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The map label for this gene is mutL [H]

Identifier: 146342898

GI number: 146342898

Start: 6304635

End: 6306476

Strand: Direct

Name: mutL [H]

Synonym: BRADO6079

Alternate gene names: 146342898

Gene position: 6304635-6306476 (Clockwise)

Preceding gene: 146342896

Following gene: 146342901

Centisome position: 84.55

GC content: 70.25

Gene sequence:

>1842_bases
ATGCCCGTCCGCCAGCTTCCCGAACAGGTCATCAACCGCATCGCCGCCGGCGAGGTGGTCGAGCGGCCCGCAAGTGTCGT
CAAGGAGCTGGTCGAGAACGCGATCGATGCCGGTGCGAGCCGCATCGACATCTTCACCGATGGCGGCGGCCGGCGCAAAA
TTGCGATCACCGACGACGGCGGCGGCATGACCGCGGCCGATCTCGCACTCGCCGTCGAACGCCACGCGACCTCGAAGCTC
GACGACGAGGACCTCTTGCAGATCCGCACGCTCGGGTTCCGCGGCGAGGCGCTGCCGTCGATCGGCTCGGTGGCGCGGCT
GTCGATCACGACGCGGCACAAGAGCGAGCCGCATGCCTGGGGCATCACGGTCGATTGCGGCGACAAGTCACAGATCGTAC
CGGCCGCACTCAACCAGGGCACCCGCGTCGAAGTGGCCGATCTCTTCCATGCGACGCCGGCGCGGCTGAAGTTCCTCAAA
ACCGACCGCACCGAGGCGGAGGCGATCCGCGAGGTGGTGCGGCGGCTGGCGATGGCGCGCCCCGACATCGCCTTCACGGT
CGCCGGAGAGGAGCGGGCGCCGGTGACCTGGGCCGCCGCTTTGCCCGGCGCGCCGGGGCAACTGACGCGGCTCGGCGACA
TCCTGGGCACCGACTTCCGCAGCCATGCGATCGCGGTGCGCAGCGAGCGCGACCATGTGGCGGTCGAAGGCTTCGCCGCC
GCGCCGGCGCTGACGCGCGCCAATGCGCTCGGGCAGTATCTGTTCGTCAACGGCCGCCCGGTGCGCGACAAATTGATCCT
CGGCGCGGTGCGCGCGGCCTATGCCGACTATCTGCCGCGCGACCGGCATCCGGTGGTGGCGCTGTTCGTGACGCTCGATC
CGCGCGAGGTCGACGCCAACGTGCATCCTGCCAAGACCGAAGTGCGCTTCCGCAATGCCGGCCTGGTGCGCGCGCTGATC
ATCCACGCGCTGAAGGAGGGCCTCGCCCGCGAAGGCCGCCGCACCGCCGCCAATGACGGCGGCGCGACCATCGCGGCGTT
CCGCCCGGCGTTCACGCCACCGCGGCCGAGCGCGGGACCGATGAACTGGGATTGGCAGCGTTCGCCATCCGCTCCGATCC
CGCGCCATGACGACGTGGACTCCATGCCCCCGGCCGTCTCGTCCGCCGCCTTCGCCGAGCCGATGCAGGCCGCGTTCGAC
GTCGGCGGCCCGCGCGCCGATCTCCGCCTGCACGAGCAGCCGGCCGCGCCCGACATGCTCGACCGCCCGCTCGGCGCCGC
GCGCACGCAGATCCACGACACCTACATCGTTTCACAGACGCGCGACGGCCTTGTCATCGTCGATCAGCACGCCGCGCATG
AGCGTATCGTCTACGAGCGGCTGAAGACCTCGCTCGCCGCGCATGGCGTGCAGCGGCAGATCCTGTTGATTCCCGATATC
GTCGAGCTCGACGAGGCCACCGTCGAGGCACTGCTCGCGCGCACCGATGAACTCGCCGCGTTCGGACTCGCCGTCGAATC
CTTCGGCCCCGGCGCGGTAGCCGTGCGCGAGACACCGTCACTGCTCGGCAAGATCAATGCGGCGGGCCTGCTGCGCGACC
TCGCCGAGCACATGGAGGAATGGGGCGAGGCGCTGCCGTTGGAGCGCCGTCTGATGCACGTCGCCGCCACCATGGCCTGC
CACGGCTCCGTCCGCGCCGGCCGCCGCCTCAAGCCGGAGGAGATGAACGCGCTGCTCCGCGTGATGGAGGAGACGCCCAA
CTCCGGCCAGTGCAACCACGGCCGCCCGACCTATGTCGAGCTGAAGCTCGCCGACGTCGAGAAGCTGTTCGGGAGGAGAT
AG

Upstream 100 bases:

>100_bases
AAAGGCTATTCTCCGGGCCAACATTGTGGCGTCGCAACGTGGCTCCCCTGCGCTGCGAGGGCTACAACAGCGTACCCGAA
TCCGACGACAGTCCCGCGCC

Downstream 100 bases:

>100_bases
CGAAGACGGCCTGGAAATACACTAGGAGGAAAACGACGCCAGCTCCAAATACGGTGTCGTCCCGGGCAAGCCGCAGCGGC
GCAACGCGCCGCGGAGGCGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MPVRQLPEQVINRIAAGEVVERPASVVKELVENAIDAGASRIDIFTDGGGRRKIAITDDGGGMTAADLALAVERHATSKL
DDEDLLQIRTLGFRGEALPSIGSVARLSITTRHKSEPHAWGITVDCGDKSQIVPAALNQGTRVEVADLFHATPARLKFLK
TDRTEAEAIREVVRRLAMARPDIAFTVAGEERAPVTWAAALPGAPGQLTRLGDILGTDFRSHAIAVRSERDHVAVEGFAA
APALTRANALGQYLFVNGRPVRDKLILGAVRAAYADYLPRDRHPVVALFVTLDPREVDANVHPAKTEVRFRNAGLVRALI
IHALKEGLAREGRRTAANDGGATIAAFRPAFTPPRPSAGPMNWDWQRSPSAPIPRHDDVDSMPPAVSSAAFAEPMQAAFD
VGGPRADLRLHEQPAAPDMLDRPLGAARTQIHDTYIVSQTRDGLVIVDQHAAHERIVYERLKTSLAAHGVQRQILLIPDI
VELDEATVEALLARTDELAAFGLAVESFGPGAVAVRETPSLLGKINAAGLLRDLAEHMEEWGEALPLERRLMHVAATMAC
HGSVRAGRRLKPEEMNALLRVMEETPNSGQCNHGRPTYVELKLADVEKLFGRR

Sequences:

>Translated_613_residues
MPVRQLPEQVINRIAAGEVVERPASVVKELVENAIDAGASRIDIFTDGGGRRKIAITDDGGGMTAADLALAVERHATSKL
DDEDLLQIRTLGFRGEALPSIGSVARLSITTRHKSEPHAWGITVDCGDKSQIVPAALNQGTRVEVADLFHATPARLKFLK
TDRTEAEAIREVVRRLAMARPDIAFTVAGEERAPVTWAAALPGAPGQLTRLGDILGTDFRSHAIAVRSERDHVAVEGFAA
APALTRANALGQYLFVNGRPVRDKLILGAVRAAYADYLPRDRHPVVALFVTLDPREVDANVHPAKTEVRFRNAGLVRALI
IHALKEGLAREGRRTAANDGGATIAAFRPAFTPPRPSAGPMNWDWQRSPSAPIPRHDDVDSMPPAVSSAAFAEPMQAAFD
VGGPRADLRLHEQPAAPDMLDRPLGAARTQIHDTYIVSQTRDGLVIVDQHAAHERIVYERLKTSLAAHGVQRQILLIPDI
VELDEATVEALLARTDELAAFGLAVESFGPGAVAVRETPSLLGKINAAGLLRDLAEHMEEWGEALPLERRLMHVAATMAC
HGSVRAGRRLKPEEMNALLRVMEETPNSGQCNHGRPTYVELKLADVEKLFGRR
>Mature_612_residues
PVRQLPEQVINRIAAGEVVERPASVVKELVENAIDAGASRIDIFTDGGGRRKIAITDDGGGMTAADLALAVERHATSKLD
DEDLLQIRTLGFRGEALPSIGSVARLSITTRHKSEPHAWGITVDCGDKSQIVPAALNQGTRVEVADLFHATPARLKFLKT
DRTEAEAIREVVRRLAMARPDIAFTVAGEERAPVTWAAALPGAPGQLTRLGDILGTDFRSHAIAVRSERDHVAVEGFAAA
PALTRANALGQYLFVNGRPVRDKLILGAVRAAYADYLPRDRHPVVALFVTLDPREVDANVHPAKTEVRFRNAGLVRALII
HALKEGLAREGRRTAANDGGATIAAFRPAFTPPRPSAGPMNWDWQRSPSAPIPRHDDVDSMPPAVSSAAFAEPMQAAFDV
GGPRADLRLHEQPAAPDMLDRPLGAARTQIHDTYIVSQTRDGLVIVDQHAAHERIVYERLKTSLAAHGVQRQILLIPDIV
ELDEATVEALLARTDELAAFGLAVESFGPGAVAVRETPSLLGKINAAGLLRDLAEHMEEWGEALPLERRLMHVAATMACH
GSVRAGRRLKPEEMNALLRVMEETPNSGQCNHGRPTYVELKLADVEKLFGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=314, Percent_Identity=38.2165605095541, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=28.9230769230769, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=28.9230769230769, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI189458896, Length=318, Percent_Identity=27.9874213836478, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4505913, Length=349, Percent_Identity=27.5071633237822, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI310128478, Length=349, Percent_Identity=27.5071633237822, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI263191589, Length=220, Percent_Identity=33.6363636363636, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI91992162, Length=360, Percent_Identity=24.7222222222222, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI91992160, Length=360, Percent_Identity=24.7222222222222, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790612, Length=334, Percent_Identity=46.7065868263473, Blast_Score=267, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71991825, Length=332, Percent_Identity=32.8313253012048, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562796, Length=341, Percent_Identity=25.8064516129032, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=314, Percent_Identity=35.3503184713376, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=358, Percent_Identity=27.0949720670391, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=737, Percent_Identity=21.9810040705563, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136968, Length=342, Percent_Identity=37.719298245614, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=25.7703081232493, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 66421; Mature: 66289

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVRQLPEQVINRIAAGEVVERPASVVKELVENAIDAGASRIDIFTDGGGRRKIAITDDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECC
GGMTAADLALAVERHATSKLDDEDLLQIRTLGFRGEALPSIGSVARLSITTRHKSEPHAW
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCEE
GITVDCGDKSQIVPAALNQGTRVEVADLFHATPARLKFLKTDRTEAEAIREVVRRLAMAR
EEEEECCCCCCCCHHHHCCCCEEEHHHHHHCCHHHHEEECCCCHHHHHHHHHHHHHHHCC
PDIAFTVAGEERAPVTWAAALPGAPGQLTRLGDILGTDFRSHAIAVRSERDHVAVEGFAA
CCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHCEEEEECCCCCEEEECCHH
APALTRANALGQYLFVNGRPVRDKLILGAVRAAYADYLPRDRHPVVALFVTLDPREVDAN
CCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECHHHCCCC
VHPAKTEVRFRNAGLVRALIIHALKEGLAREGRRTAANDGGATIAAFRPAFTPPRPSAGP
CCCCHHEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCC
MNWDWQRSPSAPIPRHDDVDSMPPAVSSAAFAEPMQAAFDVGGPRADLRLHEQPAAPDML
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHH
DRPLGAARTQIHDTYIVSQTRDGLVIVDQHAAHERIVYERLKTSLAAHGVQRQILLIPDI
HCCCCHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEECCCH
VELDEATVEALLARTDELAAFGLAVESFGPGAVAVRETPSLLGKINAAGLLRDLAEHMEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
WGEALPLERRLMHVAATMACHGSVRAGRRLKPEEMNALLRVMEETPNSGQCNHGRPTYVE
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
LKLADVEKLFGRR
EEHHHHHHHHCCC
>Mature Secondary Structure 
PVRQLPEQVINRIAAGEVVERPASVVKELVENAIDAGASRIDIFTDGGGRRKIAITDDG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECC
GGMTAADLALAVERHATSKLDDEDLLQIRTLGFRGEALPSIGSVARLSITTRHKSEPHAW
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCCEE
GITVDCGDKSQIVPAALNQGTRVEVADLFHATPARLKFLKTDRTEAEAIREVVRRLAMAR
EEEEECCCCCCCCHHHHCCCCEEEHHHHHHCCHHHHEEECCCCHHHHHHHHHHHHHHHCC
PDIAFTVAGEERAPVTWAAALPGAPGQLTRLGDILGTDFRSHAIAVRSERDHVAVEGFAA
CCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHCEEEEECCCCCEEEECCHH
APALTRANALGQYLFVNGRPVRDKLILGAVRAAYADYLPRDRHPVVALFVTLDPREVDAN
CCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECHHHCCCC
VHPAKTEVRFRNAGLVRALIIHALKEGLAREGRRTAANDGGATIAAFRPAFTPPRPSAGP
CCCCHHEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCC
MNWDWQRSPSAPIPRHDDVDSMPPAVSSAAFAEPMQAAFDVGGPRADLRLHEQPAAPDML
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHH
DRPLGAARTQIHDTYIVSQTRDGLVIVDQHAAHERIVYERLKTSLAAHGVQRQILLIPDI
HCCCCHHHHHHHHEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEECCCH
VELDEATVEALLARTDELAAFGLAVESFGPGAVAVRETPSLLGKINAAGLLRDLAEHMEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
WGEALPLERRLMHVAATMACHGSVRAGRRLKPEEMNALLRVMEETPNSGQCNHGRPTYVE
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
LKLADVEKLFGRR
EEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA