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The map label for this gene is hit [H]

Identifier: 146341437

GI number: 146341437

Start: 4728147

End: 4728572

Strand: Direct

Name: hit [H]

Synonym: BRADO4528

Alternate gene names: 146341437

Gene position: 4728147-4728572 (Clockwise)

Preceding gene: 146341436

Following gene: 146341446

Centisome position: 63.41

GC content: 65.96

Gene sequence:

>426_bases
ATGACCGCCTACGATCCCCAAAACCCGTTCGCGAAGATCCTGCGCGGTGAATTCCCCTGCGTGAAGGTGTATGAGAACGA
CCACGTGCTGGCCTTCCTCGACATCATGCCGCGCGTCCCCGGCCACACGCTGGTCATCCCGAAGGCTCCGGCCCGCAACA
TCCTCGACATCACCGAGGAAGACTACCTCCATGTCGGCCGCGCCGTGCGCACGATCGCCCGCGCCGCCAAGACGGCGTTC
GCCGCCGACGGCATCACGGTGCAGCAGTTCAACGAGCATGCCGGCGGGCAGATGGTGTTCCACCTCCACGTCCACATCAT
GCCGCGCCACAATGGCGACAGCCTGCTGCCGCCGGCCAGCCGCAAGGAGGACCCGAAGGTGCTGGAAGAGAACGCCGCGA
AGCTGATCGCGGCGCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
ATCCGGCCCGTTCCGCAAGGACCTGGACGAGCAATCTTGACCGGCGGCACGAGGCAATGAAAGTAAGGCGCCTGACGAGG
AACCGCTGAAGGATTTGCCG

Downstream 100 bases:

>100_bases
TCACGGCTCACGCATCGTCGAGCCCGATGTCCAGCGCGGCCGAGGAATGCGTGATCCAGCCGACCGAGATCAGGTCGACA
CCCGCCGCCGCGATCGCCGG

Product: putative Hit (histidine triad) family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MTAYDPQNPFAKILRGEFPCVKVYENDHVLAFLDIMPRVPGHTLVIPKAPARNILDITEEDYLHVGRAVRTIARAAKTAF
AADGITVQQFNEHAGGQMVFHLHVHIMPRHNGDSLLPPASRKEDPKVLEENAAKLIAALKG

Sequences:

>Translated_141_residues
MTAYDPQNPFAKILRGEFPCVKVYENDHVLAFLDIMPRVPGHTLVIPKAPARNILDITEEDYLHVGRAVRTIARAAKTAF
AADGITVQQFNEHAGGQMVFHLHVHIMPRHNGDSLLPPASRKEDPKVLEENAAKLIAALKG
>Mature_140_residues
TAYDPQNPFAKILRGEFPCVKVYENDHVLAFLDIMPRVPGHTLVIPKAPARNILDITEEDYLHVGRAVRTIARAAKTAFA
ADGITVQQFNEHAGGQMVFHLHVHIMPRHNGDSLLPPASRKEDPKVLEENAAKLIAALKG

Specific function: Unknown

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Homo sapiens, GI14211923, Length=98, Percent_Identity=34.6938775510204, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787346, Length=99, Percent_Identity=36.3636363636364, Blast_Score=61, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506713, Length=98, Percent_Identity=37.7551020408163, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320078, Length=134, Percent_Identity=31.3432835820896, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581222, Length=98, Percent_Identity=37.7551020408163, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574010, Length=98, Percent_Identity=37.7551020408163, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR019808
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: NA

Molecular weight: Translated: 15593; Mature: 15462

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYDPQNPFAKILRGEFPCVKVYENDHVLAFLDIMPRVPGHTLVIPKAPARNILDITEE
CCCCCCCCHHHHHHCCCCCEEEEECCCCEEEEEEHHCCCCCCEEEECCCCCCCCCCCCCH
DYLHVGRAVRTIARAAKTAFAADGITVQQFNEHAGGQMVFHLHVHIMPRHNGDSLLPPAS
HHHHHHHHHHHHHHHHHHHHHCCCEEHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCCC
RKEDPKVLEENAAKLIAALKG
CCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAYDPQNPFAKILRGEFPCVKVYENDHVLAFLDIMPRVPGHTLVIPKAPARNILDITEE
CCCCCCCHHHHHHCCCCCEEEEECCCCEEEEEEHHCCCCCCEEEECCCCCCCCCCCCCH
DYLHVGRAVRTIARAAKTAFAADGITVQQFNEHAGGQMVFHLHVHIMPRHNGDSLLPPAS
HHHHHHHHHHHHHHHHHHHHHCCCEEHHHHCCCCCCEEEEEEEEEEEECCCCCCCCCCCC
RKEDPKVLEENAAKLIAALKG
CCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]