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The map label for this gene is glmU [H]

Identifier: 146340708

GI number: 146340708

Start: 3926453

End: 3927802

Strand: Direct

Name: glmU [H]

Synonym: BRADO3760

Alternate gene names: 146340708

Gene position: 3926453-3927802 (Clockwise)

Preceding gene: 146340705

Following gene: 146340709

Centisome position: 52.66

GC content: 68.89

Gene sequence:

>1350_bases
TTGATGACCGCTCGATCCAGTCTGACCATCGTGCTTGCGGCGGGCGAGGGCACGCGGATGCGCTCGAGCCTCCCGAAGGT
GCTGCATCCCATCGCCGGCGAATCAATGCTGGCGCATGTGCTGGCGGCAGCGCCGCAGGGCGACGGCGCGGCGATCGCGG
TCGTGATCGGGCCCGGCCATGACGCCGTCGAGAAGGAGGCGAAGCGCCTGTGTCCCGACGTTGCGATCTTCGTACAGCGC
GAGCGGCTGGGCACGGCGCATGCCGTCCTCGCCGCGCGCGAGGCGATCGCGCGCGGTGCCGACGATCTCCTCGTCGCGTT
CGGCGACACCCCGCTGATCACGGCCGAAACCTTCGCGCGGCTGCGCGCGGCGCTGGCTCAGGGCGCCGCCCTTGCGGTGC
TCGGTTTCCGCGCGGTTGATCCCACCGGCTACGGCCGGCTGCTGCTGGACGGATCGAAGCTGGTCGCCATCCGGGAGCAC
GCCGATGCGTCGGAGGCGGAGCGCGCGATCACGCTGTGCAATGCCGGGGTGATGGCGATGGACGGCCGGCGCGCGCTGGC
CATCCTCGACAAGATCGGCAACACCAACAGCAAGGGCGAATACTATCTCGTCGATGCGGTGGCGATCGCGCGCAGTCAGG
GACTCGACGCGGTCGTGATCGAGACCTCCGAGGACGAGGTGCGCGGCATCAACACCAAGGCCCAGCTGGCGCAGGCCGAG
GCCGCGATGCAGGCGCGGCTGCGGCAGGCGGCGATGGACGCCGGCGTGACGTTGATTGCGCCGGAGACCGTCTATCTCGC
GGCGGACACCACGTTCGGCAGGGATGTCACCATCGAGCCGTTCGTCGTGATCGGCCCCGGCGTGTCGATCGGCGACGGGG
CGGTGGTGCATTCGTTCTCGCACGTCGTGCAGTCGAAGCTCGGCAGCAACACGCTGCTCGGACCGTTCGCACGCCTGCGG
CCGGGCACCTCGCTCGGCGACGGCGCCAAGATCGGCAATTTCGTCGAGGCCAAGGCCGCGGTGCTCGAGCCCGGCGTCAA
GGTGAATCACTTGTCGTATATCGGCGACGCCCATGTCGGCGCTCATTCCAACATCGGCGCGGGCACCATCACCTGCAACT
ATGACGGCTTCAACAAGCACAAGACGCGGATCGGCGAGGGCGCCTTCATCGGCACCAACACCTCGCTGGTGGCGCCGATC
AACATCGGCGCCCGCGCCTATATCGGCTCGGGATCGGTGATCACGCGCGACGTACCTGACGATGCGCTGGCGCTGGAGCG
CAGCCCGCAGACCACGAAGGAAGGCGCGGCGGCGCGCTTCCGGAACGCGAAGCTGCGCCAGACGAAGTGA

Upstream 100 bases:

>100_bases
ATCAGGAAAACCAGTATGGGTTTCAGCCGGCGCAGCTTGCCGCGCGCCGAAAACGATTTATGACAGCGTCAATTGTGTCG
CTCCGTGATTTTCAGGGTGC

Downstream 100 bases:

>100_bases
GAGCGCGGAAGGGACGGCGAGCGTGGAGATCGGTCAGCTCGTCTTTGACCTGATCATCGAGGCGCTGATCGCGATCGCGC
GGCTGGGAACGTTCTCCGGC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MMTARSSLTIVLAAGEGTRMRSSLPKVLHPIAGESMLAHVLAAAPQGDGAAIAVVIGPGHDAVEKEAKRLCPDVAIFVQR
ERLGTAHAVLAAREAIARGADDLLVAFGDTPLITAETFARLRAALAQGAALAVLGFRAVDPTGYGRLLLDGSKLVAIREH
ADASEAERAITLCNAGVMAMDGRRALAILDKIGNTNSKGEYYLVDAVAIARSQGLDAVVIETSEDEVRGINTKAQLAQAE
AAMQARLRQAAMDAGVTLIAPETVYLAADTTFGRDVTIEPFVVIGPGVSIGDGAVVHSFSHVVQSKLGSNTLLGPFARLR
PGTSLGDGAKIGNFVEAKAAVLEPGVKVNHLSYIGDAHVGAHSNIGAGTITCNYDGFNKHKTRIGEGAFIGTNTSLVAPI
NIGARAYIGSGSVITRDVPDDALALERSPQTTKEGAAARFRNAKLRQTK

Sequences:

>Translated_449_residues
MMTARSSLTIVLAAGEGTRMRSSLPKVLHPIAGESMLAHVLAAAPQGDGAAIAVVIGPGHDAVEKEAKRLCPDVAIFVQR
ERLGTAHAVLAAREAIARGADDLLVAFGDTPLITAETFARLRAALAQGAALAVLGFRAVDPTGYGRLLLDGSKLVAIREH
ADASEAERAITLCNAGVMAMDGRRALAILDKIGNTNSKGEYYLVDAVAIARSQGLDAVVIETSEDEVRGINTKAQLAQAE
AAMQARLRQAAMDAGVTLIAPETVYLAADTTFGRDVTIEPFVVIGPGVSIGDGAVVHSFSHVVQSKLGSNTLLGPFARLR
PGTSLGDGAKIGNFVEAKAAVLEPGVKVNHLSYIGDAHVGAHSNIGAGTITCNYDGFNKHKTRIGEGAFIGTNTSLVAPI
NIGARAYIGSGSVITRDVPDDALALERSPQTTKEGAAARFRNAKLRQTK
>Mature_449_residues
MMTARSSLTIVLAAGEGTRMRSSLPKVLHPIAGESMLAHVLAAAPQGDGAAIAVVIGPGHDAVEKEAKRLCPDVAIFVQR
ERLGTAHAVLAAREAIARGADDLLVAFGDTPLITAETFARLRAALAQGAALAVLGFRAVDPTGYGRLLLDGSKLVAIREH
ADASEAERAITLCNAGVMAMDGRRALAILDKIGNTNSKGEYYLVDAVAIARSQGLDAVVIETSEDEVRGINTKAQLAQAE
AAMQARLRQAAMDAGVTLIAPETVYLAADTTFGRDVTIEPFVVIGPGVSIGDGAVVHSFSHVVQSKLGSNTLLGPFARLR
PGTSLGDGAKIGNFVEAKAAVLEPGVKVNHLSYIGDAHVGAHSNIGAGTITCNYDGFNKHKTRIGEGAFIGTNTSLVAPI
NIGARAYIGSGSVITRDVPDDALALERSPQTTKEGAAARFRNAKLRQTK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=444, Percent_Identity=41.8918918918919, Blast_Score=327, Evalue=1e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 46645; Mature: 46645

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTARSSLTIVLAAGEGTRMRSSLPKVLHPIAGESMLAHVLAAAPQGDGAAIAVVIGPGH
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
DAVEKEAKRLCPDVAIFVQRERLGTAHAVLAAREAIARGADDLLVAFGDTPLITAETFAR
HHHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHH
LRAALAQGAALAVLGFRAVDPTGYGRLLLDGSKLVAIREHADASEAERAITLCNAGVMAM
HHHHHHCCCEEEEEEEEEECCCCCCEEEECCCEEEEEECCCCHHHHHHEEEEECCCEEEE
DGRRALAILDKIGNTNSKGEYYLVDAVAIARSQGLDAVVIETSEDEVRGINTKAQLAQAE
CCCHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCCCEEEEECCCHHHCCCCHHHHHHHHH
AAMQARLRQAAMDAGVTLIAPETVYLAADTTFGRDVTIEPFVVIGPGVSIGDGAVVHSFS
HHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCCCEEECCEEEECCCCCCCCCHHHHHHH
HVVQSKLGSNTLLGPFARLRPGTSLGDGAKIGNFVEAKAAVLEPGVKVNHLSYIGDAHVG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCC
AHSNIGAGTITCNYDGFNKHKTRIGEGAFIGTNTSLVAPINIGARAYIGSGSVITRDVPD
CCCCCCCEEEEEECCCCCHHHHCCCCCEEEECCCCEEEEECCCCEEEECCCCEEEECCCC
DALALERSPQTTKEGAAARFRNAKLRQTK
HHHEECCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMTARSSLTIVLAAGEGTRMRSSLPKVLHPIAGESMLAHVLAAAPQGDGAAIAVVIGPGH
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
DAVEKEAKRLCPDVAIFVQRERLGTAHAVLAAREAIARGADDLLVAFGDTPLITAETFAR
HHHHHHHHHHCCCEEEEEEHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHH
LRAALAQGAALAVLGFRAVDPTGYGRLLLDGSKLVAIREHADASEAERAITLCNAGVMAM
HHHHHHCCCEEEEEEEEEECCCCCCEEEECCCEEEEEECCCCHHHHHHEEEEECCCEEEE
DGRRALAILDKIGNTNSKGEYYLVDAVAIARSQGLDAVVIETSEDEVRGINTKAQLAQAE
CCCHHHHHHHHHCCCCCCCCEEEEEEEEHHHHCCCCEEEEECCCHHHCCCCHHHHHHHHH
AAMQARLRQAAMDAGVTLIAPETVYLAADTTFGRDVTIEPFVVIGPGVSIGDGAVVHSFS
HHHHHHHHHHHHHCCEEEEECCEEEEEECCCCCCCEEECCEEEECCCCCCCCCHHHHHHH
HVVQSKLGSNTLLGPFARLRPGTSLGDGAKIGNFVEAKAAVLEPGVKVNHLSYIGDAHVG
HHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCC
AHSNIGAGTITCNYDGFNKHKTRIGEGAFIGTNTSLVAPINIGARAYIGSGSVITRDVPD
CCCCCCCEEEEEECCCCCHHHHCCCCCEEEECCCCEEEEECCCCEEEECCCCEEEECCCC
DALALERSPQTTKEGAAARFRNAKLRQTK
HHHEECCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA