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The map label for this gene is uvrC [H]

Identifier: 146342875

GI number: 146342875

Start: 6278802

End: 6280868

Strand: Direct

Name: uvrC [H]

Synonym: BRADO6055

Alternate gene names: 146342875

Gene position: 6278802-6280868 (Clockwise)

Preceding gene: 146342873

Following gene: 146342876

Centisome position: 84.2

GC content: 67.73

Gene sequence:

>2067_bases
ATGACCACCCAAAGCTCCGATCCACCCCAGGCGCCGGCGCCCCCGCACCGGCGTGGCGCCGCGACCGACCTGCCGCCCGA
GGCCACCGATACGCCCGATCTCGATCCCGCCGCGTCCGGCGCGGACGAGGACGATGACGGCCGCCTGCCCGAGCTGACGG
AAGAGAGCGCCGAGCCGGTCGGCGAGGGCCCGCTCGCGATCGGCCATGCCGCGATCGAGAACGCGGTGCGGCTGGCGCCA
ACCTCGCCCGGCGTCTACCGGATGCTGAACGCGGCGCATGACGTGCTCTATGTCGGCAAGGCCAAGAACGTCAAAAAGCG
TCTTGCGTCCTATGCGCGCGCCAACGCTCCGCTGCCGGCGCGCATCCTGCGCATGATCGCGGCCACCGTGACCGTCGAGA
TCGTCTCGACCACCACGGAGACCGAAGCGTTGCTGCTCGAGGCGAACCTCATCAAGCAGCTCAAGCCGCGCTTCAACGTG
CAGCTGCGCGACGACAAGTCGTTCCCCTACATCCTCATTACCGGCGACCATTGGGCGCCGCAGATCCTCAAGCATCGCGG
CGCGCAGTCGCGGCCAGGCCGCTATTTCGGCCCGTTCGCCTCGGCCGGCGCGGTCAACCGCACCATCACGGCGCTGCAGC
GCGCCTTCCTGATCCGATCCTGCACCGATTCGTTCTTCGAGAGCCGCACCCGCCCCTGCCTCTTGCATCAGATCCGGCGC
TGCGCCGGACCCTGCACGCAGGAGATCGACTTCCCCGGCTATAGCGAGCTGGTCCGCGAGGCGACCGATTTCCTGTCCGG
CCGCAGCCAGGCGGTGAAGGCGCTGCTCGCAAGCGAGATGGAGAAGGCCTCCGCCGAGCTCGAGTTCGAGACCGCCGCCG
TCTATCGCGACCGCCTCGCGGCGCTGTCGGCGATCTCCTCGCAGCAGGGCATCAATCCGCGCACGGTCGAGGAAGCCGAC
GTGTTCGCCATCCACCAGGAGGGCGGCTTCTCCTGCGTCGAGGTGTTCTTCTTCCGCACCGGCCAGAACTGGGGCAACCG
CGCCTACTTCCCGCGCGCCGAGAAGACGTTCACACAAGAGGAGGTGCTGTCCGCCTTCCTGTCGCAGTTCTACGACGACA
AGCCGCCGCCACGGCTGATCCTGCTGTCGCACGAGATCGAGGAGGCCGAGCTGCTCGCCGAGGCGCTGTGCGTCAAGGCA
GGCCACAAAGTGGAGGTGTCCTGCCCGAAGCGCGGCGAGAAGAAGGATCTCGTCACGCATGCCCTGACCAATGCGCGCGA
GGCGCTCGGCCGCAAGCTCGCGGACACGGCGACGCAGAGCCGCTTGTTGGAGGCAATGACGACCACGCTCGGCCTGCCGC
AGGTGCCGAAGCGCATCGAGGTGTACGACAACAGCCACATCCAGGGCACCAACGCGGTCGGCGCGATGATCGTCGCCGGC
CCCGACGGCTTCATGAAGAACCAGTACCGCAAGTTCAACATCAAGTCGGAGGGGCTCACCCCCGGCGACGACTACGCGAT
GATGAAGGAGGTGCTGCAGCGCCGATTCAAGCGGCTGGTCGCGCCGTCGGAAAAGGACGTCGCGCGCGCGGCCAAGGAGG
ACGACGTGCCGCAATGGCCCGATCTCGTCATCATCGACGGCGGCCGCGGACAGCTGAACGCCGTCCGCGAGATCTTCACC
GAGCTCGGCGTCGGCAACGTCGCGCTGATGTCGGTCGCCAAGGGCCCGGATCGCGACGCCGGCCGTGAGACGCTGTTCAT
CCCGGAGCGCGAGGCGATCAAGCTCGAGCCGCGCGACCCCGTGCTGTATTTCATCCAGCGCCTGCGCGACGAGGCGCACC
GCTTCGTCATCGGCTCGCACCGCAAGCTGCGCAAGAAGGACATCCGCGAGGCCGGCCTGCAGGAGATTCCTGGCATCGGC
CCCTCACGCAAGCGCGCGCTGCTGCATCATTTCGGCACGCTGAAGGAAATCGAGCGCGCCTCGATCGCCGACCTCGGCAA
GGTCCCCGGCGTGAGCGCCGAGAGCGCGCGGAAGATCTTCGAGTACTTCCACAGCAATGCGAGCTGA

