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The map label for this gene is vmrA [H]

Identifier: 147673240

GI number: 147673240

Start: 184746

End: 186086

Strand: Direct

Name: vmrA [H]

Synonym: VC0395_A0181

Alternate gene names: 147673240

Gene position: 184746-186086 (Clockwise)

Preceding gene: 147674022

Following gene: 147674979

Centisome position: 6.11

GC content: 50.56

Gene sequence:

>1341_bases
TTGTATGATGAATCGATCGATTTACCGACAGTTTGTTCGCTACACCATTCCACGGTGGCTGCGATGCTGGTTAATGGTCT
GTATCAAGTGGTGGATGGCATCTTCATTGGCCATTATGTGGGCGCTGAGGGATTAGCTGGCATTAACGTGGCTTGGCCTG
TGATCGGTACCATCCTCGGGATCGGTATGCTGGTTGGGGTGGGCACTGGAGCTCTGGCTTCAATCAAACAGGGGGAAGGC
CATCCTGACAGTGCTAAGCGTATTCTGGCCACTGGGTTGATGAGTTTGCTGCTACTTGCCCCTATCGTGGCTGTGATTTT
GTGGTTTATGGCGGATGACTTCTTGCGTTGGCAAGGCGCTGAAGGAAGGGTGTTTGAATTAGGCCTGCAGTACCTACAAG
TGTTAATTGTTGGCTGTTTGTTCACCTTAGGCTCGATTGCGATGCCGTTTTTGCTACGTAACGATCACAGCCCCAATTTG
GCTACGTTATTAATGGTGATTGGTGCACTGACCAATATCGCACTTGATTACCTGTTTATCGCTTGGCTGCAATGGGAGCT
GACCGGTGCAGCGATCGCCACCACTCTTGCGCAGGTGGTGGTCACGTTATTAGGCTTGGCGTATTTCTTTTCTGCCCGAG
CCAATATGCGTTTAACTCGTCGTTGCTTAAGGTTGGAGTGGCACTCGTTACCCAAGATCTTCGCGATTGGCGTCTCAAGC
TTTTTTATGTACGCCTACGGTTCCACCATGGTCGCGCTGCACAACACCTTGATGATCGAGTACGGCAACGCCGTCATGGT
CGGTGCTTATGCGGTGATGGGTTACATAGTGACGATCTACTACCTGACCGTTGAAGGTATTGCGAATGGTATGCAGCCGC
TGGCCAGCTACCATTTTGGGGCGCGTAATTACGATCACATCCGTAAGTTATTACGCTTGGCGATGGGGATTGCCGTACTG
GGAGGGATGGCGTTTGTGCTGGTGCTAAACCTCTTCCCTGAGCAGGCGATTGCGATATTTAACTCCAGCGACAGCGAATT
GATCGCCGGAGCGCAAATGGGCATTAAGCTGCACCTGTTTGCGATGTATCTTGATGGTTTCTTAGTGGTGAGCGCGGCGT
ATTACCAATCCACCAATCGCGGTGGCAAAGCCATGTTTATTACCGTGGGGAATATGTCGATCATGTTACCCTTCTTGTTT
ATTTTGCCGCAGTTTTTTGGGCTGACAGGGGTATGGATCGCCTTACCCATCTCCAATATTGTGCTGAGCACTGTGGTCGG
CATTATGCTCTGGCGCGATGTGAACAAAATGGGGAAACCTACCCAAGTTTCCTATGCATGA

Upstream 100 bases:

>100_bases
TTTATCTTCTGAAGAAGCGATGATGCTGGACTTGTTATTGGGTAAAGCCCTGCGCTAGTCAGGTTTTTATTAGATAGGCT
AACTAACTAAATAGATATGT

Downstream 100 bases:

>100_bases
AAAGGAAAAGGCAAATAAAAAGGGTTGCTGATGAGCAACCCTTTGGTAAACCTTAGCTATTTTTAACGGCCAAACCAGCT
AATTGATGCCAGTAACCGTT

Product: multidrug efflux pump VmrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MYDESIDLPTVCSLHHSTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGIGMLVGVGTGALASIKQGEG
HPDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAEGRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNL
ATLLMVIGALTNIALDYLFIAWLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSS
FFMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGARNYDHIRKLLRLAMGIAVL
GGMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFAMYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLF
ILPQFFGLTGVWIALPISNIVLSTVVGIMLWRDVNKMGKPTQVSYA

Sequences:

>Translated_446_residues
MYDESIDLPTVCSLHHSTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGIGMLVGVGTGALASIKQGEG
HPDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAEGRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNL
ATLLMVIGALTNIALDYLFIAWLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSS
FFMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGARNYDHIRKLLRLAMGIAVL
GGMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFAMYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLF
ILPQFFGLTGVWIALPISNIVLSTVVGIMLWRDVNKMGKPTQVSYA
>Mature_446_residues
MYDESIDLPTVCSLHHSTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGIGMLVGVGTGALASIKQGEG
HPDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAEGRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNL
ATLLMVIGALTNIALDYLFIAWLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSS
FFMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGARNYDHIRKLLRLAMGIAVL
GGMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFAMYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLF
ILPQFFGLTGVWIALPISNIVLSTVVGIMLWRDVNKMGKPTQVSYA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48507; Mature: 48507

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA