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The map label for this gene is argH [H]

Identifier: 146343267

GI number: 146343267

Start: 6737269

End: 6738660

Strand: Reverse

Name: argH [H]

Synonym: BRADO6487

Alternate gene names: 146343267

Gene position: 6738660-6737269 (Counterclockwise)

Preceding gene: 146343269

Following gene: 146343266

Centisome position: 90.37

GC content: 67.74

Gene sequence:

>1392_bases
ATGAGCAACAAGATGTGGGGCGGCCGGTTCACGGAGCGTCCCGACGAGATCATGGAGGACATCAACGTCTCGATCGACGT
CGATCGCCACCTTTACGCGCAGGATATCGCCGCGTCCAAGGCGCACGCCGCCATGCTCGCCGCCCAGGGCATCATCACGT
CAGGTGATGCGAAAAATATGGCCAGGGGTCTAGACACGATTCTGTCAGAGATCACCAAGGGCTCGTTCGAGTTCAAGCGC
GCGCTCGAGGACATCCATATGAATGTCGAGAGCCGGCTGTCCGAGCTGATCGGCCCCGCCGCCGGCCGCCTGCACACCGC
GCGCTCCCGCAACGACCAGGTCGCCACCGATTTTCGCCTGTTCGTGCGCGACGAGATCGACGACATCGACGCGGCGCTGG
CCGCCTACCAGCAGGCTCTCGCGACCCGCGCGCTCGAATTCGCCGGCACCGTGATGCCCGGCTTCACCCATCTGCAGACG
GCGCAGCCCGTCACCTTCGGCCACCATCTCCTCGCCTATGTCGAGATGGCCGGCCGCGACCGCGGCCGCTTCGCCGACGC
CCGCGAGCGCCTCAATGAATCGCCGCTGGGCGCCGCCGCGCTCGCCGGCACCTCGTTCCCGATCGACCGCCACGCCACCG
CGCAAGCCCTCGGCTTCGACCGCCCGATGGCCAATTCGCTCGACGCCGTCTCCGACCGCGACTTCGTGCTGGAGACCCTG
TCGGCGGCGTCGATCTGCGCCGTGCATCTGTCGCGCTTCGCCGAGGAGATCGTGATCTGGACCTCGCCCTTGGTCGGCCT
GATCAAGCTGTCGGACAAGTTCACGACCGGCTCCTCGATCATGCCGCAGAAGCGCAATCCGGACGCCGCGGAGCTCGTCC
GCGCCAAGACGGGGCGCGTCATCGGCGCGCTCAACGGGCTCCTGATCGTGATGAAGGGCCTGCCGCTGGCCTATCAAAAG
GACATGCAGGAGGACAAGCAGGGCGCGATGGAGGCGTTCGCCGCGCTGTCGCTGGCGATCCGCGCCATGACCGGCATGGC
GCTCGACCTGGTGCCGGACGAAGCCCGCATGAAGGCCGCCGCCGGCGAGGGCTACGCCACCGCCACCGATCTGGCCGACT
GGCTGGTCCGCACCCTCAAGATGCCGTTCCGCGAGGCCCATCACGTGACGGGGCGCATCGTCGCGCTGGCCTCGAAGCAG
GGCGTCGCGCTGCACGAGCTGCCGCTCGAGGCGATGCAGGAGGTGGAGCCCAAGATCACGGCCGACGTGCTCGGCGTGCT
CTCGGTCGAGGCCTCGGTGAAGAGCCGCACCAGCTTCGGCGGCACCGCACCGAAGAACGTCGCGAGCCAGGCCAAGGCCT
GGCTGAAGCGTCTGGAAAAACAGCGGAAGTAG

Upstream 100 bases:

>100_bases
TGTCATCTCGGGTCGGTTGCGGCTATCAGAGGCGCGAAATTCGGGGCACGGGACGTGTGTCCCATCCAGTGGCGATCAGC
AAGGTCTAAGAGCGGCAGGC

Downstream 100 bases:

>100_bases
GGCTCCCCGCCGAAAATTGATCGGCTCGGCGTGGCACTCCGGCACTCGTCATGGCCCGCCGATCTCTGTATGGTGCCGCC
CGCATGGGGATTTCACACGT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSNKMWGGRFTERPDEIMEDINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITSGDAKNMARGLDTILSEITKGSFEFKR
ALEDIHMNVESRLSELIGPAAGRLHTARSRNDQVATDFRLFVRDEIDDIDAALAAYQQALATRALEFAGTVMPGFTHLQT
AQPVTFGHHLLAYVEMAGRDRGRFADARERLNESPLGAAALAGTSFPIDRHATAQALGFDRPMANSLDAVSDRDFVLETL
SAASICAVHLSRFAEEIVIWTSPLVGLIKLSDKFTTGSSIMPQKRNPDAAELVRAKTGRVIGALNGLLIVMKGLPLAYQK
DMQEDKQGAMEAFAALSLAIRAMTGMALDLVPDEARMKAAAGEGYATATDLADWLVRTLKMPFREAHHVTGRIVALASKQ
GVALHELPLEAMQEVEPKITADVLGVLSVEASVKSRTSFGGTAPKNVASQAKAWLKRLEKQRK

Sequences:

>Translated_463_residues
MSNKMWGGRFTERPDEIMEDINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITSGDAKNMARGLDTILSEITKGSFEFKR
ALEDIHMNVESRLSELIGPAAGRLHTARSRNDQVATDFRLFVRDEIDDIDAALAAYQQALATRALEFAGTVMPGFTHLQT
AQPVTFGHHLLAYVEMAGRDRGRFADARERLNESPLGAAALAGTSFPIDRHATAQALGFDRPMANSLDAVSDRDFVLETL
SAASICAVHLSRFAEEIVIWTSPLVGLIKLSDKFTTGSSIMPQKRNPDAAELVRAKTGRVIGALNGLLIVMKGLPLAYQK
DMQEDKQGAMEAFAALSLAIRAMTGMALDLVPDEARMKAAAGEGYATATDLADWLVRTLKMPFREAHHVTGRIVALASKQ
GVALHELPLEAMQEVEPKITADVLGVLSVEASVKSRTSFGGTAPKNVASQAKAWLKRLEKQRK
>Mature_462_residues
SNKMWGGRFTERPDEIMEDINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITSGDAKNMARGLDTILSEITKGSFEFKRA
LEDIHMNVESRLSELIGPAAGRLHTARSRNDQVATDFRLFVRDEIDDIDAALAAYQQALATRALEFAGTVMPGFTHLQTA
QPVTFGHHLLAYVEMAGRDRGRFADARERLNESPLGAAALAGTSFPIDRHATAQALGFDRPMANSLDAVSDRDFVLETLS
AASICAVHLSRFAEEIVIWTSPLVGLIKLSDKFTTGSSIMPQKRNPDAAELVRAKTGRVIGALNGLLIVMKGLPLAYQKD
MQEDKQGAMEAFAALSLAIRAMTGMALDLVPDEARMKAAAGEGYATATDLADWLVRTLKMPFREAHHVTGRIVALASKQG
VALHELPLEAMQEVEPKITADVLGVLSVEASVKSRTSFGGTAPKNVASQAKAWLKRLEKQRK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=41.6851441241685, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=41.6851441241685, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=39.689578713969, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=39.2461197339246, Blast_Score=326, Evalue=2e-89,
Organism=Escherichia coli, GI1790398, Length=446, Percent_Identity=46.1883408071749, Blast_Score=387, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=41.3716814159292, Blast_Score=345, Evalue=9e-96,
Organism=Drosophila melanogaster, GI221473854, Length=449, Percent_Identity=39.6436525612472, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI78706858, Length=449, Percent_Identity=39.6436525612472, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50215; Mature: 50084

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKMWGGRFTERPDEIMEDINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITSGDAKNM
CCCCCCCCCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHH
ARGLDTILSEITKGSFEFKRALEDIHMNVESRLSELIGPAAGRLHTARSRNDQVATDFRL
HHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHH
FVRDEIDDIDAALAAYQQALATRALEFAGTVMPGFTHLQTAQPVTFGHHLLAYVEMAGRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHCCC
RGRFADARERLNESPLGAAALAGTSFPIDRHATAQALGFDRPMANSLDAVSDRDFVLETL
CCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHCCCHHHHHHHH
SAASICAVHLSRFAEEIVIWTSPLVGLIKLSDKFTTGSSIMPQKRNPDAAELVRAKTGRV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCH
IGALNGLLIVMKGLPLAYQKDMQEDKQGAMEAFAALSLAIRAMTGMALDLVPDEARMKAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
AGEGYATATDLADWLVRTLKMPFREAHHVTGRIVALASKQGVALHELPLEAMQEVEPKIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHCCHHHHHHCCCHHH
ADVLGVLSVEASVKSRTSFGGTAPKNVASQAKAWLKRLEKQRK
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNKMWGGRFTERPDEIMEDINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITSGDAKNM
CCCCCCCCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHH
ARGLDTILSEITKGSFEFKRALEDIHMNVESRLSELIGPAAGRLHTARSRNDQVATDFRL
HHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHH
FVRDEIDDIDAALAAYQQALATRALEFAGTVMPGFTHLQTAQPVTFGHHLLAYVEMAGRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHCCC
RGRFADARERLNESPLGAAALAGTSFPIDRHATAQALGFDRPMANSLDAVSDRDFVLETL
CCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCHHHCCCHHHHHHHH
SAASICAVHLSRFAEEIVIWTSPLVGLIKLSDKFTTGSSIMPQKRNPDAAELVRAKTGRV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCH
IGALNGLLIVMKGLPLAYQKDMQEDKQGAMEAFAALSLAIRAMTGMALDLVPDEARMKAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
AGEGYATATDLADWLVRTLKMPFREAHHVTGRIVALASKQGVALHELPLEAMQEVEPKIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHCCHHHHHHCCCHHH
ADVLGVLSVEASVKSRTSFGGTAPKNVASQAKAWLKRLEKQRK
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]