGTCAGCAGGGCCAATTTACCGTGGTACGTAAAGGCAAAGCGAATTTGGATATCACGCTCAATATCCCCGGCC
GTCACAATGCGCTGAATGCCGCTGCGGCTATTGCTGTGGCTACCGAGGACGATATTCGCGATGAAGCGATTTTACGCGCA
ATGGCCAATACGCAAGGCACAGGTCGCCGTTTTGACCATCTTGGAGAGTTTGAAACCGGGAATGGCGTCGCTATGCTGGT
GGATGATTACGGTCACCACCCCACTGAAGTTGACGTGACGATTAAAGCGGCGCGTAATGGCTGGGCAGAAAAACGCTTAG
TGATGATTTTCCAGCCGCATCGTTACACGCGAACTCGCGATTTGTATGATGATTTTGCCAACGTACTTGAGCAAGTTGAT
GTACTGCTCATGCTCGATGTCTATGCTGCTGGTGAAAAGCCTATCGCAGGTGCTGATGGGCGATCTTTGTGTCGAACTAT
CCGCAGCCGAGGCAAAATCGATCCGATTTTTGTTCCGGATAGCCAAACCTTACCTTCGGTGCTTGCCAATATCTTGCAGG
ATGGTGACTTGGTACTGACGCAAGGCGCGGGCGATGTCGGGAAAGTAGCAAGGCATTTAGCCGCGCTTGAACTCAATATC
GGGCGTATGCAACAGATTTAA

Upstream 100 bases:

>100_bases
TTGTCCATGGCACAGAAGGCGCGCCAAGCCGCCAAATTAGATGCTGACAAGGTGGTGGCGCAAGCGATCATCGCCATTAC
CGAATAACGAGAACAGAATT

Downstream 100 bases:

>100_bases
AACAGCCTAAAGGTTGTCTCATTGGTGAATTCCTTGGTATCAAGCCCAGATTTCTGATGTTGGGTATTTGATACTTTGGA
TCACCTCAGTATAATCCGGA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVTDRLADKGATIFIGHEAHNVA
HASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
SAGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDFLHNLPFYGQAILCIDDPVIR
ELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNAAAAIAVATEDDIRDEAILRA
MANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPHRYTRTRDLYDDFANVLEQVD
VLLMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLTQGAGDVGKVARHLAALELNI
GRMQQI

Sequences:

>Translated_486_residues
MTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVTDRLADKGATIFIGHEAHNVA
HASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVK
SAGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDFLHNLPFYGQAILCIDDPVIR
ELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNAAAAIAVATEDDIRDEAILRA
MANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPHRYTRTRDLYDDFANVLEQVD
VLLMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLTQGAGDVGKVARHLAALELNI
GRMQQI
>Mature_485_residues
TIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVTDRLADKGATIFIGHEAHNVAH
ASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMRFRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKS
AGTNARLGSSRILIAEADESDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDFLHNLPFYGQAILCIDDPVIRE
LIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNAAAAIAVATEDDIRDEAILRAM
ANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVTIKAARNGWAEKRLVMIFQPHRYTRTRDLYDDFANVLEQVDV
LLMLDVYAAGEKPIAGADGRSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLTQGAGDVGKVARHLAALELNIG
RMQQI

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=480, Percent_Identity=72.9166666666667, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=467, Percent_Identity=27.4089935760171, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_VIBC3 (A5F5M8)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F5M8
- SMR:   A5F5M8
- STRING:   A5F5M8
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1978
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   VCHO345073:VC0395_A1978-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53042; Mature: 52911

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVT
CCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCHHHHHHH
DRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMR
HHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
FRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADE
HHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDFLHNLPFYGQAILCIDDPVIR
CCCCEEEECHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNA
HHHHHHHHHHEEECCCCCCCEEEHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCH
AAAIAVATEDDIRDEAILRAMANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVT
HEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCEEEEE
IKAARNGWAEKRLVMIFQPHRYTRTRDLYDDFANVLEQVDVLLMLDVYAAGEKPIAGADG
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCH
RSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLTQGAGDVGKVARHLAALELNI
HHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
GRMQQI
HHHCCC
>Mature Secondary Structure 
TIKHTQDLAQIRAMVPEMRRVKAIHFIGIGGAGMSGIAEVLLNEGYQISGSDLAANAVT
CCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCHHHHHHH
DRLADKGATIFIGHEAHNVAHASVVVVSTAINEQNPEIQAAREKRIPIVRRAEMLAELMR
HHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
FRHGIAVAGTHGKTTTTALVTQIYSEAGLDPTFVNGGLVKSAGTNARLGSSRILIAEADE
HHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCCCCCCCEEEEEECCC
SDASFLHLQPMVTIVTNIEADHMDTYGGDFENLKQTFIDFLHNLPFYGQAILCIDDPVIR
CCCCEEEECHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCHHHH
ELIPRVSRQVITYGFSEDADVRIENYRQNGQQGQFTVVRKGKANLDITLNIPGRHNALNA
HHHHHHHHHHEEECCCCCCCEEEHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCH
AAAIAVATEDDIRDEAILRAMANTQGTGRRFDHLGEFETGNGVAMLVDDYGHHPTEVDVT
HEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCEEEEEECCCCCCCEEEEE
IKAARNGWAEKRLVMIFQPHRYTRTRDLYDDFANVLEQVDVLLMLDVYAAGEKPIAGADG
EEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCH
RSLCRTIRSRGKIDPIFVPDSQTLPSVLANILQDGDLVLTQGAGDVGKVARHLAALELNI
HHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
GRMQQI
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA