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The map label for this gene is nuoL [H]

Identifier: 146341102

GI number: 146341102

Start: 4375085

End: 4377178

Strand: Reverse

Name: nuoL [H]

Synonym: BRADO4173

Alternate gene names: 146341102

Gene position: 4377178-4375085 (Counterclockwise)

Preceding gene: 146341103

Following gene: 146341101

Centisome position: 58.7

GC content: 63.56

Gene sequence:

>2094_bases
ATGATCCAGGCCATTGTGTTTCTGCCGCTGCTGGGCGCGATCCTGGCCGGCCTGATCGCGCTGCTTGGCGCCCATGGGCG
CCATCCGAGTGGCGACGAGGTCGAGCATCACGACGACGGGCATGGTCACGGCGCCGCCGACGCGCATGCCCATGCGCATG
ACGACCACGGCCACGATGATCATGGCCACGGCCACGACGATCACCATGTCGCCGAGCCGCCGGCCTCCGGTACCTGGGCC
GCGCAGGCGATCACGACCGCGCTGCTGTTCGTCTCGGCCGCGCTGTCCTGGGCGACCTTGGTCAGCGTCGGCTTCATGCA
CCACGAAGCCGGCGTGAAGGAGCTGCTGCCCTGGATCAATTCCGGCGAGCTGCAGGTCGCCTGGTCGCTGCGTGTCGATA
CGCTGACGGCCGTGATGCTGGTCGTGGTGACGAGCGTCTCCTCGCTCGTGCATCTCTATTCGATCGGCTACATGGACGAG
GATCCGAACCGTCCGCGCTTCTTTGCCTATCTCTCGCTGTTCACCTTCGCGATGCTGATGCTGGTGACCGCGAACAACCT
CGTGCAGCTGTTCTTCGGCTGGGAGGGCGTGGGTCTCGCCAGCTACCTGCTGATCGGCTTCTGGTTCCAGAAGCCCTCGG
CCAATGCCGCCGCGATCAAGGCCTTCGTCGTCAACCGCGTCGGCGATTTCGGCTTCGCGCTCGGCATCTTCGCGATCTTC
CTGCTGACGAAGTCGACCGACTTCGAGACCATCTTCGCCGCCGCGCCGAGCATCGCCGGCAAGACGACGATCAACTTCCT
CGGCTGGCACGCCGACGCGCTGACCTTGACCTGTTTGCTGCTGTTCATGGGCGCCATGGGCAAGTCGGCGCAGTTCCTGC
TGCACACCTGGCTGCCGGACGCGATGGAAGGTCCGACCCCGGTCTCGGCGCTGATCCATGCGGCGACCATGGTCACCGCC
GGCGTCTTCATGGTGGCGCGCCTGTCGCCGCTGTTCGAGCTCGCGCCGAACGCGCAGGCCGTCGTGATGTTCTTCGGCGC
CACCACGGCGTTCTTCGCGGCGACCATCGGCCTTGTGCAGAACGACATCAAGCGCATCGTCGCCTATTCGACCTGTTCGC
AGCTCGGCTACATGTTCGTGGCAATGGGAGCAGGGGCCTACTCGGTCGGCATGTTCCACCTGTTCACGCACGCCTTCTTC
AAGGCGTTGCTGTTCTTGGGTGCGGGCTCGGTGATCTACGCGATGCACCACGAGCAGGACATCCGCAACATGGGCGGCCT
GTGGCGCAAGATCCCGTACACCTTCGCGATGATGACGGTCGGCACTCTGGCGCTGACCGGGTTCCCGGGGTTCGCCGGCT
TCTTTTCCAAGGACGCGATCATCGAGACCGCCTATGCCGCGCACAATCCTTTCGCGACCTATGCCTACTTCCTGACGATC
GTCGCCGCCGGCCTGACCTCGTTCTACTCCTGGCGCCTGGTGTTCAAGACCTTCTTCGGCACGCCGCACGACCAGCATCA
TTACGACGCGGCTCATGAAAGCCCGATCTGGATGCTGATCCCGCTCGGCGTGCTCGGGGCGGGCTCGGTCCTGGCGGGCG
TCCTGTTCAAGGGCTTCTTCGTACATCCGCACGGCGTCGAGGAATTCTTCGGCGAGTCGCTGAAGATGAACCCGCACATC
CTCGAAGACATGGAGCACATGCCGTTCTGGCTGGGCCAGTTGCCGCTCGCCATGATGGTCATCGGATTCTTCGTGTCCTT
GTTGTTCTACGTCAAGCGTCCGGACATTCCGGAGGAGCTCGCCGCGCAGCAGCCGCTGCTCTACAACTTCCTGCTCAACA
AGTGGTACTTCGACGAGCTGTATGATTTCATCTTCGTCCGTCCGGCGAAGTGGCTCGGCCGCTTCCTCTGGAAGAAGGGC
GACGGGTTCGTCATCGACGGCTTCGGTCCGGACGGCGTCTCGGCGCGGGTGCTCGACGTCACGCGCAACGTCGTCAAGAT
CCAGACCGGTTATCTCTATCACTATGCCTTTGCCATGCTGATCGGCGTCGCCGGCCTGATCACCTGGTTCATGTTCATGG
GGGGCCAGCAATGA

Upstream 100 bases:

>100_bases
TCGCGGTCGAAGACGTCAATCTGATGAAGGGCTAAGGGCGCATGATCCGCAAGAGTGGGGGCCGGTTCGCCGGCAAGGTC
ATGCGTAAGGGAACGGGCGA

Downstream 100 bases:

>100_bases
CCACCTGGCCAATTCTCTCTGTCGTCACCTTCCTGCCGCTCGTCGGCGCGCTGCTGATCTATCTGGTCCGTGGCGACGAC
GAGGCCGCCCAGCGCAATGC

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 12; NDH-1, chain 12 [H]

Number of amino acids: Translated: 697; Mature: 697

Protein sequence:

>697_residues
MIQAIVFLPLLGAILAGLIALLGAHGRHPSGDEVEHHDDGHGHGAADAHAHAHDDHGHDDHGHGHDDHHVAEPPASGTWA
AQAITTALLFVSAALSWATLVSVGFMHHEAGVKELLPWINSGELQVAWSLRVDTLTAVMLVVVTSVSSLVHLYSIGYMDE
DPNRPRFFAYLSLFTFAMLMLVTANNLVQLFFGWEGVGLASYLLIGFWFQKPSANAAAIKAFVVNRVGDFGFALGIFAIF
LLTKSTDFETIFAAAPSIAGKTTINFLGWHADALTLTCLLLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTA
GVFMVARLSPLFELAPNAQAVVMFFGATTAFFAATIGLVQNDIKRIVAYSTCSQLGYMFVAMGAGAYSVGMFHLFTHAFF
KALLFLGAGSVIYAMHHEQDIRNMGGLWRKIPYTFAMMTVGTLALTGFPGFAGFFSKDAIIETAYAAHNPFATYAYFLTI
VAAGLTSFYSWRLVFKTFFGTPHDQHHYDAAHESPIWMLIPLGVLGAGSVLAGVLFKGFFVHPHGVEEFFGESLKMNPHI
LEDMEHMPFWLGQLPLAMMVIGFFVSLLFYVKRPDIPEELAAQQPLLYNFLLNKWYFDELYDFIFVRPAKWLGRFLWKKG
DGFVIDGFGPDGVSARVLDVTRNVVKIQTGYLYHYAFAMLIGVAGLITWFMFMGGQQ

Sequences:

>Translated_697_residues
MIQAIVFLPLLGAILAGLIALLGAHGRHPSGDEVEHHDDGHGHGAADAHAHAHDDHGHDDHGHGHDDHHVAEPPASGTWA
AQAITTALLFVSAALSWATLVSVGFMHHEAGVKELLPWINSGELQVAWSLRVDTLTAVMLVVVTSVSSLVHLYSIGYMDE
DPNRPRFFAYLSLFTFAMLMLVTANNLVQLFFGWEGVGLASYLLIGFWFQKPSANAAAIKAFVVNRVGDFGFALGIFAIF
LLTKSTDFETIFAAAPSIAGKTTINFLGWHADALTLTCLLLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTA
GVFMVARLSPLFELAPNAQAVVMFFGATTAFFAATIGLVQNDIKRIVAYSTCSQLGYMFVAMGAGAYSVGMFHLFTHAFF
KALLFLGAGSVIYAMHHEQDIRNMGGLWRKIPYTFAMMTVGTLALTGFPGFAGFFSKDAIIETAYAAHNPFATYAYFLTI
VAAGLTSFYSWRLVFKTFFGTPHDQHHYDAAHESPIWMLIPLGVLGAGSVLAGVLFKGFFVHPHGVEEFFGESLKMNPHI
LEDMEHMPFWLGQLPLAMMVIGFFVSLLFYVKRPDIPEELAAQQPLLYNFLLNKWYFDELYDFIFVRPAKWLGRFLWKKG
DGFVIDGFGPDGVSARVLDVTRNVVKIQTGYLYHYAFAMLIGVAGLITWFMFMGGQQ
>Mature_697_residues
MIQAIVFLPLLGAILAGLIALLGAHGRHPSGDEVEHHDDGHGHGAADAHAHAHDDHGHDDHGHGHDDHHVAEPPASGTWA
AQAITTALLFVSAALSWATLVSVGFMHHEAGVKELLPWINSGELQVAWSLRVDTLTAVMLVVVTSVSSLVHLYSIGYMDE
DPNRPRFFAYLSLFTFAMLMLVTANNLVQLFFGWEGVGLASYLLIGFWFQKPSANAAAIKAFVVNRVGDFGFALGIFAIF
LLTKSTDFETIFAAAPSIAGKTTINFLGWHADALTLTCLLLFMGAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTA
GVFMVARLSPLFELAPNAQAVVMFFGATTAFFAATIGLVQNDIKRIVAYSTCSQLGYMFVAMGAGAYSVGMFHLFTHAFF
KALLFLGAGSVIYAMHHEQDIRNMGGLWRKIPYTFAMMTVGTLALTGFPGFAGFFSKDAIIETAYAAHNPFATYAYFLTI
VAAGLTSFYSWRLVFKTFFGTPHDQHHYDAAHESPIWMLIPLGVLGAGSVLAGVLFKGFFVHPHGVEEFFGESLKMNPHI
LEDMEHMPFWLGQLPLAMMVIGFFVSLLFYVKRPDIPEELAAQQPLLYNFLLNKWYFDELYDFIFVRPAKWLGRFLWKKG
DGFVIDGFGPDGVSARVLDVTRNVVKIQTGYLYHYAFAMLIGVAGLITWFMFMGGQQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=423, Percent_Identity=42.789598108747, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1788614, Length=524, Percent_Identity=41.793893129771, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI1788829, Length=388, Percent_Identity=31.1855670103093, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1788831, Length=401, Percent_Identity=30.4239401496259, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788827, Length=437, Percent_Identity=27.4599542334096, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788613, Length=418, Percent_Identity=25.8373205741627, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI2367154, Length=214, Percent_Identity=29.9065420560748, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI145693160, Length=411, Percent_Identity=25.0608272506083, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 76539; Mature: 76539

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQAIVFLPLLGAILAGLIALLGAHGRHPSGDEVEHHDDGHGHGAADAHAHAHDDHGHDD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HGHGHDDHHVAEPPASGTWAAQAITTALLFVSAALSWATLVSVGFMHHEAGVKELLPWIN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
SGELQVAWSLRVDTLTAVMLVVVTSVSSLVHLYSIGYMDEDPNRPRFFAYLSLFTFAMLM
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
LVTANNLVQLFFGWEGVGLASYLLIGFWFQKPSANAAAIKAFVVNRVGDFGFALGIFAIF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLTKSTDFETIFAAAPSIAGKTTINFLGWHADALTLTCLLLFMGAMGKSAQFLLHTWLPD
HHHCCCCHHHHHHCCCCCCCCCEEHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
AMEGPTPVSALIHAATMVTAGVFMVARLSPLFELAPNAQAVVMFFGATTAFFAATIGLVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHH
NDIKRIVAYSTCSQLGYMFVAMGAGAYSVGMFHLFTHAFFKALLFLGAGSVIYAMHHEQD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
IRNMGGLWRKIPYTFAMMTVGTLALTGFPGFAGFFSKDAIIETAYAAHNPFATYAYFLTI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
VAAGLTSFYSWRLVFKTFFGTPHDQHHYDAAHESPIWMLIPLGVLGAGSVLAGVLFKGFF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHCHHHHHHHHHHHHHC
VHPHGVEEFFGESLKMNPHILEDMEHMPFWLGQLPLAMMVIGFFVSLLFYVKRPDIPEEL
CCCCCHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AAQQPLLYNFLLNKWYFDELYDFIFVRPAKWLGRFLWKKGDGFVIDGFGPDGVSARVLDV
HHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
TRNVVKIQTGYLYHYAFAMLIGVAGLITWFMFMGGQQ
HHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIQAIVFLPLLGAILAGLIALLGAHGRHPSGDEVEHHDDGHGHGAADAHAHAHDDHGHDD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HGHGHDDHHVAEPPASGTWAAQAITTALLFVSAALSWATLVSVGFMHHEAGVKELLPWIN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
SGELQVAWSLRVDTLTAVMLVVVTSVSSLVHLYSIGYMDEDPNRPRFFAYLSLFTFAMLM
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
LVTANNLVQLFFGWEGVGLASYLLIGFWFQKPSANAAAIKAFVVNRVGDFGFALGIFAIF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLTKSTDFETIFAAAPSIAGKTTINFLGWHADALTLTCLLLFMGAMGKSAQFLLHTWLPD
HHHCCCCHHHHHHCCCCCCCCCEEHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
AMEGPTPVSALIHAATMVTAGVFMVARLSPLFELAPNAQAVVMFFGATTAFFAATIGLVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHH
NDIKRIVAYSTCSQLGYMFVAMGAGAYSVGMFHLFTHAFFKALLFLGAGSVIYAMHHEQD
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
IRNMGGLWRKIPYTFAMMTVGTLALTGFPGFAGFFSKDAIIETAYAAHNPFATYAYFLTI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
VAAGLTSFYSWRLVFKTFFGTPHDQHHYDAAHESPIWMLIPLGVLGAGSVLAGVLFKGFF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHCHHHHHHHHHHHHHC
VHPHGVEEFFGESLKMNPHILEDMEHMPFWLGQLPLAMMVIGFFVSLLFYVKRPDIPEEL
CCCCCHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AAQQPLLYNFLLNKWYFDELYDFIFVRPAKWLGRFLWKKGDGFVIDGFGPDGVSARVLDV
HHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
TRNVVKIQTGYLYHYAFAMLIGVAGLITWFMFMGGQQ
HHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]