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The map label for this gene is fmt [H]

Identifier: 146340905

GI number: 146340905

Start: 4167710

End: 4168303

Strand: Direct

Name: fmt [H]

Synonym: BRADO3974

Alternate gene names: 146340905

Gene position: 4167710-4168303 (Clockwise)

Preceding gene: 146340904

Following gene: 146340906

Centisome position: 55.89

GC content: 68.69

Gene sequence:

>594_bases
ATGCGTATCACCCTCGTCGGCTCCCGACATTTCGGTGTCGCCACACTGAATATGCTGCGCGACAGAGGCATCGAGATCGC
ACGCGTGGTCGTGCATGACGGCGAGGATCGGCTCGCCGCAGCAGCGCGATCGGCCGGGATCGAGGTGGTCGTCCAGGCCG
ATCCCAAGGTCGTCCCCGCGAGCGAGATCGCGCCAGGGACCGACCTGATCGTCACCGCCCATAGCCACGCCCGTGTCAGC
CAGGAGGCGGTGGCCGCCGCCAAGCTCGGCGGCATCGGCTACCATCCGTCGCTGCTGCCGCGTCACCGCGGCATCGCAGC
CGTGGAGTGGACCATCAAGGAGGGCGATGCGATCGCGGGCGGCACCATCTACCATCTGGCCGAGCGGATGGACGCCGGCG
CCATCGCCGCCCAGGACTGGTGCTTCGTCAGGAAGGGCGAAACCGCTCGCGAATTGTGGGAGCGCGCGCTGGCGCCGCTT
GGCCTCAAGCTGCTCGGCGACGTCGTCGAATCAGCCAAGGCCACCGGCACGATCCCCGCCAAGCCGCAGGACGAGCAGTT
CGCGACCAAGGCCCCAAGCCTCACGCCGCACTGA

Upstream 100 bases:

>100_bases
CTGGGGTGTGAGGAAGGCGCAGCGGGCGCTTGACCTCGGCGCCAAGGCTTGGTTTGACCCGACTGGACGCTCCCGCCCCC
ATCATGGAAGATCCCGAACC

Downstream 100 bases:

>100_bases
CCGAGCAAACCTCGCCGGAGCCTGCGCGCCCGTAGCCGCGATCCACCGTCGGACCAGGCCGCGATCACGAACTGCCGTTC
GAACAACGCCAGGATGTGGC

Product: putative methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MRITLVGSRHFGVATLNMLRDRGIEIARVVVHDGEDRLAAAARSAGIEVVVQADPKVVPASEIAPGTDLIVTAHSHARVS
QEAVAAAKLGGIGYHPSLLPRHRGIAAVEWTIKEGDAIAGGTIYHLAERMDAGAIAAQDWCFVRKGETARELWERALAPL
GLKLLGDVVESAKATGTIPAKPQDEQFATKAPSLTPH

Sequences:

>Translated_197_residues
MRITLVGSRHFGVATLNMLRDRGIEIARVVVHDGEDRLAAAARSAGIEVVVQADPKVVPASEIAPGTDLIVTAHSHARVS
QEAVAAAKLGGIGYHPSLLPRHRGIAAVEWTIKEGDAIAGGTIYHLAERMDAGAIAAQDWCFVRKGETARELWERALAPL
GLKLLGDVVESAKATGTIPAKPQDEQFATKAPSLTPH
>Mature_197_residues
MRITLVGSRHFGVATLNMLRDRGIEIARVVVHDGEDRLAAAARSAGIEVVVQADPKVVPASEIAPGTDLIVTAHSHARVS
QEAVAAAKLGGIGYHPSLLPRHRGIAAVEWTIKEGDAIAGGTIYHLAERMDAGAIAAQDWCFVRKGETARELWERALAPL
GLKLLGDVVESAKATGTIPAKPQDEQFATKAPSLTPH

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=201, Percent_Identity=34.8258706467662, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI238814322, Length=200, Percent_Identity=32.5, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI133930964, Length=213, Percent_Identity=31.4553990610329, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585660, Length=207, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 20854; Mature: 20854

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITLVGSRHFGVATLNMLRDRGIEIARVVVHDGEDRLAAAARSAGIEVVVQADPKVVPA
CEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHCCCEEEEEECCCCCCCH
SEIAPGTDLIVTAHSHARVSQEAVAAAKLGGIGYHPSLLPRHRGIAAVEWTIKEGDAIAG
HHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEECC
GTIYHLAERMDAGAIAAQDWCFVRKGETARELWERALAPLGLKLLGDVVESAKATGTIPA
CHHHHHHHHCCCCCEEECCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
KPQDEQFATKAPSLTPH
CCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MRITLVGSRHFGVATLNMLRDRGIEIARVVVHDGEDRLAAAARSAGIEVVVQADPKVVPA
CEEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHCCCEEEEEECCCCCCCH
SEIAPGTDLIVTAHSHARVSQEAVAAAKLGGIGYHPSLLPRHRGIAAVEWTIKEGDAIAG
HHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEECC
GTIYHLAERMDAGAIAAQDWCFVRKGETARELWERALAPLGLKLLGDVVESAKATGTIPA
CHHHHHHHHCCCCCEEECCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
KPQDEQFATKAPSLTPH
CCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]