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The map label for this gene is groEL [H]

Identifier: 146342934

GI number: 146342934

Start: 6341415

End: 6343058

Strand: Direct

Name: groEL [H]

Synonym: BRADO6115

Alternate gene names: 146342934

Gene position: 6341415-6343058 (Clockwise)

Preceding gene: 146342933

Following gene: 146342935

Centisome position: 85.04

GC content: 67.4

Gene sequence:

>1644_bases
ATGGCAGCCAAGGACGTCAAATTTTCTGGCGACGCGCGCGACCGCATGCTGCGCGGCGTCGACATTCTCGCCAACGCCGT
CAAGGTGACGCTCGGCCCGAAGGGCCGCAACGTCGTCATCGAGAAGAGCTTCGGCGCTCCGCGCATCACCAAGGACGGCG
TCACCGTCGCCAAGGAGATCGAGCTCGAGGACAAGTTCGAGAACATGGGCGCGCAGATGCTGCGTGAGGTCGCCTCCAAG
ACCAACGACCTCGCCGGCGACGGCACCACCACCGCGACCGTGCTCGCCCAGGCCATCGTCCGTGAGGGCGCCAAGGCGGT
TGCCGCCGGCATGAACCCGATGGACCTCAAGCGGGGCATCGACACCGCGGTGGCCGCCGTCATCAAGGACATCGAGAAGC
GCGCCAAGCCGGTCGCGTCCTCCGCCGAGGTCGCCCAGGTCGGCACCATCTCCGCCAACGGCGACGCCGCGATCGGCAAG
ATGATCGCCCAGGCGATGCAGAAGGTCGGCAACGAGGGCGTCATCACGGTCGAGGAGAACAAGTCGCTCGAGACCGAGGT
CGACATCGTCGAGGGCATGAAGTTCGACCGCGGCTACCTGTCGCCGTACTTCGTCACCAACGCCGAGAAGATGACCGCCG
AGCTCGACGACGTCTACGTGCTCTTGCACGAGAAGAAGCTGTCGGGCCTGCAGGCCATGCTGCCGGTGCTCGAAGCCGTC
GTGCAGTCGGGCCGTCCGCTCCTGATCATCGCCGAGGACGTCGAGGGCGAGGCGCTGGCCACCCTGGTCGTCAACCGCCT
GCGTGGCGGCCTCAAGGTCGCCGCCGTCAAGGCGCCGGGCTTCGGTGACCGCCGAAAGGCCATGCTCGAGGACATCGCGA
TCCTGACCGGCGGTCAGCTGATCTCGGACGATCTCGGCATGAAGCTCGAGAACGTCACGATCAAGATGCTCGGCCGCGCC
AAGAAGGTCGTGATCGACAAGGAGAACACCACGATCGTCAACGGCGCCGGCAAGAAGGCCGACATCGAGGCGCGCGTTGG
CCAGATCAAGGCGCAGATCGAGGAGACCACCTCGGACTACGACCGTGAGAAGCTGCAGGAGCGCCTCGCCAAGCTCGCGG
GCGGCGTCGCGGTGATCCGCGTCGGCGGCGCGACCGAGGTCGAGGTCAAGGAGAAGAAGGACCGCGTCGAGGACGCCCTC
AACGCGACACGCGCCGCGGTGCAGGAAGGCATCGTCCCCGGCGGCGGCGTGGCCCTGCTGCGCGCCAAGAAGGCGGTCGG
CCGCATCACCAACCCGAACTCGGACGTCCAGGCCGGCATCAACATCGTGCTGAAGGCGCTGGAGGCTCCGATGCGCCAGA
TCGCCGAGAACGCCGGCGTCGAAGGCTCGATCGTGGTCGGCAAGATCCTCGAGGAGAAGTCCGAAACCTTCGGCTTCGAC
GCCCAGACCGAGGACTATGTCGACATGGTTGCCAAGGGCATCATCGACCCGGCCAAGGTCGTCCGCACCGCGCTGCAGGA
CGCCTCGTCGGTCGCCGGCCTGCTGGTCACCACCGAGGCCATGGTCGCCGAGCTGCCGAAGGACGCGGCGCCTGCGATGC
CGGCCGGCGGCGGCATGGGCGGCATGGGCGGCATGGGCTTCTGA

Upstream 100 bases:

>100_bases
ACAGCGGCCCCAGGCGATAGCGCTTTTACAACCTCGCTCAGGCGGCAGACGGGCGTTCACGCCCCTGGCCTGCCGAGGCC
CACATCCAGGAGAGTTTCAA

Downstream 100 bases:

>100_bases
GCCCAACCCAGTCTCAAGCCCCCATCACGAGACGTTCACGAAGGCCGCCTCCGGGCGGCCTTCTTTTTGGCCGAGTGTCC
GAGTGGGGGTGCAGTGATTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVKFSGDARDRMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDKFENMGAQMLREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDTAVAAVIKDIEKRAKPVASSAEVAQVGTISANGDAAIGK
MIAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTAELDDVYVLLHEKKLSGLQAMLPVLEAV
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQLISDDLGMKLENVTIKMLGRA
KKVVIDKENTTIVNGAGKKADIEARVGQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDAL
NATRAAVQEGIVPGGGVALLRAKKAVGRITNPNSDVQAGINIVLKALEAPMRQIAENAGVEGSIVVGKILEEKSETFGFD
AQTEDYVDMVAKGIIDPAKVVRTALQDASSVAGLLVTTEAMVAELPKDAAPAMPAGGGMGGMGGMGF

Sequences:

>Translated_547_residues
MAAKDVKFSGDARDRMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDKFENMGAQMLREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDTAVAAVIKDIEKRAKPVASSAEVAQVGTISANGDAAIGK
MIAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTAELDDVYVLLHEKKLSGLQAMLPVLEAV
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQLISDDLGMKLENVTIKMLGRA
KKVVIDKENTTIVNGAGKKADIEARVGQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDAL
NATRAAVQEGIVPGGGVALLRAKKAVGRITNPNSDVQAGINIVLKALEAPMRQIAENAGVEGSIVVGKILEEKSETFGFD
AQTEDYVDMVAKGIIDPAKVVRTALQDASSVAGLLVTTEAMVAELPKDAAPAMPAGGGMGGMGGMGF
>Mature_546_residues
AAKDVKFSGDARDRMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDKFENMGAQMLREVASKT
NDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDTAVAAVIKDIEKRAKPVASSAEVAQVGTISANGDAAIGKM
IAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTAELDDVYVLLHEKKLSGLQAMLPVLEAVV
QSGRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQLISDDLGMKLENVTIKMLGRAK
KVVIDKENTTIVNGAGKKADIEARVGQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALN
ATRAAVQEGIVPGGGVALLRAKKAVGRITNPNSDVQAGINIVLKALEAPMRQIAENAGVEGSIVVGKILEEKSETFGFDA
QTEDYVDMVAKGIIDPAKVVRTALQDASSVAGLLVTTEAMVAELPKDAAPAMPAGGGMGGMGGMGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=56.1669829222011, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=56.1669829222011, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI5453607, Length=534, Percent_Identity=23.7827715355805, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=65.6603773584906, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=54.2533081285444, Blast_Score=568, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=55.4502369668246, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17564182, Length=558, Percent_Identity=21.6845878136201, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.6539923954373, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6322524, Length=528, Percent_Identity=21.780303030303, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=56.3567362428843, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=56.3567362428843, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=52.3809523809524, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=52.3809523809524, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=52.3809523809524, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17864606, Length=544, Percent_Identity=46.3235294117647, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=37.8026070763501, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=37.8026070763501, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24645179, Length=498, Percent_Identity=22.4899598393574, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57507; Mature: 57376

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSGDARDRMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
DTAVAAVIKDIEKRAKPVASSAEVAQVGTISANGDAAIGKMIAQAMQKVGNEGVITVEEN
HHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTAELDDVYVLLHEKKLSGLQAMLPVLEAV
CCCCHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHH
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISDDLGMKLENVTIKMLGRAKKVVIDKENTTIVNGAGKKADIEARVGQIKAQIEETTSDY
EHHHHCCEEHHHHHEECCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALNATRAAVQEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVGRITNPNSDVQAGINIVLKALEAPMRQIAENAGVEGSIVVGKILEEKSETFGFD
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCC
AQTEDYVDMVAKGIIDPAKVVRTALQDASSVAGLLVTTEAMVAELPKDAAPAMPAGGGMG
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMGGMGF
CCCCCCC
>Mature Secondary Structure 
AAKDVKFSGDARDRMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHC
ELEDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHH
DTAVAAVIKDIEKRAKPVASSAEVAQVGTISANGDAAIGKMIAQAMQKVGNEGVITVEEN
HHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECC
KSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTAELDDVYVLLHEKKLSGLQAMLPVLEAV
CCCCHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHH
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISDDLGMKLENVTIKMLGRAKKVVIDKENTTIVNGAGKKADIEARVGQIKAQIEETTSDY
EHHHHCCEEHHHHHEECCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALNATRAAVQEGIVPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVGRITNPNSDVQAGINIVLKALEAPMRQIAENAGVEGSIVVGKILEEKSETFGFD
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCC
AQTEDYVDMVAKGIIDPAKVVRTALQDASSVAGLLVTTEAMVAELPKDAAPAMPAGGGMG
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMGGMGF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA