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The map label for this gene is phoR [H]

Identifier: 146343545

GI number: 146343545

Start: 7039679

End: 7040986

Strand: Reverse

Name: phoR [H]

Synonym: BRADO6782

Alternate gene names: 146343545

Gene position: 7040986-7039679 (Counterclockwise)

Preceding gene: 146343546

Following gene: 146343543

Centisome position: 94.43

GC content: 70.18

Gene sequence:

>1308_bases
ATGGCGCTCGATGCTCCCTCCCAATCCCCGGTGACCATCTTTGCGCCGTGGCCGGACCGCCTGCGGCACGCCGCCATCAT
CCTGCTGGCGGCCGCGCTGGCGCTGGCCGGCTTGGTGCTGCTCGACGAGCTGCTGCCGCTGCGCGCCCTCGCTGCATTCC
TCTGCATCGCGGCCGCGGCCCTGGTGCCATGGCGGTTACACAGCGCGGTGGCCAAGCGCGAGGACGAGCGGCTCGCCAAT
CCGGTGGAGTCGCCGGCGGTCAGCGCTGTGGTCGATGGCATCCCCGATCCCGCCGTGCTGCTCGACCGCGCCGGCCGCGT
GATCCACCTCAATGCCGCCGCGGCCCAGCTCGCGCCCGCCTTGCGCAAGGGCGAGCTCGCCCAGTTCGCGCTACGCACGC
CGGAGATCATCACCGCGCTGCGCGAGGCGATCGCCACCACCGAGATCCGCCGCGCCAGCTATCACGACCACGTGCCGGTC
GATCGCTGGATGGAGCTGATCATCACGCCGGTGCCGGTGCCCACGGCCTTCGGCGGCACCGACAAGTGCATGCTGATGAC
GTTCCGCGACCTGACGCCGCTGCGGCGGGTCGAGGAGATGCGTGCCGATTTCGTCGCCAATGCCAGCCATGAGCTGCGTA
CGCCGCTCGCCGCTCTGTCCGGCTTCATCGACACCCTGCAGGGCCCGGCCAAGGATGATCCCAAGGCGCGCGAGCGCTTC
CTCGGGATCATGCACACCCAGGCGACGCGCATGGCGCGGTTGATCGACGATCTCCTGTCGCTGTCGCGCGTCGAGTTGTC
GGCGCATGTCCGTCCCGACACGCTGGTCGATGTCGTTCCCATCATCCGCCAGGTCACCGACGGCCTCGAATCCCTGGCGC
GCGAACGCCAGGTGGTGATCGAGACCAGCCTGCCGGAGACGCCCGTCACCATCGCCGGCGACCGCGAGGAATTGTTGCGG
GTGTTCGAGAACCTGATCGAGAACGCGCTGAAATACGGCGCGTCCGGTGGCCGGGTGATCGTGTCGCTGGAGCACGCCGT
CTCGGCCGAGAACGCGCCGGAGATCCGGGTGAAGGTGCGCGATTTCGGCCCGGGCATCGCGCCCGAGCATCTGCCGCGCC
TGACCGAGCGGTTCTACCGCGTCGATGTCGGCGACAGCCGCGCGCAGGGCGGAACCGGCCTTGGCCTCGCGCTGGTGAAG
CACATCCTGAACCGCCATCGCGGCCGGCTGTTGATCGAGAGCGTGCCGCGCAACGGCGCGGCCTTCACCGCCTGCTTCCC
GCAGTCGCGGCCGGCCCGCGCCTCCTGA

Upstream 100 bases:

>100_bases
GCGCTCAGCCTCGATCCTGGTCCTCCGCCCGAGGCCGCTTTTGCAAGGAAACGCAGCGATTCCGGTGCCTGACCCGATCA
GGGGAGCTGACTAGGCCGCC

Downstream 100 bases:

>100_bases
CATGATCCAGAATGCAAAAGGCCCGGCGCGGGCCGGGCCTTTCTCGTCAGTTGTTAGTTGCCGCGGCGCGCGCGCCTCAG
CGCGTCGGCGACTTCGACGG

Product: two component sensor histidine kinase/phosphate regulon

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MALDAPSQSPVTIFAPWPDRLRHAAIILLAAALALAGLVLLDELLPLRALAAFLCIAAAALVPWRLHSAVAKREDERLAN
PVESPAVSAVVDGIPDPAVLLDRAGRVIHLNAAAAQLAPALRKGELAQFALRTPEIITALREAIATTEIRRASYHDHVPV
DRWMELIITPVPVPTAFGGTDKCMLMTFRDLTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAKDDPKARERF
LGIMHTQATRMARLIDDLLSLSRVELSAHVRPDTLVDVVPIIRQVTDGLESLARERQVVIETSLPETPVTIAGDREELLR
VFENLIENALKYGASGGRVIVSLEHAVSAENAPEIRVKVRDFGPGIAPEHLPRLTERFYRVDVGDSRAQGGTGLGLALVK
HILNRHRGRLLIESVPRNGAAFTACFPQSRPARAS

