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The map label for this gene is hisE2 [H]

Identifier: 146343352

GI number: 146343352

Start: 6828033

End: 6828434

Strand: Reverse

Name: hisE2 [H]

Synonym: BRADO6579

Alternate gene names: 146343352

Gene position: 6828434-6828033 (Counterclockwise)

Preceding gene: 146343353

Following gene: 146343351

Centisome position: 91.58

GC content: 65.92

Gene sequence:

>402_bases
ATGACTGATTCGATCGAGCGGCTCTATCGGGCGGTGCTGGCGGCCAGGGATCTGGATCCGTCACGCTCGCGCACGGCCAA
GCTGATGCAGCAGGGCACCGCCAAAATGGCCAAGAAGCTCGCCGAGGAGGCGATCGAGGTCTCGATCGATGCGGTCAGCG
GCGACGCCCAGGCCGTGGTCCGGGAAAGTGCCGACCTGATCTACAATCTGACGGTGCTGTGGGCCGATCTGGACGTCCGT
CCGGAGGACATCTGGCGCGAAATGGCGCGACGCGAGCTGATGCTGGGAATCGCCGAAAAGCTGCCGAAAACACCGGTGAA
GCTGGCGAAGACCGCGCCCGCGCGCGTGTCGGGGCGGCCAATTGTCGCGGCCGACAGCCGGGTCATCCGCAAGCGGCACT
AG

Upstream 100 bases:

>100_bases
TCGATCGTGAAAAGATCCGCCGGCCTCTGTGCCGGCGGATTTTTTTATGTCGCTGGCGAGCGTTAACACCGCCGCCATTG
ATTTTAACTATTGTGTGTCG

Downstream 100 bases:

>100_bases
CTCATCCGCTGATGGACATATCGGCCATGGACAAATGCGGCCCGGTTTGCTTCATCGCCAACCATGCTCAGACGGATCTA
CGACTGGTGTATCGACGCCG

Product: phosphoribosyl-ATP pyrophosphohydrolase (hisE-like)

Products: NA

Alternate protein names: PRA-PH 2 [H]

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MTDSIERLYRAVLAARDLDPSRSRTAKLMQQGTAKMAKKLAEEAIEVSIDAVSGDAQAVVRESADLIYNLTVLWADLDVR
PEDIWREMARRELMLGIAEKLPKTPVKLAKTAPARVSGRPIVAADSRVIRKRH

Sequences:

>Translated_133_residues
MTDSIERLYRAVLAARDLDPSRSRTAKLMQQGTAKMAKKLAEEAIEVSIDAVSGDAQAVVRESADLIYNLTVLWADLDVR
PEDIWREMARRELMLGIAEKLPKTPVKLAKTAPARVSGRPIVAADSRVIRKRH
>Mature_132_residues
TDSIERLYRAVLAARDLDPSRSRTAKLMQQGTAKMAKKLAEEAIEVSIDAVSGDAQAVVRESADLIYNLTVLWADLDVRP
EDIWREMARRELMLGIAEKLPKTPVKLAKTAPARVSGRPIVAADSRVIRKRH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008179
- InterPro:   IPR021130 [H]

Pfam domain/function: PF01503 PRA-PH [H]

EC number: =3.6.1.31 [H]

Molecular weight: Translated: 14820; Mature: 14689

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSIERLYRAVLAARDLDPSRSRTAKLMQQGTAKMAKKLAEEAIEVSIDAVSGDAQAVV
CCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RESADLIYNLTVLWADLDVRPEDIWREMARRELMLGIAEKLPKTPVKLAKTAPARVSGRP
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCC
IVAADSRVIRKRH
EEECCHHHHHCCC
>Mature Secondary Structure 
TDSIERLYRAVLAARDLDPSRSRTAKLMQQGTAKMAKKLAEEAIEVSIDAVSGDAQAVV
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RESADLIYNLTVLWADLDVRPEDIWREMARRELMLGIAEKLPKTPVKLAKTAPARVSGRP
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCC
IVAADSRVIRKRH
EEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]