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The map label for this gene is msrA [H]

Identifier: 146343890

GI number: 146343890

Start: 7454457

End: 7455113

Strand: Reverse

Name: msrA [H]

Synonym: BRADO7141

Alternate gene names: 146343890

Gene position: 7455113-7454457 (Counterclockwise)

Preceding gene: 146343891

Following gene: 146343889

Centisome position: 99.98

GC content: 66.97

Gene sequence:

>657_bases
ATGTTCTTCATGCGCAAGCCCGCTGCCTTGCCGAGCGCCGCCGAGGCGCTGCCCGGCCGTGCCCAGCCGATCCCGACCGC
CACCAAGCATTTCGTCAACGGCCGCGCTTTGCTGCCGCCCTATCCCGCCGGCCTCGAGCAGGCGGTGTTCGGGCTCGGCT
GCTTCTGGGGCGCGGAGCGCAAGTTCTGGCAGCTTGGCAACGGCATTCACGTCACGGCGGTCGGTTACGCTGGCGGCCAT
ACGCCGAACCCGACCTATGAGGAGGTGTGCTCGGGCCTGACCGCGCATACCGAGGTCGTCCTCGTCGTGTTCGATCCCAA
GATCATTTCCTATGAGCGGCTCCTGAAGACGTTCTGGGAGAGCCACGACCCGACCCAAGGCATGCGCCAGGGCAACGACG
TCGGCACGCAGTATCGCTCGGCGGTCTATACCTTCAGCGAGGCTCAGCGCGAGACGGCCGAGGCCTCCAAGCAGGCCTAT
GAAAAGGCGCTGCGTGCCAAGGGTCTCGGCGCGATCACCACGGAGATCGCGCCCGCCGGGCCGTTCTACTTCGCCGAGGA
CTATCACCAGCAGTATCTGGCCAAGAATCCGGCCGGCTATTGCGGTCTCGGCGGCACCGGCGTCGCCTGCCCGATCGGCG
TCGGCGTGAGCGCGTAG

Upstream 100 bases:

>100_bases
TCGCTGCGGTGGCGGGCGTAGAGACCTATATAATCCCACAGTGAAGGCCCTCGCGCCGCCGGACTGTTCCGGCGGGCGAT
GCCATGCCCGGAGACAGCCC

Downstream 100 bases:

>100_bases
TTCCGCCGCATCAGAGGGATCGGCTTGAACATCCGAACCCTCTCCCACGTTTGTGGGAGAGGGTTTTTCTTCGGCAGGCA
CGCAAGCGTCCGTGCTTGCG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFFMRKPAALPSAAEALPGRAQPIPTATKHFVNGRALLPPYPAGLEQAVFGLGCFWGAERKFWQLGNGIHVTAVGYAGGH
TPNPTYEEVCSGLTAHTEVVLVVFDPKIISYERLLKTFWESHDPTQGMRQGNDVGTQYRSAVYTFSEAQRETAEASKQAY
EKALRAKGLGAITTEIAPAGPFYFAEDYHQQYLAKNPAGYCGLGGTGVACPIGVGVSA

Sequences:

>Translated_218_residues
MFFMRKPAALPSAAEALPGRAQPIPTATKHFVNGRALLPPYPAGLEQAVFGLGCFWGAERKFWQLGNGIHVTAVGYAGGH
TPNPTYEEVCSGLTAHTEVVLVVFDPKIISYERLLKTFWESHDPTQGMRQGNDVGTQYRSAVYTFSEAQRETAEASKQAY
EKALRAKGLGAITTEIAPAGPFYFAEDYHQQYLAKNPAGYCGLGGTGVACPIGVGVSA
>Mature_218_residues
MFFMRKPAALPSAAEALPGRAQPIPTATKHFVNGRALLPPYPAGLEQAVFGLGCFWGAERKFWQLGNGIHVTAVGYAGGH
TPNPTYEEVCSGLTAHTEVVLVVFDPKIISYERLLKTFWESHDPTQGMRQGNDVGTQYRSAVYTFSEAQRETAEASKQAY
EKALRAKGLGAITTEIAPAGPFYFAEDYHQQYLAKNPAGYCGLGGTGVACPIGVGVSA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=207, Percent_Identity=61.3526570048309, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI208609995, Length=186, Percent_Identity=63.4408602150538, Blast_Score=255, Evalue=2e-68,
Organism=Homo sapiens, GI208609993, Length=207, Percent_Identity=47.8260869565217, Blast_Score=191, Evalue=5e-49,
Organism=Escherichia coli, GI1790665, Length=189, Percent_Identity=59.7883597883598, Blast_Score=228, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=42.3841059602649, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320881, Length=177, Percent_Identity=37.2881355932203, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664627, Length=145, Percent_Identity=42.0689655172414, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24664631, Length=145, Percent_Identity=41.3793103448276, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=41.1347517730496, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23431; Mature: 23431

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFMRKPAALPSAAEALPGRAQPIPTATKHFVNGRALLPPYPAGLEQAVFGLGCFWGAER
CCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHCCCH
KFWQLGNGIHVTAVGYAGGHTPNPTYEEVCSGLTAHTEVVLVVFDPKIISYERLLKTFWE
HHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
SHDPTQGMRQGNDVGTQYRSAVYTFSEAQRETAEASKQAYEKALRAKGLGAITTEIAPAG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
PFYFAEDYHQQYLAKNPAGYCGLGGTGVACPIGVGVSA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFFMRKPAALPSAAEALPGRAQPIPTATKHFVNGRALLPPYPAGLEQAVFGLGCFWGAER
CCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHCCCH
KFWQLGNGIHVTAVGYAGGHTPNPTYEEVCSGLTAHTEVVLVVFDPKIISYERLLKTFWE
HHHHCCCCEEEEEEECCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHH
SHDPTQGMRQGNDVGTQYRSAVYTFSEAQRETAEASKQAYEKALRAKGLGAITTEIAPAG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCC
PFYFAEDYHQQYLAKNPAGYCGLGGTGVACPIGVGVSA
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA