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The map label for this gene is lldD [H]

Identifier: 146341043

GI number: 146341043

Start: 4306301

End: 4307437

Strand: Direct

Name: lldD [H]

Synonym: BRADO4114

Alternate gene names: 146341043

Gene position: 4306301-4307437 (Clockwise)

Preceding gene: 146341041

Following gene: 146341044

Centisome position: 57.75

GC content: 67.19

Gene sequence:

>1137_bases
ATGAATCAACAGACCCCGATCGAGGCCGGGTGGCGCAACGTCGAGCTCGGCGCAAGTGACGAAAAGTTCCAGAACCTGCA
CGAGTTCATCCGCAAGGCGAGAGCGCAGCTCAACCAGAACGCCTGGGACTACATCATCGGCGGGACTGAAACCGAGACCA
CGTTGCGCCGGAACCGGATGGCGCTCGACGAAATCGCGTTCCGGCCGCGGGTGCTGCGCGACGTCTCCCGCGTCGATGCC
TCGGTCGAGCTGTTCGGGCGCAGGCTGCGCCTCCCGGTCGTGATGGCGCCAGTCGGCGCGCTCGAGATCTTCGACCCCGC
GGGCGCGGCCAGCGTCGCGCGCGGCGCCGGCCGCTTCGGGGCGGCGCACATGCTGAGCTCGGTCTCCGAGCCCGGCTTGG
AGAAAACCGCCGAGGCCGCTCCCGACGCGCTGCGCATCTTTCAGCTCTATGTACGCGGCGACGATGCCTTCGTGGAGGAC
TATGTCGGCCGTGCCGTCGCCAACAACTACACCGCATTCTGCCTGACGGTCGACACCGCCCATTACAGCCGCCGCGAGCG
CGACATCGCCAAGCGCTATGTGCGCGAGAGCCGGCTGCGCGCCACCGGTGGCGACCACCAGAAGGCGCTGAGCTGGCACA
CGGTGAAACTGATCAAGGACAAGTTCAGGCTGCCGCTGATCATCAAGGGCATCGCCACCGCCGAGGATGCGGCGATCGCT
CTCGATCACGGCGTCGACTGGATCTATGTCTCCAACCATGGCGGCCGCCAGCTCGACCATGGCCGCGGCGCGATGCACGT
GCTGCCGGAGATCGTCGCGGCGGTGAAGGGCCGGGCAAAAATTCTCGTCGATGGCGGCTTCTGCCGCGGCACCGACATCG
TCAAGGCGATCGCCTCCGGCGCCGACATGGTCGGCATCGGCCGGCTGCAATGCTGGGCGCTCGCGGCCGCCGGCGAGAAC
GGCATCCTGCGCATGCTGGAGCTGCTCGAGGACGAGGTGATCCGCGCCCTAGGCCTGCTCGGCGTCACCTCCTTCGCCGA
GCTGAACGCGTCCTACCTGCACGCCGCAACCACCACCAACATGCCCAGTGTGTTCAGCGCGTTTCCGCTGGCCGACATCG
AGCCGTACCGCTATTGA

Upstream 100 bases:

>100_bases
GGCACCACGTCGACAGATACGCAGGTCGGAATGGCTTGCACATCGCCGGTGGGATGAGCGATGCTGGATAACAAATGATA
ATATGCGCTGGGAGGCAGGA

Downstream 100 bases:

>100_bases
GGGAGCGCTCCACCGGCTCCTCATCTGGCAAAGACCCGCGTCGCGATGCTCCTTTCCGATCTCCGTCCCGGCGTGGCCGA
CGCGCTGCTGTTCGATCTCG

Product: putative FMN-dependent alpha-hydroxy acid dehydrogenase family protein glycolate oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MNQQTPIEAGWRNVELGASDEKFQNLHEFIRKARAQLNQNAWDYIIGGTETETTLRRNRMALDEIAFRPRVLRDVSRVDA
SVELFGRRLRLPVVMAPVGALEIFDPAGAASVARGAGRFGAAHMLSSVSEPGLEKTAEAAPDALRIFQLYVRGDDAFVED
YVGRAVANNYTAFCLTVDTAHYSRRERDIAKRYVRESRLRATGGDHQKALSWHTVKLIKDKFRLPLIIKGIATAEDAAIA
LDHGVDWIYVSNHGGRQLDHGRGAMHVLPEIVAAVKGRAKILVDGGFCRGTDIVKAIASGADMVGIGRLQCWALAAAGEN
GILRMLELLEDEVIRALGLLGVTSFAELNASYLHAATTTNMPSVFSAFPLADIEPYRY

Sequences:

>Translated_378_residues
MNQQTPIEAGWRNVELGASDEKFQNLHEFIRKARAQLNQNAWDYIIGGTETETTLRRNRMALDEIAFRPRVLRDVSRVDA
SVELFGRRLRLPVVMAPVGALEIFDPAGAASVARGAGRFGAAHMLSSVSEPGLEKTAEAAPDALRIFQLYVRGDDAFVED
YVGRAVANNYTAFCLTVDTAHYSRRERDIAKRYVRESRLRATGGDHQKALSWHTVKLIKDKFRLPLIIKGIATAEDAAIA
LDHGVDWIYVSNHGGRQLDHGRGAMHVLPEIVAAVKGRAKILVDGGFCRGTDIVKAIASGADMVGIGRLQCWALAAAGEN
GILRMLELLEDEVIRALGLLGVTSFAELNASYLHAATTTNMPSVFSAFPLADIEPYRY
>Mature_378_residues
MNQQTPIEAGWRNVELGASDEKFQNLHEFIRKARAQLNQNAWDYIIGGTETETTLRRNRMALDEIAFRPRVLRDVSRVDA
SVELFGRRLRLPVVMAPVGALEIFDPAGAASVARGAGRFGAAHMLSSVSEPGLEKTAEAAPDALRIFQLYVRGDDAFVED
YVGRAVANNYTAFCLTVDTAHYSRRERDIAKRYVRESRLRATGGDHQKALSWHTVKLIKDKFRLPLIIKGIATAEDAAIA
LDHGVDWIYVSNHGGRQLDHGRGAMHVLPEIVAAVKGRAKILVDGGFCRGTDIVKAIASGADMVGIGRLQCWALAAAGEN
GILRMLELLEDEVIRALGLLGVTSFAELNASYLHAATTTNMPSVFSAFPLADIEPYRY

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=342, Percent_Identity=35.672514619883, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI7705393, Length=342, Percent_Identity=35.672514619883, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI11068137, Length=354, Percent_Identity=31.9209039548023, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI1790033, Length=371, Percent_Identity=33.1536388140162, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI193208036, Length=352, Percent_Identity=35.5113636363636, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI32566217, Length=262, Percent_Identity=33.206106870229, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323587, Length=359, Percent_Identity=33.983286908078, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281363140, Length=352, Percent_Identity=34.0909090909091, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI78707190, Length=352, Percent_Identity=34.0909090909091, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI78707188, Length=352, Percent_Identity=34.0909090909091, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41498; Mature: 41498

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQQTPIEAGWRNVELGASDEKFQNLHEFIRKARAQLNQNAWDYIIGGTETETTLRRNRM
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
ALDEIAFRPRVLRDVSRVDASVELFGRRLRLPVVMAPVGALEIFDPAGAASVARGAGRFG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHCCCHHH
AAHMLSSVSEPGLEKTAEAAPDALRIFQLYVRGDDAFVEDYVGRAVANNYTAFCLTVDTA
HHHHHHHCCCCCHHHHHHHCHHHHHHHHHEECCCCHHHHHHHHHHHHCCCEEEEEEEECH
HYSRRERDIAKRYVRESRLRATGGDHQKALSWHTVKLIKDKFRLPLIIKGIATAEDAAIA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEE
LDHGVDWIYVSNHGGRQLDHGRGAMHVLPEIVAAVKGRAKILVDGGFCRGTDIVKAIASG
EECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCC
ADMVGIGRLQCWALAAAGENGILRMLELLEDEVIRALGLLGVTSFAELNASYLHAATTTN
CCEEECCHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCC
MPSVFSAFPLADIEPYRY
CCHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNQQTPIEAGWRNVELGASDEKFQNLHEFIRKARAQLNQNAWDYIIGGTETETTLRRNRM
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
ALDEIAFRPRVLRDVSRVDASVELFGRRLRLPVVMAPVGALEIFDPAGAASVARGAGRFG
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHCCCHHH
AAHMLSSVSEPGLEKTAEAAPDALRIFQLYVRGDDAFVEDYVGRAVANNYTAFCLTVDTA
HHHHHHHCCCCCHHHHHHHCHHHHHHHHHEECCCCHHHHHHHHHHHHCCCEEEEEEEECH
HYSRRERDIAKRYVRESRLRATGGDHQKALSWHTVKLIKDKFRLPLIIKGIATAEDAAIA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEE
LDHGVDWIYVSNHGGRQLDHGRGAMHVLPEIVAAVKGRAKILVDGGFCRGTDIVKAIASG
EECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCC
ADMVGIGRLQCWALAAAGENGILRMLELLEDEVIRALGLLGVTSFAELNASYLHAATTTN
CCEEECCHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCC
MPSVFSAFPLADIEPYRY
CCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA