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The map label for this gene is msrA [H]

Identifier: 146342752

GI number: 146342752

Start: 6145066

End: 6145782

Strand: Direct

Name: msrA [H]

Synonym: BRADO5925

Alternate gene names: 146342752

Gene position: 6145066-6145782 (Clockwise)

Preceding gene: 146342750

Following gene: 146342753

Centisome position: 82.41

GC content: 63.88

Gene sequence:

>717_bases
ATGCGCCTCACCCGCTCCCATTTCATCAAGACAGCCGTGCTCGGCGCCCTCGCGGTGGCCGGGATCCTGGCCTGGCAGCC
GCTGCATGCCGCCGAAGAGGCGGTCGTGATCCCGCCGCCGGCGCAGGACCAGCCGGCCAGTGACGGTCTCGAAACCGCGG
TTGTCGCCGGCGGCTGCTTCTGGGGCGTCCAGGGCGTCTACCAGCACACCGCCGGCGTGATCAGCGCGGTGTCAGGCTAT
GCCGGCGGCACCAAGGCGACGGCCGACTATCGCACAGTGTCGACCGGCAGCACGGGACATGCCGAGTCGGTGCAGATCAA
GTTCGACCCGAAGAAGGTTTCCTACGGCAAGATCCTGCAGATCTTCTTCTCCGTGGTGCATGACCCGACGCAGCTGAACC
GCCAGGGCCCCGACACCGGCACGCAATATCGCTCCGCGATCTTCACGACGTCCGAGACGCAGAAGAAGGTCGCCGAGGCC
TATATCGCCCAGCTCGACAAGGCCAAGGTGTTCGGCAAGCCGATCGTCACCAAGGTCGGCAAGCTCGAGGCGTTCTACCC
GGCTGAGGACTATCACCAGGACTACCTGACGCTGCACCCGAACCAGCCCTATATTGCCTACAACGACCTGCCGAAGATCG
ACAATCTGAAGAAGATCTTCGCCGAGAACTACATCGACAAGCCGACGCTGGTCAGGGACGCCAAGGCGACGAATTGA

Upstream 100 bases:

>100_bases
GTAACGCCGCCGGGGATGCAACGTATCTTGCGACACAGGATCGGCCGGGCCAGTCTTTCGGCCGGCAAAACGAGACAGAC
AACCAGACCGAGGATCGAAC

Downstream 100 bases:

>100_bases
GCGCCGCCTCCTGCCCGATCAGCACAACGACAGGGGTGGATCACTTTGGGTCCGCCGGAGGAACGAAGAGATGAGCGACA
CGAAAACCAGCGACAAGGTC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRLTRSHFIKTAVLGALAVAGILAWQPLHAAEEAVVIPPPAQDQPASDGLETAVVAGGCFWGVQGVYQHTAGVISAVSGY
AGGTKATADYRTVSTGSTGHAESVQIKFDPKKVSYGKILQIFFSVVHDPTQLNRQGPDTGTQYRSAIFTTSETQKKVAEA
YIAQLDKAKVFGKPIVTKVGKLEAFYPAEDYHQDYLTLHPNQPYIAYNDLPKIDNLKKIFAENYIDKPTLVRDAKATN

Sequences:

>Translated_238_residues
MRLTRSHFIKTAVLGALAVAGILAWQPLHAAEEAVVIPPPAQDQPASDGLETAVVAGGCFWGVQGVYQHTAGVISAVSGY
AGGTKATADYRTVSTGSTGHAESVQIKFDPKKVSYGKILQIFFSVVHDPTQLNRQGPDTGTQYRSAIFTTSETQKKVAEA
YIAQLDKAKVFGKPIVTKVGKLEAFYPAEDYHQDYLTLHPNQPYIAYNDLPKIDNLKKIFAENYIDKPTLVRDAKATN
>Mature_238_residues
MRLTRSHFIKTAVLGALAVAGILAWQPLHAAEEAVVIPPPAQDQPASDGLETAVVAGGCFWGVQGVYQHTAGVISAVSGY
AGGTKATADYRTVSTGSTGHAESVQIKFDPKKVSYGKILQIFFSVVHDPTQLNRQGPDTGTQYRSAIFTTSETQKKVAEA
YIAQLDKAKVFGKPIVTKVGKLEAFYPAEDYHQDYLTLHPNQPYIAYNDLPKIDNLKKIFAENYIDKPTLVRDAKATN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=162, Percent_Identity=42.5925925925926, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI208609995, Length=162, Percent_Identity=42.5925925925926, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=47.2222222222222, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1790665, Length=156, Percent_Identity=43.5897435897436, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=165, Percent_Identity=35.1515151515151, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=37.8048780487805, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664627, Length=148, Percent_Identity=35.1351351351351, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=35.2112676056338, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664631, Length=148, Percent_Identity=35.1351351351351, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25840; Mature: 25840

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTRSHFIKTAVLGALAVAGILAWQPLHAAEEAVVIPPPAQDQPASDGLETAVVAGGCF
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCHHH
WGVQGVYQHTAGVISAVSGYAGGTKATADYRTVSTGSTGHAESVQIKFDPKKVSYGKILQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHH
IFFSVVHDPTQLNRQGPDTGTQYRSAIFTTSETQKKVAEAYIAQLDKAKVFGKPIVTKVG
HHHHHHCCHHHHCCCCCCCCHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KLEAFYPAEDYHQDYLTLHPNQPYIAYNDLPKIDNLKKIFAENYIDKPTLVRDAKATN
CCEEECCCHHHCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCC
>Mature Secondary Structure
MRLTRSHFIKTAVLGALAVAGILAWQPLHAAEEAVVIPPPAQDQPASDGLETAVVAGGCF
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHCHHH
WGVQGVYQHTAGVISAVSGYAGGTKATADYRTVSTGSTGHAESVQIKFDPKKVSYGKILQ
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHH
IFFSVVHDPTQLNRQGPDTGTQYRSAIFTTSETQKKVAEAYIAQLDKAKVFGKPIVTKVG
HHHHHHCCHHHHCCCCCCCCHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KLEAFYPAEDYHQDYLTLHPNQPYIAYNDLPKIDNLKKIFAENYIDKPTLVRDAKATN
CCEEECCCHHHCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]