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The map label for this gene is moeA [H]

Identifier: 146341048

GI number: 146341048

Start: 4311163

End: 4312368

Strand: Direct

Name: moeA [H]

Synonym: BRADO4119

Alternate gene names: 146341048

Gene position: 4311163-4312368 (Clockwise)

Preceding gene: 146341047

Following gene: 146341049

Centisome position: 57.82

GC content: 70.65

Gene sequence:

>1206_bases
ATGGCGCTGATGCCGGTCTCCGATGCATTGTCCGCGGTGCTCGCCGGCGCCGAGCCGCTCGCCGAGGAATTTGTGGCGCT
GGACGACGCGTTTCACCGGGTTCTGGCGCGGGATCTCGCGGCGCTGCGGACGCAGCCTCCGGAGGCGATGTCGGCCATGG
ACGGTTACGCGCTGCGCGCAGCCGATGCCACGGCCAAGGCGCGGCTGAAGGTGATCGGCGAGGTCGCGGCGGGGCGGCCG
TTCGATCGACTCGTCGGCCCCGGCGAGGCAGCGCGCATCTTCACCGGCGGCGTGGTGCCCGAGGGCGCCGACGCGGTCGT
GATCCAGGAGGACACGACGGCGGACGGCAGCCACGTCGTGATCAATGAGCCGGCGATCAAGGGCCGCCACATCCGGCCCG
CGGGCGTCGACTTCCATGAGGGCATGGTGCTGCTGAAGGCCGGCCGCCGGCTCAGCGACCGCGACCTGTCGCTCGCGGCC
AGCATGAATTATCCGACGTTGCCGGTACGGCGCCGGCCCAAGGTTGCTCTGCTCGCGACCGGCGACGAGCTGGTGATGCC
GGGCTCGACGCCCGGCCCTGGCCAGATCGTCTATTCGAACGGCTACGGCCTGCGCGCGCTGATGCGCAGCGAGGGCGCCC
AGCCGATCGACCTCGGCATCGCCGCAGATACGCTGGAGGCCACGGTCGCCGGGATCCGCCGGTCGCGCGATGCGGAGGCC
GATATCCTGGTGACGACCGGGGGCGCCTCGGTCGGCGATCACGACCTGGTCAAGCAGGCGCTCGACGCCGAGGGCGTCGA
AATGGCGTTCTGGAAGATCGCGATGCGGCCGGGCAAGCCGATGATGCATGGCCGTCTCGGCGGCATGCGCGTGATCGGCC
TGCCGGGCAATCCGGTGTCATCCTACGTCTGCGCCGTGCTGTTTCTGGTGCCACTGATTCGCAGCCTGCTCGGTCGCGAG
GCGCAGCTGCCGCGCGAGACCGCCCTGCTCGGCCGCGAGCTCGGGGCCAATGATTCGCGCGAGGATTATTTGCGCGCACA
GCTCGACATCCGCGCGGACGGCGTGCTGGTCGCGACGCCGGTGACGCAGCAGGACTCGTCGCTGCTCGGGAATCTCGCGC
TGTCGCAGGCGCTGGTCATCCGTCCGGCGTTCGCGCCGAAGGCTGCAGCCGGAAGCCCCTGCGAGATCCTCCGCCTGCCG
CTTTGA

Upstream 100 bases:

>100_bases
GCTGCCGAAAAGCGCGCGGCGGCCTGGGCCCTTGGCCACGCCATGCGCGTTCGGCTAGAAGGCGATTCCTGTTTTCGTCC
TGCTGTTCGAAGGAACTCTC

Downstream 100 bases:

>100_bases
GCCAATTTCCCCGGCAAAGCCCGGTCTGTTCACCCTATTTTTAGGATTGCGGAACACACATCGAACATATAGTGTTCGTT
CATGATTTGTTTTTAGTATG

Product: putative molybdopterin biosynthesis protein moeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MALMPVSDALSAVLAGAEPLAEEFVALDDAFHRVLARDLAALRTQPPEAMSAMDGYALRAADATAKARLKVIGEVAAGRP
FDRLVGPGEAARIFTGGVVPEGADAVVIQEDTTADGSHVVINEPAIKGRHIRPAGVDFHEGMVLLKAGRRLSDRDLSLAA
SMNYPTLPVRRRPKVALLATGDELVMPGSTPGPGQIVYSNGYGLRALMRSEGAQPIDLGIAADTLEATVAGIRRSRDAEA
DILVTTGGASVGDHDLVKQALDAEGVEMAFWKIAMRPGKPMMHGRLGGMRVIGLPGNPVSSYVCAVLFLVPLIRSLLGRE
AQLPRETALLGRELGANDSREDYLRAQLDIRADGVLVATPVTQQDSSLLGNLALSQALVIRPAFAPKAAAGSPCEILRLP
L

Sequences:

>Translated_401_residues
MALMPVSDALSAVLAGAEPLAEEFVALDDAFHRVLARDLAALRTQPPEAMSAMDGYALRAADATAKARLKVIGEVAAGRP
FDRLVGPGEAARIFTGGVVPEGADAVVIQEDTTADGSHVVINEPAIKGRHIRPAGVDFHEGMVLLKAGRRLSDRDLSLAA
SMNYPTLPVRRRPKVALLATGDELVMPGSTPGPGQIVYSNGYGLRALMRSEGAQPIDLGIAADTLEATVAGIRRSRDAEA
DILVTTGGASVGDHDLVKQALDAEGVEMAFWKIAMRPGKPMMHGRLGGMRVIGLPGNPVSSYVCAVLFLVPLIRSLLGRE
AQLPRETALLGRELGANDSREDYLRAQLDIRADGVLVATPVTQQDSSLLGNLALSQALVIRPAFAPKAAAGSPCEILRLP
L
>Mature_400_residues
ALMPVSDALSAVLAGAEPLAEEFVALDDAFHRVLARDLAALRTQPPEAMSAMDGYALRAADATAKARLKVIGEVAAGRPF
DRLVGPGEAARIFTGGVVPEGADAVVIQEDTTADGSHVVINEPAIKGRHIRPAGVDFHEGMVLLKAGRRLSDRDLSLAAS
MNYPTLPVRRRPKVALLATGDELVMPGSTPGPGQIVYSNGYGLRALMRSEGAQPIDLGIAADTLEATVAGIRRSRDAEAD
ILVTTGGASVGDHDLVKQALDAEGVEMAFWKIAMRPGKPMMHGRLGGMRVIGLPGNPVSSYVCAVLFLVPLIRSLLGREA
QLPRETALLGRELGANDSREDYLRAQLDIRADGVLVATPVTQQDSSLLGNLALSQALVIRPAFAPKAAAGSPCEILRLPL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=366, Percent_Identity=36.0655737704918, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI10880983, Length=366, Percent_Identity=36.0655737704918, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1787049, Length=381, Percent_Identity=37.007874015748, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI25147659, Length=380, Percent_Identity=31.0526315789474, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=340, Percent_Identity=26.7647058823529, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136978, Length=413, Percent_Identity=29.0556900726392, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24638841, Length=413, Percent_Identity=29.0556900726392, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42183; Mature: 42052

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALMPVSDALSAVLAGAEPLAEEFVALDDAFHRVLARDLAALRTQPPEAMSAMDGYALRA
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEE
ADATAKARLKVIGEVAAGRPFDRLVGPGEAARIFTGGVVPEGADAVVIQEDTTADGSHVV
CCHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEE
INEPAIKGRHIRPAGVDFHEGMVLLKAGRRLSDRDLSLAASMNYPTLPVRRRPKVALLAT
EECCCCCCCCCCCCCCCHHHCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEC
GDELVMPGSTPGPGQIVYSNGYGLRALMRSEGAQPIDLGIAADTLEATVAGIRRSRDAEA
CCCEEECCCCCCCCEEEEECCCCHHHHHHHCCCCEEEECEEHHHHHHHHHHHHHCCCCCC
DILVTTGGASVGDHDLVKQALDAEGVEMAFWKIAMRPGKPMMHGRLGGMRVIGLPGNPVS
CEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCCHHH
SYVCAVLFLVPLIRSLLGREAQLPRETALLGRELGANDSREDYLRAQLDIRADGVLVATP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHEEEEEEECCEEEECC
VTQQDSSLLGNLALSQALVIRPAFAPKAAAGSPCEILRLPL
CCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHEEECCC
>Mature Secondary Structure 
ALMPVSDALSAVLAGAEPLAEEFVALDDAFHRVLARDLAALRTQPPEAMSAMDGYALRA
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEE
ADATAKARLKVIGEVAAGRPFDRLVGPGEAARIFTGGVVPEGADAVVIQEDTTADGSHVV
CCHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEE
INEPAIKGRHIRPAGVDFHEGMVLLKAGRRLSDRDLSLAASMNYPTLPVRRRPKVALLAT
EECCCCCCCCCCCCCCCHHHCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEC
GDELVMPGSTPGPGQIVYSNGYGLRALMRSEGAQPIDLGIAADTLEATVAGIRRSRDAEA
CCCEEECCCCCCCCEEEEECCCCHHHHHHHCCCCEEEECEEHHHHHHHHHHHHHCCCCCC
DILVTTGGASVGDHDLVKQALDAEGVEMAFWKIAMRPGKPMMHGRLGGMRVIGLPGNPVS
CEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEECCCCHHH
SYVCAVLFLVPLIRSLLGREAQLPRETALLGRELGANDSREDYLRAQLDIRADGVLVATP
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHEEEEEEECCEEEECC
VTQQDSSLLGNLALSQALVIRPAFAPKAAAGSPCEILRLPL
CCCCHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]