Click here to switch to the map view.

The map label for this gene is yeaU [C]

Identifier: 146339543

GI number: 146339543

Start: 2707432

End: 2708520

Strand: Direct

Name: yeaU [C]

Synonym: BRADO2534

Alternate gene names: 146339543

Gene position: 2707432-2708520 (Clockwise)

Preceding gene: 146339536

Following gene: 146339547

Centisome position: 36.31

GC content: 63.82

Gene sequence:

>1089_bases
GTGAGGATCCGCTCGATGAGCAAGAAGCCCTATCGCATCGCAGTCATTCCCGGCGACGGCATCGGCAAGGAGGTCATGCC
CGAGGGATTGCGCGTGATCGAGGCGGCCGCCAAGAAGCATGGCGTCGCGGTGCAGTTCGATCATTTCGACTTCTCGAGCT
ACGACTATTACGAGAAGCACGGCCAGATGATGCCTGACGACTGGAAGAGCCAGATCGGCGGCCATGACGCGATCTACTTC
GGCGCCGTCGGCTGGCCGGCCAAGATCGCCGACCACGTCTCGCTGTGGGGCTCGCTGATCAAGTTCCGCCGCGAGTTCGA
TCAGTATGTGAACCTGCGTCCGGTGCGGCTGATGCCGGGCGTGCCGTGCCCGCTGGCCAACCGCAAGCCGGGCGACATCG
ATTTCTGGGTGGTGCGCGAGAACACGGAAGGCGAGTACTCGTCCGTCGGCGGCCGCATGTTCCCTGACACCGACCGCGAG
TTCGTCACGCAGCAGACGGTGATGACCCGCACCGGCGTCGACCGCATCCTGAAGTTCGCGTTCGAGCTCGCGCAGTCCCG
GCCGAAGAAGCATCTGACGTCGGCGACCAAGTCCAACGGCATTTCGATCACGATGCCGTATTGGGACGAGCGGGTCGAAG
CGATGGCGAAGAACTATCCGGGCGTGAAGTGGGACAAATACCACATCGACATCCTCACCGCGAATTTCGTGCTGCATCCG
GACTGGTTCGACGTCGTCGTCGGCTCCAATTTGTTCGGCGACATCCTGTCGGATCTCGGCCCGGCCTGCACCGGCACCAT
CGGCATCGCGCCGTCCGGCAACATCAATCCGGAACGCAATTTCCCGTCGGTGTTCGAGCCGGTGCACGGCTCGGCGCCTG
ATATCGCCGGGCAGGGAATCGCCAATCCGATCGGCATGATCTGGTCGGGCGCGATGATGCTGGAGCATCTGGGGGAGAAG
ACCGCGGCGCAGTCCATCGTCGGCGCGATCGAGCGCACGCTCGCGGAGCGGACGTTGCGGACGCGGGATCTCGGCGGCAA
TGCGGATACGGTGGCGTGTGGCAAGGCGGTCGCGGAGATGGTGGATTAG

Upstream 100 bases:

>100_bases
CGCCAGCCATGCGGTCAATCTTGCACCGCAGCGTTGCGCTTGCCTCCGGTTTGGTCCATTCAGGCGATCGACGATTTCGG
CCGGGCTAACCGGCGACCAT

Downstream 100 bases:

>100_bases
CTCAGCTGTTTATCGTCGCCCCGGCGAACGCCGGGGCCCATAACCACCGGCCGTCGTTGTGGCTACCGGTCTCTGCCACC
GTTCGCTACTGATCAATCAC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MRIRSMSKKPYRIAVIPGDGIGKEVMPEGLRVIEAAAKKHGVAVQFDHFDFSSYDYYEKHGQMMPDDWKSQIGGHDAIYF
GAVGWPAKIADHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPCPLANRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDRE
FVTQQTVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKNYPGVKWDKYHIDILTANFVLHP
DWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPERNFPSVFEPVHGSAPDIAGQGIANPIGMIWSGAMMLEHLGEK
TAAQSIVGAIERTLAERTLRTRDLGGNADTVACGKAVAEMVD

Sequences:

>Translated_362_residues
MRIRSMSKKPYRIAVIPGDGIGKEVMPEGLRVIEAAAKKHGVAVQFDHFDFSSYDYYEKHGQMMPDDWKSQIGGHDAIYF
GAVGWPAKIADHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPCPLANRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDRE
FVTQQTVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKNYPGVKWDKYHIDILTANFVLHP
DWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPERNFPSVFEPVHGSAPDIAGQGIANPIGMIWSGAMMLEHLGEK
TAAQSIVGAIERTLAERTLRTRDLGGNADTVACGKAVAEMVD
>Mature_362_residues
MRIRSMSKKPYRIAVIPGDGIGKEVMPEGLRVIEAAAKKHGVAVQFDHFDFSSYDYYEKHGQMMPDDWKSQIGGHDAIYF
GAVGWPAKIADHVSLWGSLIKFRREFDQYVNLRPVRLMPGVPCPLANRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDRE
FVTQQTVMTRTGVDRILKFAFELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKNYPGVKWDKYHIDILTANFVLHP
DWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPERNFPSVFEPVHGSAPDIAGQGIANPIGMIWSGAMMLEHLGEK
TAAQSIVGAIERTLAERTLRTRDLGGNADTVACGKAVAEMVD

Specific function: Has multiple catalytic activities. Apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate, also converts meso-tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate [H]

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=337, Percent_Identity=32.3442136498516, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI28178821, Length=347, Percent_Identity=27.9538904899135, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI28178816, Length=340, Percent_Identity=27.6470588235294, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4758582, Length=345, Percent_Identity=28.4057971014493, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI28178838, Length=335, Percent_Identity=28.0597014925373, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI28178819, Length=207, Percent_Identity=29.951690821256, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788101, Length=358, Percent_Identity=66.4804469273743, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI87081683, Length=353, Percent_Identity=38.2436260623229, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1787381, Length=370, Percent_Identity=28.6486486486486, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550882, Length=351, Percent_Identity=30.7692307692308, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71986051, Length=362, Percent_Identity=31.4917127071823, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=357, Percent_Identity=26.890756302521, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17505779, Length=341, Percent_Identity=28.1524926686217, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322097, Length=361, Percent_Identity=36.2880886426593, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6324291, Length=354, Percent_Identity=31.638418079096, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324709, Length=351, Percent_Identity=31.3390313390313, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319830, Length=367, Percent_Identity=32.6975476839237, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643270, Length=348, Percent_Identity=31.8965517241379, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24643268, Length=348, Percent_Identity=31.8965517241379, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24661184, Length=346, Percent_Identity=30.3468208092486, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281362242, Length=346, Percent_Identity=28.6127167630058, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24648872, Length=346, Percent_Identity=28.6127167630058, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI161078635, Length=337, Percent_Identity=27.5964391691395, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI161078637, Length=337, Percent_Identity=27.5964391691395, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI161078633, Length=337, Percent_Identity=27.5964391691395, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24650122, Length=337, Percent_Identity=27.5964391691395, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI161078639, Length=248, Percent_Identity=31.0483870967742, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI20130355, Length=357, Percent_Identity=25.2100840336134, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 40061; Mature: 40061

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRSMSKKPYRIAVIPGDGIGKEVMPEGLRVIEAAAKKHGVAVQFDHFDFSSYDYYEKH
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHC
GQMMPDDWKSQIGGHDAIYFGAVGWPAKIADHVSLWGSLIKFRREFDQYVNLRPVRLMPG
CCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
VPCPLANRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQTVMTRTGVDRILKFA
CCCCCCCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKNYPGVKWDKYHIDILTANFVLHP
HHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECC
DWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPERNFPSVFEPVHGSAPDIAGQGI
CHHHHHHCCHHHHHHHHHCCCHHCCEEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
ANPIGMIWSGAMMLEHLGEKTAAQSIVGAIERTLAERTLRTRDLGGNADTVACGKAVAEM
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VD
CC
>Mature Secondary Structure
MRIRSMSKKPYRIAVIPGDGIGKEVMPEGLRVIEAAAKKHGVAVQFDHFDFSSYDYYEKH
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHC
GQMMPDDWKSQIGGHDAIYFGAVGWPAKIADHVSLWGSLIKFRREFDQYVNLRPVRLMPG
CCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
VPCPLANRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQTVMTRTGVDRILKFA
CCCCCCCCCCCCEEEEEEEECCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FELAQSRPKKHLTSATKSNGISITMPYWDERVEAMAKNYPGVKWDKYHIDILTANFVLHP
HHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECC
DWFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPERNFPSVFEPVHGSAPDIAGQGI
CHHHHHHCCHHHHHHHHHCCCHHCCEEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
ANPIGMIWSGAMMLEHLGEKTAAQSIVGAIERTLAERTLRTRDLGGNADTVACGKAVAEM
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8053675; 2184888; 8457548 [H]