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The map label for this gene is rnd [H]

Identifier: 146340329

GI number: 146340329

Start: 3547793

End: 3548962

Strand: Reverse

Name: rnd [H]

Synonym: BRADO3356

Alternate gene names: 146340329

Gene position: 3548962-3547793 (Counterclockwise)

Preceding gene: 146340330

Following gene: 146340324

Centisome position: 47.59

GC content: 66.5

Gene sequence:

>1170_bases
GTGCCTCGTCATGGATCGTTCATGGACTTGATCACCACCACCGCGGACCTCGCAGCCGCCTGCGCCCGCCTCGCCCAACA
CCCGGTCATCACCGTCGATACCGAGTTCCTGCGGGAGACCACCTACTACCCCCTGCTCTGCGTCGTGCAGATGGCGAGCC
AGGACGAGGCCGTGGTGATCGACGCGCTCGCCGAGGGCATCGATCTCAAGGCGTTCTTCGAGCTGATGGCCAATGAGAAG
GTCCTCAAGGTCTTCCACGCCGCCCGCCAGGATATCGAGATCATCTGGCACCGCGCCGGCATCGTGCCGCACCCGATCTT
CGACACCCAGGTCGCCGCAATGGTGCTGGGATACGGCGACAGCATCGCCTACGATCAGTTGGTCGAACGCATTACCGGTC
ACCGCCCGGACAAGACCCACCGCTTCACCGACTGGTCGCGCCGGCCGCTCACCAAGGAGCAGGCGCATTACGCCGAGGCC
GACGTCACCCATCTGCGCGACGTGTTCGCCGCGCTCGATACGGATCTCAAGAAGCGCGGCCGTAGCGACTGGGTCAGCGA
GGAGATGGAGATCCTGACCTCGCCGAAGACCTACGACTTCCATCCCGAGCGCGCCTGGGAACGGCTGAAGACCCGCGTCC
GCAAGCCGAAGGAATTAGCTGTCCTGATCGAGGTCGCCGCCTGGCGCGAGCAGGAGGCGCAGAGCCGCGACGTGCCGCGC
AGCCGTGTCATGAAGGACGACGCCGTCGGCGATATCGCCACGCACGCTCCGACGACGATCGAGAAGCTCGGCAATCTGCG
TTCGCTGCCCAAAGGCTTCGAGCGCTCGAAATGGGGCTCCGACATCGTCGCCGCCGTGCAGCGCGGGCTCGCCCGCGACC
TCGCTGGTCTGCCCAAGCTGGAGAAGCCGCGCAACAATTCCAACGGGGCCGCGATCGTCGAGCTGCTGAAAGTCCTGCTA
CGCATGACCTCCGAGCGTCACGCCGTCGCCAGCAAGGTGATCGCCACCGTCGATGATCTCGAGCAGATCGCGGCCGACGA
CCAGGCCGACGTCGCGGCGCTGCAGGGCTGGCGCCGCGAGCTGTTCGGCGAGGCTGCGCTGGCGCTGAAGCATGGCAAGC
TCGCGCTCGCCATCGACAAGGGCCGCGTCGTCAGGGTCGACCGGCCCTGA

Upstream 100 bases:

>100_bases
TTGCGTTCCGGCCGGTTTGGGCCGACAAGCGGGGACGAATTTCGTCTCGTACCCTTTGCCGACACCCTTGACTTGTCAGC
GTTTTCGGACGACGGCGTAA

Downstream 100 bases:

>100_bases
GCGGGCGACCACGGCAATTATTTACCGTTGATATCCTCACTGCTGCGGCTTGTTTCTTGCGGCGGGAAGATTCCATCGCC
GGCAACTACTCGCATGCCGT

Product: ribonuclease D (RNase D)

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MPRHGSFMDLITTTADLAAACARLAQHPVITVDTEFLRETTYYPLLCVVQMASQDEAVVIDALAEGIDLKAFFELMANEK
VLKVFHAARQDIEIIWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQLVERITGHRPDKTHRFTDWSRRPLTKEQAHYAEA
DVTHLRDVFAALDTDLKKRGRSDWVSEEMEILTSPKTYDFHPERAWERLKTRVRKPKELAVLIEVAAWREQEAQSRDVPR
SRVMKDDAVGDIATHAPTTIEKLGNLRSLPKGFERSKWGSDIVAAVQRGLARDLAGLPKLEKPRNNSNGAAIVELLKVLL
RMTSERHAVASKVIATVDDLEQIAADDQADVAALQGWRRELFGEAALALKHGKLALAIDKGRVVRVDRP

Sequences:

>Translated_389_residues
MPRHGSFMDLITTTADLAAACARLAQHPVITVDTEFLRETTYYPLLCVVQMASQDEAVVIDALAEGIDLKAFFELMANEK
VLKVFHAARQDIEIIWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQLVERITGHRPDKTHRFTDWSRRPLTKEQAHYAEA
DVTHLRDVFAALDTDLKKRGRSDWVSEEMEILTSPKTYDFHPERAWERLKTRVRKPKELAVLIEVAAWREQEAQSRDVPR
SRVMKDDAVGDIATHAPTTIEKLGNLRSLPKGFERSKWGSDIVAAVQRGLARDLAGLPKLEKPRNNSNGAAIVELLKVLL
RMTSERHAVASKVIATVDDLEQIAADDQADVAALQGWRRELFGEAALALKHGKLALAIDKGRVVRVDRP
>Mature_388_residues
PRHGSFMDLITTTADLAAACARLAQHPVITVDTEFLRETTYYPLLCVVQMASQDEAVVIDALAEGIDLKAFFELMANEKV
LKVFHAARQDIEIIWHRAGIVPHPIFDTQVAAMVLGYGDSIAYDQLVERITGHRPDKTHRFTDWSRRPLTKEQAHYAEAD
VTHLRDVFAALDTDLKKRGRSDWVSEEMEILTSPKTYDFHPERAWERLKTRVRKPKELAVLIEVAAWREQEAQSRDVPRS
RVMKDDAVGDIATHAPTTIEKLGNLRSLPKGFERSKWGSDIVAAVQRGLARDLAGLPKLEKPRNNSNGAAIVELLKVLLR
MTSERHAVASKVIATVDDLEQIAADDQADVAALQGWRRELFGEAALALKHGKLALAIDKGRVVRVDRP

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=257, Percent_Identity=23.3463035019455, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI50301240, Length=257, Percent_Identity=23.3463035019455, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1788105, Length=370, Percent_Identity=29.4594594594595, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17531757, Length=238, Percent_Identity=27.7310924369748, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=267, Percent_Identity=25.4681647940075, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI161078302, Length=261, Percent_Identity=25.6704980842912, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43623; Mature: 43492

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRHGSFMDLITTTADLAAACARLAQHPVITVDTEFLRETTYYPLLCVVQMASQDEAVVI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHCCHHHHHHHHHCCCCCCEEH
DALAEGIDLKAFFELMANEKVLKVFHAARQDIEIIWHRAGIVPHPIFDTQVAAMVLGYGD
HHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
SIAYDQLVERITGHRPDKTHRFTDWSRRPLTKEQAHYAEADVTHLRDVFAALDTDLKKRG
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RSDWVSEEMEILTSPKTYDFHPERAWERLKTRVRKPKELAVLIEVAAWREQEAQSRDVPR
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCH
SRVMKDDAVGDIATHAPTTIEKLGNLRSLPKGFERSKWGSDIVAAVQRGLARDLAGLPKL
HHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCC
EKPRNNSNGAAIVELLKVLLRMTSERHAVASKVIATVDDLEQIAADDQADVAALQGWRRE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LFGEAALALKHGKLALAIDKGRVVRVDRP
HHHHHHHHHCCCCEEEEECCCCEEEECCC
>Mature Secondary Structure 
PRHGSFMDLITTTADLAAACARLAQHPVITVDTEFLRETTYYPLLCVVQMASQDEAVVI
CCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHCCHHHHHHHHHCCCCCCEEH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HHHHHHHHHCCCCEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]