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The map label for this gene is pyrD [H]

Identifier: 146343510

GI number: 146343510

Start: 7003804

End: 7004898

Strand: Reverse

Name: pyrD [H]

Synonym: BRADO6742

Alternate gene names: 146343510

Gene position: 7004898-7003804 (Counterclockwise)

Preceding gene: 146343511

Following gene: 146343505

Centisome position: 93.94

GC content: 69.86

Gene sequence:

>1095_bases
GTGATCCGCGCCTTCGACCAGCTCTCGCTGCCGCTGCTCCGCTGGCTCGATGCCGAGGATGCGCACCGTCTCGCCATCCA
GGGCCTGAAGCTGCTGCCCGCCGTCAAGCCGCGGGCGGACGACGCCAAGCTCGCGGTGCGCGCTTTCGGGCTGAACTTCC
CGAACCCGGTCGGCATGGCCGCCGGCTTCGACAAGAACGCCGAGGTGCCGGACGCCCTGCTGCGGCTCGGCTTCGGCTTC
GTCGAGATCGGCTCGGTCACGCCGCGTCCGCAGAGCGGCAATCCGCGGCCGCGGCTGTTCCGGCTGGAGCGCGACGAGGC
GGTCATCAACCGCATGGGCTTCAACAATGACGGCGCCGAGATCGTGCTGCGCCGGCTCGCCGGTCGCGCCAACCAGGGCG
GCATCGTCGGCGTCAATGTCGGGGCCAACAAGGATTCCGCCGACCGCGTCGCCGACTACGTCCGGCTGATCGAGACCTTC
GCGCCGGTGGCGAGCTATTTCACCGTCAACATCTCCTCGCCGAACACGCCCGGCCTGCGCAATCTGCAGCAGGCGTCGCA
GCTCGATGACTTGCTGACCAAGGTGCTGGAGGCGCGCGACCGCGTCCGCCGCAAGGCCGGCGACACTCCGGTGCTGCTCA
AGATCGCGCCCGATCTCAGCCTCGCCGAGCTCGACGACGTCGTCCATGTCGCGCGCTCGCGCGGCGTCGACGGCATGATC
GTGTCGAACACCACGCTGGCCCGTCCGAACTCGCTGCGCGAGCAGATGCGCGCCAAGGAGCAGGGCGGGCTCTCGGGCCG
GCCGCTGTTCCGGCTGTCGACGCGCATGGTCGCGGAGACCTTCGTGCGCGTCGAGGGCGCCTTCCCGCTGATCGGCGTCG
GCGGCATCGACACCGGCGGCGCCGCGCTGACGAAAATTCGCGCCGGCGCCAGCTTGATCCAGCTGTACTCCTCGCTGGTC
TACAAGGGCCTCGGCCTAGTCGAGAGCATCAAGGCGGATTTGACCTCGACCCTGCTGCGCACGGGGCGCGAGTCGCTGTC
CGAGATCGTCGGCGCCGATGCGGCGACGATCACGGCGGAGGACTGGCCGGTCTAG

Upstream 100 bases:

>100_bases
TCCCCCATCTCTATGGCGAGCTCGATCTCGGCGCGGTCACCGCCGTTCACCAGATGCACAGCCGGGCCGACGGCGGTCAC
GACATTCCGGACCTCGTGCC

Downstream 100 bases:

>100_bases
TTGGCGCTTTGTCGTTATGCTGAGGACAAGCATCGCCAGCACGCTGTGAGATACAGCGCCCTCTCCCCTTGTGGGAGAGG
GCATCTCCGGCCGGTCCGCC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MIRAFDQLSLPLLRWLDAEDAHRLAIQGLKLLPAVKPRADDAKLAVRAFGLNFPNPVGMAAGFDKNAEVPDALLRLGFGF
VEIGSVTPRPQSGNPRPRLFRLERDEAVINRMGFNNDGAEIVLRRLAGRANQGGIVGVNVGANKDSADRVADYVRLIETF
APVASYFTVNISSPNTPGLRNLQQASQLDDLLTKVLEARDRVRRKAGDTPVLLKIAPDLSLAELDDVVHVARSRGVDGMI
VSNTTLARPNSLREQMRAKEQGGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGIDTGGAALTKIRAGASLIQLYSSLV
YKGLGLVESIKADLTSTLLRTGRESLSEIVGADAATITAEDWPV

