Click here to switch to the map view.

The map label for this gene is pphA [C]

Identifier: 146343813

GI number: 146343813

Start: 7375369

End: 7376115

Strand: Direct

Name: pphA [C]

Synonym: BRADO7062

Alternate gene names: 146343813

Gene position: 7375369-7376115 (Clockwise)

Preceding gene: 146343812

Following gene: 146343814

Centisome position: 98.91

GC content: 57.7

Gene sequence:

>747_bases
ATGTGGAAGACTCTCAGGTCATTGATGCGCAGGCCGGAGACTGAACAATCCGACGACAACATCGTGTGCATCTATGCAGT
AGGCGATGTGCACGGGCGTCTCGATCTTCTCTCAGAGACGTTGTCTAAGATCGATGCCGACGTAGAAATCACGCATCCTC
GGAGGTGGGTCGAGGTTTTTGTGGGCGACTATGTCGATCGCGGGGCCGATTCGTTCGGCGTCATCGACGCATTAGCCGAA
AGAGCGCGGGCTCCGCATGTCGTCTGTCTGCGCGGCAACCATGAACAGATCTTGCTGAACTTCTTCGCGGACCCGAGTCT
GCTCAAGTCATGGCGCCAATTCGGTGCGCTGCAGACACTGCAGTCATACGGCCTCAAACCGTCCGCCAATCCTGATCTCG
ACGAAAGCTTCCAGCTTGCGGATCAATTACTCCGCGCGATGCCGTCGTCGCATCTCCAGTTTCTGCAGACGCTTCCGACC
TCGTTCTCATTCGGTAATTATTTCTTTGCGCATGCCGGTATAAGGCCGGGAGTTCCGCTCGCGCAGCAGCAGGATCAAGA
CCTCCTGTGGATTCGTGAGGAATTCCTGCTCTGCGACGATGATTTCGGCCAGGTGATCGTGCATGGGCACACGCCGGCTC
GGGCCCCTGAGGTGCTCCACAATCGTATCAACCTCGACACGGGTGCCTATGCCACTGGCCGGCTGACCTGCGCGCGGCTT
CAGGGACGGCAAATCCGGTTCCTATGA

Upstream 100 bases:

>100_bases
ACTATGTTTTCGACATCCGATGTATTCGTGTTGGGAACGGTGCTCGGCTGCGCGATCTCGCAGCGAGTGAGCCGCACGAG
ATCGCAGGACTTCTAAGATC

Downstream 100 bases:

>100_bases
GCGAAACGATTCCAGTTTCCGTCGCACCGACGGACTCGCCCCGAAGCCGACGCGGCATCCCTCTCGCCATCGGTGGGCTG
ACGCTTCTGCTGTCACTCTG

Product: putative serine/threonine protein phosphatase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Protein Phosphatase; Bis(5Nucleosyl)-Tetraphosphatase ApaH; Serine/Threonine Protein Phosphatase Family Protein; Ser/Thr Protein Phosphatase Family Protein; Serine/Threonine Specific Protein Phosphatase Protein; Serine/Threonine Protein Phosphatase I; Diadenosine Tetraphosphatase; Diadenosine Tetraphosphatase-Like Protein; Phosphatase; Serinethreonine Protein Phosphatase; Phosphoprotein Phosphatase; Serine/Threonine Specific Protein Phosphatase; Calcineurin-Like Phosphoesterase; Serine-Threonine Protein Phosphatase; Bis(5-Nucleosyl)-Tetraphosphatase; Serine/Threonine Protein Phosphatase Protein; Protein Phosphatase; Serine/Threonine-Protein Phosphatase

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MWKTLRSLMRRPETEQSDDNIVCIYAVGDVHGRLDLLSETLSKIDADVEITHPRRWVEVFVGDYVDRGADSFGVIDALAE
RARAPHVVCLRGNHEQILLNFFADPSLLKSWRQFGALQTLQSYGLKPSANPDLDESFQLADQLLRAMPSSHLQFLQTLPT
SFSFGNYFFAHAGIRPGVPLAQQQDQDLLWIREEFLLCDDDFGQVIVHGHTPARAPEVLHNRINLDTGAYATGRLTCARL
QGRQIRFL

Sequences:

>Translated_248_residues
MWKTLRSLMRRPETEQSDDNIVCIYAVGDVHGRLDLLSETLSKIDADVEITHPRRWVEVFVGDYVDRGADSFGVIDALAE
RARAPHVVCLRGNHEQILLNFFADPSLLKSWRQFGALQTLQSYGLKPSANPDLDESFQLADQLLRAMPSSHLQFLQTLPT
SFSFGNYFFAHAGIRPGVPLAQQQDQDLLWIREEFLLCDDDFGQVIVHGHTPARAPEVLHNRINLDTGAYATGRLTCARL
QGRQIRFL
>Mature_248_residues
MWKTLRSLMRRPETEQSDDNIVCIYAVGDVHGRLDLLSETLSKIDADVEITHPRRWVEVFVGDYVDRGADSFGVIDALAE
RARAPHVVCLRGNHEQILLNFFADPSLLKSWRQFGALQTLQSYGLKPSANPDLDESFQLADQLLRAMPSSHLQFLQTLPT
SFSFGNYFFAHAGIRPGVPLAQQQDQDLLWIREEFLLCDDDFGQVIVHGHTPARAPEVLHNRINLDTGAYATGRLTCARL
QGRQIRFL

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 28071; Mature: 28071

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKTLRSLMRRPETEQSDDNIVCIYAVGDVHGRLDLLSETLSKIDADVEITHPRRWVEVF
CCHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHH
VGDYVDRGADSFGVIDALAERARAPHVVCLRGNHEQILLNFFADPSLLKSWRQFGALQTL
HHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHH
QSYGLKPSANPDLDESFQLADQLLRAMPSSHLQFLQTLPTSFSFGNYFFAHAGIRPGVPL
HHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCC
AQQQDQDLLWIREEFLLCDDDFGQVIVHGHTPARAPEVLHNRINLDTGAYATGRLTCARL
CCCCCCCCEEEHHHHEECCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEC
QGRQIRFL
CCCEECCC
>Mature Secondary Structure
MWKTLRSLMRRPETEQSDDNIVCIYAVGDVHGRLDLLSETLSKIDADVEITHPRRWVEVF
CCHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHH
VGDYVDRGADSFGVIDALAERARAPHVVCLRGNHEQILLNFFADPSLLKSWRQFGALQTL
HHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHH
QSYGLKPSANPDLDESFQLADQLLRAMPSSHLQFLQTLPTSFSFGNYFFAHAGIRPGVPL
HHCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCC
AQQQDQDLLWIREEFLLCDDDFGQVIVHGHTPARAPEVLHNRINLDTGAYATGRLTCARL
CCCCCCCCEEEHHHHEECCCCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEC
QGRQIRFL
CCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA