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The map label for this gene is fucA [C]

Identifier: 146341018

GI number: 146341018

Start: 4278830

End: 4279621

Strand: Reverse

Name: fucA [C]

Synonym: BRADO4089

Alternate gene names: 146341018

Gene position: 4279621-4278830 (Counterclockwise)

Preceding gene: 146341019

Following gene: 146341017

Centisome position: 57.39

GC content: 68.06

Gene sequence:

>792_bases
ATGGCCCACGCCTTCACGCCCGACAGCACGTCGACGTTGGGAGCGAACCAGCCGACGCTCGACTCGGAGGCGGTCTGGCA
GGCCCGCGTCGATCTGGCCGCCTGCTTCCGCATGGCGGCGCGGCACGGGCTGGAGGAGGGCATCTGCAACCACTTCTCGG
CGCTGGTGCCCGGCTATGACGACCTCTTCATCGTCAACCCCTATGGCTACGCCTTCCGCGAGCTGACCGCCTCGCGCCTG
CTGGTGTGCGACTTCGACGGCAACGTCATCGCCGGCGAGGGCCGTCCGGAGGCCACCGCGTTCTACATCCACGCGCGCAT
CCACAAGGCGCTGCCGCGCGCCAAGGTCGCCTTCCACACCCACATGCCCTATGCCACCGCGCTGTCGATGACCGAGGGAC
CGCCGCTGATCTTCGCCGGCCAGACTGCTCTGAAGTTCTACGGCCGCACCGCCGTCGACGAGAACTATAACGGGCTGGCG
CTCGACACGGCCGAGGGCGATCGCATCGCCGGCGCCGTCGGCGATGCCGACATCGTCTTCATGAAGCATCACGGCGTCAT
GGTGCTGGCGCCGAGCATCGCGGAAGCCTGGGACGATCTGTATTATCTGGAGCGTGCGTGCGAGGTGCAGTGCCTGGCGC
TGTCGACCGGGCGCAAGGTTGTCCCGGTCGCGCCTGATATCGCCGAGGCGGCCTATCGACAGATGCGCGAGGGGGACGCG
GAATCGGCGCGGCTGCATCTGGAGGCGATCAAGCGGACGCTGGATGCGGAGGAGCCCGCGTACCGGACGTGA

Upstream 100 bases:

>100_bases
ATAACGGATATAGCGGGCAAGGCGTTGACGCGCCTTGCCCGATCGTTTTCAAGGCGTGTTCGGACATCTGCGCCCCGCTG
CGCGACCCCAGGAAACCGCA

Downstream 100 bases:

>100_bases
GCGCGTCGCGGTCGGACGCGCAGGGTTAGCGATTCCTTAACCGGAGCGCCGCATCTTCCCCGTCATGGTCTCCCGCGCAC
GCCTGAAATCGTTCCTCACC

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAHAFTPDSTSTLGANQPTLDSEAVWQARVDLAACFRMAARHGLEEGICNHFSALVPGYDDLFIVNPYGYAFRELTASRL
LVCDFDGNVIAGEGRPEATAFYIHARIHKALPRAKVAFHTHMPYATALSMTEGPPLIFAGQTALKFYGRTAVDENYNGLA
LDTAEGDRIAGAVGDADIVFMKHHGVMVLAPSIAEAWDDLYYLERACEVQCLALSTGRKVVPVAPDIAEAAYRQMREGDA
ESARLHLEAIKRTLDAEEPAYRT

Sequences:

>Translated_263_residues
MAHAFTPDSTSTLGANQPTLDSEAVWQARVDLAACFRMAARHGLEEGICNHFSALVPGYDDLFIVNPYGYAFRELTASRL
LVCDFDGNVIAGEGRPEATAFYIHARIHKALPRAKVAFHTHMPYATALSMTEGPPLIFAGQTALKFYGRTAVDENYNGLA
LDTAEGDRIAGAVGDADIVFMKHHGVMVLAPSIAEAWDDLYYLERACEVQCLALSTGRKVVPVAPDIAEAAYRQMREGDA
ESARLHLEAIKRTLDAEEPAYRT
>Mature_262_residues
AHAFTPDSTSTLGANQPTLDSEAVWQARVDLAACFRMAARHGLEEGICNHFSALVPGYDDLFIVNPYGYAFRELTASRLL
VCDFDGNVIAGEGRPEATAFYIHARIHKALPRAKVAFHTHMPYATALSMTEGPPLIFAGQTALKFYGRTAVDENYNGLAL
DTAEGDRIAGAVGDADIVFMKHHGVMVLAPSIAEAWDDLYYLERACEVQCLALSTGRKVVPVAPDIAEAAYRQMREGDAE
SARLHLEAIKRTLDAEEPAYRT

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826325, Length=253, Percent_Identity=28.0632411067194, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI29826323, Length=253, Percent_Identity=28.0632411067194, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI29826321, Length=245, Percent_Identity=27.7551020408163, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI29826319, Length=194, Percent_Identity=29.3814432989691, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI9257190, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI297307158, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI9257192, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI297307160, Length=229, Percent_Identity=26.2008733624454, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI89276787, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115533218, Length=256, Percent_Identity=26.953125, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115533216, Length=256, Percent_Identity=26.953125, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71989560, Length=220, Percent_Identity=26.8181818181818, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989544, Length=220, Percent_Identity=26.8181818181818, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989550, Length=220, Percent_Identity=26.8181818181818, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989555, Length=227, Percent_Identity=26.8722466960352, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989541, Length=220, Percent_Identity=26.8181818181818, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281363755, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363751, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24655690, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24655685, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363761, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363759, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363753, Length=214, Percent_Identity=26.1682242990654, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363763, Length=214, Percent_Identity=26.1682242990654, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363757, Length=214, Percent_Identity=26.1682242990654, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17136738, Length=214, Percent_Identity=26.1682242990654, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 28720; Mature: 28589

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAFTPDSTSTLGANQPTLDSEAVWQARVDLAACFRMAARHGLEEGICNHFSALVPGYD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
DLFIVNPYGYAFRELTASRLLVCDFDGNVIAGEGRPEATAFYIHARIHKALPRAKVAFHT
CEEEECCCCHHHHHHHHCEEEEEECCCCEEECCCCCCCEEEEEEHHHHHHCCCCEEEEEE
HMPYATALSMTEGPPLIFAGQTALKFYGRTAVDENYNGLALDTAEGDRIAGAVGDADIVF
CCCHHHEEECCCCCCEEEECCHHHHHHCCCCCCCCCCCEEEECCCCCEEEEECCCCEEEE
MKHHGVMVLAPSIAEAWDDLYYLERACEVQCLALSTGRKVVPVAPDIAEAAYRQMREGDA
EECCCEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCHHHHHHHHHHHCCCH
ESARLHLEAIKRTLDAEEPAYRT
HHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AHAFTPDSTSTLGANQPTLDSEAVWQARVDLAACFRMAARHGLEEGICNHFSALVPGYD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
DLFIVNPYGYAFRELTASRLLVCDFDGNVIAGEGRPEATAFYIHARIHKALPRAKVAFHT
CEEEECCCCHHHHHHHHCEEEEEECCCCEEECCCCCCCEEEEEEHHHHHHCCCCEEEEEE
HMPYATALSMTEGPPLIFAGQTALKFYGRTAVDENYNGLALDTAEGDRIAGAVGDADIVF
CCCHHHEEECCCCCCEEEECCHHHHHHCCCCCCCCCCCEEEECCCCCEEEEECCCCEEEE
MKHHGVMVLAPSIAEAWDDLYYLERACEVQCLALSTGRKVVPVAPDIAEAAYRQMREGDA
EECCCEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCHHHHHHHHHHHCCCH
ESARLHLEAIKRTLDAEEPAYRT
HHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]