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The map label for this gene is pccB [H]

Identifier: 146341255

GI number: 146341255

Start: 4522810

End: 4524342

Strand: Reverse

Name: pccB [H]

Synonym: BRADO4331

Alternate gene names: 146341255

Gene position: 4524342-4522810 (Counterclockwise)

Preceding gene: 146341258

Following gene: 146341254

Centisome position: 60.68

GC content: 64.71

Gene sequence:

>1533_bases
ATGAAGGACATCCTGGACACCCTCGAGGAGCGGCGCAAAGGCGCCAAGCTCGGCGGCGGCGAGAAGCGCATCGAGGCGCA
GCATGCGCGTGGCAAGCTGACGGCGCGCGAGCGCATCGAGCTCCTGCTCGACAAGGGCTCGTTCGAGGAGTTCGACATGT
TCGTCGAGCACCGCTCGACCGAGTTCGGGATGGAGAAGACCAAGGTTCCCGGCGACGGCGTCGTCACCGGCTGGGGCACC
GTCAACGGCCGCAAGACATTCGTCTTCGCCAAGGATTTCACCGTGTTCGGCGGCTCGCTGTCCGAGACCCACGCGCTCAA
GATCACGAAGCTGCAGGACATGGCGATGAAGGCGCGCGCGCCGATCATCGGCCTGTATGATGCCGGCGGCGCCCGCATCC
AGGAGGGCGTCGCGGCGCTCGCGGGCTATTCCTACGTGTTCCGCCGCAACGTGCTGGCCTCCGGCGTGATCCCGCAGATC
TCGGTCATCATGGGGCCGTGCGCCGGCGGCGACGTGTATTCGCCTGCCATGACCGACTTCATCTTCATGGTGAAGAACAC
CAGCTATATGTTCGTCACCGGCCCCGACGTCGTGAAGACCGTGACCAACGAGGTCGTGACGGCGGAAGAGCTCGGCGGCG
CCTCGGTGCATGCGACGCGCTCCTCGATCGCCGACGGCGCTTTCGACAACGATGTCGAGACGCTGTTGCAGATGCGCCGC
CTGATCGACTTCCTGCCGTCGAACAATTCGGACGGCGTGCCGGAATGGCCGAGCTTCGACGACATCGAACGGGTCGACAT
GTCGCTCGACACGCTGATCCCCGATAATCCCAACAAGCCCTACGACATGAAGGAGCTGATCCTGAAGGTCGTGGACGAGG
GCGACTTCTTCGAGATCGCGGAAGGGTTCGCCAAGAACATCGTCACCGGCTTCGGTCGCATCGCCGGGCGCACCGTCGGC
TTCGTCGCCAACCAGCCGATGGTGCTGGCCGGCGTGCTCGACTCGGATGCCTCGCGCAAGGCGGCACGCTTCGTCCGCTT
CTGCGACGCCTTCAACATTCCGATCGTCACCTTCGTCGACGTGCCGGGATTCCTGCCGGGCACCGCCCAGGAATATGGCG
GACTGATCAAGCATGGCGCCAAGCTCCTGTTCGCCTATTCGCAGTGCACCGTGCCGCTGGTCACCGTGATCACCCGCAAG
GCCTATGGCGGCGCCTTCGACGTCATGGCCTCCAAGGAGATCGGCGCCGACATGAACTACGCCTGGCCCACGGCGCAGAT
CGCGGTCATGGGCGCCAAGGGCGCGGTCGAGATCATCTTCCGCGCGGACATGGCCGACCCGGAGAAGATCGCCGCGCGCA
CCAAGGAATATGAGGATCGTTTCCTGTCGCCGTTCATCGCCGCCGAGCGCGGCTATATCGACGACGTGATCATGCCGCAC
TCCACCCGCCGCCGCATCGCGCGCGCGCTCGCGATGCTGCGTGACAAGAAGATGGAGATGCCGGCGAAGAAGCACGACAA
TTTGCCGCTGTAG

Upstream 100 bases:

>100_bases
GTGGGGGGCGGGCAGGCAGGGCCGAAAGCGGCTTTTCGGTTCCGAAACAGCCGTGTTAGAAGGCCGCCAACACTCACGAC
ATGGGAACGGGCGGACGCGC

Downstream 100 bases:

>100_bases
GTGTTCATTCAACCCGTCTTTCTCGCCAAGCGGCGAGAATTCGTTGCGAGCGGTGGGCGCAGCCCTGGATTGCTTCGCTG
CGCCGCTGCGCTCGCAATGA

Product: putative propionyl-CoA carboxylase beta chain

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKDILDTLEERRKGAKLGGGEKRIEAQHARGKLTARERIELLLDKGSFEEFDMFVEHRSTEFGMEKTKVPGDGVVTGWGT
VNGRKTFVFAKDFTVFGGSLSETHALKITKLQDMAMKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKNTSYMFVTGPDVVKTVTNEVVTAEELGGASVHATRSSIADGAFDNDVETLLQMRR
LIDFLPSNNSDGVPEWPSFDDIERVDMSLDTLIPDNPNKPYDMKELILKVVDEGDFFEIAEGFAKNIVTGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRK
AYGGAFDVMASKEIGADMNYAWPTAQIAVMGAKGAVEIIFRADMADPEKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
STRRRIARALAMLRDKKMEMPAKKHDNLPL

Sequences:

>Translated_510_residues
MKDILDTLEERRKGAKLGGGEKRIEAQHARGKLTARERIELLLDKGSFEEFDMFVEHRSTEFGMEKTKVPGDGVVTGWGT
VNGRKTFVFAKDFTVFGGSLSETHALKITKLQDMAMKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKNTSYMFVTGPDVVKTVTNEVVTAEELGGASVHATRSSIADGAFDNDVETLLQMRR
LIDFLPSNNSDGVPEWPSFDDIERVDMSLDTLIPDNPNKPYDMKELILKVVDEGDFFEIAEGFAKNIVTGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRK
AYGGAFDVMASKEIGADMNYAWPTAQIAVMGAKGAVEIIFRADMADPEKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
STRRRIARALAMLRDKKMEMPAKKHDNLPL
>Mature_510_residues
MKDILDTLEERRKGAKLGGGEKRIEAQHARGKLTARERIELLLDKGSFEEFDMFVEHRSTEFGMEKTKVPGDGVVTGWGT
VNGRKTFVFAKDFTVFGGSLSETHALKITKLQDMAMKARAPIIGLYDAGGARIQEGVAALAGYSYVFRRNVLASGVIPQI
SVIMGPCAGGDVYSPAMTDFIFMVKNTSYMFVTGPDVVKTVTNEVVTAEELGGASVHATRSSIADGAFDNDVETLLQMRR
LIDFLPSNNSDGVPEWPSFDDIERVDMSLDTLIPDNPNKPYDMKELILKVVDEGDFFEIAEGFAKNIVTGFGRIAGRTVG
FVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVDVPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRK
AYGGAFDVMASKEIGADMNYAWPTAQIAVMGAKGAVEIIFRADMADPEKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
STRRRIARALAMLRDKKMEMPAKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=507, Percent_Identity=61.7357001972387, Blast_Score=644, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=527, Percent_Identity=59.5825426944972, Blast_Score=632, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=32.5349301397206, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=353, Percent_Identity=25.7790368271955, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI38679974, Length=353, Percent_Identity=25.7790368271955, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI38679977, Length=353, Percent_Identity=25.7790368271955, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI38679967, Length=353, Percent_Identity=25.7790368271955, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI38679960, Length=353, Percent_Identity=25.7790368271955, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI310133460, Length=126, Percent_Identity=39.6825396825397, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=503, Percent_Identity=60.6361829025845, Blast_Score=647, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=503, Percent_Identity=60.6361829025845, Blast_Score=647, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=508, Percent_Identity=32.4803149606299, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI71997163, Length=328, Percent_Identity=25, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24586065, Length=506, Percent_Identity=33.00395256917, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55907; Mature: 55907

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDILDTLEERRKGAKLGGGEKRIEAQHARGKLTARERIELLLDKGSFEEFDMFVEHRST
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
EFGMEKTKVPGDGVVTGWGTVNGRKTFVFAKDFTVFGGSLSETHALKITKLQDMAMKARA
CCCCHHCCCCCCCEEEECCCCCCCEEEEEEECCEEECCCCCCCCEEEEEHHHHHHHHHCC
PIIGLYDAGGARIQEGVAALAGYSYVFRRNVLASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVKNTSYMFVTGPDVVKTVTNEVVTAEELGGASVHATRSSIADGAFDNDVETLLQMRR
EEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCCCHHHHHHHHHHH
LIDFLPSNNSDGVPEWPSFDDIERVDMSLDTLIPDNPNKPYDMKELILKVVDEGDFFEIA
HHHHCCCCCCCCCCCCCCCCCHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
EGFAKNIVTGFGRIAGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVD
HHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRKAYGGAFDVMASKEIGADMNY
CCCCCCCCHHHHCHHHHHCHHHEEEHHHCCHHHHHHHHHHHCCCEEEEHCCHHCCCCCCC
AWPTAQIAVMGAKGAVEIIFRADMADPEKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
STRRRIARALAMLRDKKMEMPAKKHDNLPL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKDILDTLEERRKGAKLGGGEKRIEAQHARGKLTARERIELLLDKGSFEEFDMFVEHRST
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
EFGMEKTKVPGDGVVTGWGTVNGRKTFVFAKDFTVFGGSLSETHALKITKLQDMAMKARA
CCCCHHCCCCCCCEEEECCCCCCCEEEEEEECCEEECCCCCCCCEEEEEHHHHHHHHHCC
PIIGLYDAGGARIQEGVAALAGYSYVFRRNVLASGVIPQISVIMGPCAGGDVYSPAMTDF
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHEECCCCCCCCCCHHHHHE
IFMVKNTSYMFVTGPDVVKTVTNEVVTAEELGGASVHATRSSIADGAFDNDVETLLQMRR
EEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCCCHHHHHHHHHHH
LIDFLPSNNSDGVPEWPSFDDIERVDMSLDTLIPDNPNKPYDMKELILKVVDEGDFFEIA
HHHHCCCCCCCCCCCCCCCCCHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHH
EGFAKNIVTGFGRIAGRTVGFVANQPMVLAGVLDSDASRKAARFVRFCDAFNIPIVTFVD
HHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
VPGFLPGTAQEYGGLIKHGAKLLFAYSQCTVPLVTVITRKAYGGAFDVMASKEIGADMNY
CCCCCCCCHHHHCHHHHHCHHHEEEHHHCCHHHHHHHHHHHCCCEEEEHCCHHCCCCCCC
AWPTAQIAVMGAKGAVEIIFRADMADPEKIAARTKEYEDRFLSPFIAAERGYIDDVIMPH
CCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
STRRRIARALAMLRDKKMEMPAKKHDNLPL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]