BacMap

Definition	Bradyrhizobium sp. ORS278 chromosome, complete genome.
Accession	NC_009445
Length	7,456,587

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The map label for this gene is fabG [C]

Identifier: 146341235

GI number: 146341235

Start: 4505747

End: 4506625

Strand: Reverse

Name: fabG [C]

Synonym: BRADO4311

Alternate gene names: 146341235

Gene position: 4506625-4505747 (Counterclockwise)

Preceding gene: 146341236

Following gene: 146341234

Centisome position: 60.44

GC content: 66.21

Gene sequence:

>879_bases
ATGGGACTACTTGATAGCAAGGTGGCGCTGATCACCGGCGCAGGTGGTGGCCTCGGCGAGGCCTACGCAAAACTGTTCGC
GCGCGAGGGCGCGGCGGTGGTGGTCAATGATCTCGGCGGCCCGCGTGATGGCTCCGGCTCCGATCTGTCGATGGCCGAGC
AGGTGGTCGCCGCCATCAAGGCCAAGGGCGGCCGGGCGGTTGCCAATGGCGCCGACATCTCGACCATGGCCGGCGGTCAG
TCGGTGTTCGACGATGCCATCCGGCATTTCGGCCGCGCCGACATCCTGGTTAACAATGCCGGCATCCTGCGCGACCAGAC
CTTCGCCAAGTCGAGCGAGGCCGACTGGGACAAGATCATCCAGGTGCACCTCAAGGGCACCTTCTGCTGCACGCTGCCGG
TGTTCCGCTGGATGCGCGACAATGGCGGCGGCGTCATCGTCAACACCTCGTCGACATCGGGCCTGATCGGCAATTTCGGC
CAATCGAACTACGGCGCGGCGAAGGGCGGTATCTGGGGCCTGTCCAACGTGCTGGCGATCGAGGGCCGCAAGTACAACAT
CCGCGTCTGGACCCTGGCGCCGGGCGCGCTGACCAGGATGACCGCCGACCTGCCGCGCTACAAGGAGAACCCGGGCGCGG
CGCTGACGCCGGAGGGCATCGCGCCGGCCGTGCTCTACATGGTCAGCCACCTCTCCGGCGACCAGACCGGCAAGGTGCTC
GGCGTCTCCGGGCCGCGCGGCGTGCGCGAGTTGCGCATGATGGAAATGGACGGCTGGAAGCCGCCGTCCTCGTCCTGGAA
AGCGGAGGACATCGCTGAACATGCAGGGGAGATATTCTTTTCGGAGGACGAGATTCGAAAGTCCGCGCGGCGGTTTTGA

Upstream 100 bases:

>100_bases
CCCGGATTGCATCTTCGATGCAATCCGACCTCTCCCCGCACGCGGGGAGAGGTGAACAAACGGCAGCGGGGCTGCAACCG
TAAAGCGCAGGAGGACACCC

Downstream 100 bases:

>100_bases
TGTATGTCTGGCGCCGATCCGGACCGCCCGCCCAAACTCGGAGAGCGAGGCGAAAGACAGGTTCCGGAATCCAGAACGAT
GATCGGCCGTACGCGAGTCC

Product: putative short-chain dehydrogenase/reductase (SDR)

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MGLLDSKVALITGAGGGLGEAYAKLFAREGAAVVVNDLGGPRDGSGSDLSMAEQVVAAIKAKGGRAVANGADISTMAGGQ
SVFDDAIRHFGRADILVNNAGILRDQTFAKSSEADWDKIIQVHLKGTFCCTLPVFRWMRDNGGGVIVNTSSTSGLIGNFG
QSNYGAAKGGIWGLSNVLAIEGRKYNIRVWTLAPGALTRMTADLPRYKENPGAALTPEGIAPAVLYMVSHLSGDQTGKVL
GVSGPRGVRELRMMEMDGWKPPSSSWKAEDIAEHAGEIFFSEDEIRKSARRF

Sequences:

>Translated_292_residues
MGLLDSKVALITGAGGGLGEAYAKLFAREGAAVVVNDLGGPRDGSGSDLSMAEQVVAAIKAKGGRAVANGADISTMAGGQ
SVFDDAIRHFGRADILVNNAGILRDQTFAKSSEADWDKIIQVHLKGTFCCTLPVFRWMRDNGGGVIVNTSSTSGLIGNFG
QSNYGAAKGGIWGLSNVLAIEGRKYNIRVWTLAPGALTRMTADLPRYKENPGAALTPEGIAPAVLYMVSHLSGDQTGKVL
GVSGPRGVRELRMMEMDGWKPPSSSWKAEDIAEHAGEIFFSEDEIRKSARRF
>Mature_291_residues
GLLDSKVALITGAGGGLGEAYAKLFAREGAAVVVNDLGGPRDGSGSDLSMAEQVVAAIKAKGGRAVANGADISTMAGGQS
VFDDAIRHFGRADILVNNAGILRDQTFAKSSEADWDKIIQVHLKGTFCCTLPVFRWMRDNGGGVIVNTSSTSGLIGNFGQ
SNYGAAKGGIWGLSNVLAIEGRKYNIRVWTLAPGALTRMTADLPRYKENPGAALTPEGIAPAVLYMVSHLSGDQTGKVLG
VSGPRGVRELRMMEMDGWKPPSSSWKAEDIAEHAGEIFFSEDEIRKSARRF