Sequences:

>Translated_364_residues
MIRAFDQLSLPLLRWLDAEDAHRLAIQGLKLLPAVKPRADDAKLAVRAFGLNFPNPVGMAAGFDKNAEVPDALLRLGFGF
VEIGSVTPRPQSGNPRPRLFRLERDEAVINRMGFNNDGAEIVLRRLAGRANQGGIVGVNVGANKDSADRVADYVRLIETF
APVASYFTVNISSPNTPGLRNLQQASQLDDLLTKVLEARDRVRRKAGDTPVLLKIAPDLSLAELDDVVHVARSRGVDGMI
VSNTTLARPNSLREQMRAKEQGGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGIDTGGAALTKIRAGASLIQLYSSLV
YKGLGLVESIKADLTSTLLRTGRESLSEIVGADAATITAEDWPV
>Mature_364_residues
MIRAFDQLSLPLLRWLDAEDAHRLAIQGLKLLPAVKPRADDAKLAVRAFGLNFPNPVGMAAGFDKNAEVPDALLRLGFGF
VEIGSVTPRPQSGNPRPRLFRLERDEAVINRMGFNNDGAEIVLRRLAGRANQGGIVGVNVGANKDSADRVADYVRLIETF
APVASYFTVNISSPNTPGLRNLQQASQLDDLLTKVLEARDRVRRKAGDTPVLLKIAPDLSLAELDDVVHVARSRGVDGMI
VSNTTLARPNSLREQMRAKEQGGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGIDTGGAALTKIRAGASLIQLYSSLV
YKGLGLVESIKADLTSTLLRTGRESLSEIVGADAATITAEDWPV

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=361, Percent_Identity=47.9224376731302, Blast_Score=311, Evalue=7e-85,
Organism=Escherichia coli, GI1787177, Length=326, Percent_Identity=44.478527607362, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17509475, Length=361, Percent_Identity=43.213296398892, Blast_Score=275, Evalue=2e-74,
Organism=Drosophila melanogaster, GI281361352, Length=356, Percent_Identity=46.3483146067416, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI17137316, Length=356, Percent_Identity=46.3483146067416, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24640763, Length=358, Percent_Identity=25.1396648044693, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI18858217, Length=358, Percent_Identity=25.1396648044693, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39209; Mature: 39209

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRAFDQLSLPLLRWLDAEDAHRLAIQGLKLLPAVKPRADDAKLAVRAFGLNFPNPVGMA
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCCCCCCC
AGFDKNAEVPDALLRLGFGFVEIGSVTPRPQSGNPRPRLFRLERDEAVINRMGFNNDGAE
CCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCHHH
IVLRRLAGRANQGGIVGVNVGANKDSADRVADYVRLIETFAPVASYFTVNISSPNTPGLR
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHH
NLQQASQLDDLLTKVLEARDRVRRKAGDTPVLLKIAPDLSLAELDDVVHVARSRGVDGMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEE
VSNTTLARPNSLREQMRAKEQGGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGIDTGG
ECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
AALTKIRAGASLIQLYSSLVYKGLGLVESIKADLTSTLLRTGRESLSEIVGADAATITAE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
DWPV
CCCC
>Mature Secondary Structure
MIRAFDQLSLPLLRWLDAEDAHRLAIQGLKLLPAVKPRADDAKLAVRAFGLNFPNPVGMA
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCCCCCCC
AGFDKNAEVPDALLRLGFGFVEIGSVTPRPQSGNPRPRLFRLERDEAVINRMGFNNDGAE
CCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCHHH
IVLRRLAGRANQGGIVGVNVGANKDSADRVADYVRLIETFAPVASYFTVNISSPNTPGLR
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHH
NLQQASQLDDLLTKVLEARDRVRRKAGDTPVLLKIAPDLSLAELDDVVHVARSRGVDGMI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEE
VSNTTLARPNSLREQMRAKEQGGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGIDTGG
ECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
AALTKIRAGASLIQLYSSLVYKGLGLVESIKADLTSTLLRTGRESLSEIVGADAATITAE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
DWPV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA