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The map label for this gene is cya [H]

Identifier: 146343311

GI number: 146343311

Start: 6787163

End: 6789154

Strand: Reverse

Name: cya [H]

Synonym: BRADO6535

Alternate gene names: 146343311

Gene position: 6789154-6787163 (Counterclockwise)

Preceding gene: 146343316

Following gene: 146343303

Centisome position: 91.05

GC content: 65.86

Gene sequence:

>1992_bases
TTGGAGTGCATCGTCGCGGTCGAAACTGCCGACCGGCTCACACGGGGGATGCGTATCATGACCAGTTCGCCGTCGGCCGC
GTTGATCAACGCGGTGCTCGCCATGGACGTTTACAACAGAGGCGTCAACGCGACGCTCTCGGTGAATTTCAATCGCATCG
GAAGCTACGAGCTCGTGGCCGGCAGCGTCGCCGCGGCCGCGGACAATTTCGAAGCCGCAACCTATCAGCTCGTCGGCGAC
CCCTCGACGCGGATCATCTCCTATCGCGGCACGGACAGCATCGCCGACGTGCCGGCCTGGCTCGGTGGTGCCGGGCTGAC
CGGCTGGCCGACGCAGTTCCCGGATGCCGAGGCTTACTACAAGCAATGGGCGACGACGTCGCATGTGTCGCTGACCGGTC
ACTCCCTCGGCGGCGGCCTGGCCGGCTACATCGCGGCGCTGAACGACAAGGCTGCCTACGCCTATGATGCGATGCCGTTC
GAGTTCGCGGCCGAGGTCCGCTATGATCAGCTGCATGGCTTCTGGGGCGCGCTCGGCTCGCACCCGGTCGACCGCTACTC
CGACATCCATATGGTCTCGGTGTCCGGCGAGGTGCTGCAATATGTCCGCGCCGCCGCGCCCGTGCTGGAAGCGCCGCTGG
CGCTGCTGCAGCTCGGACCGGTCGCCGGCGCGCTGGCCATCGCCGATGCGGCGATCGGCATCTCATCGGAGCAGAAGACC
GTGCTCGGCGCCGGCACCGATCTGGGGCTCGATCCGATCAAGCTGCATTCGATCGCGATGCTGACGATGATGCAGTGGGC
CAGCGACAACAACGCGCAGGACTGGAAGAAGGCGGCGGCCGTGCTGCTGGCGCCGCTCGAGGATGACGCGATCGCCAAGG
CGGTCGGCATTCCCGCGGCCGGCGTCGGCGGCGAGGGCGCGCCAGCCGAAAAGATGAAGGACATGATTGCCTATTCGACG
GTCACCGACGCGATCGGCTATGGCAATAGCGCCGTGCAGGCGCTGTTCAATGGCGGGGGCGCGCTCGGCGACAGCGTCAG
CGCGTCGACCGCGGCGGGCTATCTGAAGAATGGCGGCGTCGAGAAGGCGCTGGCCGACATCGTGGTAGAGTATTCGGCGC
TGCTGGCGCAGAACCACGACGAGGTGACCTCGACGCCGGGGGTGATCGGCCATGAGCACGGCATCCTCTATCAGGACGTT
GCGAAGAACCTGATGGTGGCGGATCTGTCGTCAGACCTGTGGTCGCACACCGACACGGGATCGGCGGTCGACATCATCGG
CAAGGTCGCGCTGATCGATGCCGCCGCGAGTTTCGACGGCGAGGATGTCGCTCTGATCGACATGGCGATCAGCACGCTGT
GGGGCGGCAAGACGGACAATCTCGACTGGCTCAGCGCGGCGCTGAGCGATGCCGCGACGACGGTGGCGATCGATCCCGTA
TCGGGCGCCACGATCGCGGCCAGTGATGGTGCGCTCCTGATCGCCGGCGGCGGCAACGACGCGCTGTATGGCACTGCCAA
CGACGACCTGCTGATCGGTGGTCTCGGCAGCGATGTGCTCAAGGGCGGCGGCGGCGACAACATCCTGGTCGGCGGTGTCG
GCGCGACCTATGTCTACGCGCCCGGCGACGGCAACGACGTCATCATCAATGGCGTCGCGTCGCTCTCGAAGCCGACCGGG
ACGCTGGATTTCGGCTCGGCCTACACGGCCGACAATTTCTGGTTCGTCAAATCCGGTAACGATCTGGAGATCGACATTCT
CGGCACTCACCAGCAGGTGACCGTTGCCGACTGGTTTCTCGGCGGCTCCTACCAGCTGCAGGAGATCAAGGCCGGTGGTC
TTGAGCTCGATACGCAGGTCACGCAGCTCGTCCAGGCGATGGCGACCTACGCGCAAACGCATCAGGGCTTCGATCCGGCG
CTCGCCTCACAGCTGCCGAGCGATGCGCATCTGCACGATCAGGTCGCCGCGGCCTGGCACGTCATGACGTGA

Upstream 100 bases:

>100_bases
CATCGGGCGCAAATACACGTGTGGACGAATCGCGATTGACAAACATTGGACGTGATGTCGCACATCATGAAAGCTGGCGG
CGCGGCGGTGGTGTTTCCGA

Downstream 100 bases:

>100_bases
CGTGCCGCCCGCCTCAGTGCAGCCGCGGCGCCTTCAACAGCTTGGCGCGGTCCGTGGAGGCTACCGTGACGTCGAAGGTC
ACGCCTTCGTGGTGCACGGT

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MECIVAVETADRLTRGMRIMTSSPSAALINAVLAMDVYNRGVNATLSVNFNRIGSYELVAGSVAAAADNFEAATYQLVGD
PSTRIISYRGTDSIADVPAWLGGAGLTGWPTQFPDAEAYYKQWATTSHVSLTGHSLGGGLAGYIAALNDKAAYAYDAMPF
EFAAEVRYDQLHGFWGALGSHPVDRYSDIHMVSVSGEVLQYVRAAAPVLEAPLALLQLGPVAGALAIADAAIGISSEQKT
VLGAGTDLGLDPIKLHSIAMLTMMQWASDNNAQDWKKAAAVLLAPLEDDAIAKAVGIPAAGVGGEGAPAEKMKDMIAYST
VTDAIGYGNSAVQALFNGGGALGDSVSASTAAGYLKNGGVEKALADIVVEYSALLAQNHDEVTSTPGVIGHEHGILYQDV
AKNLMVADLSSDLWSHTDTGSAVDIIGKVALIDAAASFDGEDVALIDMAISTLWGGKTDNLDWLSAALSDAATTVAIDPV
SGATIAASDGALLIAGGGNDALYGTANDDLLIGGLGSDVLKGGGGDNILVGGVGATYVYAPGDGNDVIINGVASLSKPTG
TLDFGSAYTADNFWFVKSGNDLEIDILGTHQQVTVADWFLGGSYQLQEIKAGGLELDTQVTQLVQAMATYAQTHQGFDPA
LASQLPSDAHLHDQVAAAWHVMT

Sequences:

>Translated_663_residues
MECIVAVETADRLTRGMRIMTSSPSAALINAVLAMDVYNRGVNATLSVNFNRIGSYELVAGSVAAAADNFEAATYQLVGD
PSTRIISYRGTDSIADVPAWLGGAGLTGWPTQFPDAEAYYKQWATTSHVSLTGHSLGGGLAGYIAALNDKAAYAYDAMPF
EFAAEVRYDQLHGFWGALGSHPVDRYSDIHMVSVSGEVLQYVRAAAPVLEAPLALLQLGPVAGALAIADAAIGISSEQKT
VLGAGTDLGLDPIKLHSIAMLTMMQWASDNNAQDWKKAAAVLLAPLEDDAIAKAVGIPAAGVGGEGAPAEKMKDMIAYST
VTDAIGYGNSAVQALFNGGGALGDSVSASTAAGYLKNGGVEKALADIVVEYSALLAQNHDEVTSTPGVIGHEHGILYQDV
AKNLMVADLSSDLWSHTDTGSAVDIIGKVALIDAAASFDGEDVALIDMAISTLWGGKTDNLDWLSAALSDAATTVAIDPV
SGATIAASDGALLIAGGGNDALYGTANDDLLIGGLGSDVLKGGGGDNILVGGVGATYVYAPGDGNDVIINGVASLSKPTG
TLDFGSAYTADNFWFVKSGNDLEIDILGTHQQVTVADWFLGGSYQLQEIKAGGLELDTQVTQLVQAMATYAQTHQGFDPA
LASQLPSDAHLHDQVAAAWHVMT
>Mature_663_residues
MECIVAVETADRLTRGMRIMTSSPSAALINAVLAMDVYNRGVNATLSVNFNRIGSYELVAGSVAAAADNFEAATYQLVGD
PSTRIISYRGTDSIADVPAWLGGAGLTGWPTQFPDAEAYYKQWATTSHVSLTGHSLGGGLAGYIAALNDKAAYAYDAMPF
EFAAEVRYDQLHGFWGALGSHPVDRYSDIHMVSVSGEVLQYVRAAAPVLEAPLALLQLGPVAGALAIADAAIGISSEQKT
VLGAGTDLGLDPIKLHSIAMLTMMQWASDNNAQDWKKAAAVLLAPLEDDAIAKAVGIPAAGVGGEGAPAEKMKDMIAYST
VTDAIGYGNSAVQALFNGGGALGDSVSASTAAGYLKNGGVEKALADIVVEYSALLAQNHDEVTSTPGVIGHEHGILYQDV
AKNLMVADLSSDLWSHTDTGSAVDIIGKVALIDAAASFDGEDVALIDMAISTLWGGKTDNLDWLSAALSDAATTVAIDPV
SGATIAASDGALLIAGGGNDALYGTANDDLLIGGLGSDVLKGGGGDNILVGGVGATYVYAPGDGNDVIINGVASLSKPTG
TLDFGSAYTADNFWFVKSGNDLEIDILGTHQQVTVADWFLGGSYQLQEIKAGGLELDTQVTQLVQAMATYAQTHQGFDPA
LASQLPSDAHLHDQVAAAWHVMT

