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The map label for this gene is fadA [H]

Identifier: 146339408

GI number: 146339408

Start: 2550313

End: 2551545

Strand: Direct

Name: fadA [H]

Synonym: BRADO2393

Alternate gene names: 146339408

Gene position: 2550313-2551545 (Clockwise)

Preceding gene: 146339403

Following gene: 146339409

Centisome position: 34.2

GC content: 68.69

Gene sequence:

>1233_bases
ATGGTCGACGCACTCATCATCGATGCCTGCAGGACCCCGCGAGGTATCGGCAAGGCCGGCAAGGGGGCGCTGGCCGGTCT
GCATCCGCAGCATCTCGGCGCCACCGTGCTGCGTGCGCTGGCCGAGCGCACCGGCATCGACACCGGCGATGTCGACGACA
TCATCTGGGGCTGCTCGTCGCAGCGCGGACCGCAGAGCGGCGATCTCGGCCGCATGTCGGCGCTCGATGCCGGCTATGAC
ATCCGCGCCTCCGGCGTCACGCTCGACCGCTTCTGCGGCTCCGGCATCACCAGCGTCAACATTGCGGCTGCCCAGATCAT
GGCCGGGCAGGAGGATCTCGTCGTCGCCGGCGGCTGCGAGATGATGTCCATGGAAGGTCGGCGCGGCGAGGGGCCGCTGA
TGATGGATGCCGGCAATCTGCATCTCCGCGCGCTGCACCCGCAGTCGCACCAGGGCGTTTGCGCGGACGCCATCGCCACC
ATGGAAGGCATCACGCGGTCCGATGTCGATGCGCTCGGGCTGGAGAGCCAGAAGCGGGCGGCGGCGGCGATCGCGGGCGG
GCACTTCAAGAAGAGCCTGGTGCCGGTGCATCGCGAGGACGGCAGCCTCGCGCTCGATCACGAGGAGTATCCCCGGCCGC
AGACCACGGCCGAGGCGCTCGCCGGCTTGAAGCCGGCGTTCCCCGCGATCGCCGACTATGCGCTGGACGACAAGGGCACG
ACCTACCGCAACCTGATCCTGCAGCGCTACCCGGGTCTCGATATTCAGTTCGTGCACCACGCCGGCAACTCCTCCGGCGT
CGTCGACGGCGCCGCGGCGATCCTGCTGGCCTCGCCGTCCTACGCCAAGGCGCACGGCCTGAAGCCGCGGGCGCGAGTGG
TGGCGATGGCCAATATGGGCGACGACCCGACGCTGATGCTTAACGCCCCGGTGCCGGCGACCCGTAAGGTGCTCGCCAAG
GCCGGGCTGACCATCGACGACATCGACCTGTTCGAGATCAACGAGGCCTTCGCCGTCGTGGCCGAGAAGTACATCCGCGA
CCTCAAGCTCGACCGCGCCAAGGTCAACGTCAACGGCGGCTCGATTGCGCTCGGGCATCCGATCGGCGCCACCGGTTCCA
TCCTGATCGGAACGCTGCTCGACGAGCTGGAGCGGCGCGACCTCAAGCGCGGCTTGGTGACGATGTGTGCCGCCGGCGGC
ATGGCTCCGGCGATCATCATCGAGCGCGTCTGA

Upstream 100 bases:

>100_bases
TTCAACCACCGTTGTCGCGACCGCGGGCGCGATGCTATGCGACAGTGAAGGCGGCGGCGCGAGCGCCGACCGCACGACAA
CATCGGGCAAAGGAAACGCC

Downstream 100 bases:

>100_bases
GCGACCATTTCTCGATCGCATTGATCAACATCCGCTACGGACGACCCGCAGCGGGTGAGGGGCGCTTTGCGACTTTCCAG
GCTCTGCGTCGTTGACGCCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MVDALIIDACRTPRGIGKAGKGALAGLHPQHLGATVLRALAERTGIDTGDVDDIIWGCSSQRGPQSGDLGRMSALDAGYD
IRASGVTLDRFCGSGITSVNIAAAQIMAGQEDLVVAGGCEMMSMEGRRGEGPLMMDAGNLHLRALHPQSHQGVCADAIAT
MEGITRSDVDALGLESQKRAAAAIAGGHFKKSLVPVHREDGSLALDHEEYPRPQTTAEALAGLKPAFPAIADYALDDKGT
TYRNLILQRYPGLDIQFVHHAGNSSGVVDGAAAILLASPSYAKAHGLKPRARVVAMANMGDDPTLMLNAPVPATRKVLAK
AGLTIDDIDLFEINEAFAVVAEKYIRDLKLDRAKVNVNGGSIALGHPIGATGSILIGTLLDELERRDLKRGLVTMCAAGG
MAPAIIIERV

Sequences:

