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The map label for this gene is trxB [H]

Identifier: 146343411

GI number: 146343411

Start: 6892646

End: 6894364

Strand: Reverse

Name: trxB [H]

Synonym: BRADO6640

Alternate gene names: 146343411

Gene position: 6894364-6892646 (Counterclockwise)

Preceding gene: 146343412

Following gene: 146343410

Centisome position: 92.46

GC content: 69.4

Gene sequence:

>1719_bases
ATGACGGTGACTGACGGGACGACGGCGGGTGCCGCGGCGGGGCGTGCGGAGCTGGCCAAAACCTTTGTCCGGTTCGAGCA
GACCTTCCCGGAGCTGACGCCGCAGGAGATCGCCCGCCTGCGCGGCTTCGGCGAGATCAGGACCTATCGCGACGGTGAGC
TGCTGTTCGAGACGGGCAAGCCTGGTCCCGGCATGTTCGTGATCCTCAAGGGCCACGTCGCCATCACCCAGCGCGACGGC
CTGGGTCACGTCACGCCCGTGATCGACCAGGGCCCGGGACAGTTTCTCGCCGAGATCGGCCAGCTCTCCGGCCGGATCGC
CCTGGTCGACGGTCATGCCGAAGGCGAGGTCGAGGTCATCCTGATTCGCCCGGACAAGCTGCGGGCGCTGCTGATCGCCG
AGGCCGAGCTTGGCGAGCGCATCATGCGGGCGCTGATCCTGCGCCGGGTCAATCTGATCCAGGGCGGTGCTGGCGGCCCG
GTCCTGATCGGCCCGCCGCAATCGGCGGCGATCGCGCGGTTGCAGAGCTTTCTCACCCGCAACGGTTTTCCGCACCACCT
GCTCGATCCCGCCGCCGATCACGATGCCGCCGATCTGATCGCGCGCTATTCGCCGACGCCGGCCGAACTGCCGCTCGTCG
TGGTCTCCGACGGCAGCGTGCTGCGCAATCCCAGCGAGAACGAGCTGGCGCGCGCCGTCGGCATGATCGGCGGTCCGCGC
GGCGAGAAGATCTACGACGTCGCCGTGGTCGGCTGCGGACCGGCGGGACTTGCCACCGCGGTGTATGGCGCCTCCGAAGG
CCTCTCCGTGGCGGTGCTGGATTCCCGCGCCTTCGGCGGCCAGGCCGGCGCCAGCGCGCGCATCGAGAATTATTTCGGCT
TTCCGACCGGAATCACCGGGCTCGCGCTGACCGCCCGCGCCTTCAACCAGGCGCAGAAATTCGGCGCCGAGATCATGATC
CCGGTATCGGTGACGGCGCTCGATTGCGAGCGCAAGAATGGCGCCTTCGTGCTGGCGCTGGAGGGCGGCGACGAGGTGCG
GGCCCGCTCGGTCGTGGTCGCCAGCGGCGCGCGCTACCGGCGTCCCGATCTTGATCGCCTCAAGGAGTTCGAGGGCCGCG
GCGTCTGGTACTGGGCCTCGCCGATCGAGGCGCGGCTGTGCGCGGGCCAGGAGGTCGCGCTGGTCGGCGGCGGGAATTCG
GCGGGACAGGCGGCGGTGTTTCTCTCCGGGCACGTCAAGAAGGTGCGGATGATCATCCGCGGCGGCGGGCTCGCCGCATC
GATGTCGCGCTACCTGATCGAGCGGATCGAGGCGACGCCGAATATCGAGCTCATGTTCAACACCGAGGTGGTCGCGCTCG
ACGGCGGCACTGATGCGGGGCTTGAGCGCATCACGCTGAAGAGCCGGCTGTCCGGCGAGGAGACGCCGGCCAATATCAGC
AATCTCTTTCTCTTCGTCGGCGCCGATCCCGCCACCGGCTGGCTCGGCAATTGCGGCGTGACGCTGGACCGCGCCGGATT
CGTCGTGACCGGCGCGCAGTCCGAGCAGAATGCCGGGCGGATGGTGTCGCCGCTGGAGACCTCGGTGCCGGGTGTCTATG
CGGTGGGCGACGTGCGCTCCGGCTCGGTCAAGCGGGTCGGTGGTGCGATCGGCGAGGGCGCTCAGGTGGTGGCCGCGCTG
CACGGCTTTCTTGCCGATCCGCTGGTGCCGCCGGTCTGA

Upstream 100 bases:

>100_bases
GAGCCAGGCGGTCGCGGCCGAGACGGGCAGTGCCGTCGAGGCCCCAGGCGATGATGCCGATGATTCGGTGCGTTGAGCAG
AGTGGACGTAGGGGAGCGTG

Downstream 100 bases:

>100_bases
TTCGCCCAGCGGGTTGCACCGTCAGGGGATGACTCCGCGGAGGATGCGACCTGCCGTTGCGAACCCATCAAATCGCCGTA
ATGTCGGTCCTGTTGCGCCA

Product: nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MTVTDGTTAGAAAGRAELAKTFVRFEQTFPELTPQEIARLRGFGEIRTYRDGELLFETGKPGPGMFVILKGHVAITQRDG
LGHVTPVIDQGPGQFLAEIGQLSGRIALVDGHAEGEVEVILIRPDKLRALLIAEAELGERIMRALILRRVNLIQGGAGGP
VLIGPPQSAAIARLQSFLTRNGFPHHLLDPAADHDAADLIARYSPTPAELPLVVVSDGSVLRNPSENELARAVGMIGGPR
GEKIYDVAVVGCGPAGLATAVYGASEGLSVAVLDSRAFGGQAGASARIENYFGFPTGITGLALTARAFNQAQKFGAEIMI
PVSVTALDCERKNGAFVLALEGGDEVRARSVVVASGARYRRPDLDRLKEFEGRGVWYWASPIEARLCAGQEVALVGGGNS
AGQAAVFLSGHVKKVRMIIRGGGLAASMSRYLIERIEATPNIELMFNTEVVALDGGTDAGLERITLKSRLSGEETPANIS
NLFLFVGADPATGWLGNCGVTLDRAGFVVTGAQSEQNAGRMVSPLETSVPGVYAVGDVRSGSVKRVGGAIGEGAQVVAAL
HGFLADPLVPPV

Sequences:

>Translated_572_residues
MTVTDGTTAGAAAGRAELAKTFVRFEQTFPELTPQEIARLRGFGEIRTYRDGELLFETGKPGPGMFVILKGHVAITQRDG
LGHVTPVIDQGPGQFLAEIGQLSGRIALVDGHAEGEVEVILIRPDKLRALLIAEAELGERIMRALILRRVNLIQGGAGGP
VLIGPPQSAAIARLQSFLTRNGFPHHLLDPAADHDAADLIARYSPTPAELPLVVVSDGSVLRNPSENELARAVGMIGGPR
GEKIYDVAVVGCGPAGLATAVYGASEGLSVAVLDSRAFGGQAGASARIENYFGFPTGITGLALTARAFNQAQKFGAEIMI
PVSVTALDCERKNGAFVLALEGGDEVRARSVVVASGARYRRPDLDRLKEFEGRGVWYWASPIEARLCAGQEVALVGGGNS
AGQAAVFLSGHVKKVRMIIRGGGLAASMSRYLIERIEATPNIELMFNTEVVALDGGTDAGLERITLKSRLSGEETPANIS
NLFLFVGADPATGWLGNCGVTLDRAGFVVTGAQSEQNAGRMVSPLETSVPGVYAVGDVRSGSVKRVGGAIGEGAQVVAAL
HGFLADPLVPPV
>Mature_571_residues
TVTDGTTAGAAAGRAELAKTFVRFEQTFPELTPQEIARLRGFGEIRTYRDGELLFETGKPGPGMFVILKGHVAITQRDGL
GHVTPVIDQGPGQFLAEIGQLSGRIALVDGHAEGEVEVILIRPDKLRALLIAEAELGERIMRALILRRVNLIQGGAGGPV
LIGPPQSAAIARLQSFLTRNGFPHHLLDPAADHDAADLIARYSPTPAELPLVVVSDGSVLRNPSENELARAVGMIGGPRG
EKIYDVAVVGCGPAGLATAVYGASEGLSVAVLDSRAFGGQAGASARIENYFGFPTGITGLALTARAFNQAQKFGAEIMIP
VSVTALDCERKNGAFVLALEGGDEVRARSVVVASGARYRRPDLDRLKEFEGRGVWYWASPIEARLCAGQEVALVGGGNSA
GQAAVFLSGHVKKVRMIIRGGGLAASMSRYLIERIEATPNIELMFNTEVVALDGGTDAGLERITLKSRLSGEETPANISN
LFLFVGADPATGWLGNCGVTLDRAGFVVTGAQSEQNAGRMVSPLETSVPGVYAVGDVRSGSVKRVGGAIGEGAQVVAALH
GFLADPLVPPV

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=333, Percent_Identity=29.4294294294294, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1787114, Length=309, Percent_Identity=28.4789644012945, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320560, Length=335, Percent_Identity=31.044776119403, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321898, Length=336, Percent_Identity=29.7619047619048, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 59849; Mature: 59718

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTDGTTAGAAAGRAELAKTFVRFEQTFPELTPQEIARLRGFGEIRTYRDGELLFETGK
CEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHEEECCCCEEEECCC
PGPGMFVILKGHVAITQRDGLGHVTPVIDQGPGQFLAEIGQLSGRIALVDGHAEGEVEVI
CCCCEEEEEECCEEEEECCCCCCCCCCEECCCHHHHHHHHHCCCEEEEEECCCCCCEEEE
LIRPDKLRALLIAEAELGERIMRALILRRVNLIQGGAGGPVLIGPPQSAAIARLQSFLTR
EECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHC
NGFPHHLLDPAADHDAADLIARYSPTPAELPLVVVSDGSVLRNPSENELARAVGMIGGPR
CCCCCHHCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCEECCCCHHHHHHHHHHCCCCC
GEKIYDVAVVGCGPAGLATAVYGASEGLSVAVLDSRAFGGQAGASARIENYFGFPTGITG
CCEEEEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCHH
LALTARAFNQAQKFGAEIMIPVSVTALDCERKNGAFVLALEGGDEVRARSVVVASGARYR
HHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCEEEEEEEECCCCCC
RPDLDRLKEFEGRGVWYWASPIEARLCAGQEVALVGGGNSAGQAAVFLSGHVKKVRMIIR
CCCHHHHHHHCCCEEEEECCCHHHHHCCCCEEEEEECCCCCCCEEEEEECCCEEEEEEEE
GGGLAASMSRYLIERIEATPNIELMFNTEVVALDGGTDAGLERITLKSRLSGEETPANIS
CCCHHHHHHHHHHHHHCCCCCEEEEEECEEEEECCCCCCCHHEEEEHHHCCCCCCCCCCE
NLFLFVGADPATGWLGNCGVTLDRAGFVVTGAQSEQNAGRMVSPLETSVPGVYAVGDVRS
EEEEEEECCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCEECCHHHCCCCEEEECCCCC
GSVKRVGGAIGEGAQVVAALHGFLADPLVPPV
CCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TVTDGTTAGAAAGRAELAKTFVRFEQTFPELTPQEIARLRGFGEIRTYRDGELLFETGK
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHEEECCCCEEEECCC
PGPGMFVILKGHVAITQRDGLGHVTPVIDQGPGQFLAEIGQLSGRIALVDGHAEGEVEVI
CCCCEEEEEECCEEEEECCCCCCCCCCEECCCHHHHHHHHHCCCEEEEEECCCCCCEEEE
LIRPDKLRALLIAEAELGERIMRALILRRVNLIQGGAGGPVLIGPPQSAAIARLQSFLTR
EECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHC
NGFPHHLLDPAADHDAADLIARYSPTPAELPLVVVSDGSVLRNPSENELARAVGMIGGPR
CCCCCHHCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCEECCCCHHHHHHHHHHCCCCC
GEKIYDVAVVGCGPAGLATAVYGASEGLSVAVLDSRAFGGQAGASARIENYFGFPTGITG
CCEEEEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCCCHH
LALTARAFNQAQKFGAEIMIPVSVTALDCERKNGAFVLALEGGDEVRARSVVVASGARYR
HHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCEEEEEEEECCCCCC
RPDLDRLKEFEGRGVWYWASPIEARLCAGQEVALVGGGNSAGQAAVFLSGHVKKVRMIIR
CCCHHHHHHHCCCEEEEECCCHHHHHCCCCEEEEEECCCCCCCEEEEEECCCEEEEEEEE
GGGLAASMSRYLIERIEATPNIELMFNTEVVALDGGTDAGLERITLKSRLSGEETPANIS
CCCHHHHHHHHHHHHHCCCCCEEEEEECEEEEECCCCCCCHHEEEEHHHCCCCCCCCCCE
NLFLFVGADPATGWLGNCGVTLDRAGFVVTGAQSEQNAGRMVSPLETSVPGVYAVGDVRS
EEEEEEECCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCEECCHHHCCCCEEEECCCCC
GSVKRVGGAIGEGAQVVAALHGFLADPLVPPV
CCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]