Sequences:

>Translated_435_residues
MALDAPSQSPVTIFAPWPDRLRHAAIILLAAALALAGLVLLDELLPLRALAAFLCIAAAALVPWRLHSAVAKREDERLAN
PVESPAVSAVVDGIPDPAVLLDRAGRVIHLNAAAAQLAPALRKGELAQFALRTPEIITALREAIATTEIRRASYHDHVPV
DRWMELIITPVPVPTAFGGTDKCMLMTFRDLTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAKDDPKARERF
LGIMHTQATRMARLIDDLLSLSRVELSAHVRPDTLVDVVPIIRQVTDGLESLARERQVVIETSLPETPVTIAGDREELLR
VFENLIENALKYGASGGRVIVSLEHAVSAENAPEIRVKVRDFGPGIAPEHLPRLTERFYRVDVGDSRAQGGTGLGLALVK
HILNRHRGRLLIESVPRNGAAFTACFPQSRPARAS
>Mature_434_residues
ALDAPSQSPVTIFAPWPDRLRHAAIILLAAALALAGLVLLDELLPLRALAAFLCIAAAALVPWRLHSAVAKREDERLANP
VESPAVSAVVDGIPDPAVLLDRAGRVIHLNAAAAQLAPALRKGELAQFALRTPEIITALREAIATTEIRRASYHDHVPVD
RWMELIITPVPVPTAFGGTDKCMLMTFRDLTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAKDDPKARERFL
GIMHTQATRMARLIDDLLSLSRVELSAHVRPDTLVDVVPIIRQVTDGLESLARERQVVIETSLPETPVTIAGDREELLRV
FENLIENALKYGASGGRVIVSLEHAVSAENAPEIRVKVRDFGPGIAPEHLPRLTERFYRVDVGDSRAQGGTGLGLALVKH
ILNRHRGRLLIESVPRNGAAFTACFPQSRPARAS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=348, Percent_Identity=33.0459770114943, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786783, Length=253, Percent_Identity=30.4347826086957, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788713, Length=365, Percent_Identity=24.6575342465753, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=29.6610169491525, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790346, Length=240, Percent_Identity=28.75, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789149, Length=232, Percent_Identity=28.448275862069, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789403, Length=203, Percent_Identity=32.0197044334975, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=32.3529411764706, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790861, Length=251, Percent_Identity=28.2868525896414, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=355, Percent_Identity=24.2253521126761, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=24.8031496062992, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790551, Length=214, Percent_Identity=29.4392523364486, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=244, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790300, Length=235, Percent_Identity=30.2127659574468, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789808, Length=234, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=26.7489711934156, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788279, Length=231, Percent_Identity=26.8398268398268, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=25.3164556962025, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47369; Mature: 47238

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDAPSQSPVTIFAPWPDRLRHAAIILLAAALALAGLVLLDELLPLRALAAFLCIAAAA
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVPWRLHSAVAKREDERLANPVESPAVSAVVDGIPDPAVLLDRAGRVIHLNAAAAQLAPA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHHHHHH
LRKGELAQFALRTPEIITALREAIATTEIRRASYHDHVPVDRWMELIITPVPVPTAFGGT
HHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCC
DKCMLMTFRDLTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAKDDPKARERF
CCEEEEEHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGIMHTQATRMARLIDDLLSLSRVELSAHVRPDTLVDVVPIIRQVTDGLESLARERQVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEE
ETSLPETPVTIAGDREELLRVFENLIENALKYGASGGRVIVSLEHAVSAENAPEIRVKVR
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCEEEEEE
DFGPGIAPEHLPRLTERFYRVDVGDSRAQGGTGLGLALVKHILNRHRGRLLIESVPRNGA
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCC
AFTACFPQSRPARAS
EEEEECCCCCCCCCC
>Mature Secondary Structure 
ALDAPSQSPVTIFAPWPDRLRHAAIILLAAALALAGLVLLDELLPLRALAAFLCIAAAA
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVPWRLHSAVAKREDERLANPVESPAVSAVVDGIPDPAVLLDRAGRVIHLNAAAAQLAPA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEEHHHHHHHHH
LRKGELAQFALRTPEIITALREAIATTEIRRASYHDHVPVDRWMELIITPVPVPTAFGGT
HHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCC
DKCMLMTFRDLTPLRRVEEMRADFVANASHELRTPLAALSGFIDTLQGPAKDDPKARERF
CCEEEEEHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGIMHTQATRMARLIDDLLSLSRVELSAHVRPDTLVDVVPIIRQVTDGLESLARERQVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEE
ETSLPETPVTIAGDREELLRVFENLIENALKYGASGGRVIVSLEHAVSAENAPEIRVKVR
ECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCEEEEEE
DFGPGIAPEHLPRLTERFYRVDVGDSRAQGGTGLGLALVKHILNRHRGRLLIESVPRNGA
ECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCC
AFTACFPQSRPARAS
EEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]