Upstream 100 bases:

>100_bases
CGTGCTTAACGAAGCGTTACCGCCCTCCTCGTCTGTCCTGCCCTGTGCATGGCGCCAGCGCATGCTGGCGGGACGGCGCG
GCAGCGCTTAATTTGCTGAC

Downstream 100 bases:

>100_bases
GCGGACCGGGCGGAGTTGAGCTGTTCAACCCGTTCCGCGGTCAGCTTGAGCCCGGCTCTCTCCACGTCATTCCGGGGCGC
GCGTAGCGCGAGCCCGGAAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MTTQSSDPPQAPAPPHRRGAATDLPPEATDTPDLDPAASGADEDDDGRLPELTEESAEPVGEGPLAIGHAAIENAVRLAP
TSPGVYRMLNAAHDVLYVGKAKNVKKRLASYARANAPLPARILRMIAATVTVEIVSTTTETEALLLEANLIKQLKPRFNV
QLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLIRSCTDSFFESRTRPCLLHQIRR
CAGPCTQEIDFPGYSELVREATDFLSGRSQAVKALLASEMEKASAELEFETAAVYRDRLAALSAISSQQGINPRTVEEAD
VFAIHQEGGFSCVEVFFFRTGQNWGNRAYFPRAEKTFTQEEVLSAFLSQFYDDKPPPRLILLSHEIEEAELLAEALCVKA
GHKVEVSCPKRGEKKDLVTHALTNAREALGRKLADTATQSRLLEAMTTTLGLPQVPKRIEVYDNSHIQGTNAVGAMIVAG
PDGFMKNQYRKFNIKSEGLTPGDDYAMMKEVLQRRFKRLVAPSEKDVARAAKEDDVPQWPDLVIIDGGRGQLNAVREIFT
ELGVGNVALMSVAKGPDRDAGRETLFIPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIG
PSRKRALLHHFGTLKEIERASIADLGKVPGVSAESARKIFEYFHSNAS

Sequences:

>Translated_688_residues
MTTQSSDPPQAPAPPHRRGAATDLPPEATDTPDLDPAASGADEDDDGRLPELTEESAEPVGEGPLAIGHAAIENAVRLAP
TSPGVYRMLNAAHDVLYVGKAKNVKKRLASYARANAPLPARILRMIAATVTVEIVSTTTETEALLLEANLIKQLKPRFNV
QLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLIRSCTDSFFESRTRPCLLHQIRR
CAGPCTQEIDFPGYSELVREATDFLSGRSQAVKALLASEMEKASAELEFETAAVYRDRLAALSAISSQQGINPRTVEEAD
VFAIHQEGGFSCVEVFFFRTGQNWGNRAYFPRAEKTFTQEEVLSAFLSQFYDDKPPPRLILLSHEIEEAELLAEALCVKA
GHKVEVSCPKRGEKKDLVTHALTNAREALGRKLADTATQSRLLEAMTTTLGLPQVPKRIEVYDNSHIQGTNAVGAMIVAG
PDGFMKNQYRKFNIKSEGLTPGDDYAMMKEVLQRRFKRLVAPSEKDVARAAKEDDVPQWPDLVIIDGGRGQLNAVREIFT
ELGVGNVALMSVAKGPDRDAGRETLFIPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIG
PSRKRALLHHFGTLKEIERASIADLGKVPGVSAESARKIFEYFHSNAS
>Mature_687_residues
TTQSSDPPQAPAPPHRRGAATDLPPEATDTPDLDPAASGADEDDDGRLPELTEESAEPVGEGPLAIGHAAIENAVRLAPT
SPGVYRMLNAAHDVLYVGKAKNVKKRLASYARANAPLPARILRMIAATVTVEIVSTTTETEALLLEANLIKQLKPRFNVQ
LRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLIRSCTDSFFESRTRPCLLHQIRRC
AGPCTQEIDFPGYSELVREATDFLSGRSQAVKALLASEMEKASAELEFETAAVYRDRLAALSAISSQQGINPRTVEEADV
FAIHQEGGFSCVEVFFFRTGQNWGNRAYFPRAEKTFTQEEVLSAFLSQFYDDKPPPRLILLSHEIEEAELLAEALCVKAG
HKVEVSCPKRGEKKDLVTHALTNAREALGRKLADTATQSRLLEAMTTTLGLPQVPKRIEVYDNSHIQGTNAVGAMIVAGP
DGFMKNQYRKFNIKSEGLTPGDDYAMMKEVLQRRFKRLVAPSEKDVARAAKEDDVPQWPDLVIIDGGRGQLNAVREIFTE
LGVGNVALMSVAKGPDRDAGRETLFIPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIGP
SRKRALLHHFGTLKEIERASIADLGKVPGVSAESARKIFEYFHSNAS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=616, Percent_Identity=41.0714285714286, Blast_Score=450, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75910; Mature: 75779

