Click here to switch to the map view.

The map label for this gene is ftsI [H]

Identifier: 146342504

GI number: 146342504

Start: 5860634

End: 5862382

Strand: Reverse

Name: ftsI [H]

Synonym: BRADO5665

Alternate gene names: 146342504

Gene position: 5862382-5860634 (Counterclockwise)

Preceding gene: 146342505

Following gene: 146342503

Centisome position: 78.62

GC content: 64.78

Gene sequence:

>1749_bases
ATGACCGACCAGCTTCGGCCGCACGTGAAACCACAGGAGCCCTGGCGGCAGCGCCTGGTCCGCACGCTGCTGTACGGGCG
CGATGTCGATCGCACGGCCAAGGCGCGCGCGCGCATCGGATTGGCGATCATCGCCTTCGCCGCCGTCTATGCGGTGATCG
GCGGCCGTCTGGTGATGTTTGCGGTCGGCTCCGACGGCCCGAGCGCGCGGCGCGCCGCGCAGCAGGACGCCATTGCGACC
GCTCGGCCGGATATCATCGATCGCAACGGCGCCGTGCTGGCGACCGATGTCAAGACGCCGAGCCTGTTCGCCGAGCCGCG
CCGCCTCATTGACAAGGACGAGGCGATCGAGCTGCTCACCGCGACCTTGCCCGATCTCGATACGAACGAGGTGCGCGAGC
GCATGATGTCCCGCAAGGGCTTCGTCTGGCTCAAGCGCGAGATGACACCGAAGCAGCAGCAGGACATCCATCGCCTTGGT
CTGCCGGGCGTCGGCTTCCTGCGCGAGAACAAGCGCGTCTATCCGACCGGCAACGAGGTGGCGCATCTGATCGGCCTGGT
GAACATCGACAACCAGGGCATCGCCGGCATGGAGAAGTGGCTCGACAATCAGGGCCTCGCGGACCTGCATCGCGCCGGCT
TCGCGACCGACCGCCTGCAGCGGCCGATCGAGCTGTCGGTCGACCTGCGTGTCGAGCATGCGCTGCGCGACGAGCTGCTC
AAGGCCAAGGAGAAGTTCAAGACCAAGGCCGCGTCCGGTCTCGTGGTCAACGTCCGGACCGGTGAGATTATCGCGATGGT
GTCGCTGCCGGATTTCGATCCGAACAACCCGAAGGAGGCGCACGATCCGGACCGGATCAACCGCCTGACCACTGGCGTGT
ACGAGATGGGCTCGACGTTCAAGGCGTTCACCCTGGCGATGGCGCTCGACACCGGCAAATATGATCTCAACTCAATGTGG
GATGCACGCGGAGCGCTGCATTACGGCAAGTTCGCGATCCATGACGACGAGCCGAAGGGACGCTTCCTCAGCATGAAGGA
GGTGTTCTACTTCTCCTCCAACGTCGGCGCGGCCCGGATCGCGTTGACGCAAGGCGTGGAAGCGCACAAGGCTTTCCTGC
GCAAGATGGGCCAGTTCGACCGTTTGCGCACCGAGCTTCCGGAGAGCGCCTCGCCGATCCTGCCCAAGCGCTGGAGCGAG
TTGAATACGATCACGATCTCGTTCGGCCATGGCATGGCGGTGGCGCCGTTGCAGGGCGTGATGGGCGTCAGCGCGCTGGT
CAATGGCGGCTACCTCATTCCGCCGACCTTCATGAAGCGCACTGAGGCCGAGGCGATGCAGATCGCCAAGCGCGTGATCA
AGCCGGAGACCTCGGAGAAGATGCGCTACCTGATGCGCTTGAACGCCGAGGTCGGCACCGCGCGCAAGGCTGACGTCAAG
GGCTACTACATTGGCGGCAAAACGGGCACCGCCGAAAAGGTGATCAACGGCCGCTACGCCAAGAAGAAGGTCCTGACGCT
CTTCACCGCCGTGATCCCGGCGGACAAGCCGAAATATCAGCTCCTGATCATGCTCGACGAGCCGCAGCCGCTGAAGGAGA
CCTACGGCTTCATCACCTCCGGCTGGAACGCGGTGCCGACGGCCGGCAACGTGATCTCCCGGATCGGCCCGCTGCTCGGC
ATTGAGCCCCGGTTCGACCTGCCGCCGTCCGACCGCCAAATTCTTGCGGCATCGCGGCTGACGCAGTAA

Upstream 100 bases:

>100_bases
CGGACAATCCGGATCCGATCGGCTCGATGATCGATACGATCGACGCGATCAATGAAGAGCCCCCCGTGACCGGATCGGTC
TCTCGTCCGGAGGATCAGCG

Downstream 100 bases:

>100_bases
GCCGTCCGCGAATCGCATGGCTTTGGAGCCGCCGCCGCCCGGGGCGGGGCCAGGACCGGTACGGGACCAGGATGAAACTT
CACGACCTCCTCGGCGATCA

Product: division-specific transpeptidase, penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MTDQLRPHVKPQEPWRQRLVRTLLYGRDVDRTAKARARIGLAIIAFAAVYAVIGGRLVMFAVGSDGPSARRAAQQDAIAT
ARPDIIDRNGAVLATDVKTPSLFAEPRRLIDKDEAIELLTATLPDLDTNEVRERMMSRKGFVWLKREMTPKQQQDIHRLG
LPGVGFLRENKRVYPTGNEVAHLIGLVNIDNQGIAGMEKWLDNQGLADLHRAGFATDRLQRPIELSVDLRVEHALRDELL
KAKEKFKTKAASGLVVNVRTGEIIAMVSLPDFDPNNPKEAHDPDRINRLTTGVYEMGSTFKAFTLAMALDTGKYDLNSMW
DARGALHYGKFAIHDDEPKGRFLSMKEVFYFSSNVGAARIALTQGVEAHKAFLRKMGQFDRLRTELPESASPILPKRWSE
LNTITISFGHGMAVAPLQGVMGVSALVNGGYLIPPTFMKRTEAEAMQIAKRVIKPETSEKMRYLMRLNAEVGTARKADVK
GYYIGGKTGTAEKVINGRYAKKKVLTLFTAVIPADKPKYQLLIMLDEPQPLKETYGFITSGWNAVPTAGNVISRIGPLLG
IEPRFDLPPSDRQILAASRLTQ

Sequences:

>Translated_582_residues
MTDQLRPHVKPQEPWRQRLVRTLLYGRDVDRTAKARARIGLAIIAFAAVYAVIGGRLVMFAVGSDGPSARRAAQQDAIAT
ARPDIIDRNGAVLATDVKTPSLFAEPRRLIDKDEAIELLTATLPDLDTNEVRERMMSRKGFVWLKREMTPKQQQDIHRLG
LPGVGFLRENKRVYPTGNEVAHLIGLVNIDNQGIAGMEKWLDNQGLADLHRAGFATDRLQRPIELSVDLRVEHALRDELL
KAKEKFKTKAASGLVVNVRTGEIIAMVSLPDFDPNNPKEAHDPDRINRLTTGVYEMGSTFKAFTLAMALDTGKYDLNSMW
DARGALHYGKFAIHDDEPKGRFLSMKEVFYFSSNVGAARIALTQGVEAHKAFLRKMGQFDRLRTELPESASPILPKRWSE
LNTITISFGHGMAVAPLQGVMGVSALVNGGYLIPPTFMKRTEAEAMQIAKRVIKPETSEKMRYLMRLNAEVGTARKADVK
GYYIGGKTGTAEKVINGRYAKKKVLTLFTAVIPADKPKYQLLIMLDEPQPLKETYGFITSGWNAVPTAGNVISRIGPLLG
IEPRFDLPPSDRQILAASRLTQ
>Mature_581_residues
TDQLRPHVKPQEPWRQRLVRTLLYGRDVDRTAKARARIGLAIIAFAAVYAVIGGRLVMFAVGSDGPSARRAAQQDAIATA
RPDIIDRNGAVLATDVKTPSLFAEPRRLIDKDEAIELLTATLPDLDTNEVRERMMSRKGFVWLKREMTPKQQQDIHRLGL
PGVGFLRENKRVYPTGNEVAHLIGLVNIDNQGIAGMEKWLDNQGLADLHRAGFATDRLQRPIELSVDLRVEHALRDELLK
AKEKFKTKAASGLVVNVRTGEIIAMVSLPDFDPNNPKEAHDPDRINRLTTGVYEMGSTFKAFTLAMALDTGKYDLNSMWD
ARGALHYGKFAIHDDEPKGRFLSMKEVFYFSSNVGAARIALTQGVEAHKAFLRKMGQFDRLRTELPESASPILPKRWSEL
NTITISFGHGMAVAPLQGVMGVSALVNGGYLIPPTFMKRTEAEAMQIAKRVIKPETSEKMRYLMRLNAEVGTARKADVKG
YYIGGKTGTAEKVINGRYAKKKVLTLFTAVIPADKPKYQLLIMLDEPQPLKETYGFITSGWNAVPTAGNVISRIGPLLGI
EPRFDLPPSDRQILAASRLTQ

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=528, Percent_Identity=30.8712121212121, Blast_Score=189, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64676; Mature: 64545

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQLRPHVKPQEPWRQRLVRTLLYGRDVDRTAKARARIGLAIIAFAAVYAVIGGRLVMF
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AVGSDGPSARRAAQQDAIATARPDIIDRNGAVLATDVKTPSLFAEPRRLIDKDEAIELLT
EECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHH
ATLPDLDTNEVRERMMSRKGFVWLKREMTPKQQQDIHRLGLPGVGFLRENKRVYPTGNEV
HHCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCEEECCCEECCCCHHH
AHLIGLVNIDNQGIAGMEKWLDNQGLADLHRAGFATDRLQRPIELSVDLRVEHALRDELL
EEHHEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCHHHHCCCCEEEEEEEHHHHHHHHHH
KAKEKFKTKAASGLVVNVRTGEIIAMVSLPDFDPNNPKEAHDPDRINRLTTGVYEMGSTF
HHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
KAFTLAMALDTGKYDLNSMWDARGALHYGKFAIHDDEPKGRFLSMKEVFYFSSNVGAARI
HHHHEEEEECCCCCCHHHHHHHCCCCEECEEEEECCCCCCCEEEHHHHEEEECCCCCEEE
ALTQGVEAHKAFLRKMGQFDRLRTELPESASPILPKRWSELNTITISFGHGMAVAPLQGV
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCEEEHHHHHH
MGVSALVNGGYLIPPTFMKRTEAEAMQIAKRVIKPETSEKMRYLMRLNAEVGTARKADVK
HHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
GYYIGGKTGTAEKVINGRYAKKKVLTLFTAVIPADKPKYQLLIMLDEPQPLKETYGFITS
EEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHC
GWNAVPTAGNVISRIGPLLGIEPRFDLPPSDRQILAASRLTQ
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
TDQLRPHVKPQEPWRQRLVRTLLYGRDVDRTAKARARIGLAIIAFAAVYAVIGGRLVMF
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AVGSDGPSARRAAQQDAIATARPDIIDRNGAVLATDVKTPSLFAEPRRLIDKDEAIELLT
EECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHHHHHHHH
ATLPDLDTNEVRERMMSRKGFVWLKREMTPKQQQDIHRLGLPGVGFLRENKRVYPTGNEV
HHCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCEEECCCEECCCCHHH
AHLIGLVNIDNQGIAGMEKWLDNQGLADLHRAGFATDRLQRPIELSVDLRVEHALRDELL
EEHHEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCHHHHCCCCEEEEEEEHHHHHHHHHH
KAKEKFKTKAASGLVVNVRTGEIIAMVSLPDFDPNNPKEAHDPDRINRLTTGVYEMGSTF
HHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
KAFTLAMALDTGKYDLNSMWDARGALHYGKFAIHDDEPKGRFLSMKEVFYFSSNVGAARI
HHHHEEEEECCCCCCHHHHHHHCCCCEECEEEEECCCCCCCEEEHHHHEEEECCCCCEEE
ALTQGVEAHKAFLRKMGQFDRLRTELPESASPILPKRWSELNTITISFGHGMAVAPLQGV
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCEEEHHHHHH
MGVSALVNGGYLIPPTFMKRTEAEAMQIAKRVIKPETSEKMRYLMRLNAEVGTARKADVK
HHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCC
GYYIGGKTGTAEKVINGRYAKKKVLTLFTAVIPADKPKYQLLIMLDEPQPLKETYGFITS
EEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHC
GWNAVPTAGNVISRIGPLLGIEPRFDLPPSDRQILAASRLTQ
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]