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The map label for this gene is nuoF [H]

Identifier: 146341108

GI number: 146341108

Start: 4381941

End: 4383266

Strand: Reverse

Name: nuoF [H]

Synonym: BRADO4179

Alternate gene names: 146341108

Gene position: 4383266-4381941 (Counterclockwise)

Preceding gene: 146341109

Following gene: 146341107

Centisome position: 58.78

GC content: 65.91

Gene sequence:

>1326_bases
ATGCTCGACGACAAGGACCGCATCTTCACCAATCTCTACGGCCTGCAGGATTGGGGCCTCGAGGGCGCGCGCCGGCGCGG
CAGCTGGGATGGCACCAAGGGGCTGATCGACAAGGGCCGCGACTGGATCATCAACGAGATGAAGGCGTCGGGCCTGCGCG
GCCGCGGCGGCGCCGGCTTCCCGACCGGCCTGAAATGGTCGTTCATGCCGAAAGAGTCGACCGACGGCCGTCCGAGCTAT
CTCGTGGTCAACGCCGACGAATCCGAGCCCGGCACCTGCAAGGATCGCGAGATCATGCGGCATGATCCGCATCATCTCGT
CGAGGGCTGCCTGCTCGCCAGCTTCGCGATGAACGCGCACACCTGCTACATCTATGTGCGCGGCGAGTTCATCCGCGAGC
GCGAGCGGCTGCAAGCGGCGATCGACCAGGCGTATGAAGCGAAGCTGGTCGGCAAGGACAACGTCCACGGCTGGCCGTTC
GACATCTATGTCGCGCATGGTGCCGGCGCCTATATCTGCGGCGAAGAGACCGCGCTGCTCGAGAGCCTCGAGGGCAAGAA
GGGCCAGCCGCGGCTGAAGCCGCCATTCCCGGCGAATGTTGGCCTCTATGGCTGCCCGACGACCGTCAACAATGTCGAGT
CGATCGCGGTGGCGCCGACCATCCTGCGCCGCGGCGCGTCCTGGTTCGCCGGCATCGGCCGTCCGAACAATGTCGGCACC
AAGCTGTTCTGCATCTCCGGTCACGTCGAGCGGCCCTGCAACGTCGAAGAGGCGATGGGCATCCCGTTCCGCGAGCTCAT
CGAGAAGCATTGCGGCGGCATTCGCGGCGGCTGGGACAATCTGAAGGCGGTGATCCCCGGCGGCTCGTCGGTGCGCATGG
TGCCGGCCGAGCAGATCATCGACACGCCGATGGATTTCGACAGCCTGTCGAAGCTGCGCTCGGGCCTGGGCACGGCGGCC
GTGATCGTGATGGACAAGTCGACCGACCTGATCCGGGCGATTGCGCGCATCTCGTATTTCTACAAGCATGAGAGCTGCGG
CCAGTGCACGCCGTGCCGCGAGGGCACCGGCTGGATGTGGCGCGTGCTGACCCGCATGGCCGAGGGCCGCGCCCACAAGC
GCGAGATCGACATGCTGCTGGAGGTCACCAAGCAGATCGAGGGACACACGATCTGTGCGCTGGGCGACGCCGCGGCCTGG
CCGATCCAGGGCCTGATTACGCATTTCCGTCACGAGATCGAAGCGCGCATCGACCAATATTCGCACAAGGCCGATGTCGA
CGACGTCGGCGTGCGCGATCCCGCGCACATGGTGGCGGCGGAGTAG

Upstream 100 bases:

>100_bases
ACGCTGGAGTCCAGTCTGCTGTGGGCGCTGGTGTTCGGCGGCTGCGCCGCCTTCGTCGCCAACATGCAGTCGAACCGCTG
ATGTCAGAGGAAGCCGTCTG

Downstream 100 bases:

>100_bases
GTGGTGGCGGTCCTGTCCGCCAGCGAGGTTTTCCTCCGCGCTTGCGCCCTCACGGCGCGCAGCGCGGTGGTCCGTGGTTT
GAGAGAGATGTGAGGCAATG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MLDDKDRIFTNLYGLQDWGLEGARRRGSWDGTKGLIDKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKESTDGRPSY
LVVNADESEPGTCKDREIMRHDPHHLVEGCLLASFAMNAHTCYIYVRGEFIRERERLQAAIDQAYEAKLVGKDNVHGWPF
DIYVAHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGASWFAGIGRPNNVGT
KLFCISGHVERPCNVEEAMGIPFRELIEKHCGGIRGGWDNLKAVIPGGSSVRMVPAEQIIDTPMDFDSLSKLRSGLGTAA
VIVMDKSTDLIRAIARISYFYKHESCGQCTPCREGTGWMWRVLTRMAEGRAHKREIDMLLEVTKQIEGHTICALGDAAAW
PIQGLITHFRHEIEARIDQYSHKADVDDVGVRDPAHMVAAE

