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The map label for this gene is iclR [H]

Identifier: 146341823

GI number: 146341823

Start: 5142175

End: 5143020

Strand: Reverse

Name: iclR [H]

Synonym: BRADO4952

Alternate gene names: 146341823

Gene position: 5143020-5142175 (Counterclockwise)

Preceding gene: 146341824

Following gene: 146341822

Centisome position: 68.97

GC content: 68.44

Gene sequence:

>846_bases
GTGATCCGTCGCAAGACGATCGAGCCACGCGCAGATGCCGCGGCCGAGCCCCGCGACGGCGGCGTGCAATCCGTCGGCCG
CGCGCTGCAGATCCTGGAAATTCTCGCCGAGGACGACGAAGGCTATCGCCTCAGCGATCTCGCCATCCGCGCCGGCCTGT
CCACCTCCACCGTGCATCGCCTGCTGACGACGCTCGAGAAGCGCCGCTTCGTCCAGTTCGACAGGATGGAATCGAAATGG
CACGTCGGCGCGCAGAGCTTCGCCGTCGGCGCGATCTTCACCCGCCGGCGCAATTTCGTCGCGCTCGCCATTCCCTATCT
GCGGCGCCTGCGCGATCAGTCGCGCGAAACCGCCAATCTCGCCGTCGTCGACGATGAATCGCTGATGGTGCTGCTGCGGC
TCGAAAGCCGCGAGATCATGCGCTCGCTGACCAAGGTCGGCGGCCGCCTGTCGATGGTCGCCTCCGGCATGGGCAAGGCC
GTGCTCGCGACCTATTCGGACGACGACGTCAACGGCATCATCCACCGCCAGGGCATGCCGCGCTTGACCGAGAAGTCGAT
CATCCGCGCCAGCGACCTGTTCCGCGAGCTGGAGACCATCCGCCGCCAGGGCTACGCCGTCGACGACGAGGAGGCGAGGC
TCGGCCTGCGCTGCATCGCCGCCGTCGTTCACGATTCCTGCCGCGAGCCCCTGGCCGCGATCTCGGTCTCGGGCCTAGCG
AGCCGGCTGACGGAGGAGCGGGTGCCGATGGTCGGGGGAATGGTGCGGGATATTGCGGCGGAGCTGACGGCGGCACTTGG
GGGCGGGGGGCCGCCTGGTGGCAACGAGGATCGGCAGCCCGATTGA

Upstream 100 bases:

>100_bases
GCTCTCGCCGGGGCGGCACTTTATTTGATAGCGTGACGAAGCAAGATCCGTCCGTCCTGCAACGACGCCGCCTCATGAGG
GCCGCGCAGAGAGGCGCCAC

Downstream 100 bases:

>100_bases
CCGCAGCGCCCGCGGCATCGATAATCTCGGTTAGCGCGAGTTTTTCGATTTGCACAACCAGACCGTTCCTGGGAGCTATG
TCCATGTCGATCAGCGATGA

Product: glyoxylate bypass operon transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MIRRKTIEPRADAAAEPRDGGVQSVGRALQILEILAEDDEGYRLSDLAIRAGLSTSTVHRLLTTLEKRRFVQFDRMESKW
HVGAQSFAVGAIFTRRRNFVALAIPYLRRLRDQSRETANLAVVDDESLMVLLRLESREIMRSLTKVGGRLSMVASGMGKA
VLATYSDDDVNGIIHRQGMPRLTEKSIIRASDLFRELETIRRQGYAVDDEEARLGLRCIAAVVHDSCREPLAAISVSGLA
SRLTEERVPMVGGMVRDIAAELTAALGGGGPPGGNEDRQPD

Sequences:

>Translated_281_residues
MIRRKTIEPRADAAAEPRDGGVQSVGRALQILEILAEDDEGYRLSDLAIRAGLSTSTVHRLLTTLEKRRFVQFDRMESKW
HVGAQSFAVGAIFTRRRNFVALAIPYLRRLRDQSRETANLAVVDDESLMVLLRLESREIMRSLTKVGGRLSMVASGMGKA
VLATYSDDDVNGIIHRQGMPRLTEKSIIRASDLFRELETIRRQGYAVDDEEARLGLRCIAAVVHDSCREPLAAISVSGLA
SRLTEERVPMVGGMVRDIAAELTAALGGGGPPGGNEDRQPD
>Mature_281_residues
MIRRKTIEPRADAAAEPRDGGVQSVGRALQILEILAEDDEGYRLSDLAIRAGLSTSTVHRLLTTLEKRRFVQFDRMESKW
HVGAQSFAVGAIFTRRRNFVALAIPYLRRLRDQSRETANLAVVDDESLMVLLRLESREIMRSLTKVGGRLSMVASGMGKA
VLATYSDDDVNGIIHRQGMPRLTEKSIIRASDLFRELETIRRQGYAVDDEEARLGLRCIAAVVHDSCREPLAAISVSGLA
SRLTEERVPMVGGMVRDIAAELTAALGGGGPPGGNEDRQPD

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=257, Percent_Identity=42.8015564202335, Blast_Score=210, Evalue=9e-56,
Organism=Escherichia coli, GI1786715, Length=254, Percent_Identity=36.2204724409449, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1788131, Length=262, Percent_Identity=29.0076335877863, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1789999, Length=231, Percent_Identity=32.034632034632, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786468, Length=251, Percent_Identity=27.8884462151394, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788581, Length=224, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30923; Mature: 30923

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRKTIEPRADAAAEPRDGGVQSVGRALQILEILAEDDEGYRLSDLAIRAGLSTSTVHR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHH
LLTTLEKRRFVQFDRMESKWHVGAQSFAVGAIFTRRRNFVALAIPYLRRLRDQSRETANL
HHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCE
AVVDDESLMVLLRLESREIMRSLTKVGGRLSMVASGMGKAVLATYSDDDVNGIIHRQGMP
EEECCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCEECCCCC
RLTEKSIIRASDLFRELETIRRQGYAVDDEEARLGLRCIAAVVHDSCREPLAAISVSGLA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
SRLTEERVPMVGGMVRDIAAELTAALGGGGPPGGNEDRQPD
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIRRKTIEPRADAAAEPRDGGVQSVGRALQILEILAEDDEGYRLSDLAIRAGLSTSTVHR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHH
LLTTLEKRRFVQFDRMESKWHVGAQSFAVGAIFTRRRNFVALAIPYLRRLRDQSRETANL
HHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCE
AVVDDESLMVLLRLESREIMRSLTKVGGRLSMVASGMGKAVLATYSDDDVNGIIHRQGMP
EEECCCCEEEEEEHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCEECCCCC
RLTEKSIIRASDLFRELETIRRQGYAVDDEEARLGLRCIAAVVHDSCREPLAAISVSGLA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
SRLTEERVPMVGGMVRDIAAELTAALGGGGPPGGNEDRQPD
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]