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The map label for this gene is gltR [H]

Identifier: 146341404

GI number: 146341404

Start: 4692359

End: 4693249

Strand: Direct

Name: gltR [H]

Synonym: BRADO4494

Alternate gene names: 146341404

Gene position: 4692359-4693249 (Clockwise)

Preceding gene: 146341397

Following gene: 146341405

Centisome position: 62.93

GC content: 70.15

Gene sequence:

>891_bases
ATGGAACTGAGCGACCTGCAGACCTTCGCTGCGGTGGCCCGTACCGGCGGCATCACGCGGGCCGCGGAGGTCCTCAACAC
GGTTCAGTCCAACGTCACGCAGCGGATCAAGGCACTGGAAGCCGAGATCGGCACTCCACTGTTCGACCGCCATAGCCGCG
GCATGACCCTGACCGGCGCCGGCCAGCGGCTGTTGCCTTACGCCGATCGTATGGCGGCGCTGTCGCGCGAAGCCGTGCTC
GCCGCGCGCGACGACGGCGAGCCGCGGGGGCCGCTGATGATCGGCTCGATGGAGACGACCGCCGCGGTGCGTCTGCCGAT
GCGGCTCGCCGACTTCCACCGGCGCTTTCCCGCGGTGGCGTTGAGCCTGCGGACCGCGCCGACCTCGGATCTCGTGGCCG
GCGTGCTCGACGGCACGCTGGATGGCGCCTTCGTCGCAGGTCCGATCGACCATCCCGAACTCAGCGGCATCGTTGCCTTC
GAGGAAGAACTCGTCCTGGTGACGGCCCGGCGGTTCGAGAGCCTCTCCTCTTTGCGCGCGGCCACCGCCGCGTCGGGCCC
GACCGCGCTGGTGTTCAGGACCGGCTGCACCTATCGGCAGCGTCTGGAGCAGGTGTTCAACGATTTCGGCTGGCCTGCCG
CTTCGCGCATCGAGCTCGGCACGCTTGACGGCATGATCGGCTGCGTCGCCGCCGGCATGGGCGTCGCGCTGCTGCCGCGC
GCGGTCGCGACGCGGCACGAGATGAGCGGCAGCATCGGCCTGCATGCGCTCGATCCGACCCATGCGCAGGTCAAGACGCT
CTTCATCCACCGCCGCGCCGCGCGCCGCAGCAGCGCATTGTCCGCGTTCATAGCGGGCCTGAGCCGCCGAGATCGCGACA
TCGCCGCCTGA

Upstream 100 bases:

>100_bases
TCTCCTCGCCTCTGGACGCTGAGACTAGGCGCCGGTAACATTCTCTGAAAATGAATAATTGAGAACTCTGCCATCGCAGA
ATCAAAACGGAGAGCGGGTT

Downstream 100 bases:

>100_bases
GGGCCTTCATCCAGAGATTGTCGGCAGCACGACGCGCGAGCGATTCATTCCATCGCGCGAAATGATGCGACGGCTCTGCA
AATCGCGGCTATTTTGACCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MELSDLQTFAAVARTGGITRAAEVLNTVQSNVTQRIKALEAEIGTPLFDRHSRGMTLTGAGQRLLPYADRMAALSREAVL
AARDDGEPRGPLMIGSMETTAAVRLPMRLADFHRRFPAVALSLRTAPTSDLVAGVLDGTLDGAFVAGPIDHPELSGIVAF
EEELVLVTARRFESLSSLRAATAASGPTALVFRTGCTYRQRLEQVFNDFGWPAASRIELGTLDGMIGCVAAGMGVALLPR
AVATRHEMSGSIGLHALDPTHAQVKTLFIHRRAARRSSALSAFIAGLSRRDRDIAA

Sequences:

>Translated_296_residues
MELSDLQTFAAVARTGGITRAAEVLNTVQSNVTQRIKALEAEIGTPLFDRHSRGMTLTGAGQRLLPYADRMAALSREAVL
AARDDGEPRGPLMIGSMETTAAVRLPMRLADFHRRFPAVALSLRTAPTSDLVAGVLDGTLDGAFVAGPIDHPELSGIVAF
EEELVLVTARRFESLSSLRAATAASGPTALVFRTGCTYRQRLEQVFNDFGWPAASRIELGTLDGMIGCVAAGMGVALLPR
AVATRHEMSGSIGLHALDPTHAQVKTLFIHRRAARRSSALSAFIAGLSRRDRDIAA
>Mature_296_residues
MELSDLQTFAAVARTGGITRAAEVLNTVQSNVTQRIKALEAEIGTPLFDRHSRGMTLTGAGQRLLPYADRMAALSREAVL
AARDDGEPRGPLMIGSMETTAAVRLPMRLADFHRRFPAVALSLRTAPTSDLVAGVLDGTLDGAFVAGPIDHPELSGIVAF
EEELVLVTARRFESLSSLRAATAASGPTALVFRTGCTYRQRLEQVFNDFGWPAASRIELGTLDGMIGCVAAGMGVALLPR
AVATRHEMSGSIGLHALDPTHAQVKTLFIHRRAARRSSALSAFIAGLSRRDRDIAA

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=291, Percent_Identity=36.7697594501718, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI145693105, Length=299, Percent_Identity=27.4247491638796, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082132, Length=260, Percent_Identity=29.6153846153846, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI157672245, Length=281, Percent_Identity=27.0462633451957, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788481, Length=292, Percent_Identity=26.7123287671233, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788887, Length=246, Percent_Identity=29.6747967479675, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790208, Length=256, Percent_Identity=28.90625, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790399, Length=265, Percent_Identity=26.7924528301887, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=29.9595141700405, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790262, Length=259, Percent_Identity=27.4131274131274, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788297, Length=248, Percent_Identity=27.0161290322581, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=242, Percent_Identity=25.6198347107438, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787601, Length=159, Percent_Identity=28.3018867924528, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081904, Length=162, Percent_Identity=30.2469135802469, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI48994962, Length=73, Percent_Identity=45.2054794520548, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31571; Mature: 31571

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSDLQTFAAVARTGGITRAAEVLNTVQSNVTQRIKALEAEIGTPLFDRHSRGMTLTGA
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECC
GQRLLPYADRMAALSREAVLAARDDGEPRGPLMIGSMETTAAVRLPMRLADFHRRFPAVA
CCCHHHHHHHHHHHHHHHEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCHHHE
LSLRTAPTSDLVAGVLDGTLDGAFVAGPIDHPELSGIVAFEEELVLVTARRFESLSSLRA
EEECCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
ATAASGPTALVFRTGCTYRQRLEQVFNDFGWPAASRIELGTLDGMIGCVAAGMGVALLPR
HHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHH
AVATRHEMSGSIGLHALDPTHAQVKTLFIHRRAARRSSALSAFIAGLSRRDRDIAA
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MELSDLQTFAAVARTGGITRAAEVLNTVQSNVTQRIKALEAEIGTPLFDRHSRGMTLTGA
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECC
GQRLLPYADRMAALSREAVLAARDDGEPRGPLMIGSMETTAAVRLPMRLADFHRRFPAVA
CCCHHHHHHHHHHHHHHHEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCHHHE
LSLRTAPTSDLVAGVLDGTLDGAFVAGPIDHPELSGIVAFEEELVLVTARRFESLSSLRA
EEECCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
ATAASGPTALVFRTGCTYRQRLEQVFNDFGWPAASRIELGTLDGMIGCVAAGMGVALLPR
HHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHH
AVATRHEMSGSIGLHALDPTHAQVKTLFIHRRAARRSSALSAFIAGLSRRDRDIAA
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]