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The map label for this gene is ddc [H]

Identifier: 146341924

GI number: 146341924

Start: 5248383

End: 5249867

Strand: Reverse

Name: ddc [H]

Synonym: BRADO5059

Alternate gene names: 146341924

Gene position: 5249867-5248383 (Counterclockwise)

Preceding gene: 146341925

Following gene: 146341923

Centisome position: 70.41

GC content: 69.09

Gene sequence:

>1485_bases
TTGCGGCCAGCCGAGACGCTCGATCCACAGGACTGGTCCGAGCTGCGCGCGCAAGGTCATCGCATGCTCGACGACATGAT
CGACTACGTTGCCGGCATCCGCGACCGCACGGTGTGGCAGCCGATGTCGCAGGCGACGCGGCAGCGCTTTCGCAGCGATC
TTCCGCACAGGCCGACCGATCTCGCCGAGGTCTATCGTGATTTCAGCGAGCTCGTCGTTCCCCACGCCACCGGCAACGTG
CATCCCGGATTCATGGGCTGGGTGCATGGCGGCGGCACGGTGGTCGGCATGCTCGCGGAGATGCTGGCGGCTGGATTGAA
CGCCAATCTCGGCGGCCGCGACCACGCGCCGATCGAGATCGAGCGCGAGGTCGTCGACTGGACGCGGCAGCTGTTCGGCT
TCCCGCAAGGCGCCAGCGGCCTGTTCGTCACCGGCACCTCGATGGCGAACCTGATGGCGGTCGTGATCGCGCGCCGTGCC
GCGCTGGGGGCCGCGGTTCGTCGCGACGGGCTCGGCGAGTCCGGCCAGCGCCTGCGCGCCTACACGTCGAAGGCCGCGCA
TGGCTGCATCGCCAAGGCGATGGACATCTGCGGGCTGGGCAGCGCTGCGCTGCGCAGCATCGCCGTCGACGCGGCACATC
GGATCAGTATCGCCGCGCTGCGCGAAGCCGTGGCGGCCGATCGCGCGGCAGGCCTGAATCCGTTCCTCGTCGTGGCATCG
GCAGGAACGGTCGACATCGGCGCCATCGACGATCTCGCCGATGTCGCCGAGCTGTGCCGCAGCGAGGGCCTGTGGTTTCA
CGTCGACGGCGCATTCGGCGCGCTGGCCATGATGTCGGAGGAGCTCGCGCCCAGGCTCGCCGGTATCACGCGCGCGGATT
CGATCGCGCTCGACTTCCACAAATGGGGGCAGGTGCCTTACGACGCGGGATTCCTGCTGGTGCGCGACGGCGAGAGGCAT
CGTGACGCCTTTGCCTCACCGGCCGCCTATCTCCGCCGCGAGACGCGCGGGCTTGCCGCCGGCGCGGAATGGCCATGCGA
CCTCGGGCCCGATCTGTCGCGCGGCTTTCGGGCGCTGAAGACCTGGTTCACGCTGCGGACGTTCGGCACCGACCGGCTCG
GCAGCATGATCGCCAGGAGTTGCCGGCTGGCGCGACACCTCGCGGCAAGGGTGCGTGCGGAGCCGGAGCTGGAGCTGCTG
GCGCCGGTCAATCTGAACATCGTCTGCTTTCGCTACCGGTGCCAAGATGCCGACGCGATCAACGGCGCCGTCGTCGCCGA
CATCCATGAATCCGGTCTCGCGGCGCCGTCGACGACGATGCTGGAGGGCCGCCTGGCGATCCGCGCCGCGATCGTCAACC
ATCGCACCGGCGTCGATGACGTCGATCGGCTGGTCGACGCGGTCCTGATGTTCGGACGTCAGCGCGCAGCCGGTGTCGCG
CCATTGATCGATGCCCACGCGCCGCCACTGGTGCCGGGATGGTAA

Upstream 100 bases:

>100_bases
TGCGCAAGATCTTCGCAGCCTTCGCCGACATGATCACCAGGCGCGCCGTCGCGGCGGCGGAGCAGGCGGCGTGAGCACGG
AGCTGCGCAGCGACGCGTCG

Downstream 100 bases:

>100_bases
ATTGCTGGATCGTTCCAGGGCGATGTTACCACCCGCAAAGATGAACCGAGATGGTGCGCGGGAGCTTTCGAAAGTTGGTT
GACGCGTGGTGAAGATGCCA

Product: putative pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MRPAETLDPQDWSELRAQGHRMLDDMIDYVAGIRDRTVWQPMSQATRQRFRSDLPHRPTDLAEVYRDFSELVVPHATGNV
HPGFMGWVHGGGTVVGMLAEMLAAGLNANLGGRDHAPIEIEREVVDWTRQLFGFPQGASGLFVTGTSMANLMAVVIARRA
ALGAAVRRDGLGESGQRLRAYTSKAAHGCIAKAMDICGLGSAALRSIAVDAAHRISIAALREAVAADRAAGLNPFLVVAS
AGTVDIGAIDDLADVAELCRSEGLWFHVDGAFGALAMMSEELAPRLAGITRADSIALDFHKWGQVPYDAGFLLVRDGERH
RDAFASPAAYLRRETRGLAAGAEWPCDLGPDLSRGFRALKTWFTLRTFGTDRLGSMIARSCRLARHLAARVRAEPELELL
APVNLNIVCFRYRCQDADAINGAVVADIHESGLAAPSTTMLEGRLAIRAAIVNHRTGVDDVDRLVDAVLMFGRQRAAGVA
PLIDAHAPPLVPGW

Sequences:

>Translated_494_residues
MRPAETLDPQDWSELRAQGHRMLDDMIDYVAGIRDRTVWQPMSQATRQRFRSDLPHRPTDLAEVYRDFSELVVPHATGNV
HPGFMGWVHGGGTVVGMLAEMLAAGLNANLGGRDHAPIEIEREVVDWTRQLFGFPQGASGLFVTGTSMANLMAVVIARRA
ALGAAVRRDGLGESGQRLRAYTSKAAHGCIAKAMDICGLGSAALRSIAVDAAHRISIAALREAVAADRAAGLNPFLVVAS
AGTVDIGAIDDLADVAELCRSEGLWFHVDGAFGALAMMSEELAPRLAGITRADSIALDFHKWGQVPYDAGFLLVRDGERH
RDAFASPAAYLRRETRGLAAGAEWPCDLGPDLSRGFRALKTWFTLRTFGTDRLGSMIARSCRLARHLAARVRAEPELELL
APVNLNIVCFRYRCQDADAINGAVVADIHESGLAAPSTTMLEGRLAIRAAIVNHRTGVDDVDRLVDAVLMFGRQRAAGVA
PLIDAHAPPLVPGW
>Mature_494_residues
MRPAETLDPQDWSELRAQGHRMLDDMIDYVAGIRDRTVWQPMSQATRQRFRSDLPHRPTDLAEVYRDFSELVVPHATGNV
HPGFMGWVHGGGTVVGMLAEMLAAGLNANLGGRDHAPIEIEREVVDWTRQLFGFPQGASGLFVTGTSMANLMAVVIARRA
ALGAAVRRDGLGESGQRLRAYTSKAAHGCIAKAMDICGLGSAALRSIAVDAAHRISIAALREAVAADRAAGLNPFLVVAS
AGTVDIGAIDDLADVAELCRSEGLWFHVDGAFGALAMMSEELAPRLAGITRADSIALDFHKWGQVPYDAGFLLVRDGERH
RDAFASPAAYLRRETRGLAAGAEWPCDLGPDLSRGFRALKTWFTLRTFGTDRLGSMIARSCRLARHLAARVRAEPELELL
APVNLNIVCFRYRCQDADAINGAVVADIHESGLAAPSTTMLEGRLAIRAAIVNHRTGVDDVDRLVDAVLMFGRQRAAGVA
PLIDAHAPPLVPGW

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=468, Percent_Identity=28.6324786324786, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI132814448, Length=468, Percent_Identity=28.6324786324786, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI92110055, Length=469, Percent_Identity=27.7185501066098, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI197383062, Length=457, Percent_Identity=25.601750547046, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI197276620, Length=446, Percent_Identity=25.7847533632287, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4503875, Length=446, Percent_Identity=25.7847533632287, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI58331246, Length=449, Percent_Identity=24.7216035634744, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI194294551, Length=344, Percent_Identity=28.7790697674419, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17534817, Length=465, Percent_Identity=27.5268817204301, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17534819, Length=465, Percent_Identity=27.5268817204301, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71981211, Length=514, Percent_Identity=24.124513618677, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71981217, Length=523, Percent_Identity=23.7093690248566, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI133931025, Length=422, Percent_Identity=26.0663507109005, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17555682, Length=496, Percent_Identity=26.008064516129, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17551992, Length=504, Percent_Identity=22.2222222222222, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71993062, Length=413, Percent_Identity=27.6029055690073, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71993058, Length=408, Percent_Identity=26.7156862745098, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17543922, Length=305, Percent_Identity=24.9180327868852, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24586044, Length=480, Percent_Identity=29.1666666666667, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24652373, Length=469, Percent_Identity=31.9829424307036, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28573972, Length=466, Percent_Identity=28.5407725321888, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24585135, Length=419, Percent_Identity=29.3556085918854, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24585139, Length=480, Percent_Identity=27.0833333333333, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI221476190, Length=466, Percent_Identity=27.2532188841202, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24585143, Length=466, Percent_Identity=27.2532188841202, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI17136190, Length=418, Percent_Identity=28.4688995215311, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI17136594, Length=333, Percent_Identity=29.4294294294294, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21356415, Length=425, Percent_Identity=26.1176470588235, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24657193, Length=289, Percent_Identity=27.681660899654, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24657185, Length=289, Percent_Identity=27.681660899654, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24657188, Length=289, Percent_Identity=27.681660899654, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 53268; Mature: 53268

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPAETLDPQDWSELRAQGHRMLDDMIDYVAGIRDRTVWQPMSQATRQRFRSDLPHRPTD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
LAEVYRDFSELVVPHATGNVHPGFMGWVHGGGTVVGMLAEMLAAGLNANLGGRDHAPIEI
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
EREVVDWTRQLFGFPQGASGLFVTGTSMANLMAVVIARRAALGAAVRRDGLGESGQRLRA
HHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YTSKAAHGCIAKAMDICGLGSAALRSIAVDAAHRISIAALREAVAADRAAGLNPFLVVAS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
AGTVDIGAIDDLADVAELCRSEGLWFHVDGAFGALAMMSEELAPRLAGITRADSIALDFH
CCCEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
KWGQVPYDAGFLLVRDGERHRDAFASPAAYLRRETRGLAAGAEWPCDLGPDLSRGFRALK
HCCCCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
TWFTLRTFGTDRLGSMIARSCRLARHLAARVRAEPELELLAPVNLNIVCFRYRCQDADAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCC
NGAVVADIHESGLAAPSTTMLEGRLAIRAAIVNHRTGVDDVDRLVDAVLMFGRQRAAGVA
CCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCC
PLIDAHAPPLVPGW
HHHHCCCCCCCCCC
>Mature Secondary Structure
MRPAETLDPQDWSELRAQGHRMLDDMIDYVAGIRDRTVWQPMSQATRQRFRSDLPHRPTD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
LAEVYRDFSELVVPHATGNVHPGFMGWVHGGGTVVGMLAEMLAAGLNANLGGRDHAPIEI
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
EREVVDWTRQLFGFPQGASGLFVTGTSMANLMAVVIARRAALGAAVRRDGLGESGQRLRA
HHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YTSKAAHGCIAKAMDICGLGSAALRSIAVDAAHRISIAALREAVAADRAAGLNPFLVVAS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
AGTVDIGAIDDLADVAELCRSEGLWFHVDGAFGALAMMSEELAPRLAGITRADSIALDFH
CCCEECCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEHH
KWGQVPYDAGFLLVRDGERHRDAFASPAAYLRRETRGLAAGAEWPCDLGPDLSRGFRALK
HCCCCCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
TWFTLRTFGTDRLGSMIARSCRLARHLAARVRAEPELELLAPVNLNIVCFRYRCQDADAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCC
NGAVVADIHESGLAAPSTTMLEGRLAIRAAIVNHRTGVDDVDRLVDAVLMFGRQRAAGVA
CCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHCCCC
PLIDAHAPPLVPGW
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]