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=239, Percent_Identity=48.9539748953975, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=34.1085271317829, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=35.1020408163265, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI10190704, Length=270, Percent_Identity=32.962962962963, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4758504, Length=223, Percent_Identity=34.0807174887892, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI31542939, Length=216, Percent_Identity=30.0925925925926, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=29.8039215686275, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI109715829, Length=256, Percent_Identity=28.515625, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI19923817, Length=273, Percent_Identity=24.9084249084249, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI126723191, Length=195, Percent_Identity=31.2820512820513, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI83715985, Length=180, Percent_Identity=34.4444444444444, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI40807363, Length=178, Percent_Identity=32.0224719101124, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031737, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI59889578, Length=173, Percent_Identity=29.4797687861272, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI209862901, Length=200, Percent_Identity=30, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI19923983, Length=200, Percent_Identity=30, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=33.7349397590361, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082100, Length=220, Percent_Identity=34.5454545454545, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=27.3809523809524, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787905, Length=258, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=28.2868525896414, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=32.2709163346614, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=29.0836653386454, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789057, Length=213, Percent_Identity=31.924882629108, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=29.6875, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787526, Length=241, Percent_Identity=28.2157676348548, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787820, Length=235, Percent_Identity=26.8085106382979, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789378, Length=259, Percent_Identity=26.2548262548263, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=237, Percent_Identity=50.6329113924051, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=33.7301587301587, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=34.6303501945525, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=31.3953488372093, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997099, Length=228, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=223, Percent_Identity=32.7354260089686, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555612, Length=283, Percent_Identity=29.6819787985866, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=199, Percent_Identity=29.6482412060301, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=275, Percent_Identity=26.9090909090909, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=29.9492385786802, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=269, Percent_Identity=26.0223048327138, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=202, Percent_Identity=28.2178217821782, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=229, Percent_Identity=27.0742358078603, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=251, Percent_Identity=26.6932270916335, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=198, Percent_Identity=29.7979797979798, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=207, Percent_Identity=28.5024154589372, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=196, Percent_Identity=29.0816326530612, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=250, Percent_Identity=25.2, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=205, Percent_Identity=27.8048780487805, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=190, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=210, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=190, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=222, Percent_Identity=48.6486486486487, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI18859837, Length=237, Percent_Identity=48.5232067510549, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=34.5098039215686, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17737361, Length=216, Percent_Identity=29.6296296296296, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=28, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI23397609, Length=192, Percent_Identity=29.1666666666667, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221331218, Length=259, Percent_Identity=28.957528957529, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24665243, Length=259, Percent_Identity=28.957528957529, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=28.6274509803922, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357041, Length=195, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221331216, Length=260, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24665247, Length=260, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30860; Mature: 30729

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLDSKVALITGAGGGLGEAYAKLFAREGAAVVVNDLGGPRDGSGSDLSMAEQVVAAIK
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AKGGRAVANGADISTMAGGQSVFDDAIRHFGRADILVNNAGILRDQTFAKSSEADWDKII
CCCCEEEECCCCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCCCCCCHHHEE
QVHLKGTFCCTLPVFRWMRDNGGGVIVNTSSTSGLIGNFGQSNYGAAKGGIWGLSNVLAI
EEEECCEEEEHHHHHHHHHCCCCEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCEEEE
EGRKYNIRVWTLAPGALTRMTADLPRYKENPGAALTPEGIAPAVLYMVSHLSGDQTGKVL
CCCEEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
GVSGPRGVRELRMMEMDGWKPPSSSWKAEDIAEHAGEIFFSEDEIRKSARRF
ECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHEEECHHHHHHHHHCC
>Mature Secondary Structure 
GLLDSKVALITGAGGGLGEAYAKLFAREGAAVVVNDLGGPRDGSGSDLSMAEQVVAAIK
CCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AKGGRAVANGADISTMAGGQSVFDDAIRHFGRADILVNNAGILRDQTFAKSSEADWDKII
CCCCEEEECCCCCEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCCCCCCHHHEE
QVHLKGTFCCTLPVFRWMRDNGGGVIVNTSSTSGLIGNFGQSNYGAAKGGIWGLSNVLAI
EEEECCEEEEHHHHHHHHHCCCCEEEEECCCCCCCEECCCCCCCCCCCCCCCCCCCEEEE
EGRKYNIRVWTLAPGALTRMTADLPRYKENPGAALTPEGIAPAVLYMVSHLSGDQTGKVL
CCCEEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
GVSGPRGVRELRMMEMDGWKPPSSSWKAEDIAEHAGEIFFSEDEIRKSARRF
ECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHEEECHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]