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 68331; Mature: 68331

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MECIVAVETADRLTRGMRIMTSSPSAALINAVLAMDVYNRGVNATLSVNFNRIGSYELVA
CCEEEEECCHHHHHHCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEC
GSVAAAADNFEAATYQLVGDPSTRIISYRGTDSIADVPAWLGGAGLTGWPTQFPDAEAYY
CHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHH
KQWATTSHVSLTGHSLGGGLAGYIAALNDKAAYAYDAMPFEFAAEVRYDQLHGFWGALGS
HHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCC
HPVDRYSDIHMVSVSGEVLQYVRAAAPVLEAPLALLQLGPVAGALAIADAAIGISSEQKT
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCE
VLGAGTDLGLDPIKLHSIAMLTMMQWASDNNAQDWKKAAAVLLAPLEDDAIAKAVGIPAA
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCHHHHHHCCCCC
GVGGEGAPAEKMKDMIAYSTVTDAIGYGNSAVQALFNGGGALGDSVSASTAAGYLKNGGV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCH
EKALADIVVEYSALLAQNHDEVTSTPGVIGHEHGILYQDVAKNLMVADLSSDLWSHTDTG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHEEEHHHHHHHCCCCCC
SAVDIIGKVALIDAAASFDGEDVALIDMAISTLWGGKTDNLDWLSAALSDAATTVAIDPV
CHHHHHHHHHEEEHHCCCCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCC
SGATIAASDGALLIAGGGNDALYGTANDDLLIGGLGSDVLKGGGGDNILVGGVGATYVYA
CCCEEEECCCEEEEEECCCCCEEECCCCCEEEECCCHHHHCCCCCCEEEEECCCEEEEEE
PGDGNDVIINGVASLSKPTGTLDFGSAYTADNFWFVKSGNDLEIDILGTHQQVTVADWFL
CCCCCEEEEECHHHCCCCCCCEECCCEECCCCEEEEECCCEEEEEEECCCCEEEEEEEEE
GGSYQLQEIKAGGLELDTQVTQLVQAMATYAQTHQGFDPALASQLPSDAHLHDQVAAAWH
CCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHE
VMT
ECC
>Mature Secondary Structure
MECIVAVETADRLTRGMRIMTSSPSAALINAVLAMDVYNRGVNATLSVNFNRIGSYELVA
CCEEEEECCHHHHHHCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEC
GSVAAAADNFEAATYQLVGDPSTRIISYRGTDSIADVPAWLGGAGLTGWPTQFPDAEAYY
CHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHH
KQWATTSHVSLTGHSLGGGLAGYIAALNDKAAYAYDAMPFEFAAEVRYDQLHGFWGALGS
HHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCC
HPVDRYSDIHMVSVSGEVLQYVRAAAPVLEAPLALLQLGPVAGALAIADAAIGISSEQKT
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCE
VLGAGTDLGLDPIKLHSIAMLTMMQWASDNNAQDWKKAAAVLLAPLEDDAIAKAVGIPAA
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEEECCCCCHHHHHHCCCCC
GVGGEGAPAEKMKDMIAYSTVTDAIGYGNSAVQALFNGGGALGDSVSASTAAGYLKNGGV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCH
EKALADIVVEYSALLAQNHDEVTSTPGVIGHEHGILYQDVAKNLMVADLSSDLWSHTDTG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHEEEHHHHHHHCCCCCC
SAVDIIGKVALIDAAASFDGEDVALIDMAISTLWGGKTDNLDWLSAALSDAATTVAIDPV
CHHHHHHHHHEEEHHCCCCCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCC
SGATIAASDGALLIAGGGNDALYGTANDDLLIGGLGSDVLKGGGGDNILVGGVGATYVYA
CCCEEEECCCEEEEEECCCCCEEECCCCCEEEECCCHHHHCCCCCCEEEEECCCEEEEEE
PGDGNDVIINGVASLSKPTGTLDFGSAYTADNFWFVKSGNDLEIDILGTHQQVTVADWFL
CCCCCEEEEECHHHCCCCCCCEECCCEECCCCEEEEECCCEEEEEEECCCCEEEEEEEEE
GGSYQLQEIKAGGLELDTQVTQLVQAMATYAQTHQGFDPALASQLPSDAHLHDQVAAAWH
CCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHE
VMT
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]