Click here to switch to the map view.

The map label for this gene is xseA [H]

Identifier: 146342911

GI number: 146342911

Start: 6320327

End: 6321943

Strand: Direct

Name: xseA [H]

Synonym: BRADO6092

Alternate gene names: 146342911

Gene position: 6320327-6321943 (Clockwise)

Preceding gene: 146342901

Following gene: 146342913

Centisome position: 84.76

GC content: 70.75

Gene sequence:

>1617_bases
ATGCCGCCCGCGGAAGCCCTGCCCAACGCGCCCGAATTCACCGTCTCCGAGCTGTCCTCCGCGCTGAAACGCACGGTCGA
GGACCAGTTCGGGCACGTCCGCGTGCGCGGCGAGATCAGCGGCTTTCGCGGCCCGCATTCCTCGGGTCATTGCTATTTCG
CGCTCAAGGACGAGAGCGCCAAGATCGAGGCGGTGATCTGGAAGGGCGTGCACGGCCGGATGCGCTTCAAGCCTCAGGAG
GGGCTCGAGGTCATCGCGACCGGCAAGCTCACCACCTATCCGAACTCCTCGAAGTACCAGATCGTGATCGAGGCGCTTGA
GCCGGCCGGCATCGGCGCGCTGATGGCGCTGATGGAGGAGCGCAAGCGGAAGCTCGGCGCCGAGGGCCTGTTCGATCCCG
CGCGCAAGCAGCTTCTGCCCTGGCTGCCCGAGGTGATCGGCGTCGTCACCTCGCCGACCGGCGCGGTTATCCGCGACATC
CTGCACCGGCTGGAGGACCGCTTTCCCCGCCGGGTGCTGGTGTGGCCAGTGAAGGTGCAGGGCGACGGCTCGGCCGAGCA
GGTCGCGGCCGCGATCCGCGGCTTCAACGACCTGCCGGAGGATGGCCCGATCCCCCGTCCGGACGTGCTGATCGTCGCGC
GCGGCGGCGGCTCGCTCGAGGATCTCTGGTCGTTCAACGAGGAGATCGTGGTCCGCGCGGCCGCGGAGAGCATGATCCCG
CTGATCTCCGCCGTCGGCCACGAGACCGACGTCACGCTGATCGATTTCGCCGCCGATAAGCGCGCGCCGACGCCGACGGC
CGCGGCCGAAATGGCAGTGCCTGTCCGCAGCGAGCTGATGCAGGAGGTCGCGAGCCTCGCCCGCCGCGTCAGCGTGTGCT
GGCAGCGCGGCCAGGAGAGCCGCCGCAACGAGCTGCGCGCCGCCGCGCGCGCTTTGCCCGGCGCGAGCGACCTGCTGGCC
ATTCCGCGGCAGCGGCTTGATGCCGCGTCGTCCAGCCTGCCGCGCGCGCTCAAGACCAACACGCACGTGCATTTCCGCCA
GTTCGCGGCCGCCAGCGCCAAGCTGACATTGCGCGTGCTGCATGGGCAGATCTCACAGGCCGATCATCGTCTCGTCGTGT
CGTCAGAACGGCTGTCGCTGTCGGCGCGCGCGCTGCTGCACCGGCGCCGCGAGCGTTTCGAGGCGCTCGACGCCCGCTTC
AAGGCGTCGCGCCAGGCCTATGCGCAGGCCAAGCGCCAGGCGATCGCGCGCGAGCGCGACCGCGCCGAGCGGCTGGCCGA
TCGCGCCAGCCGCGCGCTCGCGACCTCGATCCTGCGTCTGCGGGCGCGCACCGATCACGCGGGTCAGTTGCTGTCGGCGC
TGTCCTATCGCAGCGTGCTGGCGCGCGGCTTCGCATTGGTGCGCGACGAGGCCGGCCATCCGCTGCATCAGGCGGCGGGC
ATCGAGTCGGGCGCGGCCTTGTCGATCGAGTTCGCCGACGGCAGGGTCGCGGCGACGGCGGGCGCGGGAAGTCCCCTCCC
GACGTCAGCTCCTGCCGCGCCGAAGCCTGTGCGAGAAAGCAAACCCGCCGCAGCGAAGCGCACGCCCGATCCCGCGGATC
AAGGCAGCCTGTTCTGA

