Click here to switch to the map view.

The map label for this gene is yvaG [H]

Identifier: 146340084

GI number: 146340084

Start: 3288659

End: 3289480

Strand: Direct

Name: yvaG [H]

Synonym: BRADO3093

Alternate gene names: 146340084

Gene position: 3288659-3289480 (Clockwise)

Preceding gene: 146340083

Following gene: 146340085

Centisome position: 44.1

GC content: 65.69

Gene sequence:

>822_bases
TTGCTCCAGCACTACGGAGAGCTGCTCATGCATATCGACCTCTCGGGTAAAACCGCGCTTGTCACCGGTTCCACAGCCGG
CATCGGCTTTGCGATCGCCAAAGGACTCGCCGCGTCCGGCGCGGAGGTGATCCTCAACGGACGTGCCCAAGGCCGTGTCG
ATGACGCCGTCGCGCGCCTGAAGCAGGCAGTGCCGTCCGCCAAGGTCCGCGGCGTCGCCGGCGATGTCGCCCAGGTCGAC
GGCGGCAACGCCATCGTCACGGCAGTCCCCGAGGTCCACATCCTCGTCAACAATGCCGGGATCTTCGAGCCGAAGGACTT
TTTCGAGATTCCCGACGAGGACTGGAGCCGCTTCTTCGAGGTCAACGTGCTCTCCGGCGTGCGCATGGCGCGCGCCTACA
TGCAGGGCATGCTGAAGCGCAACTGGGGCCGCATCATCTTCATCTCCTCGGAGTCGGCGCTGAACATCCCGACCGAGATG
ATCCACTACGGCATGACCAAGACCGCGCAGCTGTCGGTCTCGCGCGGCCTCGCCAAGCTGACGCGCGGCACCGGCGTCAC
GGTCAATTCCGTGCTGCCGGGTCCGACGATGTCGGAAGGCGTGGAGACCTTCGTCAAGGATCTGGCGCGGCAGAACAGCC
AGTCGGAGCAGGAAGCGGCATCGGCTTTCGTCCGGCAGCACCGCCCAGCCTCGCTGCTGCAGCGCTTCGCCAGCGTCGAC
GAGATCGCCAACTTGGTCGTCTACGTCGCGTCCAAGGAGGCCTCCGCAACCAACGGCGCCGCGCTGCGCGCCGAGGGCGG
CATCATCGATACGATTGCGTAG

Upstream 100 bases:

>100_bases
TGCAGGCCTTGGCGGACAAGCCGCTCATCCGGGCTACCCTCAAAAAGGATCAGTTCTGCGCGCAGCGCGTTGGGGTCGGC
GCAATGGCGACCTACATGCG

Downstream 100 bases:

>100_bases
TCGTCGTTGCGTAGCCCGCATGAGCGCAGCGACATGCGGGTCCACACGCACAGCGCGTGAGACCCCGGATGTCGCTTCGC
TTATCCGGGCTACGACATGA

Product: putative short-chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MLQHYGELLMHIDLSGKTALVTGSTAGIGFAIAKGLAASGAEVILNGRAQGRVDDAVARLKQAVPSAKVRGVAGDVAQVD
GGNAIVTAVPEVHILVNNAGIFEPKDFFEIPDEDWSRFFEVNVLSGVRMARAYMQGMLKRNWGRIIFISSESALNIPTEM
IHYGMTKTAQLSVSRGLAKLTRGTGVTVNSVLPGPTMSEGVETFVKDLARQNSQSEQEAASAFVRQHRPASLLQRFASVD
EIANLVVYVASKEASATNGAALRAEGGIIDTIA

Sequences:

>Translated_273_residues
MLQHYGELLMHIDLSGKTALVTGSTAGIGFAIAKGLAASGAEVILNGRAQGRVDDAVARLKQAVPSAKVRGVAGDVAQVD
GGNAIVTAVPEVHILVNNAGIFEPKDFFEIPDEDWSRFFEVNVLSGVRMARAYMQGMLKRNWGRIIFISSESALNIPTEM
IHYGMTKTAQLSVSRGLAKLTRGTGVTVNSVLPGPTMSEGVETFVKDLARQNSQSEQEAASAFVRQHRPASLLQRFASVD
EIANLVVYVASKEASATNGAALRAEGGIIDTIA
>Mature_273_residues
MLQHYGELLMHIDLSGKTALVTGSTAGIGFAIAKGLAASGAEVILNGRAQGRVDDAVARLKQAVPSAKVRGVAGDVAQVD
GGNAIVTAVPEVHILVNNAGIFEPKDFFEIPDEDWSRFFEVNVLSGVRMARAYMQGMLKRNWGRIIFISSESALNIPTEM
IHYGMTKTAQLSVSRGLAKLTRGTGVTVNSVLPGPTMSEGVETFVKDLARQNSQSEQEAASAFVRQHRPASLLQRFASVD
EIANLVVYVASKEASATNGAALRAEGGIIDTIA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=29.3893129770992, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI7705855, Length=210, Percent_Identity=35.2380952380952, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI5031737, Length=259, Percent_Identity=29.7297297297297, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI7706523, Length=254, Percent_Identity=30.7086614173228, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI7705925, Length=259, Percent_Identity=27.027027027027, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI126723191, Length=173, Percent_Identity=34.6820809248555, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33667109, Length=187, Percent_Identity=33.6898395721925, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4504505, Length=200, Percent_Identity=28.5, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI126723750, Length=263, Percent_Identity=26.2357414448669, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=27.4131274131274, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI109715829, Length=246, Percent_Identity=27.6422764227642, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=25.0950570342205, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10190704, Length=281, Percent_Identity=28.4697508896797, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=264, Percent_Identity=32.5757575757576, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1790717, Length=272, Percent_Identity=29.0441176470588, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082100, Length=263, Percent_Identity=28.1368821292776, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787905, Length=267, Percent_Identity=28.4644194756554, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786812, Length=245, Percent_Identity=28.9795918367347, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=266, Percent_Identity=25.9398496240602, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082160, Length=267, Percent_Identity=25.8426966292135, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=28.4584980237154, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788459, Length=264, Percent_Identity=25.3787878787879, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=32.4175824175824, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=264, Percent_Identity=32.5757575757576, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17560676, Length=261, Percent_Identity=28.3524904214559, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=32.4528301886792, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=262, Percent_Identity=30.5343511450382, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=28.3464566929134, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=29.4339622641509, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=26.9662921348315, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=30.4511278195489, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=25.968992248062, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71992402, Length=222, Percent_Identity=28.3783783783784, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=30.188679245283, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=27.3764258555133, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=203, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=27.4436090225564, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=28.1853281853282, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=30.2238805970149, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32565532, Length=143, Percent_Identity=29.3706293706294, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=211, Percent_Identity=29.8578199052133, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=249, Percent_Identity=28.1124497991968, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=29.5019157088123, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639444, Length=258, Percent_Identity=29.0697674418605, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643142, Length=259, Percent_Identity=28.1853281853282, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI23397609, Length=260, Percent_Identity=27.6923076923077, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644339, Length=263, Percent_Identity=27.3764258555133, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=28.6274509803922, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859837, Length=196, Percent_Identity=27.5510204081633, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=26.5625, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28980; Mature: 28980

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQHYGELLMHIDLSGKTALVTGSTAGIGFAIAKGLAASGAEVILNGRAQGRVDDAVARL
CCCHHCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
KQAVPSAKVRGVAGDVAQVDGGNAIVTAVPEVHILVNNAGIFEPKDFFEIPDEDWSRFFE
HHHCCCHHHCCCCCCCEEECCCCEEEEECCEEEEEEECCCCCCCHHHCCCCCHHHHHEEE
VNVLSGVRMARAYMQGMLKRNWGRIIFISSESALNIPTEMIHYGMTKTAQLSVSRGLAKL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHH
TRGTGVTVNSVLPGPTMSEGVETFVKDLARQNSQSEQEAASAFVRQHRPASLLQRFASVD
HCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
EIANLVVYVASKEASATNGAALRAEGGIIDTIA
HHHHEEEEEECCCCCCCCCCEEEECCCEEECCC
>Mature Secondary Structure
MLQHYGELLMHIDLSGKTALVTGSTAGIGFAIAKGLAASGAEVILNGRAQGRVDDAVARL
CCCHHCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
KQAVPSAKVRGVAGDVAQVDGGNAIVTAVPEVHILVNNAGIFEPKDFFEIPDEDWSRFFE
HHHCCCHHHCCCCCCCEEECCCCEEEEECCEEEEEEECCCCCCCHHHCCCCCHHHHHEEE
VNVLSGVRMARAYMQGMLKRNWGRIIFISSESALNIPTEMIHYGMTKTAQLSVSRGLAKL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHH
TRGTGVTVNSVLPGPTMSEGVETFVKDLARQNSQSEQEAASAFVRQHRPASLLQRFASVD
HCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
EIANLVVYVASKEASATNGAALRAEGGIIDTIA
HHHHEEEEEECCCCCCCCCCEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]