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The map label for this gene is mazG [H]

Identifier: 146340792

GI number: 146340792

Start: 4022669

End: 4023487

Strand: Direct

Name: mazG [H]

Synonym: BRADO3851

Alternate gene names: 146340792

Gene position: 4022669-4023487 (Clockwise)

Preceding gene: 146340790

Following gene: 146340794

Centisome position: 53.95

GC content: 65.81

Gene sequence:

>819_bases
ATGACCCCTTCCCGCGACATCTCACGCCTCATCGAGATCATGGCGGCGCTGCGCACACCCGTCACCGGCTGTCCCTGGGA
CGTCGAGCAGACGTTCGAGACGATCGCGCCCTACACGATCGAGGAGGCCTACGAGGTTGCGGATGCGATCACGCGGGCGG
ATCTCGACGATCTCCAAGAGGAGCTCGGTGATCTCCTGCTGCAGGTGGTCTATCACGCCCGCATCGCCGAGGAGCAAGGC
GCGTTCGCGTTCGGCGACGTCGTGGAGGGCATCACCAGGAAGATGATCCGCCGCCATCCGCATGTCTTCCCCGACAAGGA
CGGCAATGTCACCAAGCCCACCAAGGGCACCTGGGACCGCATCAAGGCCGAGGAAAAGGCCGAGCGCGCGGCGCGGCGGC
CAGCCGAGGACCAGAGCAGCGAGTCCTCGCTGCTGTCGGGTGTGAAGGCCGGCCAGCCCGCGCTGGTGCGCGCGATGGAG
TTGCAGAAGAAAGCGGCGACGGTGGGCTTCGACTGGAACGACCCGCGCGCCGTGCTGCAGAAGATCCGCGAGGAGGCCGA
CGAGATCGAAGCCGCGCTCGATAAGAGGGATGCGACCGAGCTGACCGACGAGACCGGCGATCTCCTGTTCGCCCTCGTCA
ACCTCGCACGTCATGCCCAGGTCGATCCGGAGACCGCGCTACGCGCCACCAACGCCAAGTTCGAACGCCGCTTCGCGCAC
ATCGAGCACACGCTCGCCGCAAAGGGGCGGACGCTGGACGAAGCCTCGCTCGATGAAATGGATGAGCTGTGGAACGAAGC
GAAGGGCCTGGAGAAGTAG

Upstream 100 bases:

>100_bases
CCAACCCGCGCGCGGCGTCCGGCCGTGCGCGGTTTTCGCTGGGACGCGCGCATGGCTTGAGGCATACAGGGTCAAGGAAA
AGTTGCCGCCAGGACCAGCA

Downstream 100 bases:

>100_bases
TTAAGGCGCCTCTACTCGTCGTCCCAGGGCGAGCCTCCGTGGCGCATGGCGCGCAAAGGCGCCGGTCCGGCACCCCAACG
CCACAGCGGGGCACGGTCCG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTPSRDISRLIEIMAALRTPVTGCPWDVEQTFETIAPYTIEEAYEVADAITRADLDDLQEELGDLLLQVVYHARIAEEQG
AFAFGDVVEGITRKMIRRHPHVFPDKDGNVTKPTKGTWDRIKAEEKAERAARRPAEDQSSESSLLSGVKAGQPALVRAME
LQKKAATVGFDWNDPRAVLQKIREEADEIEAALDKRDATELTDETGDLLFALVNLARHAQVDPETALRATNAKFERRFAH
IEHTLAAKGRTLDEASLDEMDELWNEAKGLEK

Sequences:

>Translated_272_residues
MTPSRDISRLIEIMAALRTPVTGCPWDVEQTFETIAPYTIEEAYEVADAITRADLDDLQEELGDLLLQVVYHARIAEEQG
AFAFGDVVEGITRKMIRRHPHVFPDKDGNVTKPTKGTWDRIKAEEKAERAARRPAEDQSSESSLLSGVKAGQPALVRAME
LQKKAATVGFDWNDPRAVLQKIREEADEIEAALDKRDATELTDETGDLLFALVNLARHAQVDPETALRATNAKFERRFAH
IEHTLAAKGRTLDEASLDEMDELWNEAKGLEK
>Mature_271_residues
TPSRDISRLIEIMAALRTPVTGCPWDVEQTFETIAPYTIEEAYEVADAITRADLDDLQEELGDLLLQVVYHARIAEEQGA
FAFGDVVEGITRKMIRRHPHVFPDKDGNVTKPTKGTWDRIKAEEKAERAARRPAEDQSSESSLLSGVKAGQPALVRAMEL
QKKAATVGFDWNDPRAVLQKIREEADEIEAALDKRDATELTDETGDLLFALVNLARHAQVDPETALRATNAKFERRFAHI
EHTLAAKGRTLDEASLDEMDELWNEAKGLEK

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=264, Percent_Identity=47.7272727272727, Blast_Score=243, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30432; Mature: 30301

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSRDISRLIEIMAALRTPVTGCPWDVEQTFETIAPYTIEEAYEVADAITRADLDDLQE
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ELGDLLLQVVYHARIAEEQGAFAFGDVVEGITRKMIRRHPHVFPDKDGNVTKPTKGTWDR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
IKAEEKAERAARRPAEDQSSESSLLSGVKAGQPALVRAMELQKKAATVGFDWNDPRAVLQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KIREEADEIEAALDKRDATELTDETGDLLFALVNLARHAQVDPETALRATNAKFERRFAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IEHTLAAKGRTLDEASLDEMDELWNEAKGLEK
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TPSRDISRLIEIMAALRTPVTGCPWDVEQTFETIAPYTIEEAYEVADAITRADLDDLQE
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ELGDLLLQVVYHARIAEEQGAFAFGDVVEGITRKMIRRHPHVFPDKDGNVTKPTKGTWDR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHH
IKAEEKAERAARRPAEDQSSESSLLSGVKAGQPALVRAMELQKKAATVGFDWNDPRAVLQ
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KIREEADEIEAALDKRDATELTDETGDLLFALVNLARHAQVDPETALRATNAKFERRFAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
IEHTLAAKGRTLDEASLDEMDELWNEAKGLEK
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]