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQSSDPPQAPAPPHRRGAATDLPPEATDTPDLDPAASGADEDDDGRLPELTEESAEPV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
GEGPLAIGHAAIENAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLASYARANAPLPA
CCCCCHHHHHHHHHCEEECCCCCHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCCHH
RILRMIAATVTVEIVSTTTETEALLLEANLIKQLKPRFNVQLRDDKSFPYILITGDHWAP
HHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCHHH
QILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLIRSCTDSFFESRTRPCLLHQIRR
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
CAGPCTQEIDFPGYSELVREATDFLSGRSQAVKALLASEMEKASAELEFETAAVYRDRLA
HCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALSAISSQQGINPRTVEEADVFAIHQEGGFSCVEVFFFRTGQNWGNRAYFPRAEKTFTQE
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCHH
EVLSAFLSQFYDDKPPPRLILLSHEIEEAELLAEALCVKAGHKVEVSCPKRGEKKDLVTH
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ALTNAREALGRKLADTATQSRLLEAMTTTLGLPQVPKRIEVYDNSHIQGTNAVGAMIVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEEEEEEC
PDGFMKNQYRKFNIKSEGLTPGDDYAMMKEVLQRRFKRLVAPSEKDVARAAKEDDVPQWP
CCHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
DLVIIDGGRGQLNAVREIFTELGVGNVALMSVAKGPDRDAGRETLFIPEREAIKLEPRDP
CEEEEECCCCHHHHHHHHHHHCCCCCEEEHHCCCCCCCCCCCCEEECCCCCCEEECCCCH
VLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIGPSRKRALLHHFGTLKEIERA
HHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SIADLGKVPGVSAESARKIFEYFHSNAS
HHHHHHCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTQSSDPPQAPAPPHRRGAATDLPPEATDTPDLDPAASGADEDDDGRLPELTEESAEPV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
GEGPLAIGHAAIENAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLASYARANAPLPA
CCCCCHHHHHHHHHCEEECCCCCHHHHHHHHHHHEEEECCHHHHHHHHHHHHHCCCCCHH
RILRMIAATVTVEIVSTTTETEALLLEANLIKQLKPRFNVQLRDDKSFPYILITGDHWAP
HHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCHHH
QILKHRGAQSRPGRYFGPFASAGAVNRTITALQRAFLIRSCTDSFFESRTRPCLLHQIRR
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
CAGPCTQEIDFPGYSELVREATDFLSGRSQAVKALLASEMEKASAELEFETAAVYRDRLA
HCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALSAISSQQGINPRTVEEADVFAIHQEGGFSCVEVFFFRTGQNWGNRAYFPRAEKTFTQE
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCHH
EVLSAFLSQFYDDKPPPRLILLSHEIEEAELLAEALCVKAGHKVEVSCPKRGEKKDLVTH
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
ALTNAREALGRKLADTATQSRLLEAMTTTLGLPQVPKRIEVYDNSHIQGTNAVGAMIVAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEEEEEEC
PDGFMKNQYRKFNIKSEGLTPGDDYAMMKEVLQRRFKRLVAPSEKDVARAAKEDDVPQWP
CCHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
DLVIIDGGRGQLNAVREIFTELGVGNVALMSVAKGPDRDAGRETLFIPEREAIKLEPRDP
CEEEEECCCCHHHHHHHHHHHCCCCCEEEHHCCCCCCCCCCCCEEECCCCCCEEECCCCH
VLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIGPSRKRALLHHFGTLKEIERA
HHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
SIADLGKVPGVSAESARKIFEYFHSNAS
HHHHHHCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]