Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 146341803

GI number: 146341803

Start: 5122609

End: 5123658

Strand: Reverse

Name: serA [H]

Synonym: BRADO4922

Alternate gene names: 146341803

Gene position: 5123658-5122609 (Counterclockwise)

Preceding gene: 146341807

Following gene: 146341802

Centisome position: 68.71

GC content: 69.9

Gene sequence:

>1050_bases
ATGGCCGCGAATTCCAAGCGCGTGTTCTACGTCAAATATCTCGCCCATCCGATCTTCAGCGAGCTGCTGGCGGCGCGCCC
CGACGTCCGGCTCGACCGGCTGGAGAACGAGAGTGCCGAGGCCGACACGGCGCCTATCCTCGCGGCGGCCCATGCCTACC
AGATCGGCGCGGCCCGCGACGAGCTCGCCCCGCGCTTTCATGTCGATGCGTACCTGCTGCGCCGCGCGCCGAACCTCTTG
ATCGTCTCGAGCAACGGCGCCGGCTACGATCCGGTCGATGTCGAGGCCTGCACGGCAGCCGGCGTCCTGGTCGTCAACCA
GTCCGGCGGCAACGCCCATTCGGTCGCCGAGCACACGCTCGGCATGATGCTGACGCTGTCCAAGCGCATCATCCAGTCCG
ACCGCAGGCTGCGCCGCGATCGCGACGTCAACCGCAACGACCTGATCGGCAACGAGGTGCAGGGCCGCACCGTCGGCATC
GTCGGTCTCGGCAATGTCGGCCGCAGGGTGGCCGAGCTGTGCCGCGGCCTGCTGGGCATGACGGTGCTGGCCTATGATCC
GTATCTCTCGGCCGAGGAGATCGCCGCGCGTGGTGCGGAGAAGGTGGAGTTGGATGATCTGATGCGGCGCGCCGACTTTG
TCTCGGTCAACTGCCCGCTGACCCGGGAAAGCCGGGGCATGATCGGCGCGGCAGAGTTCGCGCTGATGCAGCCGAGCGCC
TATTTCGTCACCACCGCGCGCGGCTTCATCCATGACGAGGACGCGCTGCTGGCGGCCCTGGCCGAGCGGCGCATCGCCGG
GGCCGGGCTCGACGTCTGGTCCAAGGAGCCGCCGCCGCCGGACCATCCGCTGCTGCAGCTCGACAATGTCCTGGCGAGCC
CGCATACGGCGGGCGTGACCCGCGAGGCGCGGCAGAACATGGGCCGGATCGCCGCCGAGCAGCTGCTCGCCGCGCTCGAC
GGCAGCCGGCCGCCGCGGCTGATCAACCCCGAGGCGTGGCCGCGCTACAGCGCCCGGTTCCGCGAGGCGTTCGGAGTGAC
GCCGGAGTAG

Upstream 100 bases:

>100_bases
GCTTGACGGCGCGGGATCGATTGTCAACATGCCGGCCCGGCCGGTCAGGCAACCGCCGTTCGTGTCGACAAGCAGCAAAA
AACCAGGAGGTCGCCCGGCC

Downstream 100 bases:

>100_bases
CTGGGAAGGGTCCAACGCGAGGAGAAGATTTCATGCGTCGCCGGCTGCAGCGCAGCAATGAATCTTCTCTCCGGAGCGGT
CGAGGCGAAGCGGATATTGC

Product: putative D-3-phosphoglycerate dehydrogenase (PGDH)

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MAANSKRVFYVKYLAHPIFSELLAARPDVRLDRLENESAEADTAPILAAAHAYQIGAARDELAPRFHVDAYLLRRAPNLL
IVSSNGAGYDPVDVEACTAAGVLVVNQSGGNAHSVAEHTLGMMLTLSKRIIQSDRRLRRDRDVNRNDLIGNEVQGRTVGI
VGLGNVGRRVAELCRGLLGMTVLAYDPYLSAEEIAARGAEKVELDDLMRRADFVSVNCPLTRESRGMIGAAEFALMQPSA
YFVTTARGFIHDEDALLAALAERRIAGAGLDVWSKEPPPPDHPLLQLDNVLASPHTAGVTREARQNMGRIAAEQLLAALD
GSRPPRLINPEAWPRYSARFREAFGVTPE

Sequences:

>Translated_349_residues
MAANSKRVFYVKYLAHPIFSELLAARPDVRLDRLENESAEADTAPILAAAHAYQIGAARDELAPRFHVDAYLLRRAPNLL
IVSSNGAGYDPVDVEACTAAGVLVVNQSGGNAHSVAEHTLGMMLTLSKRIIQSDRRLRRDRDVNRNDLIGNEVQGRTVGI
VGLGNVGRRVAELCRGLLGMTVLAYDPYLSAEEIAARGAEKVELDDLMRRADFVSVNCPLTRESRGMIGAAEFALMQPSA
YFVTTARGFIHDEDALLAALAERRIAGAGLDVWSKEPPPPDHPLLQLDNVLASPHTAGVTREARQNMGRIAAEQLLAALD
GSRPPRLINPEAWPRYSARFREAFGVTPE
>Mature_348_residues
AANSKRVFYVKYLAHPIFSELLAARPDVRLDRLENESAEADTAPILAAAHAYQIGAARDELAPRFHVDAYLLRRAPNLLI
VSSNGAGYDPVDVEACTAAGVLVVNQSGGNAHSVAEHTLGMMLTLSKRIIQSDRRLRRDRDVNRNDLIGNEVQGRTVGIV
GLGNVGRRVAELCRGLLGMTVLAYDPYLSAEEIAARGAEKVELDDLMRRADFVSVNCPLTRESRGMIGAAEFALMQPSAY
FVTTARGFIHDEDALLAALAERRIAGAGLDVWSKEPPPPDHPLLQLDNVLASPHTAGVTREARQNMGRIAAEQLLAALDG
SRPPRLINPEAWPRYSARFREAFGVTPE

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=266, Percent_Identity=36.4661654135338, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI61743967, Length=265, Percent_Identity=33.5849056603774, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=33.5849056603774, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI6912396, Length=262, Percent_Identity=32.0610687022901, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI145580578, Length=265, Percent_Identity=32.0754716981132, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI4557499, Length=265, Percent_Identity=32.0754716981132, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=32.4324324324324, Blast_Score=115, Evalue=4e-26,
Organism=Escherichia coli, GI87082289, Length=316, Percent_Identity=33.2278481012658, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789279, Length=285, Percent_Identity=31.5789473684211, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=32.1428571428571, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI87081824, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=242, Percent_Identity=32.6446280991736, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=271, Percent_Identity=31.7343173431734, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=252, Percent_Identity=30.952380952381, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=252, Percent_Identity=30.952380952381, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=265, Percent_Identity=31.6981132075472, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=269, Percent_Identity=30.1115241635688, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=152, Percent_Identity=34.8684210526316, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921140, Length=266, Percent_Identity=34.5864661654135, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=32.1656050955414, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=32.9317269076305, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551003, Length=249, Percent_Identity=32.9317269076305, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=32.9317269076305, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=32.9317269076305, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=32.9317269076305, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=31.6, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646446, Length=274, Percent_Identity=29.9270072992701, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646448, Length=274, Percent_Identity=29.9270072992701, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646452, Length=274, Percent_Identity=29.9270072992701, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646450, Length=274, Percent_Identity=29.9270072992701, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=30.188679245283, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24585516, Length=245, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 38019; Mature: 37888

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANSKRVFYVKYLAHPIFSELLAARPDVRLDRLENESAEADTAPILAAAHAYQIGAARD
CCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHH
ELAPRFHVDAYLLRRAPNLLIVSSNGAGYDPVDVEACTAAGVLVVNQSGGNAHSVAEHTL
HCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHH
GMMLTLSKRIIQSDRRLRRDRDVNRNDLIGNEVQGRTVGIVGLGNVGRRVAELCRGLLGM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHC
TVLAYDPYLSAEEIAARGAEKVELDDLMRRADFVSVNCPLTRESRGMIGAAEFALMQPSA
CCEEECCCCCHHHHHHCCCCCCCHHHHHHHHCEEEECCCCCCCCCCCEEHHHHHEECCCE
YFVTTARGFIHDEDALLAALAERRIAGAGLDVWSKEPPPPDHPLLQLDNVLASPHTAGVT
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
REARQNMGRIAAEQLLAALDGSRPPRLINPEAWPRYSARFREAFGVTPE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AANSKRVFYVKYLAHPIFSELLAARPDVRLDRLENESAEADTAPILAAAHAYQIGAARD
CCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHH
ELAPRFHVDAYLLRRAPNLLIVSSNGAGYDPVDVEACTAAGVLVVNQSGGNAHSVAEHTL
HCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHH
GMMLTLSKRIIQSDRRLRRDRDVNRNDLIGNEVQGRTVGIVGLGNVGRRVAELCRGLLGM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHC
TVLAYDPYLSAEEIAARGAEKVELDDLMRRADFVSVNCPLTRESRGMIGAAEFALMQPSA
CCEEECCCCCHHHHHHCCCCCCCHHHHHHHHCEEEECCCCCCCCCCCEEHHHHHEECCCE
YFVTTARGFIHDEDALLAALAERRIAGAGLDVWSKEPPPPDHPLLQLDNVLASPHTAGVT
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
REARQNMGRIAAEQLLAALDGSRPPRLINPEAWPRYSARFREAFGVTPE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]