>Translated_410_residues
MVDALIIDACRTPRGIGKAGKGALAGLHPQHLGATVLRALAERTGIDTGDVDDIIWGCSSQRGPQSGDLGRMSALDAGYD
IRASGVTLDRFCGSGITSVNIAAAQIMAGQEDLVVAGGCEMMSMEGRRGEGPLMMDAGNLHLRALHPQSHQGVCADAIAT
MEGITRSDVDALGLESQKRAAAAIAGGHFKKSLVPVHREDGSLALDHEEYPRPQTTAEALAGLKPAFPAIADYALDDKGT
TYRNLILQRYPGLDIQFVHHAGNSSGVVDGAAAILLASPSYAKAHGLKPRARVVAMANMGDDPTLMLNAPVPATRKVLAK
AGLTIDDIDLFEINEAFAVVAEKYIRDLKLDRAKVNVNGGSIALGHPIGATGSILIGTLLDELERRDLKRGLVTMCAAGG
MAPAIIIERV
>Mature_410_residues
MVDALIIDACRTPRGIGKAGKGALAGLHPQHLGATVLRALAERTGIDTGDVDDIIWGCSSQRGPQSGDLGRMSALDAGYD
IRASGVTLDRFCGSGITSVNIAAAQIMAGQEDLVVAGGCEMMSMEGRRGEGPLMMDAGNLHLRALHPQSHQGVCADAIAT
MEGITRSDVDALGLESQKRAAAAIAGGHFKKSLVPVHREDGSLALDHEEYPRPQTTAEALAGLKPAFPAIADYALDDKGT
TYRNLILQRYPGLDIQFVHHAGNSSGVVDGAAAILLASPSYAKAHGLKPRARVVAMANMGDDPTLMLNAPVPATRKVLAK
AGLTIDDIDLFEINEAFAVVAEKYIRDLKLDRAKVNVNGGSIALGHPIGATGSILIGTLLDELERRDLKRGLVTMCAAGG
MAPAIIIERV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=416, Percent_Identity=34.1346153846154, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI167614485, Length=421, Percent_Identity=33.4916864608076, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4501853, Length=420, Percent_Identity=34.2857142857143, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI4557237, Length=423, Percent_Identity=30.9692671394799, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI4504327, Length=450, Percent_Identity=30.4444444444444, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI194353979, Length=89, Percent_Identity=50.561797752809, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1787663, Length=434, Percent_Identity=39.63133640553, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI1788554, Length=430, Percent_Identity=39.7674418604651, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI48994986, Length=426, Percent_Identity=37.3239436619718, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI87082165, Length=421, Percent_Identity=37.5296912114014, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1788683, Length=450, Percent_Identity=28.2222222222222, Blast_Score=115, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI133906874, Length=422, Percent_Identity=34.5971563981043, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=417, Percent_Identity=30.6954436450839, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI25147385, Length=420, Percent_Identity=28.5714285714286, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17551802, Length=452, Percent_Identity=26.3274336283186, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17535917, Length=417, Percent_Identity=26.6187050359712, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322031, Length=415, Percent_Identity=33.4939759036145, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=429, Percent_Identity=30.7692307692308, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24655093, Length=421, Percent_Identity=35.1543942992874, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24640423, Length=426, Percent_Identity=32.3943661971831, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=32.8358208955224, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17137578, Length=451, Percent_Identity=28.8248337028825, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 42912; Mature: 42912

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDALIIDACRTPRGIGKAGKGALAGLHPQHLGATVLRALAERTGIDTGDVDDIIWGCSS
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
QRGPQSGDLGRMSALDAGYDIRASGVTLDRFCGSGITSVNIAAAQIMAGQEDLVVAGGCE
CCCCCCCCCCCHHHCCCCCEEEECCEEHHHHHCCCCCEEHHHHHHHHCCCCCEEEECCCE
MMSMEGRRGEGPLMMDAGNLHLRALHPQSHQGVCADAIATMEGITRSDVDALGLESQKRA
EEECCCCCCCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHH
AAAIAGGHFKKSLVPVHREDGSLALDHEEYPRPQTTAEALAGLKPAFPAIADYALDDKGT
HHHHHCCCHHHCCCCEECCCCCEEECHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCC
TYRNLILQRYPGLDIQFVHHAGNSSGVVDGAAAILLASPSYAKAHGLKPRARVVAMANMG
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHCCCCCHHEEEEEECCC
DDPTLMLNAPVPATRKVLAKAGLTIDDIDLFEINEAFAVVAEKYIRDLKLDRAKVNVNGG
CCCEEEEECCCCHHHHHHHHCCCEEECCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCC
SIALGHPIGATGSILIGTLLDELERRDLKRGLVTMCAAGGMAPAIIIERV
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MVDALIIDACRTPRGIGKAGKGALAGLHPQHLGATVLRALAERTGIDTGDVDDIIWGCSS
CCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
QRGPQSGDLGRMSALDAGYDIRASGVTLDRFCGSGITSVNIAAAQIMAGQEDLVVAGGCE
CCCCCCCCCCCHHHCCCCCEEEECCEEHHHHHCCCCCEEHHHHHHHHCCCCCEEEECCCE
MMSMEGRRGEGPLMMDAGNLHLRALHPQSHQGVCADAIATMEGITRSDVDALGLESQKRA
EEECCCCCCCCCEEEECCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHH
AAAIAGGHFKKSLVPVHREDGSLALDHEEYPRPQTTAEALAGLKPAFPAIADYALDDKGT
HHHHHCCCHHHCCCCEECCCCCEEECHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCC
TYRNLILQRYPGLDIQFVHHAGNSSGVVDGAAAILLASPSYAKAHGLKPRARVVAMANMG
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHCCCCCHHEEEEEECCC
DDPTLMLNAPVPATRKVLAKAGLTIDDIDLFEINEAFAVVAEKYIRDLKLDRAKVNVNGG
CCCEEEEECCCCHHHHHHHHCCCEEECCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCC
SIALGHPIGATGSILIGTLLDELERRDLKRGLVTMCAAGGMAPAIIIERV
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]