Upstream 100 bases:

>100_bases
CTCTGTATAACAGAGTTATCGAAAAGACAATCGCTTGATTGGCGGTGCCGGCCGAAAGTCCCTACCTTGGCGGCTGCTCC
CAAACCCGAATCAGCCAGCG

Downstream 100 bases:

>100_bases
CGGCAGATCAGCGCGCGAGCCAGTCGGCCACGAGCTTCTGCGCATCGGCGCGCGCTTCGGGATCGGAGCCGACATGGCCG
CGCTCGGGCGCGGCGGCATC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MPPAEALPNAPEFTVSELSSALKRTVEDQFGHVRVRGEISGFRGPHSSGHCYFALKDESAKIEAVIWKGVHGRMRFKPQE
GLEVIATGKLTTYPNSSKYQIVIEALEPAGIGALMALMEERKRKLGAEGLFDPARKQLLPWLPEVIGVVTSPTGAVIRDI
LHRLEDRFPRRVLVWPVKVQGDGSAEQVAAAIRGFNDLPEDGPIPRPDVLIVARGGGSLEDLWSFNEEIVVRAAAESMIP
LISAVGHETDVTLIDFAADKRAPTPTAAAEMAVPVRSELMQEVASLARRVSVCWQRGQESRRNELRAAARALPGASDLLA
IPRQRLDAASSSLPRALKTNTHVHFRQFAAASAKLTLRVLHGQISQADHRLVVSSERLSLSARALLHRRRERFEALDARF
KASRQAYAQAKRQAIARERDRAERLADRASRALATSILRLRARTDHAGQLLSALSYRSVLARGFALVRDEAGHPLHQAAG
IESGAALSIEFADGRVAATAGAGSPLPTSAPAAPKPVRESKPAAAKRTPDPADQGSLF

Sequences:

>Translated_538_residues
MPPAEALPNAPEFTVSELSSALKRTVEDQFGHVRVRGEISGFRGPHSSGHCYFALKDESAKIEAVIWKGVHGRMRFKPQE
GLEVIATGKLTTYPNSSKYQIVIEALEPAGIGALMALMEERKRKLGAEGLFDPARKQLLPWLPEVIGVVTSPTGAVIRDI
LHRLEDRFPRRVLVWPVKVQGDGSAEQVAAAIRGFNDLPEDGPIPRPDVLIVARGGGSLEDLWSFNEEIVVRAAAESMIP
LISAVGHETDVTLIDFAADKRAPTPTAAAEMAVPVRSELMQEVASLARRVSVCWQRGQESRRNELRAAARALPGASDLLA
IPRQRLDAASSSLPRALKTNTHVHFRQFAAASAKLTLRVLHGQISQADHRLVVSSERLSLSARALLHRRRERFEALDARF
KASRQAYAQAKRQAIARERDRAERLADRASRALATSILRLRARTDHAGQLLSALSYRSVLARGFALVRDEAGHPLHQAAG
IESGAALSIEFADGRVAATAGAGSPLPTSAPAAPKPVRESKPAAAKRTPDPADQGSLF
>Mature_537_residues
PPAEALPNAPEFTVSELSSALKRTVEDQFGHVRVRGEISGFRGPHSSGHCYFALKDESAKIEAVIWKGVHGRMRFKPQEG
LEVIATGKLTTYPNSSKYQIVIEALEPAGIGALMALMEERKRKLGAEGLFDPARKQLLPWLPEVIGVVTSPTGAVIRDIL
HRLEDRFPRRVLVWPVKVQGDGSAEQVAAAIRGFNDLPEDGPIPRPDVLIVARGGGSLEDLWSFNEEIVVRAAAESMIPL
ISAVGHETDVTLIDFAADKRAPTPTAAAEMAVPVRSELMQEVASLARRVSVCWQRGQESRRNELRAAARALPGASDLLAI
PRQRLDAASSSLPRALKTNTHVHFRQFAAASAKLTLRVLHGQISQADHRLVVSSERLSLSARALLHRRRERFEALDARFK
ASRQAYAQAKRQAIARERDRAERLADRASRALATSILRLRARTDHAGQLLSALSYRSVLARGFALVRDEAGHPLHQAAGI
ESGAALSIEFADGRVAATAGAGSPLPTSAPAAPKPVRESKPAAAKRTPDPADQGSLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=501, Percent_Identity=34.9301397205589, Blast_Score=255, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 58351; Mature: 58220

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPAEALPNAPEFTVSELSSALKRTVEDQFGHVRVRGEISGFRGPHSSGHCYFALKDESA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEEEEEECCCC
KIEAVIWKGVHGRMRFKPQEGLEVIATGKLTTYPNSSKYQIVIEALEPAGIGALMALMEE
EEEEEEEECCCCCEEECCCCCCEEEEECCEEECCCCCCEEEEEEECCCCCHHHHHHHHHH
RKRKLGAEGLFDPARKQLLPWLPEVIGVVTSPTGAVIRDILHRLEDRFPRRVLVWPVKVQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GDGSAEQVAAAIRGFNDLPEDGPIPRPDVLIVARGGGSLEDLWSFNEEIVVRAAAESMIP
CCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHH
LISAVGHETDVTLIDFAADKRAPTPTAAAEMAVPVRSELMQEVASLARRVSVCWQRGQES
HHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
RRNELRAAARALPGASDLLAIPRQRLDAASSSLPRALKTNTHVHFRQFAAASAKLTLRVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHH
HGQISQADHRLVVSSERLSLSARALLHRRRERFEALDARFKASRQAYAQAKRQAIARERD
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAERLADRASRALATSILRLRARTDHAGQLLSALSYRSVLARGFALVRDEAGHPLHQAAG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
IESGAALSIEFADGRVAATAGAGSPLPTSAPAAPKPVRESKPAAAKRTPDPADQGSLF
CCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PPAEALPNAPEFTVSELSSALKRTVEDQFGHVRVRGEISGFRGPHSSGHCYFALKDESA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEEEEEECCCC
KIEAVIWKGVHGRMRFKPQEGLEVIATGKLTTYPNSSKYQIVIEALEPAGIGALMALMEE
EEEEEEEECCCCCEEECCCCCCEEEEECCEEECCCCCCEEEEEEECCCCCHHHHHHHHHH
RKRKLGAEGLFDPARKQLLPWLPEVIGVVTSPTGAVIRDILHRLEDRFPRRVLVWPVKVQ
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GDGSAEQVAAAIRGFNDLPEDGPIPRPDVLIVARGGGSLEDLWSFNEEIVVRAAAESMIP
CCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHH
LISAVGHETDVTLIDFAADKRAPTPTAAAEMAVPVRSELMQEVASLARRVSVCWQRGQES
HHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
RRNELRAAARALPGASDLLAIPRQRLDAASSSLPRALKTNTHVHFRQFAAASAKLTLRVL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHH
HGQISQADHRLVVSSERLSLSARALLHRRRERFEALDARFKASRQAYAQAKRQAIARERD
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAERLADRASRALATSILRLRARTDHAGQLLSALSYRSVLARGFALVRDEAGHPLHQAAG
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCC
IESGAALSIEFADGRVAATAGAGSPLPTSAPAAPKPVRESKPAAAKRTPDPADQGSLF
CCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]