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The map label for this gene is Hgd [H]

Identifier: 146340010

GI number: 146340010

Start: 3213254

End: 3214135

Strand: Direct

Name: Hgd [H]

Synonym: BRADO3016

Alternate gene names: 146340010

Gene position: 3213254-3214135 (Clockwise)

Preceding gene: 146340007

Following gene: 146340011

Centisome position: 43.09

GC content: 67.8

Gene sequence:

>882_bases
GTGACCACGATCGGCATCATCGGACTTGGCAACATGGGGCGGGGGATGGCCACGACGCTCAAGGGCGCGGGCTTCGCCGT
CACCGGATACGACGCATCCGAAGCGACGCGGGCCGCGCTCGCCAAAGAGGACATAGTGATCGTGGACGGCATCGGCGCAG
TCGTCGCCTCAGCCGATATCGTGATCCTGTCGCTGCCGACCGCCGAGATCGTCGAGCGCGTGGTGGCGGGCGAGGGCGGC
ATCCTCGCGCATGCGGAAGCGGGTGTCGTCATCGTCGACACCTCGACCTCTCACCCCGAGACCTCGCGGCGACTGGCCGG
CCTGCTGAAGGCGAAAAGCATGGGCTTCGTCGATGCGCCGGTCAGCGGCGGGCCGAAGGGGGCCGCGACCGGCACCATGA
CGATGGTGATTGGTGCCGCCGACGAGGATCTCGCGCGGGTGCTGCCGGTGCTGGAGAAGATGAGCGCCAGGCGCGTGCAT
GTCGGCGGCGTCGGCGCCGGCAACGTCGCCAAGATCGTCAACAATCTTCTCTGCGCCGCACATCTGCTCACCGCCGCCGA
AGCGCTGCGCATCGCGGCTGCGGCCGGCGTCAATGCCTTCAGGCTGCTCGACGGCCTCAATGCGGGCTCGGGCCGCTCCG
GCGTGACGCAAGTCAATGTGCCTAACTGGATCCTCAACGGCGCCTTCGATTCCGGCTTCACGATGCAGCTGATGCGCAAG
GATGTGCGACTGGCGGCGCAGTTCATCGGTGAGCTCGGCCTCGCGCTGCCGATGGCCGCGGACACCGCGCGCATCTGGGC
GGACAGTGCTGGCAGCATCACCGACTCCGAGGATTTCAACCGCATCGTCGAGCTGCAGCTCGGCCCGATCAGCCAGCCGT
GA

Upstream 100 bases:

>100_bases
GAAAAGCGTTGACTTGCAGTCAACACTAACGCCGCGGGCTGCTCATGTCTGCCGCAAATCGCGGCGGCTAGGCTTCCTCG
GCAATGGCGCAGGAGGCCTC

Downstream 100 bases:

>100_bases
GAGCGCAAGCCATGACGCATTTCATCGATCCCCGCCTACGCGACGCGGCGCTGCCGTTCTGGCCCGAGTTCGAGACGATC
GGCTCGCATGTCGGCGGCGA

Product: putative 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTTIGIIGLGNMGRGMATTLKGAGFAVTGYDASEATRAALAKEDIVIVDGIGAVVASADIVILSLPTAEIVERVVAGEGG
ILAHAEAGVVIVDTSTSHPETSRRLAGLLKAKSMGFVDAPVSGGPKGAATGTMTMVIGAADEDLARVLPVLEKMSARRVH
VGGVGAGNVAKIVNNLLCAAHLLTAAEALRIAAAAGVNAFRLLDGLNAGSGRSGVTQVNVPNWILNGAFDSGFTMQLMRK
DVRLAAQFIGELGLALPMAADTARIWADSAGSITDSEDFNRIVELQLGPISQP

Sequences:

>Translated_293_residues
MTTIGIIGLGNMGRGMATTLKGAGFAVTGYDASEATRAALAKEDIVIVDGIGAVVASADIVILSLPTAEIVERVVAGEGG
ILAHAEAGVVIVDTSTSHPETSRRLAGLLKAKSMGFVDAPVSGGPKGAATGTMTMVIGAADEDLARVLPVLEKMSARRVH
VGGVGAGNVAKIVNNLLCAAHLLTAAEALRIAAAAGVNAFRLLDGLNAGSGRSGVTQVNVPNWILNGAFDSGFTMQLMRK
DVRLAAQFIGELGLALPMAADTARIWADSAGSITDSEDFNRIVELQLGPISQP
>Mature_292_residues
TTIGIIGLGNMGRGMATTLKGAGFAVTGYDASEATRAALAKEDIVIVDGIGAVVASADIVILSLPTAEIVERVVAGEGGI
LAHAEAGVVIVDTSTSHPETSRRLAGLLKAKSMGFVDAPVSGGPKGAATGTMTMVIGAADEDLARVLPVLEKMSARRVHV
GGVGAGNVAKIVNNLLCAAHLLTAAEALRIAAAAGVNAFRLLDGLNAGSGRSGVTQVNVPNWILNGAFDSGFTMQLMRKD
VRLAAQFIGELGLALPMAADTARIWADSAGSITDSEDFNRIVELQLGPISQP

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=251, Percent_Identity=33.8645418326693, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI40556376, Length=273, Percent_Identity=29.3040293040293, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI145693186, Length=257, Percent_Identity=31.9066147859922, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=31.4878892733564, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1789092, Length=292, Percent_Identity=27.3972602739726, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=276, Percent_Identity=32.9710144927536, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24655230, Length=290, Percent_Identity=27.9310344827586, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19922568, Length=290, Percent_Identity=27.9310344827586, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 29792; Mature: 29661

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIGIIGLGNMGRGMATTLKGAGFAVTGYDASEATRAALAKEDIVIVDGIGAVVASADI
CCEEEEEEECCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHCCEEEEECCHHHHHCCCE
VILSLPTAEIVERVVAGEGGILAHAEAGVVIVDTSTSHPETSRRLAGLLKAKSMGFVDAP
EEEECCHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEECC
VSGGPKGAATGTMTMVIGAADEDLARVLPVLEKMSARRVHVGGVGAGNVAKIVNNLLCAA
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
HLLTAAEALRIAAAAGVNAFRLLDGLNAGSGRSGVTQVNVPNWILNGAFDSGFTMQLMRK
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHH
DVRLAAQFIGELGLALPMAADTARIWADSAGSITDSEDFNRIVELQLGPISQP
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHCEEEEEEECCCCCC
>Mature Secondary Structure 
TTIGIIGLGNMGRGMATTLKGAGFAVTGYDASEATRAALAKEDIVIVDGIGAVVASADI
CEEEEEEECCCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHCCEEEEECCHHHHHCCCE
VILSLPTAEIVERVVAGEGGILAHAEAGVVIVDTSTSHPETSRRLAGLLKAKSMGFVDAP
EEEECCHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEECC
VSGGPKGAATGTMTMVIGAADEDLARVLPVLEKMSARRVHVGGVGAGNVAKIVNNLLCAA
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHH
HLLTAAEALRIAAAAGVNAFRLLDGLNAGSGRSGVTQVNVPNWILNGAFDSGFTMQLMRK
HHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEECCCCEEEECCCCCCHHHHHHHH
DVRLAAQFIGELGLALPMAADTARIWADSAGSITDSEDFNRIVELQLGPISQP
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA