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The map label for this gene is hisD [H]

Identifier: 146343408

GI number: 146343408

Start: 6889366

End: 6890661

Strand: Reverse

Name: hisD [H]

Synonym: BRADO6637

Alternate gene names: 146343408

Gene position: 6890661-6889366 (Counterclockwise)

Preceding gene: 146343409

Following gene: 146343407

Centisome position: 92.41

GC content: 69.29

Gene sequence:

>1296_bases
ATGCCCATTCGCCTGTCCCGCGCCAGCGCCGATTTCGACACCCAGTTTCGGCAGTTTCTCGCCGCCAAGCGCGAGGTCTC
CGCCGACGTCGAAGCCGCCGCCCGCGCCATCGTGGATGACGTCGCCAGGCGCGGCGATGCGGCGCTGCTCGAGGCGACGG
CCAAGTTCGACCGGCTGGAGCTGAGCGCCGCCACGCTGCGCGTCACGGCGTCCGAAATCGAAGCCGCGGTGAAAGCTTGC
GACACGGCGACCGTCGATGCGCTGACATTCGCCCGCGACCGCATCGAGGCCTTTCACCTCAAGCAGCTGCCCCAGGACCA
GCGCTTCACCGATGTCGCCGGCGTCGAGCTCGGCTGGCGCTGGAGCGCGATCGAATCGGCCGGGCTCTATGTCCCGGGCG
GCACGGCGGCGTATCCGTCCTCGGTGCTGATGAACGCCATTCCCGCCAAGGTCGCAGGCGTCTCTCGCCTCGTCATGGTG
GTGCCGGCGCCGGACGGCAAGCTCAATCCACTGGTACTGGCGGCGGCGCATCTTGGCGGCGTTTCCGAGATCTACCGCGT
TGGCGGTGCCCAGGCCGTGGCGGCGCTGGCGCATGGCACCGCGACGATCGCCCCGGTCGCCAAGATCGTCGGCCCCGGCA
ATGCCTATGTCGCCGCCGCCAAGCGGCTGGTGTTCGGCAAGGTCGGCATCGACATGATCGCAGGCCCCTCCGAGGTGCTG
GTGATCGCCGATGACAGCGGCAATGCCGACTGGATCGCGGCCGATCTGCTCGCCCAGGCCGAGCACGATGCCAGCGCGCA
GTCGATCCTGATCACCGACAGCCGCCGCCTGGCCGATGACGTCGCCCGCGCCGTCGAGAGCCAGCTCAAGACCCTGCCCC
GCGCCGCGATCGCCGGCGCGTCCTGGGCCGATTTCGGCGCCATCATCGAGGTCGACCACCTCGACGAGGCCGTGCCGCTC
GCGGACGCCATCGCCGCCGAGCATCTCGAGATCATGACCGCCGATCCCGATGCGTTCGCGGCCAAGGTCCGCAATGCCGG
TGCCATCTTCCTCGGCGCGCACACGCCGGAGGCGATCGGCGACTATGTCGGCGGCTCCAATCACGTGCTGCCCACCGCGC
GCTCGGCGCGGTTCTCCTCCGGTCTCGGCGTGCTCGACTTCATGAAGCGCACGTCGCTGTTGAAATGCGGTCCGGAGCAG
TTGCGCGCGCTGGGGCCAGCGGCGATGACTCTGGGCAAGGCCGAGGGTCTCGACGCCCATTCACGCTCCGTGGGAATACG
CCTCAATCTGCCATGA

Upstream 100 bases:

>100_bases
GCTGACCGGGTAGGGGCCGGTTCAAAGGGTTGACGGCCCCGCGCTGCCGCGCCATTGAGCAGGGGGTCTGGGGCAGCCAC
CCCTTCGGAAAGTGCCAGAG

Downstream 100 bases:

>100_bases
CCCAGCACCCGCCAGGCGACGACCGGACCAATCGCATCGTGGCGGTGACGCTCGACGAGGAGTCGATCGGCCGCTCCGGT
CCGGACATCGAGCATGAGCG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MPIRLSRASADFDTQFRQFLAAKREVSADVEAAARAIVDDVARRGDAALLEATAKFDRLELSAATLRVTASEIEAAVKAC
DTATVDALTFARDRIEAFHLKQLPQDQRFTDVAGVELGWRWSAIESAGLYVPGGTAAYPSSVLMNAIPAKVAGVSRLVMV
VPAPDGKLNPLVLAAAHLGGVSEIYRVGGAQAVAALAHGTATIAPVAKIVGPGNAYVAAAKRLVFGKVGIDMIAGPSEVL
VIADDSGNADWIAADLLAQAEHDASAQSILITDSRRLADDVARAVESQLKTLPRAAIAGASWADFGAIIEVDHLDEAVPL
ADAIAAEHLEIMTADPDAFAAKVRNAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSLLKCGPEQ
LRALGPAAMTLGKAEGLDAHSRSVGIRLNLP

Sequences:

>Translated_431_residues
MPIRLSRASADFDTQFRQFLAAKREVSADVEAAARAIVDDVARRGDAALLEATAKFDRLELSAATLRVTASEIEAAVKAC
DTATVDALTFARDRIEAFHLKQLPQDQRFTDVAGVELGWRWSAIESAGLYVPGGTAAYPSSVLMNAIPAKVAGVSRLVMV
VPAPDGKLNPLVLAAAHLGGVSEIYRVGGAQAVAALAHGTATIAPVAKIVGPGNAYVAAAKRLVFGKVGIDMIAGPSEVL
VIADDSGNADWIAADLLAQAEHDASAQSILITDSRRLADDVARAVESQLKTLPRAAIAGASWADFGAIIEVDHLDEAVPL
ADAIAAEHLEIMTADPDAFAAKVRNAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSLLKCGPEQ
LRALGPAAMTLGKAEGLDAHSRSVGIRLNLP
>Mature_430_residues
PIRLSRASADFDTQFRQFLAAKREVSADVEAAARAIVDDVARRGDAALLEATAKFDRLELSAATLRVTASEIEAAVKACD
TATVDALTFARDRIEAFHLKQLPQDQRFTDVAGVELGWRWSAIESAGLYVPGGTAAYPSSVLMNAIPAKVAGVSRLVMVV
PAPDGKLNPLVLAAAHLGGVSEIYRVGGAQAVAALAHGTATIAPVAKIVGPGNAYVAAAKRLVFGKVGIDMIAGPSEVLV
IADDSGNADWIAADLLAQAEHDASAQSILITDSRRLADDVARAVESQLKTLPRAAIAGASWADFGAIIEVDHLDEAVPLA
DAIAAEHLEIMTADPDAFAAKVRNAGAIFLGAHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSLLKCGPEQL
RALGPAAMTLGKAEGLDAHSRSVGIRLNLP

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=397, Percent_Identity=42.8211586901763, Blast_Score=270, Evalue=9e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=437, Percent_Identity=38.4439359267735, Blast_Score=270, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44855; Mature: 44723

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRLSRASADFDTQFRQFLAAKREVSADVEAAARAIVDDVARRGDAALLEATAKFDRLE
CCEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
LSAATLRVTASEIEAAVKACDTATVDALTFARDRIEAFHLKQLPQDQRFTDVAGVELGWR
EEHHEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEECCE
WSAIESAGLYVPGGTAAYPSSVLMNAIPAKVAGVSRLVMVVPAPDGKLNPLVLAAAHLGG
EHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHEEEEHHHCC
VSEIYRVGGAQAVAALAHGTATIAPVAKIVGPGNAYVAAAKRLVFGKVGIDMIAGPSEVL
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCEEE
VIADDSGNADWIAADLLAQAEHDASAQSILITDSRRLADDVARAVESQLKTLPRAAIAGA
EEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCC
SWADFGAIIEVDHLDEAVPLADAIAAEHLEIMTADPDAFAAKVRNAGAIFLGAHTPEAIG
CCCCCCCEEEECCCCCCCCHHHHHHHHHEEEEECCCHHHHHHHCCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLGVLDFMKRTSLLKCGPEQLRALGPAAMTLGKAEGLDAH
HHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHCCHHHHHHHCHHHHHHCCCCCCCCC
SRSVGIRLNLP
CCCEEEEEECC
>Mature Secondary Structure 
PIRLSRASADFDTQFRQFLAAKREVSADVEAAARAIVDDVARRGDAALLEATAKFDRLE
CEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEE
LSAATLRVTASEIEAAVKACDTATVDALTFARDRIEAFHLKQLPQDQRFTDVAGVELGWR
EEHHEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEECCE
WSAIESAGLYVPGGTAAYPSSVLMNAIPAKVAGVSRLVMVVPAPDGKLNPLVLAAAHLGG
EHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHEEEEHHHCC
VSEIYRVGGAQAVAALAHGTATIAPVAKIVGPGNAYVAAAKRLVFGKVGIDMIAGPSEVL
HHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCEEE
VIADDSGNADWIAADLLAQAEHDASAQSILITDSRRLADDVARAVESQLKTLPRAAIAGA
EEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCC
SWADFGAIIEVDHLDEAVPLADAIAAEHLEIMTADPDAFAAKVRNAGAIFLGAHTPEAIG
CCCCCCCEEEECCCCCCCCHHHHHHHHHEEEEECCCHHHHHHHCCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLGVLDFMKRTSLLKCGPEQLRALGPAAMTLGKAEGLDAH
HHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHCCHHHHHHHCHHHHHHCCCCCCCCC
SRSVGIRLNLP
CCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]