Sequences:

>Translated_441_residues
MLDDKDRIFTNLYGLQDWGLEGARRRGSWDGTKGLIDKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKESTDGRPSY
LVVNADESEPGTCKDREIMRHDPHHLVEGCLLASFAMNAHTCYIYVRGEFIRERERLQAAIDQAYEAKLVGKDNVHGWPF
DIYVAHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGASWFAGIGRPNNVGT
KLFCISGHVERPCNVEEAMGIPFRELIEKHCGGIRGGWDNLKAVIPGGSSVRMVPAEQIIDTPMDFDSLSKLRSGLGTAA
VIVMDKSTDLIRAIARISYFYKHESCGQCTPCREGTGWMWRVLTRMAEGRAHKREIDMLLEVTKQIEGHTICALGDAAAW
PIQGLITHFRHEIEARIDQYSHKADVDDVGVRDPAHMVAAE
>Mature_441_residues
MLDDKDRIFTNLYGLQDWGLEGARRRGSWDGTKGLIDKGRDWIINEMKASGLRGRGGAGFPTGLKWSFMPKESTDGRPSY
LVVNADESEPGTCKDREIMRHDPHHLVEGCLLASFAMNAHTCYIYVRGEFIRERERLQAAIDQAYEAKLVGKDNVHGWPF
DIYVAHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGASWFAGIGRPNNVGT
KLFCISGHVERPCNVEEAMGIPFRELIEKHCGGIRGGWDNLKAVIPGGSSVRMVPAEQIIDTPMDFDSLSKLRSGLGTAA
VIVMDKSTDLIRAIARISYFYKHESCGQCTPCREGTGWMWRVLTRMAEGRAHKREIDMLLEVTKQIEGHTICALGDAAAW
PIQGLITHFRHEIEARIDQYSHKADVDDVGVRDPAHMVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=420, Percent_Identity=66.1904761904762, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI260656005, Length=420, Percent_Identity=66.1904761904762, Blast_Score=584, Evalue=1e-167,
Organism=Escherichia coli, GI1788620, Length=420, Percent_Identity=43.5714285714286, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17531727, Length=433, Percent_Identity=63.9722863741339, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI19920794, Length=425, Percent_Identity=66.5882352941177, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI45550452, Length=419, Percent_Identity=64.200477326969, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24653819, Length=422, Percent_Identity=45.4976303317536, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24653817, Length=422, Percent_Identity=42.1800947867299, Blast_Score=348, Evalue=6e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48804; Mature: 48804

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDKDRIFTNLYGLQDWGLEGARRRGSWDGTKGLIDKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCHHCCCCHHHCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESTDGRPSYLVVNADESEPGTCKDREIMRHDPHHLVEGCLLASFAMNAH
CCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCE
TCYIYVRGEFIRERERLQAAIDQAYEAKLVGKDNVHGWPFDIYVAHGAGAYICGEETALL
EEEEEEECHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGASWFAGIGRPNNVGT
HHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC
KLFCISGHVERPCNVEEAMGIPFRELIEKHCGGIRGGWDNLKAVIPGGSSVRMVPAEQII
EEEEEECCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECHHHHH
DTPMDFDSLSKLRSGLGTAAVIVMDKSTDLIRAIARISYFYKHESCGQCTPCREGTGWMW
CCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
RVLTRMAEGRAHKREIDMLLEVTKQIEGHTICALGDAAAWPIQGLITHFRHEIEARIDQY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
SHKADVDDVGVRDPAHMVAAE
HCCCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MLDDKDRIFTNLYGLQDWGLEGARRRGSWDGTKGLIDKGRDWIINEMKASGLRGRGGAGF
CCCCHHHHHHHHHCCHHCCCCHHHCCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESTDGRPSYLVVNADESEPGTCKDREIMRHDPHHLVEGCLLASFAMNAH
CCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCE
TCYIYVRGEFIRERERLQAAIDQAYEAKLVGKDNVHGWPFDIYVAHGAGAYICGEETALL
EEEEEEECHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGASWFAGIGRPNNVGT
HHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC
KLFCISGHVERPCNVEEAMGIPFRELIEKHCGGIRGGWDNLKAVIPGGSSVRMVPAEQII
EEEEEECCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEECHHHHH
DTPMDFDSLSKLRSGLGTAAVIVMDKSTDLIRAIARISYFYKHESCGQCTPCREGTGWMW
CCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
RVLTRMAEGRAHKREIDMLLEVTKQIEGHTICALGDAAAWPIQGLITHFRHEIEARIDQY
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
SHKADVDDVGVRDPAHMVAAE
HCCCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]